ID title journal pub_time pmid gene_name gene_id cancer_type drug_name drug_id method_RNA method_drug tissue RNA_exp_pattern sensitive_or_resistant target_gene pathway validated_or_predicted variant epigenetic_regulation prognostic 1 SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer Tumour Biol 2014 25070488 SIRT5 ENSG00000124523 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of SIRT5 was detected by protein extraction and western blot, real-time quantitative PCR (q-PCR), Cell proliferation assay, Soft sugar colony formation assay, and Tumor xenograft experiments. cell lines (A549, LU99 and NCI-H460) up-regulated resistant NRF2 NA validated NA mRNA and protein overexpression related 2 SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer Tumour Biol 2014 25070488 SIRT5 ENSG00000124523 lung cancer 5-fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The role of SIRT5 was detected by protein extraction and western blot, real-time quantitative PCR (q-PCR), Cell proliferation assay, Soft sugar colony formation assay, and Tumor xenograft experiments. cell lines (A549, LU99 and NCI-H460) up-regulated resistant NRF2 NA validated NA mRNA and protein overexpression related 3 SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer Tumour Biol 2014 25070488 SIRT5 ENSG00000124523 lung cancer Bleomycin DB00290 (APRD00453, EXPT00718) qRT-PCR The role of SIRT5 was detected by protein extraction and western blot, real-time quantitative PCR (q-PCR), Cell proliferation assay, Soft sugar colony formation assay, and Tumor xenograft experiments. cell lines (A549, LU99 and NCI-H460) up-regulated resistant NRF2 NA validated NA mRNA and protein overexpression related 4 GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer Epigenetics 2017 27918237 GPX3 ENSG00000211445 colorectal cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR The role of mRNA expression on the drug sensitivity was detected by the MSP,qRT-PCR,drug cytotoxic assays,cell growth rate assays,acute and clinical drug exposure experiments,RNA knockdown experiment,tumor xenograft studys. cell lines (RKO, SW48, LOVO, HCT116, SW480, SW620, COLO205, CACO2, HT29) down-regulated sensitive NA NA validated NA promoter hypermethylation related 5 GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer Epigenetics 2017 27918237 GPX3 ENSG00000211445 colorectal cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of mRNA expression on the drug sensitivity was detected by the MSP,qRT-PCR,drug cytotoxic assays,cell growth rate assays,acute and clinical drug exposure experiments,RNA knockdown experiment,tumor xenograft studys. cell lines (RKO, SW48, LOVO, HCT116, SW480, SW620, COLO205, CACO2, HT29) down-regulated sensitive NA NA validated NA promoter methylation related 6 Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity Oncotarget 2016 27058625 RECK ENSG00000122707 breast cancer Methotrexate DB00563 (APRD00353) qRT-PCR The role of mRNA expression on the drug sensitivity was detected by the COBRA ,qRT-PCR,immunoblot assay,siRNA transfection experiments,cell matrigel invasion assay,adenovirus-mediated gene transfer experiments cell lines (MCF7, MCF-10A, MDA-MB-453, T-47D, ZR-75-1, SK-BR-3, MDA-MB-468, HCC1937, HCC1954, MDA-MB-231, BT549, Hs-578-T, HCC38, SUM-159PT) and tissues down-regulated resistant NA NA validated NA CpG island promoter/exon-1 methylation related 7 Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity Oncotarget 2016 27058625 RECK ENSG00000122707 breast cancer Methotrexate DB00563 (APRD00353) qRT-PCR The role of mRNA expression on the drug sensitivity was detected by the COBRA ,qRT-PCR,immunoblot assay,siRNA transfection experiments,cell matrigel invasion assay,adenovirus-mediated gene transfer experiments cell lines (MCF7, MCF-10A, MDA-MB-453, T-47D, ZR-75-1, SK-BR-3, MDA-MB-468, HCC1937, HCC1954, MDA-MB-231, BT549, Hs-578-T, HCC38, SUM-159PT) and tissues down-regulated resistant NA NA validated NA CpG islangd intron-1 methylation related 8 Altered DNA methyltransferases promoter methylation and mRNA expression are associated with tamoxifen response in breast tumors J Cell Physiol 2018 29574992 DNMT3A ENSG00000119772 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The expression of the mRNA was detected by the methylation-specific high-resolution melt curve analysis (MS-HRM),qRT-PCR. tissues down-regulated sensitive NA NA validated NA promoter hypermethylation related 9 Altered DNA methyltransferases promoter methylation and mRNA expression are associated with tamoxifen response in breast tumors J Cell Physiol 2018 29574992 DNMT3B ENSG00000088305 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The expression of the mRNA was detected by the methylation-specific high-resolution melt curve analysis (MS-HRM),qRT-PCR. tissues up-regulated resistant NA NA validated NA mRNA overexpression related 10 Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer Epigenomics 2017 28403629 SLFN11 ENSG00000172716 colorectal cancer Cisplatin DB00675 (APRD00123) qRT-PCR The expression of the mRNA was detected by the MSP analysis,qRT-PCR,western blotting analysis,siRNA knockdown experiments,drug treatment experiments,cell viability assay,colony formation assay,flow cytometry for cell cycle & apoptosis. cell lines (RKO, DLD1, SW620, LOVO, Ls180 and DKO) and patients tissues down-regulated resistant RPA DNA damage repair pathways validated NA promoter hypermethylation related 11 Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines Oncol Rep 2016 26497773 ABCG2 ENSG00000118777 colorectal cancer 5-fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The role of expression of mRNA on the sensitivity of the drugs was detected by the RT-PCR,qRT-PCR,MSP assay,bisulfite sequencing analysis,5_aza_2'_deoxycytidine treatment,cell proliferation assay. cell lines down-regulated sensitive NA NA validated NA promoter hypermethylation related 12 Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines Oncol Rep 2016 26497773 ABCG2 ENSG00000118777 colorectal cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR The role of expression of mRNA on the sensitivity of the drugs was detected by the RT-PCR,qRT-PCR,MSP assay,bisulfite sequencing analysis,5_aza_2'_deoxycytidine treatment,cell proliferation assay. cell lines down-regulated sensitive NA NA validated NA promoter hypermethylation related 13 Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines Oncol Rep 2016 26497773 ABCG2 ENSG00000118777 colorectal cancer Irinotecan DB00762 (APRD00579) qRT-PCR The role of expression of mRNA on the sensitivity of the drugs was detected by the RT-PCR,qRT-PCR,MSP assay,bisulfite sequencing analysis,5_aza_2'_deoxycytidine treatment,cell proliferation assay. cell lines down-regulated sensitive NA NA validated NA promoter hypermethylation related 14 Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic Colorectal Cancer Neoplasia 2019 30562637 CHFR ENSG00000072609 colorectal cancer Irinotecan DB00762 (APRD00579) NA The effect of the mRNA expression on the drug sensitivity was detected by the MSP analysis,TCGA and CCLE database analysis,siRNA interferencing experiments,cell growth inhibition assays,western blotting analysis. cell lines (RKO, HT-29, HCT-116, SNU-81, SW480, DLD-1, SNU-407, CaCo-2, LoVo, SW620, SNU-C4, and SNU-C5) and patients tissues down-regulated sensitive Topoisomerase I NA validated NA promoter hypermethylation related 15 Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer Cell Physiol Biochem 2018 29414807 TPM2 ENSG00000198467 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The role of expression of mRNA on the sensitivity of the drugs was detected by the RT-PCR,BSP assay,western blotting analysis,cell migration and invasion assay,drug susceptibility experiments,immunohistochemistry staining. cell lines (MCF7, T47D, UACC-812, BT-549) and patients down-regulated resistant MMP2 NA validated NA promoter hypermethylation related 16 Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERalpha-GREB1 Transcriptional Axis Cancer Res 2018 29212856 GREB1 ENSG00000196208 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,siRNA transfection experiments,chromatin immunoprecipitation assay,IHC analysis,TCGA database analysis. cell lines (MCF-7, ZR-75-1 and T-47D) patients tissues down-regulated resistant ERS1 (ER-ALPHA) EZH2_ER¦Á_GREB1 pathway validated NA promoter hypermethylation related 17 ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer Oncotarget 2017 28199979 ATM ENSG00000149311 breast cancer Cetuximab DB00002 (BTD00071, BIOD00071) qRT-PCR The sensitivity of the drug was detected by the qRT-PCR,microdissection assay,cell viability assay,siRNA transfection experiments,immunofluorescence staining,cell lysis and western blotting,immunohistochemistry staining. cell lines (Caco-2, HT29, SW480, DLD1, HCT116, LS174T, RKO) down-regulated resistant NA EGFR signaling pathways validated mutation NA related 18 ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer Oncotarget 2017 28199979 CDH1 ENSG00000039068 breast cancer Cetuximab DB00002 (BTD00071, BIOD00071) qRT-PCR The sensitivity of the drug was detected by the qRT-PCR,microdissection assay,cell viability assay,siRNA transfection experiments,immunofluorescence staining,cell lysis and western blotting,immunohistochemistry staining. cell lines (Caco-2, HT29, SW480, DLD1, HCT116, LS174T, RKO) down-regulated resistant NA EGFR signaling pathways validated NA protein low expression related 19 Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer Oncotarget 2016 27191984 UGCG ENSG00000148154 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,immunohistochemical analyses,MSP analysis,western blotting analysis,5-aza-2¡ä-deoxycytidine (5-Aza-dc) treatment,MTS assay. cell lines (MCF-7, MDA-MB-231, T47D) down-regulated sensitive MDR1 NA validated NA promoter hypermethylation related 20 Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer Ann Oncol 2015 26113646 MGMT ENSG00000170430 glioblastoma Temozolomide DB00853 (APRD00557) NA We evaluated the prognostic and predictive value of MGMT_ethylation_esting both in tumor and cell-free circulating DNA (cfDNA) from plasma samples using an ultra-sensitive_wo-step digital PCR technique (methyl-BEAMing). Results were compared with two established techniques,_ethylation-specific PCR (MSP) and Bs-pyrosequencing. patients tissues down-regulated sensitive NA NA validated NA promoter hypermethylation related 21 Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer Ann Oncol 2015 26113646 MGMT ENSG00000170431 colorectal cancer Dacarbazine DB00851 (APRD00331) NA We evaluated the prognostic and predictive value of MGMT_ethylation_esting both in tumor and cell-free circulating DNA (cfDNA) from plasma samples using an ultra-sensitive_wo-step digital PCR technique (methyl-BEAMing). Results were compared with two established techniques,_ethylation-specific PCR (MSP) and Bs-pyrosequencing. patients tissues down-regulated sensitive NA NA validated NA promoter hypermethylation related 22 Promoter Methylation of RASSF1A indicates Prognosis for Patients with Stage II and III Colorectal Cancer Treated with Oxaliplatin-Based Chemotherapy Med Sci Monit 2017 29128865 RASSF1A ENSG00000068028 colorectal cancer Oxaliplatin DB00526 (APRD00186) NA The role of the promoter state on the sensitivity of the drug was detected by the MSP. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 23 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR1 ENSG00000139874 thyroid cancer KE108 NA RT-PCR The role of SSTR1 was detected by real-time quantitative PCR (q-PCR), capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 24 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR2 ENSG00000180616 thyroid cancer KE108 NA RT-PCR The role of SSTR2 was detected by real-time quantitative PCR (q-PCR), capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 25 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR3 ENSG00000278195 thyroid cancer KE108 NA RT-PCR The role of SSTR3 was detected by real-time quantitative PCR (q-PCR), Capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 26 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR5 ENSG00000162009 thyroid cancer KE108 NA RT-PCR The role of SSTR5 was detected by real-time quantitative PCR (q-PCR), capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 27 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR1 ENSG00000139874 thyroid cancer Pasireotide DB06663 RT-PCR The role of SSTR1 was detected by real-time quantitative PCR (q-PCR), capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 28 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR2 ENSG00000180616 thyroid cancer Pasireotide DB06663 RT-PCR The role of SSTR2 was detected by real-time quantitative PCR (q-PCR), capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 29 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR3 ENSG00000278195 thyroid cancer Pasireotide DB06663 RT-PCR The role of SSTR3 was detected by real-time quantitative PCR (q-PCR), Capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 30 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers Surgery 2019 30415874 SSTR5 ENSG00000162009 thyroid cancer Pasireotide DB06663 RT-PCR The role of SSTR5 was detected by real-time quantitative PCR (q-PCR), capillary immunoblotting,human tissue microarrays. tissue and cell lines (Hth7, FTC-236, 8505C) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 31 Epirubicin suppresses proliferative and metastatic potential by downregulating transforming growth factor-¦Â-induced expression in urothelial carcinoma Cancer Sci 2018 28940965 TGFBI ENSG00000120708 bladder cancer Epirubicin DB00445 (APRD00361) RT-PCR The role of TGFBI was detected by RT-PCR and western blot, Capillary immunoblotting,Human tissue microarrays.UC cell proliferation was analyzed by WST-1 assay and Hoechst 33258 staining. The effect of TGFBI on UC cell metastasis was analyzed using adhesion, migration and invasion assays. cell lines (RT112 and 253J) up-regulated sensitive MMPs/calpain_2 NA validated NA mRNA and protein overexpression related 32 Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin Gastroenterology 2001 11522752 Claudin-4 ENSG00000189143 pancreatic cancer CPE (Clostridium perfringens enterotoxin) NA Northern Blot The role of Claudin-4 was detected by RNA probe,northern blotting analysis£¬immunocytochemistry,tumor xenograft studys. cell lines (PANC-1, MiaPaCa-2, Capan-1, Capan-2, AsPC-1) and patients tissues up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 33 The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 19272804 STAT3 ENSG00000168610 salivary gland cancer Sulindac DB00605 (APRD01243) RT-PCR The expression levels of STAT3 or SURVIVN were determined by RT-PCR and western blotting analysis,gene transfection experiments,cell cyle and proliferation analysis,annexin V analysis, flow cytometry assay. cell lines (HSY and HSG) up-regulated resistant NA STAT3 signaling pathway validated NA mRNA and protein overexpression related 34 The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 19272804 BIRC5 ENSG00000089685 salivary gland cancer Sulindac DB00605 (APRD01243) RT-PCR The expression levels of STAT3 or SURVIVN were determined by RT-PCR and western blotting analysis,gene transfection experiments,cell cyle and proliferation analysis,annexin V analysis, flow cytometry assay. cell lines (HSY and HSG) up-regulated resistant NA STAT3 signaling pathway validated NA mRNA and protein overexpression related 35 CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner Oncol Rep 2017 27922681 CXCR4 ENSG00000121966 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR The expression levels of CXCR4 were determined by qRT-PCR,immunohistochemistry,western blot analysis,immunofluorescence assay,siRNA transfect assay,cell apoptosis assay. cell line(A549) and patients tissues up-regulated resistant CYP1B1 CXCR4 signaling pathway validated NA mRNA and protein overexpression related 36 CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner Oncol Rep 2017 27922681 CYP1B1 ENSG00000138061 lung cancer Cisplatin DB00515 (APRD00359) Bioinformatics The expression of the CYP1B1 was detected using the bioinformatics technology ,siRNA transfection experiments cell line(A549) and patients tissues up-regulated resistant NA CXCR4 signaling pathway validated NA mRNA and protein overexpression related 37 Increased expression of acetaldehyde dehydrogenase in cisplatin-resistant human lung adenocarcinoma A549/DDP cells Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2015 25940289 ALDH1B1 ENSG00000137124 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR ALDHB1 in human lung cancer A549 cells and cisplatin-resistant A549/DDP cells were ascertained by flow cytometry. The proliferation and sensitivity of A549/DDP cells to cisplatin were evaluated by MTT assay before and after ALDH inhibitor diethylaminobenzaldehyde (DEAB) treatment. The differential expression of ALDH subtypes in cells was determined by real-time quantitative PCR, and was further confirmed by a Western blotting. cell lines (A549/DDP and A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 38 Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP Thorac Cancer 2017 27813328 ALDH1A1 ENSG00000165092 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR Reverse transcriptase-PCR was applied to measure the messenger RNA expression of ALDH1A1, while Western blot assay was employed to evaluate the protein expression of ALDH1A1.A short hairpin RNA was used to knockdown ALDH1A1 expression. A MTT assay was used to determine the effect of ALDH1A1 decrease on cell viability. The cell apoptotic rate was tested using flow cytometry assay. cell lines (A549/DDP and A549) up-regulated resistant BCL2/BAX NA validated NA mRNA and protein overexpression related 39 Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP Thorac Cancer 2017 27813328 ALDH1A1 ENSG00000165092 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR Reverse transcriptase-PCR was applied to measure the messenger RNA expression of ALDH1A1, while Western blot assay was employed to evaluate the protein expression of ALDH1A1.A short hairpin RNA was used to knockdown ALDH1A1 expression. A MTT assay was used to determine the effect of ALDH1A1 decrease on cell viability. The cell apoptotic rate was tested using flow cytometry assay. cell lines (A549/DDP and A549) up-regulated resistant AKT PI3K/AKT signal pathway validated NA mRNA and protein overexpression related 40 Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP Thorac Cancer 2017 27813328 ALDH1A1 ENSG00000165092 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR Reverse transcriptase-PCR was applied to measure the messenger RNA expression of ALDH1A1, while Western blot assay was employed to evaluate the protein expression of ALDH1A1.A short hairpin RNA was used to knockdown ALDH1A1 expression. A MTT assay was used to determine the effect of ALDH1A1 decrease on cell viability. The cell apoptotic rate was tested using flow cytometry assay. cell lines (PC9, and PC9/GR) up-regulated resistant BCL2/BAX NA validated NA mRNA and protein overexpression related 41 Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP Thorac Cancer 2017 27813328 ALDH1A1 ENSG00000165092 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR Reverse transcriptase-PCR was applied to measure the messenger RNA expression of ALDH1A1, while Western blot assay was employed to evaluate the protein expression of ALDH1A1.A short hairpin RNA was used to knockdown ALDH1A1 expression. A MTT assay was used to determine the effect of ALDH1A1 decrease on cell viability. The cell apoptotic rate was tested using flow cytometry assay. cell lines (PC9, and PC9/GR) up-regulated resistant AKT PI3K/AKT signal pathway validated NA mRNA and protein overexpression related 42 Detection and quantitation of thymidylate synthase mRNA in human colon adenocarcinoma cell line resistant to 5-fluorouracil by competitive PCR Anticancer Res 1998 9673356 TYMS ENSG00000176890 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) PCR and Northern blot The amount of_RNA_as quantified by competitive PCR technique and northern blotting analysis in both cell lines. cell lines (SNU-C1/FU and SNU-C1 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 43 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 FOXM1 ENSG00000111206 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of FoxM1 on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant AURKB/Skp2/PLK1/ CDC25B/survivin/cyclin B1 PI3K/AKT signal pathway validated NA mRNA and protein overexpression related 44 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 AURKB ENSG00000178999 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of the downstream mRNA on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 45 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 SKP2 ENSG00000145604 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of the downstream mRNA on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 46 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 PLK1 ENSG00000166851 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of the downstream mRNA on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 47 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 CDC25B ENSG00000101224 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of the downstream mRNA on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 48 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 BIRC5 ENSG00000089685 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of the downstream mRNA on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 49 FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 2012 22447226 CCNB1 ENSG00000134057 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The mRNA and protein expression of the downstream mRNA on the sensitivity of the drug were tested with qRT-PCR,western blotting analysis, RNA interference experiments,cell proliferation and apoptosis assay by flow cytometry. cell line (NCI-H292, SPC-A-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 50 Expression of excision repair cross-complementation gene in drug-resistant process of carboplatin administration in tongue squamous cell cancer (Tca8113) Zhonghua Kou Qiang Yi Xue Za Zhi 2011 22041635 ERCC1 ENSG00000012061 tongue squamous_ancer Carboplatin DB00958 (APRD00466) RT-PCR The expressions of ERCC-1 at mRNA and protein level on the sensitivity of the drugs were detected by reverse transcription polymerase chain reaction (RT-PCR) and western blotting analysis,MTT. cell line (Tca8113) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 51 EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome PLoS One 2013 24073208 BSG ENSG00000172270 renal cancer Sunitinib DB01268 (DB07417) RT-PCR The effect of expressions of EMMPRIN mRNA and protein on the sensitivity of the drug were detected by RT-PCR,western blotting,siRNA transfection experiments,MTS assay,cell invasion assay,tumor xenograft studys. cell lines (786-O, Caki-1, OUR-10 and 786-Suni) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 52 Predictive value of CHFR and MLH1 methylation in human gastric cancer Gastric Cancer 2015 24748501 CHFR ENSG00000072609 gastric cancer Docetaxel DB01248 (APRD00932) NA The promoter state of the CHFR or MLH1 was detected by the methylation-specific PCR,nested methylation-specific polymerase chain reaction. patients tissues down-regulated sensitive NA NA validated NA promoter hypermethylation related 53 Predictive value of CHFR and MLH1 methylation in human gastric cancer Gastric Cancer 2015 24748501 MLH1 ENSG00000076242 gastric cancer Oxaliplatin DB00526 (APRD00186) NA The promoter state of the CHFR or MLH1 was detected by the methylation-specific PCR,nested methylation-specific polymerase chain reaction. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 54 Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma BMC Cancer 2017 28235398 TSPYL5 ENSG00000180543 prostate cancer Docetaxel DB01248 (APRD00932) qRT-PCR and RT-PCR The effect of the expression of mRNA was detected by the qRT-PCR,RT-PCR,western blotting analysis,5-aza-2¡ä-deoxycytidine treatment experiments,MSP,pyrosequencing. cell lines (DU145, LNCaP and RWPE-1) down-regulated resistant CDKN1A PTEN/AKT signaling pathway validated NA promoter hypermethylation related 55 Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma BMC Cancer 2017 28235398 TSPYL5 ENSG00000180543 prostate cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR and RT-PCR The effect of the expression of mRNA was detected by the qRT-PCR,RT-PCR,western blotting analysis,5-aza-2¡ä-deoxycytidine treatment experiments,MSP,pyrosequencing. cell lines (DU145, LNCaP and RWPE-1) down-regulated resistant CDKN1A PTEN/AKT signaling pathway validated NA promoter hypermethylation related 56 Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer Genet Mol Res 2015 26345914 EGFR ENSG00000146648 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR The effect of the mRNA expression on the drug sensitivity was detected by the RT-PCR,MSP,cell proliferation and apoptosis assay,tumor xenograft experiments. cell lines (HCC827, H1299, RPMI-1640) and patients tissues down-regulated resistant NA EGFR signaling pathways validated NA promoter hypermethylation related 57 PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma Epigenetics 2017 29099287 PAX5 ENSG00000196092 esophageal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effect of the mRNA expression on the drug sensitivity was detected by the qRT-PCR,MSP,5Aza-20-deoxycytidine treatment experiments,siRNA transfection experiments,cancer pathway finder array,western blotting analysis. cell lines (TE1, TE2, TE3, NUEC1, NUEC2, T.Tn, WSSC, Het-1A) and patients tissues down-regulated resistant GLUT1 NA validated NA promoter hypermethylation related 58 PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma Epigenetics 2017 29099287 SLC2A1 ENSG00000117394 esophageal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effect of the mRNA expression on the drug sensitivity was detected by the qRT-PCR,MSP,5Aza-20-deoxycytidine treatment experiments,siRNA transfection experiments,cancer pathway finder array,western blotting analysis. cell lines (TE1, TE2, TE3, NUEC1, NUEC2, T.Tn, WSSC, Het-1A) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 59 A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma Nat Commun 2018 30054476 MGMT ENSG00000170431 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The expression of the mRNA on the sensitivity of the drug was detected by the RT-PCR,western blotting analysis,RNA-sequencing analysis,MSP,chromatin immunoprecipitation,ChIP-seq analysis,chromatin conformation capture assay,enhancer activation assays. cell lines (SKMG3, HEK293T) and patients tissues up-regulated resistant NA NA validated NA K-M enhancer activated related 60 Inactivation of ADAMTS18 by aberrant promoter hypermethylation contribute to lung cancer progression J Cell Physiol 2019 30417422 ADAMTS18 ENSG00000140873 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR Immunohistochemistry, quantitative reverse-transcription polymerase chain reaction (qRT-PCR), and methylation-specific PCR were used to assay ADAMTS18 expression and promoter methylation in lung tumor tissues and adjacent tissues. Cell viability, transwell, and wound-healing assays, as well as flow cytometry were used to characterize the biological activity of ADAMTS18. The influence of ADAMTS18 on protein expression was assayed using western blots analysis, and its effect on chemosensitivity was assayed by the response to cisplatin. cell lines (H1299, A549) down-regulated resistant EGFR/AKT/P53 EGFR/AKT signaling pathway validated NA promoter hypermethylation related 61 Interferon Consensus Sequence-Binding Protein 8, a Tumor Suppressor, Suppresses Tumor Growth and Invasion of Non-Small Cell Lung Cancer by Interacting with the Wnt/beta-Catenin Pathway Cell Physiol Biochem 2018 30466106 IRF8 ENSG00000140968 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR IRF8 expression were determined by Q- PCR. MSP and A+T determined promotor methylation. MTS, clonogenic, Transwell assay, Flow cytometry, three-dimensional culture and AO/EB stain verified cell function. In vivo tumorigenesis examed the in vivo effects. By Chip-QPCR, RT-PCR, Western blot and Immunofluorescence staining, the mechanisms were studied. cell lines (A549 and H1299) down-regulated resistant ¦Â-catenin Wnt/¦Â-Catenin signaling pathway validated NA promoter hypermethylation related 62 Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance Genome Med 2018 30029672 LRP12 ENSG00000147650 lung cancer Carboplatin DB00958 (APRD00466) NA We used MeDIP-Seq to generate genome-wide DNA methylation profiles of 22 PDXs, their parental primary NSCLC, and their corresponding normal tissues and complemented the data with gene expression analyses of the same tissues. Candidate biomarkers were validated with quantitative methylation-specific PCRs (qMSP) in an independent cohort. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 63 The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer Cell Death Dis 2018 29367628 UBC13 ENSG00000177889 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,siRNA transfection experiments,cell viability assays,DNMT1 ubiquitination assay,BSP assay. cell lines (SKOV3, A2780 ) and patients tissues down-regulated resistant DNMT1 DNMT1/CHFR/Aurora A signaling pathway validated NA mRNA and protein low expression related 64 5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter Anticancer Res 2019 31366497 TYMP ENSG00000025708 epidermoid carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The_ensitivity_o drugs was determined on several_ancer_ell lines by the MTT assay. Protein and mRNA levels were examined by immunoblot and RT-PCR, respectively. Gene silencing, binding of Sp1 to DNA and_ethylation_f DNA was performed by siRNA, ChIP assay and sodium bisulfate genomic sequencing, respectively. cell line (a KB3-1) down-regulated resistant NA NA validated NA promoter hypermethylation related 65 Correlation between the methylation of SULF2 and WRN promoter and the irinotecan chemosensitivity in gastric cancer BMC Gastroenterol 2013 24359226 SULF2 ENSG00000196562 gastric cancer Irinotecan DB00762 (APRD00579) NA The promoter state of the SULF2 or WRN was detected by MSP,histoculture drug response assay. patients tissues down-regulated sensitive ISG15 NA validated NA promoter hypermethylation related 66 Correlation between the methylation of SULF2 and WRN promoter and the irinotecan chemosensitivity in gastric cancer BMC Gastroenterol 2013 24359226 WRN ENSG00000165392 gastric cancer Irinotecan DB00762 (APRD00579) NA The promoter state of the SULF2 or WRN was detected by MSP,histoculture drug response assay. patients tissues down-regulated sensitive NA NA validated NA promoter hypermethylation related 67 Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin Cell Prolif 2019 31012173 SIX2 ENSG00000170577 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR Quantitative reverse transcription PCR and Western blot were performed to detect six2 expression in clinical samples. Moreover, transwell migration, tumour spheroid formation and in vivo tumour formation assays were used to examine the effects of six2 on NSCLC cell progression. Additionally, methylation analysis was carried out to measure E-cadherin methylation level in different cells. Finally, cell viability assay was performed to explore the effects of six2 on chemotherapeutic sensitivity of NSCLC cells. cell lines (A549, NCI_H1299 cells, HEK293T, BEAS_2B) up-regulated resistant E-cadherin NA validated NA mRNA and protein overexpression related 68 Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer J Natl Cancer Inst 2016 27381626 BRCA1 ENSG00000012048 breast cancer Cisplatin DB00515 (APRD00359) qRT-PCR BRCA1 expression was investigated using quantitative real-time polymerase chain reaction and immunoblotting. Next-generation sequencing, methylation-specific multiplex ligation-dependent probe amplification (MLPA) and Target Locus Amplification (TLA)-based sequencing were used to determine mechanisms of BRCA1 re-expression in therapy-resistant tumors. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 69 Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer J Natl Cancer Inst 2016 27381626 BRCA1 ENSG00000012048 breast cancer Melphalan DB01042 (APRD00118) qRT-PCR BRCA1 expression was investigated using quantitative real-time polymerase chain reaction and immunoblotting. Next-generation sequencing, methylation-specific multiplex ligation-dependent probe amplification (MLPA) and Target Locus Amplification (TLA)-based sequencing were used to determine mechanisms of BRCA2 re-expression in therapy-resistant tumors. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 70 Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer J Natl Cancer Inst 2016 27381626 BRCA1 ENSG00000012048 breast cancer Nimustine DB13069 qRT-PCR BRCA1 expression was investigated using quantitative real-time polymerase chain reaction and immunoblotting. Next-generation sequencing, methylation-specific multiplex ligation-dependent probe amplification (MLPA) and Target Locus Amplification (TLA)-based sequencing were used to determine mechanisms of BRCA3 re-expression in therapy-resistant tumors. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 71 Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer J Natl Cancer Inst 2016 27381626 BRCA1 ENSG00000012048 breast cancer Olaparib DB09074 (DB05940) qRT-PCR BRCA1 expression was investigated using quantitative real-time polymerase chain reaction and immunoblotting. Next-generation sequencing, methylation-specific multiplex ligation-dependent probe amplification (MLPA) and Target Locus Amplification (TLA)-based sequencing were used to determine mechanisms of BRCA4 re-expression in therapy-resistant tumors. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 72 SULF2 methylation is associated with in vitro cisplatin sensitivity and clinical efficacy for gastric cancer patients treated with a modified FOLFOX regimen PLoS One 2013 24124496 SULF2 ENSG00000196562 gastric cancer Cisplatin DB00515 (APRD00359) NA The promoter state of the SULF2 or WRN was detected by MSP. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 73 Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel Cancer Res 2007 18056460 TP73 ENSG00000078900 cancer Cisplatin DB00515 (APRD00359) qRT-PCR and RT-PCR The expression of the mRNA on the sensitivity of the drug was detected by the RT-PCR,qRT-PCR,western blotting analysis,RNA interference experiments,bisulfite-PCR methylation analysis. cell lines (TK10 ,SKMEL28) down-regulated sensitive NA NA validated NA promoter hypermethylation related 74 Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines PLoS One 2016 26751376 MTAP ENSG00000099810 breast cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,MSP,siRNA transfection experiments,wound healing assay,cytotoxicity experiments. cell lines (MDA-MB-231, MDA-MB-435S, MDA-MB-468, MCF7, SK-BR-3, T47-D and ZR-75-1) and patients tissues down-regulated sensitive CDKN2A NA validated NA promoter hypermethylation related 75 Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines PLoS One 2016 26751376 MTAP ENSG00000099810 breast cancer Azacitidine DB00928 (APRD00809) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,MSP,siRNA transfection experiments,wound healing assay,cytotoxicity experiments. cell lines (MDA-MB-231, MDA-MB-435S, MDA-MB-468, MCF7, SK-BR-3, T47-D and ZR-75-1) and patients tissues down-regulated sensitive CDKN2A NA validated NA promoter hypermethylation related 76 Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines PLoS One 2016 26751376 MTAP ENSG00000099810 breast cancer Methotrexate DB00563 (APRD00353) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,MSP,siRNA transfection experiments,wound healing assay,cytotoxicity experiments. cell lines (MDA-MB-231, MDA-MB-435S, MDA-MB-468, MCF7, SK-BR-3, T47-D and ZR-75-1) and patients tissues down-regulated sensitive CDKN2A NA validated NA promoter hypermethylation related 77 Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells J Natl Cancer Inst 1994 7910854 MDR1 ENSG00000085563 colon cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) Northern Blot Levels of mdr-1 DNA were measured by slot-blot and Southern-blot analyses. mdr mRNA expression levels were measured by Northern-blot analysis. cell lines (CT-26) up-regulated resistant CDKN3A NA validated NA mRNA overexpression related 78 FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro Mol Oncol 2018 29573334 FGFR2 ENSG00000066468 gastric cancer Regorafenib DB08896 qRT-PCR The sensitivity of the drug was detected by the cell growth inhibition assays,copy number assays by qRT-PCR,western blotting analysis,cell cycle analysis,small interfering RNA knockdown,tumor xenograft study, cell lines ((SNU_1, SNU_5, SNU_16, SNU_216, SNU_484, SNU_601, SNU_620, SNU_638, SNU_668, SNU_719, AGS, MKN_45, NCI_N87, KATO_III) up-regulated sensitive NA FGFR2 pathway validated amplification NA related 79 FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro Mol Oncol 2018 29573334 FGFR2 ENSG00000066468 colorectal cancer Regorafenib DB08896 qRT-PCR The sensitivity of the drug was detected by the cell growth inhibition assays,copy number assays by qRT-PCR,western blotting analysis,cell cycle analysis,small interfering RNA knockdown,tumor xenograft study, cell lines (SNU_283, SNU_1033, SNU_C1, SNU_C2A, SNU_C4, SW_403, SW_480, HT_29, Colo_205, NCI_H716) up-regulated sensitive NA FGFR2 pathway validated amplification NA related 80 Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi Genes Chromosomes Cancer 2017 28316110 PSMD4 ENSG00000159352 breast cancer Talazoparib DB11760 DNA sequence The sensitivity of the drugs was detected by the fluorescent in situ hybridization,RNA isolation and expression microarray analysis,RNAi transfection experiments,cell proliferation analysis,soft agar assay for colony formation,western blotting analysis. cell lines (HCC1187) up-regulated sensitive PARP1 NA validated amplification NA related 81 Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma Oncotarget 2016 27013591 EGFR ENSG00000146648 esophageal_ancer Icotinib DB11737 NA Immunohistochemistry and fluorescence in situ hybridization (FISH) was used to assess EGFR expression and gene amplification status patients tissues up-regulated sensitive NA EGFR signaling pathways validated amplification NA related 82 YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib Am J Respir Crit Care Med 2019 31166114 YES1 ENSG00000176105 lung cancer Dasatinib DB01254 qRT-PCR The sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,immunohistochemistry,iRNA knockdown experiments,MTT and clonogenic assays,cell proliferation assay,cell apoptosis analysis, cell lines and patients tissues up-regulated sensitive NA PI3K/AKT/mTOR pathway validated amplification NA related 81 MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer Int J Cancer 2019 30694565 MET ENSG00000105976 head and neck_ancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the RT-PCR,western blotting analysis,RNA silencing experiments,cell proliferation assay,immunohistochemical staining,fluorescent in situ hybridization,mass spectrometry proteomics cell lines (SNU1076,HSC4 ,CAL33,HSC2,FaDu,H1975 ) and patients tissues up-regulated resistant HER2/HER3 MAPK signaling pathway validated amplification NA related 82 Correlation between complete response to anthracycline-based chemotherapy and topoisomerase II-alpha gene amplification and protein overexpression in locally advanced/metastatic breast cancer Int J Oncol 2004 14654958 TOP2A ENSG00000131747 breast cancer Anthracycline NA NA Topo-II gene status were evaluated by FISH,topo-II protein was evaluated by IHC cell lines up-regulated sensitive NA NA validated amplification NA related 83 Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate Breast Cancer Res Treat 2010 20024612 FGFR1 ENSG00000077782 breast cancer Brivanib DB11958 Bioinformatics The role of the mRNA on the sensitivity of the drug was detected by the boinformatics technology,western blotting analysis,cell proliferation assay,FGFR-1 tyrosine kinase assay. cell lines and patients tissues up-regulated sensitive ERK/AKT NA validated amplification NA related 84 Resistance to cetuximab in EGFR-overexpressing esophageal squamous cell carcinoma xenografts due to FGFR2 amplification and overexpression J Pharmacol Sci 2014 25242085 FGFR2 ENSG00000066468 esophageal_ancer Cetuximab DB00002 (BTD00071, BIOD00071) Bioinformatics The effect of mRNA expression on the sensitivity of the drug was detected by the boinformatics technology,western blotting analysis,cell viability assay,tumor xenograft studys. cell lines (TE-6) up-regulated resistant NA FGFR2 pathway validated amplification NA related 85 Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation Cancer Res 2010 20663904 SRC3 ENSG00000124151 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,CGH assay,immunohistochemical staining assay,reverse phase protein array,small interfering RNA transfection,colony formation assay. cell lines up-regulated resistant NA EGFR signaling pathways validated amplification NA related 86 Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis Oncogene 2014 23770855 SETDB1 ENSG00000143379 lung cancer Plicamycin (Mithramycin) DB06810 qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,fluorescent in situ hybridization,shRNA transfection experiments,MTT,confocal microscopy experiments. cell lines (A549, NCI-H1299, NCI-H1975, NCI-H1993, NCI-H2170, NCI-H1437,NCI-H1395,HCC-33, N417, NCI-H446, NCI-H1048, NCI-H1963, NCI-H2029, DMS-114 and DMS-273) up-regulated sensitive NA NA validated amplification NA related 87 Overexpression of cyclin D1 correlates with sensitivity to cisplatin in squamous cell carcinoma cell lines of the head and neck Acta Otolaryngol 2004 15484403 CCND1 ENSG00000110092 head and neck_ancer Cisplatin DB00515 (APRD00359) RT-PCR This was a laboratory study of 23 established University of Michigan SCC cell lines. Chemosensitivity was assessed by means of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cyclin D1 amplification status was evaluated by real-time polymerase chain reaction (PCR; data were verified by differential and conventional PCR) using a chromosome 18q microsatellite marker probe (D18S70) as an internal control. Cyclin D1 protein expression was tested using Western blotting. up-regulated sensitive NA NA validated amplification NA related 88 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers Clin Breast Cancer 2013 23830798 RARA ENSG00000131759 breast cancer Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) NA Array comparative genomic hybridization and gene expression arrays were used to characterize RARA amplifications and expression in 103 breast cancer samples. In vitro activity of ATRA was characterized in T47D, SKBR3, and BT474 cell lines. cell lines (T47D, SKBR3, and BT474) up-regulated sensitive CASP1/IRF1 NA validated amplification NA related 89 Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Cell Commun Signal 2017 28143584 TCTP ENSG00000133112 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR Using immunohistochemistry, we assessed TCTP levels in surgical samples from adenomas and adenocarcinomas of the colon, compared to normal colon tissue. We also studied the regulation of TCTP in HCT116 colon cancer cells in response to 5-FU and oxaliplatin by western blotting. TCTP mRNA levels were assessed by RT-qPCR. We used mTOR kinase inhibitors to demonstrate mTOR-dependent translational regulation of TCTP under these conditions. Employing the Real-Time Cell Analysis (RTCA) System and the MTS assay, we investigated the effect of TCTP-knockdown on the sensitivity of HCT116 cells to the anti-cancer drugs 5-FU and oxaliplatin cell lines (HCT116 ) and patients tissues down-regulated resistant BCL-XL/MCL-1 mTORC1 signalling pathway validated NA protein overexpression related 90 Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Cell Commun Signal 2017 28143584 TCTP ENSG00000133112 colorectal cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR Using immunohistochemistry, we assessed TCTP levels in surgical samples from adenomas and adenocarcinomas of the colon, compared to normal colon tissue. We also studied the regulation of TCTP in HCT116 colon cancer cells in response to 5-FU and oxaliplatin by western blotting. TCTP mRNA levels were assessed by RT-qPCR. We used mTOR kinase inhibitors to demonstrate mTOR-dependent translational regulation of TCTP under these conditions. Employing the Real-Time Cell Analysis (RTCA) System and the MTS assay, we investigated the effect of TCTP-knockdown on the sensitivity of HCT116 cells to the anti-cancer drugs 5-FU and oxaliplatin cell lines (HCT116 ) and patients tissues down-regulated resistant BCL-XL/MCL-1 mTORC1 signalling pathway validated NA protein overexpression related 91 Txr1: an important factor in oxaliplatin resistance in gastric cancer Med Oncol 2014 24362794 TXR1 ENSG00000205352 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between Txr1 expression and_rug-resistance of oxaliplatin in GC was studied with_rug_ntervention, gene silencing technology, real-time PCR and western blot analysis. cell lines (SGC7901) and patients tissues up-regulated resistant TSP1/survivin NA validated NA mRNA and protein overexpression related 92 Txr1: an important factor in oxaliplatin resistance in gastric cancer Med Oncol 2014 24362794 BIRC5 ENSG00000089685 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between Txr1 expression and_rug-resistance of oxaliplatin in GC was studied with_rug_ntervention, gene silencing technology, real-time PCR and western blot analysis. cell lines (SGC7901) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 93 Txr1: an important factor in oxaliplatin resistance in gastric cancer Med Oncol 2014 24362794 TSP1 ENSG00000137801 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between Txr1 expression and_rug-resistance of oxaliplatin in GC was studied with_rug_ntervention, gene silencing technology, real-time PCR and western blot analysis. cell lines (SGC7901) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 94 FBI-1 promotes cell proliferation and enhances resistance to chemotherapy of hepatocellular carcinoma in vitro and in vivo Cancer 2012 21713761 FBI1 ENSG00000178951 hepatocellular carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR Real-time quantitative reverse transcriptase-polymerase chain reaction analysis, Western blot analysis, and immunohistochemical staining were used to detect expression levels of FBI-1 and to analyze its relation to clinicopathologic parameters and to the prognosis of patients with HCC. cell lines (HepG2 and SMMC-7721) up-regulated resistant P53 NA validated NA mRNA and protein overexpression related 95 FBI-1 promotes cell proliferation and enhances resistance to chemotherapy of hepatocellular carcinoma in vitro and in vivo Cancer 2012 21713761 FBI1 ENSG00000178951 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR Real-time quantitative reverse transcriptase-polymerase chain reaction analysis, Western blot analysis, and immunohistochemical staining were used to detect expression levels of FBI-1 and to analyze its relation to clinicopathologic parameters and to the prognosis of patients with HCC. cell lines (HepG2 and SMMC-7721) up-regulated resistant P53 NA validated NA mRNA and protein overexpression related 96 WNT5A modulates cell cycle progression and contributes to the chemoresistance in pancreatic cancer cells Hepatobiliary Pancreat Dis Int 2014 25308364 WNTA5 ENSG00000114251 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The expressions of WNT5A was detected by RT-PCR,western blotting analysis,and the correlation between WNT5A expression and clinicopathological characteristics was analyzed by gene cloning and RNA interference,cytotoxicity assay and cell proliferation,flow cytometry for cell cycle assay. cell lines (PANC-1 and MIAPaCa2) and patients tissues up-regulated resistant AKT/Cyclin D1 PI3K/AKT signal pathway validated NA mRNA and protein overexpression related 97 WNT5A modulates cell cycle progression and contributes to the chemoresistance in pancreatic cancer cells Hepatobiliary Pancreat Dis Int 2014 25308364 AKT ENSG00000142208 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The expressions of WNT5A was detected by RT-PCR,western blotting analysis,and the correlation between WNT5A expression and clinicopathological characteristics was analyzed by gene cloning and RNA interference,cytotoxicity assay and cell proliferation,flow cytometry for cell cycle assay. cell lines (PANC-1 and MIAPaCa2) and patients tissues NA resistant Cyclin D1 PI3K/AKT signal pathway validated NA phosphorylation related 98 WNT5A modulates cell cycle progression and contributes to the chemoresistance in pancreatic cancer cells Hepatobiliary Pancreat Dis Int 2014 25308364 CCND1 ENSG00000110092 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The expressions of WNT5A was detected by RT-PCR,western blotting analysis,and the correlation between WNT5A expression and clinicopathological characteristics was analyzed by gene cloning and RNA interference,cytotoxicity assay and cell proliferation,flow cytometry for cell cycle assay. cell lines (PANC-1 and MIAPaCa2) and patients tissues up-regulated resistant pRb-E2F complex NA validated NA mRNA and protein overexpression related 99 Knockdown of RhoGDIalpha induces apoptosis and increases lung cancer cell chemosensitivity to paclitaxel Neoplasma 2012 22668020 RhoGDI¦Á NA lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR RhoGDI¦Á expression was assessed by RT-PCR, Western blotting and immunohistochemistry. Apoptosis was determined by flow cytometric assessment, and cell viability was measured with the MTT assay cell lines ( A549 and H157) and patients tissues up-regulated resistant JNK/ERK/Bad/I¦ÊB¦Á NA validated NA mRNA and protein overexpression related 100 Hypoxia/IL-1alpha axis promotes gastric cancer progression and drug resistance J Dig Dis 2017 28608600 IL-1alpha ENSG00000115008 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR Reverse-transcription polymerase chain reaction was performed to characterize IL-1¦Á expression in different GC cell lines cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 101 ERBB2 amplifications in esophageal adenocarcinoma Ann Thorac Surg 2004 15511476 ERBB2 ENSG00000141736 esophageal_ancer Trastuzumab DB00072 (BTD00098, BIOD00098) qRT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the qRT-PCR,southern blotting analysis,immunohistochemistry,a Rec-A protein assisted restriction endonuclease mapping technique. cell lines (OE19,OE33,KATO-III, Hs746T, AGS, SNU-1, SNU-5, SNU-16,RF-48, RF-1, NCI-N87, SNU-601, SNU-620, SNU-638, SNU-668, and SNU-719) up-regulated sensitive NA NA validated amplification NA related 102 Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer Breast Cancer Res 2009 19624808 ERBB2 ENSG00000141736 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) NA Using immunohistochemistry and fluorescence in situ hybridisation, we retrospectively investigated primary breast cancer tissues from 48 patients who were under Herceptin treatment. patients tissues up-regulated sensitive NA NA validated amplification NA related 103 Amplification and expression of a multidrug resistance gene in human glioma cell lines J Neurosurg 1990 2294193 MDR1 ENSG00000085563 glioma Vincristine DB00541 (APRD00495) Northern Blot The effect of expression of the mRNA on the sensitivity of the drug was detected by the northern blotting analysis,southern blotting analysis, cell lines (GB-l,U-373 ) up-regulated resistant NA NA validated amplification NA related 104 Amplification and expression of a multidrug resistance gene in human glioma cell lines J Neurosurg 1990 2294193 MDR1 ENSG00000085563 glioma Etoposide DB00773 (APRD00239) Northern Blot The effect of expression of the mRNA on the sensitivity of the drug was detected by the northern blotting analysis,southern blotting analysis, cell lines (GB-l,U-373 ) up-regulated resistant NA NA validated amplification NA related 105 Amplification and expression of a multidrug resistance gene in human glioma cell lines J Neurosurg 1990 2294193 MDR1 ENSG00000085563 glioma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) Northern Blot The effect of expression of the mRNA on the sensitivity of the drug was detected by the northern blotting analysis,southern blotting analysis, cell lines (GB-l,U-373 ) up-regulated resistant NA NA validated amplification NA related 106 Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells BMC Med Genomics 2008 18694510 CAV1 ENSG00000105974 colon cancer Methotrexate DB00563 (APRD00353) RT-PCR RT-Real-time PCR was used to validate the expression levels of selected_enes_nd copy-number was determined by qPCR. Functional validations were performed either by siRNAs or by transfection of an expression plasmid. cell lines (HT-29) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 107 Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells BMC Med Genomics 2008 18694510 ENO2 ENSG00000111674 colon cancer Methotrexate DB00563 (APRD00353) RT-PCR RT-Real-time PCR was used to validate the expression levels of selected_enes_nd copy-number was determined by qPCR. Functional validations were performed either by siRNAs or by transfection of an expression plasmid. cell lines (HT-29) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 108 Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells BMC Med Genomics 2008 18694510 PRKCA ENSG00000154229 colon cancer Methotrexate DB00563 (APRD00353) RT-PCR RT-Real-time PCR was used to validate the expression levels of selected_enes_nd copy-number was determined by qPCR. Functional validations were performed either by siRNAs or by transfection of an expression plasmid. cell lines (HT-29) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 109 Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells BMC Med Genomics 2008 18694510 CDH1 ENSG00000039068 colon cancer Methotrexate DB00563 (APRD00353) RT-PCR RT-Real-time PCR was used to validate the expression levels of selected_enes_nd copy-number was determined by qPCR. Functional validations were performed either by siRNAs or by transfection of an expression plasmid. cell lines (HT-29) down-regulated resistant NA NA validated NA mRNA and protein low expression related 110 Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells Mol Cancer 2010 21044322 RGS10 ENSG00000148908 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,bioinformatics technology,RGS gene modulation,cellular viability assays,annexin V-FITC staining assay. cell lines (SKOV-3,MDR-HeyA8) down-regulated resistant AKT G-Protein signaling pathway validated NA mRNA and protein low expression related 111 Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells Mol Cancer 2010 21044322 RGS17 ENSG00000091844 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,bioinformatics technology,RGS gene modulation,cellular viability assays,annexin V-FITC staining assay. cell lines (SKOV-3,MDR-HeyA8) down-regulated resistant AKT G-Protein signaling pathway validated NA mRNA and protein low expression related 112 Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells Mol Cancer 2010 21044322 RGS10 ENSG00000148908 ovarian_ancer Vincristine DB00541 (APRD00495) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,bioinformatics technology,RGS gene modulation,cellular viability assays,annexin V-FITC staining assay. cell lines (SKOV-3,MDR-HeyA8) down-regulated resistant AKT G-Protein signaling pathway validated NA mRNA and protein low expression related 113 Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells Mol Cancer 2010 21044322 RGS17 ENSG00000091844 ovarian_ancer Vincristine DB00541 (APRD00495) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,bioinformatics technology,RGS gene modulation,cellular viability assays,annexin V-FITC staining assay. cell lines (SKOV-3,MDR-HeyA8) down-regulated resistant AKT G-Protein signaling pathway validated NA mRNA and protein low expression related 114 Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells Mol Cancer 2010 21044322 RGS10 ENSG00000148908 ovarian_ancer Docetaxel DB01248 (APRD00932) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,bioinformatics technology,RGS gene modulation,cellular viability assays,annexin V-FITC staining assay. cell lines (SKOV-3,MDR-HeyA8) down-regulated resistant AKT G-Protein signaling pathway validated NA mRNA and protein low expression related 115 Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells Mol Cancer 2010 21044322 RGS17 ENSG00000091844 ovarian_ancer Docetaxel DB01248 (APRD00932) qRT-PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,bioinformatics technology,RGS gene modulation,cellular viability assays,annexin V-FITC staining assay. cell lines (SKOV-3,MDR-HeyA8) down-regulated resistant AKT G-Protein signaling pathway validated NA mRNA and protein low expression related 116 ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases Int J Cancer 2004 15027118 ABCG2 ENSG00000118777 colon cancer Irinotecan DB00762 (APRD00579) RT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the RT-PCR,drug sensitivity assay,efflux pumps immunoblotting,nucleotide sequencing. cell lines (HCT116) and patients tissues up-regulated resistant NA NA validated amplification NA related 117 AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway Cancer Res 2007 17616691 AKT ENSG00000142208 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the RT-PCR,immunoblotting and immunohistochemical analysis,genomic DNA analysis,aenovirus transfection experiments. cell lines (A549) and patients tissues up-regulated resistant NA mTOR/p70S6K1 pathway validated amplification NA related 118 Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells Oncol Res 2008 18669163 AURKA ENSG00000087586 cancer Cisplatin DB00515 (APRD00359) NA The effect of expression of the mRNA on the sensitivity of the drug was detected by the immunohistochemical analysis,western blotting analysis,cell cycle analysis,colony formation analysis,immunofluorescence assay,RNA interference experiments. cell lines (HCT116,SW480,HeLa,H1299) up-regulated resistant NA NA validated amplification NA related 119 Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells Oncol Res 2008 18669163 AURKA ENSG00000087586 cancer Etoposide DB00773 (APRD00239) NA The effect of expression of the mRNA on the sensitivity of the drug was detected by the immunohistochemical analysis,western blotting analysis,cell cycle analysis,colony formation analysis,immunofluorescence assay,RNA interference experiments. cell lines (HCT116,SW480,HeLa,H1299) up-regulated resistant NA NA validated amplification NA related 120 Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells Oncol Res 2008 18669163 AURKA ENSG00000087586 cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) NA The effect of expression of the mRNA on the sensitivity of the drug was detected by the immunohistochemical analysis,western blotting analysis,cell cycle analysis,colony formation analysis,immunofluorescence assay,RNA interference experiments. cell lines (HCT116,SW480,HeLa,H1299) up-regulated resistant NA NA validated amplification NA related 121 Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT Oncogene 2006 16462766 EVI1 ENSG00000085276 colon cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the qRT-PCR,vectors transfection experiments,immunocytochemistry,transient transfection assays,cell apoptosis analysis,RNA interference experiments. cell lines (RIE-1,HEC-1B) up-regulated resistant AKT PI3K/AKT signal pathway validated amplification NA related 122 Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma Oncotarget 2016 26811497 GCS ENSG00000148154 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The role of GCS was determined by qPCR analysis ,Immunoblot analysis,RNA interference experiments,Immunohistochemical staining. cell lines (HepG2 and Hep3B) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 123 Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway J Exp Clin Cancer Res 2019 30791926 GK5 ENSG00000175066 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR Real-time PCR and Western blot were used to examine the expression of GK5 mRNA and protein in gefitinib-sensitive and -resistant human lung adenocarcinoma cells. The cell counting kit-8, EdU assay, flow cytometry, and JC-1 dye were used to measure cell proliferation, cell cycle, and the mitochondrial membrane potential cell lines (PC9R ,H1975,PCR9 ) up-regulated resistant SCD1 GK5-SCD1 signaling pathway validated NA mRNA and protein overexpression related 124 Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway J Exp Clin Cancer Res 2019 30791926 SCD1 ENSG00000099194 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR Real-time PCR and Western blot were used to examine the expression of GK5 mRNA and protein in gefitinib-sensitive and -resistant human lung adenocarcinoma cells. The cell counting kit-8, EdU assay, flow cytometry, and JC-1 dye were used to measure cell proliferation, cell cycle, and the mitochondrial membrane potential cell lines (PC9R ,H1975,PCR9 ) up-regulated resistant NA GK5-SCD1 signaling pathway validated NA mRNA and protein overexpression related 125 TM4SF1 Promotes Gemcitabine Resistance of Pancreatic Cancer In Vitro and In Vivo PLoS One 2015 26709920 TM4SF1 ENSG00000169908 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The expression of TM4SF1 was evaluated by quantitative RT-PCR. TM4SF1 siRNA transfection was carried out using Hiperfect transfection reagent to knock down TM4SF1. The transcripts were analyzed by quantitative RT-PCR, RT-PCR and western blotting for further study. The cell proliferation and apoptosis were obtained to investigate the sensitivity to gemcitabine of pancreatic cancer cells after silencing TM4SF1 in vitro cell lines (L3.6pl, BxPC-3, SU86.86,MIA PaCa-2, PANC-1, Hs766T, AsPC-1) up-regulated resistant ABCB1/ABCC1 NA validated NA mRNA and protein overexpression related 126 MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes Oncogenesis 2013 23774063 MUC1 ENSG00000185499 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,iRNA knockdown experiments,MTT,immunohistochemistry. cell lines (BxPC3 ,GP2-293) up-regulated resistant ABCC1/ABCC3/ABCC5 PI3K/AKT signal pathway validated NA mRNA and protein overexpression related 127 MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes Oncogenesis 2013 23774063 MUC1 ENSG00000185499 pancreatic cancer Etoposide DB00773 (APRD00239) qRT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,iRNA knockdown experiments,MTT,immunohistochemistry. cell lines (BxPC3 ,GP2-293) up-regulated resistant ABCC1/ABCC3/ABCC5 PI3K/AKT signal pathway validated NA mRNA and protein overexpression related 128 pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs PLoS One 2010 21152064 PP32 ENSG00000140350 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The protein and mRNA expressions of PP32 were respectively determined using Western Blotting and real-time PCR,Transient transfection of pp32 expression vector and siRNA for Ribonucleoprotein immunoprecipitation binding,Immunofluorescence,Growth assay,Drug Sensitivity Assays.(RNP-IP) assays. cell line (MiaPaCa2) up-regulated resistant HUR NA validated NA mRNA and protein overexpression related 129 pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs PLoS One 2010 21152064 PP32 ENSG00000140350 pancreatic cancer Cytarabine DB00987 (APRD00499) qRT-PCR The protein and mRNA expressions of PP32 were respectively determined using Western Blotting and real-time PCR,Transient transfection of pp32 expression vector and siRNA for Ribonucleoprotein immunoprecipitation binding,Immunofluorescence,Growth assay,Drug Sensitivity Assays.(RNP-IP) assays. cell line (MiaPaCa2) up-regulated resistant HUR NA validated NA mRNA and protein overexpression related 130 Inhibition of nemo-like kinase increases taxol sensitivity in laryngeal cancer Asian Pac J_ancer_rev. 2013 24460265 NLK ENSG00000087095 laryngeal_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The role of NLK was detected by real-time RT-PCR, Western blotting and flow cytometry analysis. cell line (Hep-2 ) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 131 Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation Mol Cancer 2010 20196838 PXR ENSG00000144852 colorectal cancer Irinotecan DB00762 (APRD00579) qPCR PXR mRNA expression was quantified by RT-quantitative PCR, transfection and siRNA strategies. Cellular response to irinotecan and its active metabolic SN38 was assessed by cell viability assays, HPLC metabolic profiles and mRNA quantification of PXR target genes. We showed that PXR was strongly expressed in colon tumor samples and displayed a great variability of expression cell lines (LS174T, SW480, SW620) and patients tissues up-regulated resistant UGT1A1 NA validated NA mRNA and protein overexpression related 132 iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe Clin Cancer Res 2011 21926165 IASPP ENSG00000104881 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR Expression and amplification status of iASPP was examined using immunohistochemistry, quantitative real-time PCR, and immunoblotting, and correlated with clinicopathologic parameters. cell lines and patients tissues up-regulated resistant separase NA validated amplification NA related 133 iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe Clin Cancer Res 2011 21926165 IASPP ENSG00000104881 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT-PCR Expression and amplification status of iASPP was examined using immunohistochemistry, quantitative real-time PCR, and immunoblotting, and correlated with clinicopathologic parameters. cell lines and patients tissues up-regulated resistant separase NA validated amplification NA related 134 Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer PLoS One 2014 24932685 IGF2 ENSG00000167244 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of IGF2 was determined by qPCR analysis,Proliferation Kinetics and Cytotoxicity Assays,ELISA for Receptor Phosphorylation,Western Blot Analysis of Protein Expression,Therapeutic Studies in Xenograft-bearing Mice,IGF2 and IR KnockdownIGF2 and IR Knockdown,Cell Cycle and Apoptosis Analysis. cell lines (A2780, HEY,NIH:OVCAR8) up-regulated resistant NA IGF signaling pathway validated NA mRNA and protein overexpression related 135 Forkhead box transcription factor 1 expression in gastric cancer: FOXM1 is a poor prognostic factor and mediates resistance to docetaxel J Transl Med 2013 24004449 FOXM1 ENSG00000111206 gastric cancer Docetaxel DB01248 (APRD00932) qRT-PCR We examined the expression of FOXM1 by immunohistochemistry , western blot analysis ,qRT-PCRthe association of FOXM1 expression and chemosensitivity to docetaxel in gastric cancer cells was further explored by MTT assay,Plasmids and transfections,Molecular evolution assay,Tubulin assay. cell lines (SGC-7901, AGS, MKN-28,GES-1 and HFE-145) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 136 NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway Oncogene 2009 19305429 NAC1 ENSG00000160877 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of mRNA was determined by qRT-PCR analysis,Immunohistochemistry and western blot,drug sensitivity and cell viability assays. cell lines ( 293 T, OVCAR3, SKOV3, A2780,HeLa cells,) up-regulated resistant Gadd45gip1 Gadd45 signaling pathway validated NA mRNA and protein overexpression related 137 NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway Oncogene 2009 19305429 GADD45GIP1 ENSG00000179271 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of mRNA was determined by qRT-PCR analysis,Immunohistochemistry and western blot,drug sensitivity and cell viability assays. cell lines ( 293 T, OVCAR3, SKOV3, A2780,HeLa cells,) down-regulated resistant NA Gadd45 signaling pathway validated NA mRNA and protein overexpression related 138 Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells Br J Cancer 2017 28222070 PTBP3 ENSG00000119314 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The mRNA and proteins of PTBP3 was determined by RT-PCR analysis, western blot. The role of PTBP3 was determined by MTT assays,Flow cytometry analysis. cell lines (AGS, BGC823,MGC803, MKN45, SGC7901) and patients tissues up-regulated resistant AKT HDAC6/Akt/TYMS pathway validated NA mRNA and protein overexpression related 139 APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance Oncol Rep 2018 30226610 APOBEC3B ENSG00000179750 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The role of APOBEC3B was determined by RT-PCR analysis,Immunohistochemistry and ICC , western blot,cell proliferation assay levels. cell lines (LN229, A172, T98G and U251MG) and patients tissues up-regulated resistant NA TGF-¦Â pathway validated NA mRNA and protein overexpression related 140 Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation Tumour Biol 2016 27473087 NOTCH1 ENSG00000148400 hodgkin lymphoma Sirolimus(Rapamycin) DB00877 (APRD00178, DB02439) qRT-PCR The effect of mRNA expression on the sensitivity of the drugs was determined by qRT-PCR analysis,Western blotting,DNA sequence analysis.The role of Rapamycin on NOTHCH1 was determined by Immunocyto- and immunohistochemistry,Xenograft experiment. microscopy,Quantification of apoptosis cell lines (DEV, L1236, KMH2) up-regulated resistant NA NOTCH1 signaling pathway validated NA mRNA and protein overexpression related 141 Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation Tumour Biol 2016 27473087 MTOR ENSG00000198793 hodgkin lymphoma Sirolimus(Rapamycin) DB00877 (APRD00178, DB02439) qRT-PCR The effect of mRNA expression on the sensitivity of the drugs was determined by qRT-PCR analysis,Western blotting,DNA sequence analysis.The role of Rapamycin on NOTHCH1 was determined by Immunocyto- and immunohistochemistry,Xenograft experiment. microscopy,Quantification of apoptosis cell lines (DEV, L1236, KMH2) up-regulated resistant NA MTOR signaling pathway validated NA mRNA and protein overexpression related 142 Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma Br J Cancer 2019 30765873 AXL ENSG00000167601 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) NA The role of AXL was determined by IHC Immunoblotting,RNA knockdown interference experiments,18FDG cell uptake assay,cell cycle analysis,Migration and invasion assays,Wound healing assays,Matrigel clonogenic assay. cell lines ( PLC/PRF/5, Hep3B, HuH7, SKHep-1, SNU-449, SNU-387) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 143 Knockdown of frizzled-7 inhibits cell growth and metastasis and promotes chemosensitivity of esophageal squamous cell carcinoma cells by inhibiting Wnt signaling Biochem Biophys Res Commun 2017 28669726 FZD7 ENSG00000155760 esophageal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The mRNA and protein of FZD7 was detected and extracted real-time quantitative PCR (RT-qPCR) , Western blot analysis. The association between the FZD7 and Cisplatin was detected by iRNA knockeddown experiment, Cell proliferation assay , Colony formation assay, Cell apoptosis assay , Transwell migration and invasion assays , Luciferase reporter assay. cell lines (TE-1, EC109, TE-10, TE-11,HEEC) up-regulated resistant NA WNT singaling pathway validated NA mRNA and protein overexpression related 144 Molecular analysis of two human doxorubicin-resistant cell lines: evidence for differing multidrug resistance mechanisms Anticancer Res 1991 1673331 MDR1 ENSG00000085563 colon cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) NA Southern analysis and for overexpression of its messenger RNA. cell lines (LoVo/DR5) up-regulated resistant NA NA validated amplification NA related 145 Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis Biochem Pharmacol 2008 17945194 AKR1C1 ENSG00000187134 colon cancer Methotrexate DB00563 (APRD00353) RT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the RT-PCR,hybridization,western blotting analysis,luciferase assays,RNA transfection experiments,cell cycle and apoptosis assays. cell lines (HT-29) up-regulated resistant SP1 NA validated NA mRNA and protein overexpression related 146 UDP-glucuronosyltransferase 1A6 overexpression in breast cancer cells resistant to methotrexate Biochem Pharmacol 2011 20854796 UGT1A6 ENSG00000167165 breast cancer Methotrexate DB00563 (APRD00353) RT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the RT-PCR,hybridization,western blotting analysis,luciferase assays,RNA transfection experiments,cell cycle and apoptosis assays. cell lines (MCF7 and MDA-MB-468) up-regulated resistant AhR/ARNT NA validated NA mRNA and protein overexpression related 147 Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion Gut 2011 21068133 CHD1L ENSG00000131778 hepatocellular carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR A CHD1L-overexpressing_ell model was generated and the mechanism of chemoresistance involving CHD1L was investigated. An adenovirus-mediated silencing method was used to knockdown CHD1L, and its effects on tumorigenicity and chemoresistance were investigated in vivo and in vitro. cell lines and patients tissues up-regulated resistant NA Nur77 signaling pathway validated amplification NA related 148 Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study BMC Cancer 2008 18700047 PTEN ENSG00000171862 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR CRC patients treated with cetuximab by the Hellenic Cooperative Oncology group, whose formalin-fixed paraffin-embedded tumor tissue was available, were included. Tissue was tested for PTEN by IHC and fluorescence in situ hybridization (FISH). patients tissues up-regulated resistant NA NA validated amplification NA related 149 Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors Cancer Res 2001 11454699 TYMS ENSG00000176890 cancer Raltitrexed DB00293 (APRD00430, EXPT01092) RT-PCR TS mRNA and protein were consistently_verexpressed_n all_rug-resistant tumor cell lines compared with the_ensitive_arent cell lines. Southern blot and FISH analysis demonstrated that the TS_ene_as amplified in 5-FU- and TDX-resistant cell lines. cell lines and patients tissues up-regulated resistant NA NA validated amplification NA related 150 Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors Cancer Res 2001 11454699 TYMS ENSG00000176890 cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR TS mRNA and protein were consistently_verexpressed_n all_rug-resistant tumor cell lines compared with the_ensitive_arent cell lines. Southern blot and FISH analysis demonstrated that the TS_ene_as amplified in 5-FU- and TDX-resistant cell lines. cell lines and patients tissues up-regulated resistant NA NA validated amplification NA related 151 P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells Cancer Res 2004 15173011 CDKN1B ENSG00000111276 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) RT-PCR The effect of expression of the mRNA on the sensitivity of the drug was detected by the IHC,hybridization,cell cycle analysis,immunoblotting analysis,kinase assays,transfection assay. cell lines (SKBR3 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 152 Retinoic-acid-resistant neuroblastoma cell lines show altered MYC regulation and high sensitivity to fenretinide Med Pediatr Oncol 2000 11107126 MYCN £¨N-myc) ENSG00000134323 neuroblastoma Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) Northern Blot Expression of MYCN were measured using northern and western blotting analysis,retroviral vector transfection experiments,cell apoptosis assay. cell lines (SMS-SAN, SMS-LHN, SMS-KAN, SMS-KANR, SMSKCNR, LA-N-5, LA-N-6, SK-N BE(2), SK-N-SH, SKN-FI, SK-N-RA, LHN 12X RR, KCNR 12X, RR, and LA-N-5 12X RR) up-regulated resistant NA NA validated amplification NA related 153 Retinoic-acid-resistant neuroblastoma cell lines show altered MYC regulation and high sensitivity to fenretinide Med Pediatr Oncol 2000 11107126 MYCN £¨N-myc) ENSG00000134323 neuroblastoma Fenretinide DB05076 (DB03922) Northern Blot Expression of MYCN were measured using northern and western blotting analysis,retroviral vector transfection experiments,cell apoptosis assay. cell lines (SMS-SAN, SMS-LHN, SMS-KAN, SMS-KANR, SMSKCNR, LA-N-5, LA-N-6, SK-N BE(2), SK-N-SH, SKN-FI, SK-N-RA, LHN 12X RR, KCNR 12X, RR, and LA-N-5 12X RR) up-regulated sensitive NA NA validated amplification NA related 154 Inverse expression of mdr 1 and c-myc genes in a rhabdomyosarcoma cell line resistant to actinomycin d J Pathol 1996 8943821 MDR1 ENSG00000085563 rhabdomyosarcoma Dactinomycin DB00970 (APRD00124) PCR The effect of the mRNA expression on the sensitivity of the drug was detected by the PCR,hybridization. cell lines (RD-DAC) up-regulated resistant P-glycoprotein NA validated NA mRNA and protein overexpression related 155 Inverse expression of mdr 1 and c-myc genes in a rhabdomyosarcoma cell line resistant to actinomycin d J Pathol 1996 8943821 MYC ENSG00000136997 rhabdomyosarcoma Dactinomycin DB00970 (APRD00124) Northern blot and Southern blot The effect of the mRNA expression on the sensitivity of the drug was detected by the northern blotting analysis and southern blotting analysis. cell lines (RD-DAC) down-regulated resistant MDR1 NA validated NA mRNA low expression related 156 Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines Anticancer Res 1996 8712728 MYC ENSG00000136997 lung cancer Cisplatin DB00515 (APRD00359) NA The relationship between the mRNA expression and the drug sensitivity was detected by the RNA transfection experiments. cell lines (GLC4) up-regulated resistant NA NA validated amplification NA related 157 Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines Anticancer Res 1996 8712728 MYC ENSG00000136997 lung cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) NA The relationship between the mRNA expression and the drug sensitivity was detected by the RNA transfection experiments. cell lines (GLC4) up-regulated resistant NA NA validated amplification NA related 158 MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor Lung Cancer 2015 26547802 MET ENSG00000105976 lung cancer Crizotinib DB08865 (DB08700) RT-PCR The relationship between the gene and drug sensitivity was detected by the database bioinformatics technology,RT-PCR,western blotting analysis,cell growth inhibition assay,soft-agar assay,cell growth assay,cell transfection experiments. cell lines (HEK293) up-regulated sensitive MET and ERK1/2 NA validated mutation (exon 14 deletion) protein overexpression related 159 C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance Mol Cancer Ther 2002 12479221 ABCG2 ENSG00000118777 breast cancer Irinotecan DB00762 (APRD00579) RT-PCR and Northern blot The effect of the mRNA expression on the drug sensitivity was detected by the RT-PCR,northern blotting analysis,western blotting analysis,cell transfection experiments,growth inhibition assay. cell lines (A549, NCI-H460, KM-12, HT-29, OVCAR-5, and RPMI8226) down-regulated sensitive NA NA validated mutation (C421A substituting Lys for Gln-141) protein low expression related 160 C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance Mol Cancer Ther 2002 12479221 ABCG2 ENSG00000118777 breast cancer Irinotecan DB00762 (APRD00579) RT-PCR and Northern blot The effect of the mRNA expression on the drug sensitivity was detected by the RT-PCR,northern blotting analysis,western blotting analysis,cell transfection experiments,growth inhibition assay. cell lines (A549, NCI-H460, KM-12, HT-29, OVCAR-5, and RPMI8226) down-regulated sensitive NA NA validated mutation (C376T exon 4 substituting stop codon for Gln-126) protein low expression related 161 C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance Mol Cancer Ther 2002 12479221 ABCG2 ENSG00000118778 breast cancer Mitoxantrone DB01204 (APRD00371) RT-PCR and Northern blot The effect of the mRNA expression on the drug sensitivity was detected by the RT-PCR,northern blotting analysis,western blotting analysis,cell transfection experiments,growth inhibition assay. cell lines (A549, NCI-H460, KM-12, HT-29, OVCAR-5, and RPMI8226) down-regulated sensitive NA NA validated mutation (C421A substituting Lys for Gln-141) protein low expression related 162 C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance Mol Cancer Ther 2002 12479221 ABCG2 ENSG00000118779 breast cancer Mitoxantrone DB01204 (APRD00371) RT-PCR and Northern blot The effect of the mRNA expression on the drug sensitivity was detected by the RT-PCR,northern blotting analysis,western blotting analysis,cell transfection experiments,growth inhibition assay. cell lines (A549, NCI-H460, KM-12, HT-29, OVCAR-5, and RPMI8226) down-regulated sensitive NA NA validated mutation (C376T exon 4 substituting stop codon for Gln-126) protein low expression related 163 Role of 3' repressor sequences of p53 in anti-cancer drug sensitivity of human lung tumor cells Gene 2016 27591972 P53 ENSG00000141510 lung cancer Vinorelbine DB00361 (APRD00101) Rneasy kit The drug sensitivity was detected by the rneasy kit,cell cycle assays,cell apoptotic analysis,drug sensitivity assay. cell lines (801D) down-regulated sensitive NA P53 signaling pathway validated mutation ( deletion of 37 amino acid residues (356-393) and 3' non-coding mRNAs at the C-terminus) NA related 164 YAP promotes erlotinib resistance in human non-small cell lung cancer cells Oncotarget 2016 27409162 YAP ENSG00000137693 lung cancer Erlotinib DB00530 (APRD00951) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR£¬western blotting analysis,siRNA transfection experiments,luciferase reporter assay,wound-healing assay,transwell invasion assay. cell lines (H1975 and HCC827) up-regulated resistant AREG /CTGF /ERBB3 Hippo/YAP signaling pathway validated NA mRNA and protein overexpression related 165 Relationship between Mutations of the Epidermal Growth Factor Receptor Gene and Drug-Resistance to Gefitinib in Human Lung Cancer in vitro Zhongguo Fei Ai Za Zhi 2009 20712953 EGFR ENSG00000146648 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR The effect of expression of the mRNA on the drug sensitivity was detected by the RT-PCR. cell lines (PC9, PC9/AB2, PC9/AB11, PC9/BB4) down-regulated resistant EGFR EGFR/AKT/MAPK signaling pathway validated mutation (15 bp deletion at exon 19) NA related 166 Relationship between Mutations of the Epidermal Growth Factor Receptor Gene and Drug-Resistance to Gefitinib in Human Lung Cancer in vitro Zhongguo Fei Ai Za Zhi 2009 20712953 EGFR ENSG00000146648 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR The effect of expression of the mRNA on the drug sensitivity was detected by the RT-PCR. cell lines (PC9, PC9/AB2, PC9/AB11, PC9/BB4) down-regulated resistant EGFR EGFR/AKT/MAPK signaling pathway validated mutation (A to G point-mutation at exon 20) NA related 167 Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer Carcinogenesis 2013 23764753 EGFR ENSG00000146648 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the RT-PCR,lentivirus and small interfering RNA transfection experiments,western blotting analysis,gelatin zymography,cell proliferation and drug sensitivity assay,transwell migration and invasion assay. cell lines (SKOV3, CAOV3 and ES2) and patients tissues down-regulated resistant Bcl-2/BAD NA validated mutation (Exon 4 deletion) NA related 168 Knockdown of clusterin expression increases the in vitro sensitivity of human prostate cancer cells to paclitaxel J Toxicol Environ Health A 2014 25343293 CLU ENSG00000120885 prostate cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The effect of expression of the mRNA on the drug sensitivity was detected by the RT-PCR,cell viability assay,siRNA transfection experiments,western blotting analysis. cell lines (PC3) up-regulated resistant PP2AC NA validated NA mRNA and protein overexpression related 169 Cdc20/p55 mediates the resistance to docetaxel in castration-resistant prostate cancer in a Bim-dependent manner Cancer Chemother Pharmacol 2018 29605876 CDC20 ENSG00000117399 prostate cancer Docetaxel DB01248 (APRD00932) NA The effect of expression of the mRNA on the drug sensitivity was detected by the western blotting analysis,cell transfection experiments,western blotting analysis,cell viability analysis,apoptosis assays,colony formation assays. cell lines (LNCaP, PC3, and DU145) up-regulated resistant BIM NA validated NA mRNA and protein overexpression related 170 RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation Acta Pharmacol Sin 2014 24909514 RIP3 ENSG00000129465 breast cancer Parthenolide DB13063 RT-PCR The_xpression_f RIP3_RNA_n human breast_ancer_ell lines (MCF-7, MDA-MB-231, MDA-MB-435 and T47D) was detected using RT-PCR. Both MDA-MB-231 and MCF-7 cells were transfected with RIP3_xpression_r blank vectors via lentivirus. Cell viability was measured with MTT assay; intracellular ROS level and cell apoptosis were analyzed using flow cytometry. cell lines (MCF-7, MDA-MB-231, MDA-MB-435 and T47D) up-regulated sensitive ROS NA validated NA protein overexpression related 171 Transcriptional regulation of MDR-1 by HOXC6 in multidrug-resistant cells Oncogene 2013 22907429 HOXC6 ENSG00000197757 cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the qRT-PCR,MTT assay,promoter-luciferase reporter assay,chromatin immunoprecipitation assay,western blotting analysis,siRNA interference experiments,caspase-3 activity assays. cell lines (LNCaP) up-regulated resistant MDR1 NA validated NA mRNA and protein overexpression related 172 Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin Clin Cancer Res 2009 19509135 CTR2 ENSG00000136867 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR CTR2 levels were determined by quantitative reverse transcription-PCR and Western blot analysis. Cisplatin (DDP) was quantified by inductively coupled plasma mass spectrometry and (64)Cu and [(14)C]carboplatin (CBDCA) accumulation by gamma and scintillation counting. cell lines down-regulated sensitive NA NA validated NA mRNA and protein low expression related 173 Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin Clin Cancer Res 2009 19509135 CTR2 ENSG00000136867 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT-PCR CTR2 levels were determined by quantitative reverse transcription-PCR and Western blot analysis. Cisplatin (DDP) was quantified by inductively coupled plasma mass spectrometry and (64)Cu and [(14)C]carboplatin (CBDCA) accumulation by gamma and scintillation counting. cell lines down-regulated sensitive NA NA validated NA mRNA and protein low expression related 174 Relationship between thymidylate synthase (TYMS) gene polymorphism and TYMS protein levels in patients with high-risk breast cancer Anticancer Res 2010 21036767 TYMS ENSG00000176890 breast cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the RT-PCR,TYMS protein ELISA assay. patients tissues down-regulated sensitive NA NA validated mutation (3'-UTR 6 bp deletion) NA related 175 Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells Oncogene 2011 21057529 VEGF ENSG00000112715 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the RT-PCR,cell proliferation assay,western blot analysis,propidium iodide staining and flow cytometry,annexin V staining,immunohistochemical staining,siRNA interference study. cell lines (HCT116 and LS174T) up-regulated resistant caspase-3, cleaved PARP and Bax/survivin NA validated NA mRNA and protein overexpression related 176 A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA Blood 1992 1728309 NR3C1 ENSG00000113580 melanoma Dexamethasone DB01234 (APRD00674) Northern blot The role of the mRNA on the sensitivity of the drug was detected by the northern blotting analysis,southern blotting analysis,glucocorticoid binding assay. cell lines (MM.1S,MM.1R) down-regulated resistant NA NA validated mutation (deletion in its 3' end) NA related 177 BRCA1 and BRCA2 mRNA-expression prove to be of clinical impact in ovarian cancer Br J Cancer 2018 30111871 BRCA1 ENSG00000012048 ovarian_ancer Platinum DB12257 qRT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the qRT-PCR. patients tissues down-regulated sensitive NA NA validated NA mRNA and protein low expression related 178 BRCA1 and BRCA2 mRNA-expression prove to be of clinical impact in ovarian cancer Br J Cancer 2018 30111871 BRCA2 ENSG00000139618 ovarian_ancer Platinum DB12257 qRT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the qRT-PCR. patients tissues down-regulated sensitive NA NA validated NA mRNA and protein low expression related 179 SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15 Oncogene 2012 22158045 SLUF2 ENSG00000196562 lung cancer Camptothecin DB04690 PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the PCR,MSP,combined bisulfite modification and restriction analysis,quantitative TaqMan assays,cell survival, migration analysis,siRNA knockdown experiments,tumor xenograft study. patients tissues down-regulated sensitive ISG15 FGF and Wnt signaling pathway validated NA promoter hypermethylation related 180 SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15 Oncogene 2012 22158045 SLUF2 ENSG00000196562 lung cancer Topotecan DB01030 (APRD00687) PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the PCR,MSP,combined bisulfite modification and restriction analysis,quantitative TaqMan assays,cell survival, migration analysis,siRNA knockdown experiments,tumor xenograft study. patients tissues down-regulated sensitive ISG15 FGF and Wnt signaling pathway validated NA promoter hypermethylation related 181 Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation Cancer Lett 2008 18565644 ENDOG ENSG00000167136 prostate cancer Cisplatin DB00515 (APRD00359) RT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the RT-PCR,western blotting analysis,MSP,siRNA silencing experiments,immunohistochemistry and image analysis,endonuclease activity assay. cell lines (PC3,22Rv1 and LNCaP) down-regulated resistant NA NA validated NA promoter hypermethylation related 182 Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation Cancer Lett 2008 18565644 ENDOG ENSG00000167136 prostate cancer Etoposide DB00773 (APRD00239) RT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the RT-PCR,western blotting analysis,MSP,siRNA silencing experiments,immunohistochemistry and image analysis,endonuclease activity assay. cell lines (PC3,22Rv1 and LNCaP) down-regulated resistant NA NA validated NA promoter hypermethylation related 183 A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer Oncogene 1999 10327053 MLH1 ENSG00000076242 ovarian_ancer Cisplatin DB00515 (APRD00359) PCR The effect of the mRNA on the role of the drug sensitivity were detected by the PCR,southern blotting analysis,5-azacytidine treatment experiments,immunohistochemistry. cell lines and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 184 Methylation-mediated repression of GADD45alpha in prostate cancer and its role as a potential therapeutic target Cancer Res 2009 19190346 GADD45A ENSG00000116717 prostate cancer Docetaxel DB01248 (APRD00932) qRT-PCR The relationship between the mRNA expression andd the drug sensitivity was detected by the qRT-PCR,shRNA transfection experiments,western blotting analysis,immunofluorescence staining,bisulfite genomic sequencing and methylation analysis,chromatin immunoprecipitation,cell viability and apoptosis assay. cell lines (Du145, LNCaP, and PC3) and patients tissues down-regulated resistant MeCP2. NA validated NA 4 CpG region upstream of the proximal promoter methylation related 185 Methylation-mediated silencing of TMS1 in pancreatic cancer and its potential contribution to chemosensitivity Anticancer Res 2010 21036703 TMS1 ENSG00000132824 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR Methylation_nalysis was performed by_ethylation-specific PCR (MS-PCR) and gene expression was analyzed by quantitative reverse transcriptase PCR (qRT-PCR). MIA PaCa-2 cells were transfected with pCMV6-XL5/TMS1 plasmid and the effect of TMS1 expression on_ensitivity_o gemcitabine and docetaxel was determined. Cell viability was measured using Cell Titer Blue assay. cell lines (MIA PaCa2, ASPC1 and PANC1) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 186 Methylation-mediated silencing of TMS1 in pancreatic cancer and its potential contribution to chemosensitivity Anticancer Res 2010 21036703 TMS1 ENSG00000132824 pancreatic cancer Docetaxel DB01248 (APRD00932) qRT-PCR Methylation_nalysis was performed by_ethylation-specific PCR (MS-PCR) and gene expression was analyzed by quantitative reverse transcriptase PCR (qRT-PCR). MIA PaCa-2 cells were transfected with pCMV6-XL5/TMS1 plasmid and the effect of TMS1 expression on_ensitivity_o gemcitabine and docetaxel was determined. Cell viability was measured using Cell Titer Blue assay. cell lines (MIA PaCa2, ASPC1 and PANC1) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 187 GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling Anticancer Drugs 2009 19396019 GSTP1 ENSG00000084207 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the RT-PCR,MSP,immunoblotting analysis,cell viability assay, cell lines (MGC803 ,BGC823 and SGC7901) down-regulated sensitive NA MAPK/ERK signaling pathway validated NA promoter hypermethylation related 188 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 ARHGDIB ENSG00000111348 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 189 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 ARMCX2 ENSG00000184867 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 190 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 COL1A ENSG00000108821 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 191 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 FLNA ENSG00000196924 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 192 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 FLNC ENSG00000128591 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 193 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 MEST ENSG00000106484 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 194 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 MLH1 ENSG00000076242 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 195 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 NTS ENSG00000133636 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 196 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 PSMB9 ENSG00000240065 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 197 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling Oncogene 2012 22249249 MDK ENSG00000110492 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,DNA Methylation Kit analysis,database analysis,bisulphite modification and pyrosequencing analysis,drug treatment study. cell lines (A2780p5, A2780p6, A2780/cp70, A2780/MCP1 and A2780/MCP6) and patients tissues down-regulated resistant NA NA validated NA CpG sites methylation related 198 Methylation status of breast cancer resistance protein detected by methylation-specific polymerase chain reaction analysis is correlated inversely with its expression in drug-resistant lung cancer cells Cancer 2008 18219662 BCRP ENSG00000118779 lung cancer SN-38 DB05482 (DB12552) RT-PCR BCRP re-expression by means of reverse transcriptase-polymersae chain reaction, Western blot, and flow cytometric analyses. Subsequently, bisulfite sequencing analysis in both PC-6 cells and SN-38-resistant PC-6/SN2-5H, highly expressing BCRP cells was performed to identify the methylated region in the BCRP promoter. Finally, the authors established an MSP method on the basis of methylated and unmethylated DNA sequences. cell lines (PC-6) down-regulated sensitive NA NA validated NA promoter hypermethylation related 199 Hypermethylation of CpG sites at the promoter region is associated with deregulation of mitochondrial ATPsyn-beta and chemoresistance in acute myeloid leukemia Cancer Biomark 2016 26835708 ATP5F1B ENSG00000110955 acute myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR Quantitative RT-PCR and_ethylation_pecific PCR were performed to assess mRNA expression and_ethylation_tatus of ATPsyn-¦Â gene on primary bone marrow nuclear cells (BMMCs), and cell proliferation assay was used to determine the_ensitivity_f BMMCs to adriamycin. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 200 Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis Cell Death Dis 2012 22764101 ASS1 ENSG00000130707 lymphoma Pegargiminase (pegylated arginine deiminase) DB06592 RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,MSP,IHC,flow cytometry analysis,immunoblotting assay. cell lines (NcNc,Karpas-422,MyLa ,SeAx ) down-regulated sensitive caspase-3/PARP NA validated NA promoter hypermethylation related 201 Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines Int J Cancer 2003 12794758 MLH1 ENSG00000076242 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR MLH1 mRNA and protein expression were determined by RT-PCR and immunoblots. The_ethylation_tatus for hMLH1 was investigated by_ethylation-specific PCR. cell lines (SW48 ,HCT116) down-regulated resistant MMR MMR signaling pathway validated NA promoter hypermethylation related 202 Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer Cancer Res Treat 2016 26511811 ADGRL2 ENSG00000117114 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR and qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,qRT-PCR,bisulfite genomic sequencing analyses and pyrosequencing,chromatin immunoprecipitation,siRNA transfection experiments,cell growth inhibition assays. cell lines and patients tissues down-regulated sensitive NA NA validated NA CpG sites methylation related 203 Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer Cancer Res Treat 2016 26511811 ADGRL2 ENSG00000117114 colon cancer Cisplatin DB00515 (APRD00359) RT-PCR and qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,qRT-PCR,bisulfite genomic sequencing analyses and pyrosequencing,chromatin immunoprecipitation,siRNA transfection experiments,cell growth inhibition assays. cell lines and patients tissues down-regulated sensitive NA NA validated NA CpG sites methylation related 204 TET1 promotes cisplatin-resistance via demethylating the vimentin promoter in ovarian cancer Cell Biol Int 2017 28150354 TET1 ENSG00000138336 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the qRT-PCR,siRNA and plasmid transfection experiments,MSP,western blotting analysis,cell apoptosis assays,cell invasion and migration assay ,IHC. cell lines (A2780 ,CP70) and patients tissues up-regulated resistant vimentin NA validated NA mRNA and protein overexpression related 205 Kr¨¹ppel-Like Factor 4 Enhances_ensitivity_f Cisplatin to Esophageal Squamous Cell Carcinoma (ESCC) Cells Med Sci Monit 2017 28694421 KLF4 ENSG00000136826 esophageal_ancer Cisplatin DB00515 (APRD00359) RT-PCR Methylation-specific PCR (MS-PCR) were used to detect the methylation status for KLF4. The expression of the mRNA was RT-PCR.Cell ability, apoptosis, and cell cycle were measured using methyl thiazolyl tetrazolium (MTT) assay, Annexin V affinity assay, and flow cytometry, respectively. cell lines (CaEs-17, TE-1, EC109, KYSE510, KYSE140, KYSE70, and KYSE30s) down-regulated resistant NA NA validated NA promoter hypermethylation related 206 BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer Epigenetics 2012 23069641 BRCA1 ENSG00000012048 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,MSP,MTT analysis. cell lines (SK-OV-3, IGR-OV1, OVCAR-3 and OVCAR-5) down-regulated sensitive NA NA validated NA promoter hypermethylation related 207 5-Aza-CdR can reverse gefitinib resistance caused by DAPK gene promoter methylation in lung adenocarcinoma cells Int J Clin Exp Pathol 2015 26722491 DAPK ENSG00000196730 lung cancer Gefitinib DB00317 (APRD00997, DB07998) NA The cell proliferation was determined by MTT assay. The apoptotic rates were detected by flow cytometry. The methylation of DAPK gene promoter region was examined by methylation-specific PCR (MSP). The expressions of DAPK protein were detected by Western blot. cell lines (PC9) down-regulated resistant NA NA validated NA promoter hypermethylation related 208 DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically Oncotarget 2016 27612427 DCTPP1 ENSG00000179958 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,BSP analysis,RNA knockdown experiments,tumor xenograft study,cell apoptosis analysis,cell cycle analysis. cell lines (BGC-823) up-regulated resistant MDR1/P-gp NA validated NA mRNA and protein overexpression related 209 DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically Oncotarget 2016 27612427 MDR1 ENSG00000085563 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,BSP analysis,RNA knockdown experiments,tumor xenograft study,cell apoptosis analysis,cell cycle analysis. cell lines (BGC-823) down-regulated sensitive NA NA validated NA promoter hypermethylation related 210 Histone Deacetylase-1-mediated Suppression of FAS in Chemoresistant Ovarian Cancer Cells Anticancer Res 2016 27272793 FAS ENSG00000026103 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The cell surface and transcript expressions of death receptors in parental chemosensitive (A2780) and their derivative chemoresistant (A2780-AD) ovarian cancer cells were determined by flow cytometry and quantitative real-time polymerase chain reaction, respectively. The epigenetic regulation of FAS promoters in both A2780 and A2780-AD ovarian epithelial cells were determined by chromatin immunoprecipitation assays. cell lines (A2780) down-regulated resistant HDAC1 NA validated NA low acetylated histone H3 associated with FAS promoter related 211 Histone Deacetylase-1-mediated Suppression of FAS in Chemoresistant Ovarian Cancer Cells Anticancer Res 2016 27272793 HDAC1 ENSG00000116478 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The cell surface and transcript expressions of death receptors in parental chemosensitive (A2780) and their derivative chemoresistant (A2780-AD) ovarian cancer cells were determined by flow cytometry and quantitative real-time polymerase chain reaction, respectively. The epigenetic regulation of FAS promoters in both A2780 and A2780-AD ovarian epithelial cells were determined by chromatin immunoprecipitation assays. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 212 Different epigenetic mechanisms of ERalpha implicated in the fate of fulvestrant-resistant breast cancer J Steroid Biochem Mol Biol 2017 27888136 ESR1 ENSG00000091831 breast cancer Fulvestrant DB00947 (APRD00654) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,MSP,MTT analysis. cell lines (MCF-7 and T-47D) down-regulated resistant NA ER signaling pathway validated NA mRNA and protein low expression related 213 Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs Oncotarget 2016 26625211 SLFN11 ENSG00000172716 lung cancer Cisplatin DB00515 (APRD00359) qRT_PCR The effect of the mRNA on the role of the drug sensitivity were detected by the qRT-PCR,bisulfite sequencing technology,DNA methylation arrays,shRNA interference experiments,mass spectrometry analysis,colocalization assay,cell viability assays. cell lines (HCT-116, HCT15, MCF-7, MDA-MB-231,293T,OVCAR-8, H23, DU145,U251) down-regulated resistant NA NA validated NA promoter hypermethylation related 214 Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs Oncotarget 2016 26625211 SLFN11 ENSG00000172716 lung cancer Cisplatin DB00515 (APRD00359) qRT_PCR The effect of the mRNA on the role of the drug sensitivity were detected by the qRT-PCR,bisulfite sequencing technology,DNA methylation arrays,shRNA interference experiments,mass spectrometry analysis,colocalization assay,cell viability assays. cell lines (HCT-116, HCT15, MCF-7, MDA-MB-231,293T,OVCAR-8, H23, DU145,U251) down-regulated resistant NA NA validated NA promoter hypermethylation related 215 Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs Oncotarget 2016 26625211 SLFN11 ENSG00000172716 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT_PCR The effect of the mRNA on the role of the drug sensitivity were detected by the qRT-PCR,bisulfite sequencing technology,DNA methylation arrays,shRNA interference experiments,mass spectrometry analysis,colocalization assay,cell viability assays. cell lines (HCT-116, HCT15, MCF-7, MDA-MB-231,293T,OVCAR-8, H23, DU145,U251) down-regulated resistant NA NA validated NA promoter hypermethylation related 216 Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs Oncotarget 2016 26625211 SLFN11 ENSG00000172716 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT_PCR The effect of the mRNA on the role of the drug sensitivity were detected by the qRT-PCR,bisulfite sequencing technology,DNA methylation arrays,shRNA interference experiments,mass spectrometry analysis,colocalization assay,cell viability assays. cell lines (HCT-116, HCT15, MCF-7, MDA-MB-231,293T,OVCAR-8, H23, DU145,U251) down-regulated resistant NA NA validated NA promoter hypermethylation related 217 Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas Int J Cancer 2010 19626585 ERCC1 ENSG00000012061 glioma Cisplatin DB00515 (APRD00359) RT-PCR The levels of ERCC1 DNA methylation, mRNA and protein in 32 human glioma samples were examined by methylation specific PCR, real-time RT-PCR and immunohistochemistry, respectively. Meanwhile, cisplatin sensitivities to these human glioma samples were tested by histoculture drug response assay. cell lines (T98-G,UW28, MGR1, MGR2, and SF767) and patients tissues down-regulated sensitive NA NER signaling pathway validated NA upstream 5Kb region of the ERCC1 promoter methylation related 218 Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy BMC Cancer 2014 25164070 ASS1 ENSG00000130707 hepatocellular carcinoma Cisplatin DB00515 (APRD00359) NA ASS1 protein expression in both untreated and_rug_reated human HCC cell lines was assessed by western blot. The correlation between ASS1 protein levels, ADI-PEG 20_ensitivity_nd cisplatin resistance in these cell lines was established using a luminescence-based cell viability assay. Epigenetic regulation of ASS1 was analyzed by bisulfite conversion and_ethylation-specific PCR. cell lines (Sk-Hep1, Huh7, Tong, HCC36, Hep3B, Malhavu, PLC5,Huh6,HepG2, SNU398,SNU182,A7280) down-regulated resistant Sp1 NA validated NA promoter hypermethylation related 219 Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy BMC Cancer 2014 25164070 ASS1 ENSG00000130707 hepatocellular carcinoma Pegargiminase DB06592 NA ASS1 protein expression in both untreated and_rug_reated human HCC cell lines was assessed by western blot. The correlation between ASS1 protein levels, ADI-PEG 20_ensitivity_nd cisplatin resistance in these cell lines was established using a luminescence-based cell viability assay. Epigenetic regulation of ASS1 was analyzed by bisulfite conversion and_ethylation-specific PCR. cell lines (Sk-Hep1, Huh7, Tong, HCC36, Hep3B, Malhavu, PLC5,Huh6,HepG2, SNU398,SNU182,A7280) down-regulated sensitive Sp2 NA validated NA promoter hypermethylation related 220 Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells Mol Cancer 2010 20868484 ERCC5 ENSG00000134899 cancer nemorubicin NA RT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the RT-PCR,western blotting analysis,MSP. cell lines (L1210 ,HCT116 ) down-regulated resistant NER DNA repair mechanism validated NA promoter hypermethylation related 221 CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines Lung Cancer 2015 25638724 PTEN ENSG00000171862 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT_PCR DNA methylation status of the PTEN promoter in PC9 and gefitinib-resistant cells were examined using methylation-specific PCR. The expression of the mRNA was detected by the qRT-PCR.The effect of DNA methylation on PTEN expression was evaluated by treatment of lung cancer cell lines with 5-aza-2'-deoxycytidine (5AZA-CdR). cell lines (PC9,GEF1-1 and GEF2-1) down-regulated resistant AKT AKT signaling pathway validated NA promoter hypermethylation related 222 CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines Lung Cancer 2015 25638724 PTEN ENSG00000171862 lung cancer Erlotinib DB00530 (APRD00951) qRT_PCR DNA methylation status of the PTEN promoter in PC9 and gefitinib-resistant cells were examined using methylation-specific PCR. The expression of the mRNA was detected by the qRT-PCR.The effect of DNA methylation on PTEN expression was evaluated by treatment of lung cancer cell lines with 5-aza-2'-deoxycytidine (5AZA-CdR). cell lines (PC9,GEF1-1 and GEF2-1) down-regulated resistant AKT AKT signaling pathway validated NA promoter hypermethylation related 223 Downregulation of DCC sensitizes multiple myeloma cells to bortezomib treatment Mol Med Rep 2019 31059005 DCC ENSG00000187323 melanoma Bortezomib DB00188 (APRD00828, DB07475) NA NA cell lines down-regulated sensitive NA NA validated NA promoter hypermethylation related 224 Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression Biochem Cell Biol 2007 17612628 DPYD ENSG00000188641 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) Spectrophotometrically by UV absorbance The relationship between the mRNA expression and the drug sensitivity was detected by spectrophotometrically by UV absorbance,RNA transfection experiments,CHIP assay,bisulfite genomic sequencing. cell lines (RKO,WiDr ) down-regulated sensitive SP1 NA validated NA promoter hypermethylation related 225 Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer Oncol Rep 2007 17143476 CHFR ENSG00000072609 endometrial_ancer Taxanes NA RT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the MSP, cell lines (HEC108,HOOUA,HHUA,SNG-II, HEC1B and KLE) down-regulated sensitive NA NA validated NA promoter hypermethylation related 226 Role of neurofilament light polypeptide in head and neck cancer chemoresistance Mol Cancer Res 2012 22246235 NEFL ENSG00000277586 head and neck_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,MSP,siRNA experiments,MTT,western blotting analysis,colony formation assay,immunoprecipitation. cell lines (O11, O12, O13, O22, O28, O29 ,HN17B/HN17Bcp, SCC25/SCC25cp) and patients tissues down-regulated resistant TSC1 MTOR signaling pathway validated NA promoter hypermethylation related 227 Transglutaminase 2 as a cisplatin resistance marker in non-small cell lung cancer J Cancer Res Clin Oncol 2010 19763620 TGM2 ENSG00000198959 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR TGM2_romoter_ethylation_as analyzed by sodium bisulfite sequencing. The expression of the mRNA was detected by the RT-PCR. Cisplatin_ensitivity_as analyzed by treatment of cisplatin in NSCLC cell lines with/without TGM2 or TGM2 siRNA transfection. cell lines (HCC-95 and HCC-1588) down-regulated sensitive NF- kB NF-KB signaling pathway validated NA promoter hypermethylation related 228 Low c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas Sci Rep 2016 26879272 MET ENSG00000105976 glioma Temozolomide DB00853 (APRD00557) NA C-Met expression was measured using immunohistochemistry in 783 gliomas, and we further analyzed c-Met mRNA levels using the Agilent Whole Genome mRNA Microarray in 286 frozen samples. In vitro, we performed cell migration and invasion assays. Cell sensitivity to temozolomide (TMZ) chemotherapy was determined using MTT assays. patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 229 Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance Cell Cycle 2012 22487682 DAPK ENSG00000196730 lung cancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,qMSP,cell viability and drug sensitivity assay,immunoblot analysis,short interference RNA transfection experiments. cell lines (H226 ,H226C,H226D ,H226T) down-regulated resistant EGFR EGFR signaling pathways validated NA promoter hypermethylation related 230 Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance Cell Cycle 2012 22487682 DAPK ENSG00000196730 lung cancer Erlotinib DB00530 (APRD00951) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,qMSP,cell viability and drug sensitivity assay,immunoblot analysis,short interference RNA transfection experiments. cell lines (SCC1 ,SCC1T) down-regulated resistant EGFR EGFR signaling pathways validated NA promoter hypermethylation related 231 Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance Cell Cycle 2012 22487682 DAPK ENSG00000196730 head and neck_ancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,qMSP,cell viability and drug sensitivity assay,immunoblot analysis,short interference RNA transfection experiments. cell lines (H226 ,H226C,H226D ,H226T) down-regulated resistant EGFR EGFR signaling pathways validated NA promoter hypermethylation related 232 Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance Cell Cycle 2012 22487682 DAPK ENSG00000196730 head and neck_ancer Erlotinib DB00530 (APRD00951) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,qMSP,cell viability and drug sensitivity assay,immunoblot analysis,short interference RNA transfection experiments. cell lines (SCC1 ,SCC1T) down-regulated resistant EGFR EGFR signaling pathways validated NA promoter hypermethylation related 233 Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes Int J Oncol 2007 17786301 CHFR ENSG00000072609 cervical_ancer Taxanes NA RT-PCR The effect of the mRNA on the role of the drug sensitivity were detected by the RT-PCR, MSP,cell-cycle analysis,siRNA transfection experiments,immunoblotting. cell lines (SKG-I, SKG-II, SKG-IIIa,SKG-IIIb,HeLa,TCO-I) down-regulated sensitive NA NA validated NA aberrant methylation related 234 Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy Gynecol Oncol 2005 15894365 DNAJC15 ENSG00000120675 ovarian_ancer Carboplatin DB00958 (APRD00466) PCR The_ethylation_tatus of 35 CpG sites within the MCJ CpG island was determined by sequencing of sodium bisulfite modified tumor DNA in 41 patients with stage III/IV epithelial ovarian tumors. Levels of_ethylation_f the MCJ CpG island were then compared with response to therapy and overall survival in the patients. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 235 Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy Gynecol Oncol 2005 15894365 DNAJC15 ENSG00000120675 ovarian_ancer Cisplatin DB00515 (APRD00359) PCR The_ethylation_tatus of 35 CpG sites within the MCJ CpG island was determined by sequencing of sodium bisulfite modified tumor DNA in 41 patients with stage III/IV epithelial ovarian tumors. Levels of_ethylation_f the MCJ CpG island were then compared with response to therapy and overall survival in the patients. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 236 Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy Gynecol Oncol 2005 15894365 DNAJC15 ENSG00000120675 ovarian_ancer Taxoid NA PCR The_ethylation_tatus of 35 CpG sites within the MCJ CpG island was determined by sequencing of sodium bisulfite modified tumor DNA in 41 patients with stage III/IV epithelial ovarian tumors. Levels of_ethylation_f the MCJ CpG island were then compared with response to therapy and overall survival in the patients. patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 237 Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance Genes Chromosomes Cancer 2010 21960365 PCDH10 ENSG00000138650 acute lymphoblastic leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) NA The relationship between the mRNA expression and the drug sensitivity was detected by MSP,quantitative high-throughput analysis,MTT analysis. cell lines and patients tissues down-regulated resistant hBex1 hBex1/PCDH10 signaling pathway validated NA promoter hypermethylation related 238 Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance Genes Chromosomes Cancer 2010 21960365 PCDH10 ENSG00000138650 acute lymphoblastic leukemia Methotrexate DB00563 (APRD00353) NA The relationship between the mRNA expression and the drug sensitivity was detected by MSP,quantitative high-throughput analysis,MTT analysis. cell lines and patients tissues down-regulated resistant hBex1 hBex1/PCDH10 signaling pathway validated NA promoter hypermethylation related 239 Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance Genes Chromosomes Cancer 2010 21960365 PCDH10 ENSG00000138650 acute lymphoblastic leukemia Dexamethasone DB01234 (APRD00674) NA The relationship between the mRNA expression and the drug sensitivity was detected by MSP,quantitative high-throughput analysis,MTT analysis. cell lines and patients tissues down-regulated resistant hBex1 hBex1/PCDH10 signaling pathway validated NA promoter hypermethylation related 240 Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance Genes Chromosomes Cancer 2010 21960365 PCDH10 ENSG00000138650 acute lymphoblastic leukemia Bortezomib DB00188 (APRD00828, DB07475) NA The relationship between the mRNA expression and the drug sensitivity was detected by MSP,quantitative high-throughput analysis,MTT analysis. cell lines and patients tissues down-regulated resistant hBex1 hBex1/PCDH10 signaling pathway validated NA promoter hypermethylation related 241 Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation Cell Death Dis 2014 24743738 NRF2 ENSG00000116044 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,western blotting analysis,cell proliferation assay,colony formation analysis,cell apoptosis assay,HO-1 activity,immunocytochemistry,ChIP assay,siRNA and shRNA transfection experiments,MSP analysis,tumor xenograft studys. cell lines (SNUC5/5-FUR,SNUC5) up-regulated resistant HO1 NA validated NA promoter hypomethylation related 242 Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation Cell Death Dis 2014 24743738 HMOX1 ENSG00000100292 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,western blotting analysis,cell proliferation assay,colony formation analysis,cell apoptosis assay,HO-1 activity,immunocytochemistry,ChIP assay,siRNA and shRNA transfection experiments,MSP analysis,tumor xenograft studys. cell lines (SNUC5/5-FUR,SNUC5) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 243 Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer Cancer Res 2011 21402713 PLK2 ENSG00000145632 ovarian_ancer Carboplatin DB00958 (APRD00466) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,MSP analysis,western blotting analysis,cytotoxicity assays,annexin V assay,RNA knockdown experiments. cell lines (A2780,SKOV-3) and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 244 Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer Cancer Res 2011 21402713 PLK2 ENSG00000145632 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,MSP analysis,western blotting analysis,cytotoxicity assays,annexin V assay,RNA knockdown experiments. cell lines (A2780,SKOV-3) and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 245 PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas Tumour Biol 2014 24510345 PTPN6 ENSG00000111679 glioma Bortezomib DB00188 (APRD00828, DB07475) PCR PTPN6 expression was analyzed with immunohistochemistry in 89 high-grade glioma patients. Correlation between PTPN6 expression and overall survival was analyzed with Kaplan-Meier univariate analysis and Cox regression multivariate analysis. Differences in drug sensitivity to a panel of 16 chemotherapeutic drugs between PTPN6-overexpressing clones and control clones were analyzed in vitro with the fluorometric microculture cytotoxicity assay. Cell cycle analysis was done with Krishan staining and flow cytometry. Apoptosis was analyzed with a cell death detection ELISA kit as well as cleaved caspase-3 and caspase-9 Western blotting. cell lines and patients tissues up-regulated resistant NA NA validated NA promoter hypomethylation related 246 PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas Tumour Biol 2014 24510345 PTPN6 ENSG00000111679 glioma Cisplatin DB00515 (APRD00359) PCR PTPN6 expression was analyzed with immunohistochemistry in 89 high-grade glioma patients. Correlation between PTPN6 expression and overall survival was analyzed with Kaplan-Meier univariate analysis and Cox regression multivariate analysis. Differences in drug sensitivity to a panel of 16 chemotherapeutic drugs between PTPN6-overexpressing clones and control clones were analyzed in vitro with the fluorometric microculture cytotoxicity assay. Cell cycle analysis was done with Krishan staining and flow cytometry. Apoptosis was analyzed with a cell death detection ELISA kit as well as cleaved caspase-3 and caspase-9 Western blotting. cell lines and patients tissues up-regulated resistant NA NA validated NA promoter hypomethylation related 247 PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas Tumour Biol 2014 24510345 PTPN6 ENSG00000111679 glioma Melphalan DB01042 (APRD00118) PCR PTPN6 expression was analyzed with immunohistochemistry in 89 high-grade glioma patients. Correlation between PTPN6 expression and overall survival was analyzed with Kaplan-Meier univariate analysis and Cox regression multivariate analysis. Differences in drug sensitivity to a panel of 16 chemotherapeutic drugs between PTPN6-overexpressing clones and control clones were analyzed in vitro with the fluorometric microculture cytotoxicity assay. Cell cycle analysis was done with Krishan staining and flow cytometry. Apoptosis was analyzed with a cell death detection ELISA kit as well as cleaved caspase-3 and caspase-9 Western blotting. cell lines and patients tissues up-regulated resistant NA NA validated NA promoter hypomethylation related 248 Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer Cancer Res 2005 15899800 PSAT1 ENSG00000135069 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the bisulfite treatment,microarray hybridization,RT-PCR. patients tissues down-regulated sensitive ER-ALPHA NA validated NA promoter hypermethylation related 249 Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression BMC Cancer 2008 18992151 WTH3 ENSG00000222014 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,shRNA knockdown experimetns,MTT assays,transient transfection and luciferase assays. cell lines (MCF7/AdrR and MCF7/WT) down-regulated resistant P53/MDR1 NA validated NA promoter hypermethylation related 250 Epigenetic silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation Int J Cancer 2017 28656647 ASPP1 ENSG00000088808 clear cell renal cell carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,bisulphite sequencing PCR,immunohisochemistry ,western blotting analysis,MTT,soft agar assay ,tumor xenograft study,cell apoptosis analysis,luciferase assay cell lines (786-O, 769-P and CAKI-1) and patients tissues down-regulated resistant P53 NA validated NA promoter hypermethylation related 251 SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response Br J Cancer 2008 18458674 SPARC ENSG00000113140 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,DNA bisulfite sequencing, methylation-specific PCR,chromatin immunoprecipitation assay,cell viability, proliferation and clonogenic assay,immunoblotting analysis. cell lines (MIP101, RKO, HCT 116, and HT-29 CRC) down-regulated resistant NA NA validated NA promoter hypermethylation related 252 5-aza-2'-deoxycytidine improves the sensitivity of endometrial cancer cells to progesterone therapy Int J Gynecol Cancer 2012 22683940 PGR ENSG00000082175 endometrial_ancer Progesterone DB00396 (APRD00700) RT-PCR The expression of PR, PR target genes, and matrix metalloproteinase (MMP) was investigated by real-time polymerase chain reaction and Western blot._romoter_ethylation_as detected by_ethylation-specific polymerase chain reaction. The effects of 5-aza-CdR and/or MPA on cell proliferation, apoptosis, and invasion of EC cells were evaluated by 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium assay, flow cytometry, invasion assay, and gelatin zymography, respectively. cell lines (Ishikawa ,KLE) down-regulated resistant MMP2/MMP9 NA validated NA promoter hypermethylation related 253 The role of RASSF1A in uveal melanoma Invest Ophthalmol Vis Sci 2012 22447862 RASSF1A ENSG00000068028 melanoma Cisplatin DB00515 (APRD00359) qRT-PCR The phenotypic effect of methylation-induced inactivation of RASSF1A in UM was explored using a stable RASSF1A-expressing UM-15 clone. RASSF1A expression was assessed using QRT-PCR. Proliferation was evaluated in vitro using MTT assays. cell lines and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 254 Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell lines Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell lines 2014 24033105 ASNS ENSG00000070669 acute lymphoblastic leukemia L-asparaginase DB00023 (BTD00011, BIOD00011) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,pyrosequencing-based methylation analysis. cell lines and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 255 Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma J Neurooncol 2011 20593219 P53 ENSG00000141510 glioma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,MS-PCR,cell viability assay,western blotting analysis,gene knockdown experiments. cell lines (U87MG, U251MG, U343MG, U373MG, SF767, LN443 and LNZ308,BTICs--BT012, BT025, BT042, BT048, BT060 and BT069) down-regulated sensitive P53 NA validated NA mRNA and protein low expression related 256 Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cell PLoS One 2011 22216282 PTK6 ENSG00000101213 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by bisulfite-modified DNA sequencing and methylation-specific PCR,RT-PCR,MethylCap-seq technology. cell lines (A2780CP /A2780) down-regulated sensitive NA NA validated NA promoter hypermethylation related 257 Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cell PLoS One 2011 22216282 PRKCE ENSG00000171132 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by bisulfite-modified DNA sequencing and methylation-specific PCR,RT-PCR,MethylCap-seq technology. cell lines (A2780CP /A2780) down-regulated sensitive NA NA validated NA promoter hypermethylation related 258 Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cell PLoS One 2011 22216282 BCL2L1 ENSG00000171552 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by bisulfite-modified DNA sequencing and methylation-specific PCR,RT-PCR,MethylCap-seq technology. cell lines (A2780CP /A2780) down-regulated sensitive NA NA validated NA promoter hypermethylation related 259 Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines Mol Cancer Ther 2009 19531575 TOP1 ENSG00000198900 colorectal cancer Irinotecan DB00762 (APRD00579) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,qMSP analysis,bisulfite DNA sequencing,cell proliferation,cycle,apoptosis analysis. cell lines (HT29, SW620, WiDr, and LS174T) down-regulated resistant SP1 NA validated NA promoter hypermethylation related 260 Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines Mol Cancer Ther 2009 19531575 CDKN2A ENSG00000147889 colorectal cancer Irinotecan DB00762 (APRD00580) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,qMSP analysis,bisulfite DNA sequencing,cell proliferation,cycle,apoptosis analysis. cell lines (HT29, SW620, WiDr, and LS174T) down-regulated resistant SP1 NA validated NA promoter hypermethylation related 261 IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer Oncogene 2010 20023704 IGFBP3 ENSG00000146674 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,hybridization technology,siRNA transfection experiments,MSP,BS analysis. cell lines and patients tissues down-regulated resistant IGF-I IGF-I signaling pathway validated NA promoter hypermethylation related 262 Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma Cancer Res 2006 16818640 BEX1 ENSG00000133169 glioma Camptothecin DB04690 RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,western blotting analysis,cell proliferation assay,cell cycle assays,bisulfite sequencing analysis,chromatin immunoprecipitation assays,transfection and colony formation assays,tumor xenograft studys. cell lines (T98 and U87) and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 263 Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma Cancer Res 2006 16818640 BEX2 ENSG00000133134 glioma Camptothecin DB04690 RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,western blotting analysis,cell proliferation assay,cell cycle assays,bisulfite sequencing analysis,chromatin immunoprecipitation assays,transfection and colony formation assays,tumor xenograft studys. cell lines (T98 and U87) and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 264 Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells J Biol Chem 2001 11509559 RFC ENSG00000035928 breast cancer Methotrexate DB00563 (APRD00353) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,bisulfite treatment and methylation-specific PCR,chromatin immunoprecipitation,cDNA transfection experiments. cell lines (MDA-MB-231,MCF-7 ) down-regulated resistant NA NA validated NA promoter hypermethylation related 265 Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors Mol Cancer 2004 15149548 RASSF1A ENSG00000068028 germ cell tumor Cisplatin DB00515 (APRD00359) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,MSP,bisulphite sequencing,tissue microarray and immunohistochemical analysis. cell lines (833K-E,169A, 240A and 218A) and patients tissues down-regulated resistant MGMT NA validated NA promoter hypermethylation related 266 Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors Mol Cancer 2004 15149548 HIC1 ENSG00000177374 germ cell tumor Cisplatin DB00515 (APRD00359) RT-PCR cell lines (833K-E,169A, 240A and 218A) and patients tissues down-regulated resistant MGMT NA validated NA promoter hypermethylation related 267 Arsenic trioxide re-sensitizes ERalpha-negative breast cancer cells to endocrine therapy by restoring ERalpha expression in vitro and in vivo Oncol Rep 2011 21687957 ESR1 ENSG00000091831 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR MS-PCR was used to detect the change in the_ethylation_tatus of ER¦Á. RT-PCR, immunohistochemistry and Western blot analyses were used to detect changes in the mRNA and protein expression of DNA_ethyl-transferase-1 (DNMT1) and ER¦Á. Cell proliferation was examined using the MTT assay. A xenograft model in nude mice was used to further examine the results we observed in vitro. cell lines (MDA-MB-435,MCF-7) down-regulated resistant DNMT1 NA validated NA promoter hypermethylation related 268 Arsenic trioxide re-sensitizes ERalpha-negative breast cancer cells to endocrine therapy by restoring ERalpha expression in vitro and in vivo Oncol Rep 2011 21687957 DNMT1 ENSG00000130816 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR MS-PCR was used to detect the change in the_ethylation_tatus of ER¦Á. RT-PCR, immunohistochemistry and Western blot analyses were used to detect changes in the mRNA and protein expression of DNA_ethyl-transferase-1 (DNMT1) and ER¦Á. Cell proliferation was examined using the MTT assay. A xenograft model in nude mice was used to further examine the results we observed in vitro. cell lines (MDA-MB-435,MCF-7) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 269 Epigenetic reversal of acquired resistance to 5-fluorouracil treatment Mol Cancer Ther 2009 19383845 CMPK1 ENSG00000162368 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,MTS,Pyro Q-CpG Analysis,tumor xenograft study. cell lines (HCT-8) down-regulated resistant NA NA validated NA promoter hypermethylation related 270 Epigenetic reversal of acquired resistance to 5-fluorouracil treatment Mol Cancer Ther 2009 19383845 CMPK1 ENSG00000162368 colorectal cancer 5-fluorouridine DB01629 (EXPT00263) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,MTS,Pyro Q-CpG Analysis,tumor xenograft study. cell lines (HCT-8) down-regulated resistant NA NA validated NA promoter hypermethylation related 271 CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells Exp Dermatol 2012 22082219 CRABP2 ENSG00000143320 cutaneous squamous_ancer Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,MTT analysis,DNA methylation analysis,gene transfection experiments. cell lines (COLO 16) down-regulated resistant RA (retinoic acid) CRABP-II signalling pathway validated NA mRNA low expression related 272 CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells Exp Dermatol 2012 22082219 FABP5 ENSG00000164687 cutaneous squamous_ancer Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,MTT analysis,DNA methylation analysis,gene transfection experiments. cell lines (COLO 16) up-regulated resistant NA FABP5 signaling pathway validated NA mRNA overexpression related 273 Epigenetic regulation of REG1A and chemosensitivity of cutaneous melanoma Epigenetics 2013 23903855 REG1A ENSG00000115386 melanoma Dacarbazine DB00851 (APRD00331) qRT-PCR Melanoma specimens with clinically well annotated stage III lymph node melanoma metastasis tissue microarray were assessed by IHC. MALDI-TOF-mass spectrometry and HM450K array were used to identify REG1A promoter region CpG site methylation. The expression of the mRNA was detected by the qRT-PCR,western blotting analysis.Chemotherapeutic agent response by melanoma cells as related to REG1A protein expression was assessed. cell lines (M7, M12, M14, M15, NB0561, JC0562) and patients tissues down-regulated resistant NA cyclin D1 signaling pathway validated NA promoter hypermethylation related 274 Epigenetic regulation of REG1A and chemosensitivity of cutaneous melanoma Epigenetics 2013 23903855 REG1A ENSG00000115386 melanoma Cisplatin DB00515 (APRD00359) qRT-PCR Melanoma specimens with clinically well annotated stage III lymph node melanoma metastasis tissue microarray were assessed by IHC. MALDI-TOF-mass spectrometry and HM450K array were used to identify REG1A promoter region CpG site methylation. The expression of the mRNA was detected by the qRT-PCR,western blotting analysis.Chemotherapeutic agent response by melanoma cells as related to REG1A protein expression was assessed. cell lines (M7, M12, M14, M15, NB0561, JC0562) and patients tissues down-regulated resistant NA cyclin D1 signaling pathway validated NA promoter hypermethylation related 275 CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells Mol Oncol 2012 22153617 CRABP2 ENSG00000143320 medulloblastoma Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,immunocytochemical and immunohistochemical staining,western blotting analysis,bisulfite sequencing PCR,plasmid and RNA interference transfection experiments. cell lines (Med-3,UW228-2,UW228-3) down-regulated resistant RA (retinoic acid) CRABP-II signalling pathway validated NA promoter hypermethylation related 276 Induction of the connexin 32 gene by epigallocatechin-3-gallate potentiates vinblastine-induced cytotoxicity in human renal carcinoma cells Chemotherapy 2013 24335094 CJB1 ENSG00000169562 renal cancer Vinblastine DB00570 (APRD00708) RT-PCR We estimated the methylation status in the promoter region of the Cx32 gene in RCC cells by methylation-specific PCR and the expression of the mRNA was detected by the real-time RT-PCR (mRNA level) and immunoblotting (protein level). cell lines (Caki-1) down-regulated resistant MDR1/JNK/SRC NA validated NA promoter hypermethylation related 277 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 SAT ENSG00000130066 cancer Cisplatin DB00515 (APRD00359) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA promoter hypermethylation related 278 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 TCIM ENSG00000176907 cancer Cisplatin DB00515 (APRD00360) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA promoter hypermethylation related 279 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 LAMB3 ENSG00000196878 cancer Cisplatin DB00515 (APRD00361) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA promoter hypermethylation related 280 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 TUBB ENSG00000196230 cancer Cisplatin DB00515 (APRD00362) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA promoter hypermethylation related 281 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 G0S2 ENSG00000123689 cancer Cisplatin DB00515 (APRD00363) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA promoter hypermethylation related 282 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 MCAM ENSG00000076706 cancer Cisplatin DB00515 (APRD00364) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA promoter hypermethylation related 283 Identification of hypermethylated genes associated with cisplatin resistance in human cancers Cancer Res 2010 20215521 S100P ENSG00000163993 cancer Cisplatin DB00515 (APRD00365) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisulfite sequencing analysis,MSP,RNA interference transfection,cell viability assay. cell lines (KB-3-1 and SCC25) down-regulated resistant NA NA validated NA mRNA low expression related 284 The transglutaminase 2 gene is aberrantly hypermethylated in glioma J Neurooncol 2011 20596752 TGM2 ENSG00000198959 glioma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,SDS-PAGE,immunoblotting,sodium bisulfite analysis,pyrosequencing,MTT, RNA transfection experiments. cell lines down-regulated sensitive NF¦ÊB NF-KB signaling pathway validated NA promoter hypermethylation related 285 Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT Int J Cancer 2001 11279615 MGMT ENSG00000170431 melanoma Fotemustine DB04106 (EXPT03300) Northern blot The effect of the mRNA expression on the drug sensitivity were detected by the northern blotting analysis,western blotting analysis,DNA southern blotting analysis,CAT assays,cell survival analysis. cell lines (MeWo, MeWoFote4, MeWoFote40, MeWoCis1, MeWoEto0.01 and HeLa S3) down-regulated sensitive NA NA validated NA promoter and boby hypermethylation related 286 Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT Int J Cancer 2001 11279615 MGMT ENSG00000170431 melanoma N-4S-4-Amino-5-2-aminoethyl-amino]pentyl-N-nitroguanidine DB02027 (EXPT01253) Northern blot The effect of the mRNA expression on the drug sensitivity were detected by the northern blotting analysis,western blotting analysis,DNA southern blotting analysis,CAT assays,cell survival analysis. cell lines (MeWo, MeWoFote4, MeWoFote40, MeWoCis1, MeWoEto0.01 and HeLa S3) down-regulated sensitive NA NA validated NA promoter and boby hypermethylation related 287 Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer Breast Cancer Res 2019 31277676 TGFBI ENSG00000120708 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) qRT-PCR We performed a genome-wide DNA_ethylation(450K array) and a transcriptomic analysis (RNA-Seq) comparing trastuzumab-sensitive(SK) and trastuzumab-resistant (SKTR) HER2+ human breast_ancer_ell models. The_ethylation_nd expression levels of candidate genes were validated by bisulfite pyrosequencing and qRT-PCR, respectively. Functional assays were conducted in the SK and SKTR models by gene silencing and overexpression._ethylation_nalysis in 24 HER2+ human BC samples with complete response or non-response to trastuzumab-based treatment was conducted by bisulfite pyrosequencing. cell lines (SK,SKTR) down-regulated resistant NA NA validated NA promoter and boby hypermethylation related 288 Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer Breast Cancer Res 2019 31277676 CXCL2 ENSG00000081041 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) qRT-PCR We performed a genome-wide DNA_ethylation(450K array) and a transcriptomic analysis (RNA-Seq) comparing trastuzumab-sensitive(SK) and trastuzumab-resistant (SKTR) HER2+ human breast_ancer_ell models. The_ethylation_nd expression levels of candidate genes were validated by bisulfite pyrosequencing and qRT-PCR, respectively. Functional assays were conducted in the SK and SKTR models by gene silencing and overexpression._ethylation_nalysis in 24 HER2+ human BC samples with complete response or non-response to trastuzumab-based treatment was conducted by bisulfite pyrosequencing. cell lines (SK,SKTR) down-regulated resistant NA NA validated NA promoter and boby hypermethylation related 289 Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer Breast Cancer Res 2019 31277676 SLC38A1 ENSG00000111371 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) qRT-PCR We performed a genome-wide DNA_ethylation(450K array) and a transcriptomic analysis (RNA-Seq) comparing trastuzumab-sensitive(SK) and trastuzumab-resistant (SKTR) HER2+ human breast_ancer_ell models. The_ethylation_nd expression levels of candidate genes were validated by bisulfite pyrosequencing and qRT-PCR, respectively. Functional assays were conducted in the SK and SKTR models by gene silencing and overexpression._ethylation_nalysis in 24 HER2+ human BC samples with complete response or non-response to trastuzumab-based treatment was conducted by bisulfite pyrosequencing. cell lines (SK,SKTR) down-regulated resistant NA NA validated NA promoter and boby hypermethylation related 290 Effect of combined therapy with low-dose 5-aza-2'-deoxycytidine and irinotecan on colon cancer cell line HCT-15 Ann Surg Oncol 2007 17195906 CDKN2A ENSG00000147889 colon cancer Irinotecan DB00762 (APRD00579) RT-PCR The changes in mRNA expression of several apoptosis-related genes were investigated by reverse transcriptase-polymerase chain reaction (PCR). Promoter methylation was detected by methylation-specific PCR and combined bisulfite restriction analysis. Suppression of tumor growth was observed during the treatment with DAC and/or CPT-11 and apoptosis in the tumors was investigated by TUNEL cell lines (HCT-15) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 291 Effect of combined therapy with low-dose 5-aza-2'-deoxycytidine and irinotecan on colon cancer cell line HCT-15 Ann Surg Oncol 2007 17195906 BNIP3 ENSG00000176171 colon cancer Irinotecan DB00762 (APRD00579) RT-PCR The changes in mRNA expression of several apoptosis-related genes were investigated by reverse transcriptase-polymerase chain reaction (PCR). Promoter methylation was detected by methylation-specific PCR and combined bisulfite restriction analysis. Suppression of tumor growth was observed during the treatment with DAC and/or CPT-11 and apoptosis in the tumors was investigated by TUNEL cell lines (HCT-15) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 292 Effect of combined therapy with low-dose 5-aza-2'-deoxycytidine and irinotecan on colon cancer cell line HCT-15 Ann Surg Oncol 2007 17195906 XAF1 ENSG00000132530 colon cancer Irinotecan DB00762 (APRD00579) RT-PCR The changes in mRNA expression of several apoptosis-related genes were investigated by reverse transcriptase-polymerase chain reaction (PCR). Promoter methylation was detected by methylation-specific PCR and combined bisulfite restriction analysis. Suppression of tumor growth was observed during the treatment with DAC and/or CPT-11 and apoptosis in the tumors was investigated by TUNEL cell lines (HCT-15) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 293 Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: involvement of Nanog suppression Cancer Res 2009 19567677 NANOG ENSG00000111704 embryonic carcinoma Apicidin NA RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,bisufite sequencing analysis,chromatin immunoprecipitation assay,cell proliferation, cell cycle, and apoptosis analysis assays,soft-agar colony-forming assay. cell lines (NCCIT ) up-regulated resistant NA NA validated NA mRNA overexpression related 294 The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines Prostate 2007 17440963 MDR1 ENSG00000085563 prostate cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR Expression of several potential genes that had been related to_rug-resistance was compared with parent cells by RT-PCR and Western blotting._ethylation_nalysis of multiple_rug_esistance (MDR1)_romoter_as carried out using bisulfite-modified DNA from cell lines. Knockdown experiments using small interfering RNA (siRNA) were also performed to confirm responsibility of_rug-resistance. Finally, cDNA microarray was performed to quantify gene expression in PC-3 and PC-3-TxR cells. cell lines (DU145,PC-3) down-regulated sensitive P-glycoprotein NA validated NA promoter hypermethylation related 295 Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells Biomed Pharmacother 2018 29772441 SIX2 ENSG00000170577 hepatocellular carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell viability and apoptosis assays,cell spheroid formation assay,lentivirus vectors transfection experiments. cell lines (SMMC7721, Bel-7402, Hep3B, HepG2, Huh7, L02 ) up-regulated resistant E-cadherin NA validated NA mRNA and protein overexpression related 296 Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells Biomed Pharmacother 2018 29772441 CDH1 ENSG00000039068 hepatocellular carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell viability and apoptosis assays,cell spheroid formation assay,lentivirus vectors transfection experiments. cell lines (SMMC7721, Bel-7402, Hep3B, HepG2, Huh7, L02 ) down-regulated resistant NA NA validated NA promoter hypermethylation related 297 Overexpression of ABCB4 contributes to acquired doxorubicin resistance in breast cancer cells in vitro Cancer Chemother Pharmacol 2018 29777275 ABCB4 ENSG00000005471 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR In doxorubicin-sensitive_nd -resistant breast_ancer_ell lines MCF-7 and MDA-MB-231, the expression levels of ABCB4 were detected using real-time quantitative PCR and Western blot analysis, the DNA_ethylation_nd histone acetylation status of ABCB4 gene were investigated by bisulfite-sequencing PCR (BSP) and chromatin immunoprecipitation (ChIP) assays, and the doxorubicin_ensitivity_nd intracellular doxorubicin accumulation were observed using cell cytotoxicity assay and flow cytometry. cell lines (MCF-7 and MDA-MB-231) up-regulated resistant NA NA validated NA promoter hypomethylation related 298 Overexpression of ABCB4 contributes to acquired doxorubicin resistance in breast cancer cells in vitro Cancer Chemother Pharmacol 2018 29777275 ABCB4 ENSG00000005471 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR In doxorubicin-sensitive_nd -resistant breast_ancer_ell lines MCF-7 and MDA-MB-231, the expression levels of ABCB4 were detected using real-time quantitative PCR and Western blot analysis, the DNA_ethylation_nd histone acetylation status of ABCB4 gene were investigated by bisulfite-sequencing PCR (BSP) and chromatin immunoprecipitation (ChIP) assays, and the doxorubicin_ensitivity_nd intracellular doxorubicin accumulation were observed using cell cytotoxicity assay and flow cytometry. cell lines (MCF-7 and MDA-MB-231) up-regulated resistant NA NA validated NA incereased promoter histone acetylation related 299 Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen Cancer Chemother Pharmacol 2000 11138465 MLH1 ENSG00000076242 cancer Temozolomide DB00853 (APRD00557) NA The effect of the mRNA expression on the drug sensitivity were detected by the western blotting analysis,bioinformatics technology. cell lines (CCRF-CEM,HCT 116 ,KM12 ,SK-OV-3 ,IGROV-1) down-regulated resistant NA MMR signaling pathway validated NA mRNA and protein low expression related 300 Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen Cancer Chemother Pharmacol 2000 11138465 MSH2 ENSG00000095002 cancer Temozolomide DB00853 (APRD00557) NA The effect of the mRNA expression on the drug sensitivity were detected by the western blotting analysis,bioinformatics technology. cell lines (CCRF-CEM,HCT 116 ,KM12 ,SK-OV-3 ,IGROV-1) down-regulated resistant NA MMR signaling pathway validated NA mRNA and protein low expression related 301 ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells Neoplasia 2018 30025229 ETV7 ENSG00000010030 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,gene reporter assay,bisulfite-conversion assay,cell death and viablity analysis,chromatin immunoprecipitation assay,immunoprecipitation,database analysis. cell lines (MCF7 and MDA-MB-231) up-regulated resistant DNAJC15 NA validated NA mRNA and protein overexpression related 302 ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells Neoplasia 2018 30025229 DNAJC15 ENSG00000120675 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,gene reporter assay,bisulfite-conversion assay,cell death and viablity analysis,chromatin immunoprecipitation assay,immunoprecipitation,database analysis. cell lines (MCF7 and MDA-MB-231) down-regulated resistant NA NA validated NA mRNA and protein low expression related 303 ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells Neoplasia 2018 30025229 DNAJC15 ENSG00000120675 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,gene reporter assay,bisulfite-conversion assay,cell death and viablity analysis,chromatin immunoprecipitation assay,immunoprecipitation,database analysis. cell lines (MCF7 and MDA-MB-231) down-regulated resistant NA NA validated NA promoter hypermethylation related 304 Epigenetic silencing of CYP24 in the tumor microenvironment J Steroid Biochem Mol Biol 2010 20304059 CYP24 ENSG00000019186 cancer Calcitriol (1¦Á,25-dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,MSP analysis,siRNA transfection experiments. cell lines (MDEC,TDEC) down-regulated resistant NA vitamin D signaling pathway validated NA promoter hypermethylation related 305 Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells 2010 19669768 IGF1R ENSG00000140443 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR A plasmid-based polymerase III_romoter_ystem was used to deliver and express short interfering RNA (siRNA) targeting IGF-IR to reduce its expression in SW480 cells. Western blot analysis was used to measure the protein level of IGF-IR. We assessed the effects of IGF-IR silencing on_ancer_ell growth by a cell growth curve. The effect of the 5-fluorouracil (5-FU)-induced cell death by knockdown of IGF-IR was also investigated by_ethyl_hiazolyl tetrazolium assay. cell lines (SW480) up-regulated resistant NA IGF signaling pathway validated NA mRNA and protein overexpression related 306 DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells PLoS One 2012 22427797 ENT1 ENSG00000112759 cervical_ancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,iRNA transfection assay,histone deacetylase assay,MSP,BSP analysis,ChIP analysis. cell lines (HeLa, SiHa and C33A) down-regulated resistant NA NA validated NA promoters H3K9m2 related 307 DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells PLoS One 2012 22427797 DCK ENSG00000156136 cervical_ancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,iRNA transfection assay,histone deacetylase assay,MSP,BSP analysis,ChIP analysis. cell lines (HeLa, SiHa and C33A) down-regulated resistant NA NA validated NA promoters H3K9m2 related 308 DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells PLoS One 2012 22427797 EHMT2 ENSG00000224143 cervical_ancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,iRNA transfection assay,histone deacetylase assay,MSP,BSP analysis,ChIP analysis. cell lines (HeLa, SiHa and C33A) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 309 Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells Clin Cancer Res 2008 18579663 PPP1R1B ENSG00000131771 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,cell viability assay,immunoblot analysis,immunoprecipitation,small interfering RNA transfection experiments,pyrosequencing analysis. cell lines (BT-474, SKBR-3, and HCC-1569) up-regulated resistant ERBB2, pAKT (Ser(473)), and BCL2 NA validated NA mRNA and protein overexpression related 310 Methylated BNIP3 gene in colorectal cancer prognosis Oncol Lett 2010 22966396 BNIP3 ENSG00000176171 colorectal cancer Irinotecan DB00762 (APRD00579) RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the RT-PCR,RNeasy kit,methylight analysis. cell lines (HCT-15 and HT29) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 311 Integrated molecular profiling of SOD2 expression in multiple myeloma Blood 2007 17192397 SOD2 ENSG00000285441 melanoma 2-Methoxyestradiol DB02342 (EXPT01362) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,sodium bisulfite sequencing analysis, shRNA transfection experiments,MTT assay,cell proliferation assay. cell lines down-regulated resistant NFAT, forkhead proteins, and XBP1 JAK/STAT pathway validated NA promoter hypermethylation related 312 Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal Cancer Cancers (Basel) 2019 31635093 B4GALT1 ENSG00000086062 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) NA This study aims to investigate the diagnostic, prognostic, and therapy-response predictive value of the glyco-gene_4GALT1_n colorectal cancer (CRC) patients. A Kaplan_Meier analysis was conducted in 1418 CRC patients (GEO and TCGA datasets) to assess the prognostic and therapy-response predictive values of the aberrant expression and methylation status of_4GALT1. Quantitative methylation-specific PCR (QMSP) and droplet digital quantitative methylation-specific PCR (dd-QMSP) were respectively used to detect hypermethylated_4GALT1_n metastasis and plasma in four cohorts of metastatic CRC cases (mCRC). cell lines and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 313 ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells Autophagy 2017 28981387 ALDH1A1 ENSG00000165092 cancer Hydroxychloroquine DB01611 quantitative fluorescent analysis The effect of the mRNA expression on the drug sensitivity were detected by the quantitative fluorescent,MSP analysis,MTT and clonogenic assays,flow cytometry,RNA interference experiments,tumor xenograft experiments. cell lines down-regulated resistant RA (retinoic acid) NA validated NA mRNA and protein low expression related 314 ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells Autophagy 2017 28981387 HLTF ENSG00000071794 cancer Hydroxychloroquine DB01611 quantitative fluorescent analysis The effect of the mRNA expression on the drug sensitivity were detected by the quantitative fluorescent,MSP analysis,MTT and clonogenic assays,flow cytometry,RNA interference experiments,tumor xenograft experiments. cell lines down-regulated sensitive NA NA validated NA promoter hypermethylation related 315 Hypermethylation of mismatch repair gene hMSH2 associates with platinum-resistant disease in epithelial ovarian cancer Clin Epigenetics 2019 31666131 MSH2 ENSG00000095002 ovarian_ancer Cisplatin DB00515 (APRD00365) qRT-PCR By initially screening of 16 platinum-sensitive/resistant samples from EOC patients with reduced representation bisulfite sequencing (RRBS), the upstream region of the hMSH2 gene was discovered hypermethylated in the platinum-resistant group. The effect of hMSH2 methylation on the cellular response to cisplatin was explored by demethylation and knockdown assays in ovarian cancer cell line A2780. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry was employed to examine the methylation levels of hMSH2 upstream region in additional 40 EOC patient samples. RT-qPCR and IHC assay was used to detect the hMSH2 mRNA and protein expression in extended 150 patients. cell lines (A2780 ) down-regulated resistant NA NA validated NA promoter hypermethylation (upstream region from -_1193 to -_1125 of MSH2) related 316 Epigenetic modification of alpha-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer Korean J Physiol Pharmacol 2018 29302211 NAGA ENSG00000198951 ovarian_ancer Cisplatin DB00515 (APRD00365) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,CpG methylation microarray,transient transfection experiments. cell lines (SK-OV-3, ES-2, PA-1, Caov-3, TOV-21G, TOV-112D, OV-90, OVCAR-3,,MDAH 2774, A2780) down-regulated resistant GcMAF NA validated NA promoter hypermethylation ( CpG site at position +251 ) related 317 Platinum sensitivity and DNA repair in a recently established panel of patient-derived ovarian carcinoma xenografts Oncotarget 2018 29872499 CDK12 ENSG00000167258 ovarian_ancer Cisplatin DB00515 (APRD00365) RT-PCR The mRNA levels of the selected genes were evaluated by Real Time-PCR (RT-PCR) with_d hoc_alidated primers and gene_romoter_ethylation_y pyrosequencing. tissues up-regulated resistant NA DNA repair pathways validated NA mRNA overexpression related 318 Platinum sensitivity and DNA repair in a recently established panel of patient-derived ovarian carcinoma xenografts Oncotarget 2018 29872499 PALB2 ENSG00000083093 ovarian_ancer Cisplatin DB00515 (APRD00365) RT-PCR The mRNA levels of the selected genes were evaluated by Real Time-PCR (RT-PCR) with_d hoc_alidated primers and gene_romoter_ethylation_y pyrosequencing. tissues up-regulated resistant NA DNA repair pathways validated NA mRNA overexpression related 319 Platinum sensitivity and DNA repair in a recently established panel of patient-derived ovarian carcinoma xenografts Oncotarget 2018 29872499 ERCC4 ENSG00000175595 ovarian_ancer Cisplatin DB00515 (APRD00365) RT-PCR The mRNA levels of the selected genes were evaluated by Real Time-PCR (RT-PCR) with_d hoc_alidated primers and gene_romoter_ethylation_y pyrosequencing. tissues up-regulated resistant NA DNA repair pathways validated NA mRNA overexpression related 320 Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer Clin Cancer Res 2017 28465444 PMAIP1 ENSG00000141682 breast cancer Pimasertib DB14904 qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,co-immunoprecipitation, TUNEL staining, and chromatin immunoprecipitation (ChIP),cell proliferation assay, apoptosis analysis, soft agar assay, transfections, immunoblotting analysis, and immunohistochemistry (IHC). cell lines (BT-549, SUM185PE, MDA-MB-157, MDA-MB-453, MDA-MB-231, HCC70, MDA-MB-468, MDA-MB-436, HCC1806, HCC1937, and Hs578T) down-regulated resistant MCL1 NA validated NA gene histone deacetylation related 321 Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer Clin Cancer Res 2017 28465444 MCL1 ENSG00000143384 breast cancer Pimasertib DB14904 qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,co-immunoprecipitation, TUNEL staining, and chromatin immunoprecipitation (ChIP),cell proliferation assay, apoptosis analysis, soft agar assay, transfections, immunoblotting analysis, and immunohistochemistry (IHC). cell lines (BT-549, SUM185PE, MDA-MB-157, MDA-MB-453, MDA-MB-231, HCC70, MDA-MB-468, MDA-MB-436, HCC1806, HCC1937, and Hs578T) up-regulated resistant NA NA validated NA mRNA overexpression related 322 Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer Clin Cancer Res 2017 28465444 PMAIP1 ENSG00000141682 breast cancer Pimasertib DB14904 qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,co-immunoprecipitation, TUNEL staining, and chromatin immunoprecipitation (ChIP),cell proliferation assay, apoptosis analysis, soft agar assay, transfections, immunoblotting analysis, and immunohistochemistry (IHC). cell lines (BT-549, SUM185PE, MDA-MB-157, MDA-MB-453, MDA-MB-231, HCC70, MDA-MB-468, MDA-MB-436, HCC1806, HCC1937, and Hs578T) down-regulated resistant MCL1 NA validated NA gene histone deacetylation related 323 Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer Clin Cancer Res 2017 28465444 MCL1 ENSG00000143384 breast cancer Pimasertib DB14904 qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,co-immunoprecipitation, TUNEL staining, and chromatin immunoprecipitation (ChIP),cell proliferation assay, apoptosis analysis, soft agar assay, transfections, immunoblotting analysis, and immunohistochemistry (IHC). cell lines (BT-549, SUM185PE, MDA-MB-157, MDA-MB-453, MDA-MB-231, HCC70, MDA-MB-468, MDA-MB-436, HCC1806, HCC1937, and Hs578T) up-regulated resistant NA NA validated NA mRNA overexpression related 324 Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase Theranostics 2018 29556358 PHGDH ENSG00000092621 lung cancer Erlotinib DB00530 (APRD00951) qRT-PCR The necessary genes required for the acquired erlotinib resistance in lung adenocarcinoma cells were screened out by_NA-Seq analysis. Then the protein and_RNA_evels of PHGDH were confirmed by immunoblotting and qRT-PCR in the erlotinib resistant cells. The effects of PHGDH inhibition or overexpression on erlotinib resistance were examined using cell culture and tumor xenograft mouse models respectively. To explore mechanism, the ROS level and DNA damage marker, ¦ÃH2AX, were tested by DCFH-DA staining and immunofluorescence after PHGDH inhibition. cell lines (16HBE,293FT,PC9ER1, PC9ER3, PC9ER4, HCC827ER9,PC9,HCC827 ) up-regulated resistant ¦ÃH2AX DNA repair pathways validated NA mRNA and protein overexpression related 325 Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors Clin Cancer Res 2018 29391350 SLFN11 ENSG00000172716 cancer Camptothecin DB04690 qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell viability assays,bioinformatics analyses. cell lines (K562, HCT116, OVCAR-3, SK-MEL-28, OVCAR-4, UACC-257, MCF7 and CCRF-CEM) up-regulated sensitive Topoisomerase I NA validated NA gene histone acetylation related 326 Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors Clin Cancer Res 2018 29391350 SLFN11 ENSG00000172716 cancer Topotecan DB01030 (APRD00687) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell viability assays,bioinformatics analyses. cell lines (K562, HCT116, OVCAR-3, SK-MEL-28, OVCAR-4, UACC-257, MCF7 and CCRF-CEM) up-regulated sensitive Topoisomerase I NA validated NA gene histone acetylation related 327 Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors Clin Cancer Res 2018 29391350 SLFN11 ENSG00000172716 cancer Hydroxyurea DB01005 (APRD00023) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell viability assays,bioinformatics analyses. cell lines (K562, HCT116, OVCAR-3, SK-MEL-28, OVCAR-4, UACC-257, MCF7 and CCRF-CEM) up-regulated sensitive Topoisomerase I NA validated NA gene histone acetylation related 328 Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors Clin Cancer Res 2018 29391350 SLFN11 ENSG00000172716 cancer Cisplatin DB00515 (APRD00365) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell viability assays,bioinformatics analyses. cell lines (K562, HCT116, OVCAR-3, SK-MEL-28, OVCAR-4, UACC-257, MCF7 and CCRF-CEM) up-regulated sensitive Topoisomerase I NA validated NA gene histone acetylation related 329 Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells Breast Cancer Res Treat 2014 24924415 KDM1B ENSG00000165097 breast cancer Decitabine DB01262 qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,shRNA transfection experiments,colony formation. cell lines (MDA-MB-231) down-regulated sensitive NA NA validated NA mRNA low expression related 330 Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression Proc Natl Acad Sci U S A 2016 27185910 KDM5D ENSG00000012817 prostate cancer Docetaxel DB01248 (APRD00932) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,RNA interference experiments, DNA transfection experiments, immunoblotting, cell fractionation, and coimmunoprecipitation. cell lines (LNCaP, 22RV1, VCAP, PC3, and DU145) down-regulated resistant AR AR signaling pathway validated NA mRNA low expression related 331 APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target Cancer Biomark 2016 27802207 APEX1 ENSG00000100823 ovarian_ancer Camptothecin DB04690 NA Immunohistochemistry (IHC) was used to detect the APE1 protein levels in tissue samples from twelve ovarian cancer (OC) patients and eleven non-OC patients. APE1 knockdown was achieved via the stable transfection of SKOV3 and A2780 cells with a construct encoding a short hairpin DNA directed against the APE1 gene. Then, cell proliferation, colony formation, cell cycle and apoptosis assays were performed to reveal the consequences of APE1 silencing in ovarian cancer cells. cell lines (SKOV3 and A2780) up-regulated resistant NA BAX and BCL-2 apoptotic pathways validated NA protein overexpression related 332 ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage J Biol Chem 2018 29191829 ST6GAL1 ENSG00000073849 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,colony formation assay,alkaline comet assay,immunoblotting analysis. cell lines (MiaPaCa-2,BxPC-3,Suit-2,S2-CP9 and S2-013) up-regulated resistant RRM1, RRM2, hENT1, and DCK NA validated NA mRNA and protein overexpression related 333 Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib Int J Mol Med 2018 29115375 STAT5A ENSG00000126561 chronic myeloid leukemia Imatinib DB00619 (APRD01028, EXPT02967, DB03261) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,cell counting assay,cell apoptosis assessment,immunofluorescence analysis. cell lines (K562) up-regulated resistant ROS NA validated NA mRNA and protein overexpression related 334 Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib Int J Mol Med 2018 29115375 STAT5B ENSG00000173757 chronic myeloid leukemia Imatinib DB00619 (APRD01028, EXPT02967, DB03261) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,cell counting assay,cell apoptosis assessment,immunofluorescence analysis. cell lines (K562) up-regulated resistant ROS NA validated NA mRNA and protein overexpression related 335 MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance Mol Neurobiol 2018 28478507 NCL ENSG00000115053 glioma Temozolomide DB00853 (APRD00557) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,immunoprecipitation,lentivirus-mediated gene knockdown experiments,colony formation assay,bioinformatics technology. cell lines (U87MG, U373MG, and A172) up-regulated sensitive Sox2, Oct4, and Bmi1 NA validated NA gene histone acetylation related 336 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 SIRT3 ENSG00000142082 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) up-regulated sensitive GSTP1 GSTP1/JNK signaling pathway validated NA mRNA and protein overexpression related 337 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 SIRT3 ENSG00000142082 hepatocellular carcinoma Cisplatin DB00515 (APRD00365) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) up-regulated sensitive GSTP1 GSTP1/JNK signaling pathway validated NA mRNA and protein overexpression related 338 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 SIRT3 ENSG00000142082 hepatocellular carcinoma Epirubicin DB00445 (APRD00361) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) up-regulated sensitive GSTP1 GSTP1/JNK signaling pathway validated NA mRNA and protein overexpression related 339 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 SIRT3 ENSG00000142082 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) up-regulated sensitive GSTP1 GSTP1/JNK signaling pathway validated NA mRNA and protein overexpression related 340 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 GSTP1 ENSG00000228476 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) down-regulated sensitive NA GSTP1/JNK signaling pathway validated NA mRNA and protein low expression related 341 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 GSTP1 ENSG00000228476 hepatocellular carcinoma Cisplatin DB00515 (APRD00365) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) down-regulated sensitive NA GSTP1/JNK signaling pathway validated NA mRNA and protein low expression related 342 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 GSTP1 ENSG00000228476 hepatocellular carcinoma Epirubicin DB00445 (APRD00361) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) down-regulated sensitive NA GSTP1/JNK signaling pathway validated NA mRNA and protein low expression related 343 Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway Oncotarget 2016 27367026 GSTP1 ENSG00000228476 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines (SMMC-7721, Huh-7 and PLC/PRF/5 ) down-regulated sensitive NA GSTP1/JNK signaling pathway validated NA mRNA and protein low expression related 344 Investigation of the potential theranostic role of KDM5B/miR-29c signaling axis in paclitaxel resistant endometrial carcinoma Gene 2019 30658067 KDM5B ENSG00000117139 endometrial_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,gene interference experiments,cell viability and paclitaxel sensitivity assay,colony formation assay,invasion assay, cell lines (Ishikawa, HEC-1A) and patients tissues up-regulated resistant NA KDM5B/miR-29c signaling pathway validated NA mRNA and protein overexpression related 345 Induction of pancreatic cancer cell apoptosis and enhancement of gemcitabine sensitivity by RAP80 siRNA Dig Dis Sci 2012 22573342 UIMC1 ENSG00000087206 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR Chemically synthesized siRNA RAP80 was transfected into human pancreatic_ancer_ell lines SW1990 and Capan-2. The IC(50) of gemcitabine was determined by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cell apoptosis was detected by using flow cytometry. Expression of apoptosis-related genes, Bax, Bcl-2, TRAIL, survivin, and caspase-8 was detected by using reverse transcription-polymerase chain reaction (RT-PCR) and western blot. cell lines (SW1990 and Capan-2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 346 Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells Oncol Rep 2013 23817620 HDAC4 ENSG00000068024 breast cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines ( MDA-MB-231,MCF-7) up-regulated resistant SMAD4 TGF ¦Â signaling pathway validated NA mRNA and protein overexpression related 347 Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells Oncol Rep 2013 23817620 SMAD4 ENSG00000141646 breast cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines ( MDA-MB-231,MCF-7) down-regulated sensitive NA TGF ¦Â signaling pathway validated NA gene histone deacetylation (H3) related 348 Simultaneous NF-¦ÊB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo Int J Cancer 2014 24615207 CDH1 ENSG00000039068 lung cancer Celastrol NA RT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,western blotting analysis,cell proliferation assay,apoptosis analysis,co-Immunoprecipitation assay. cell lines and patients tissues down-regulated resistant NA NA validated NA mRNA and proteion low expression related 349 Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription Eur J Pharmacol 2018 30273544 HDAC6 ENSG00000094631 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,cell proliferation assay,ELISA analysis,gene promoter analysis. cell lines (MG-63 and HOS) up-regulated resistant IL8 NA validated NA mRNA and protein overexpression related 350 Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription Eur J Pharmacol 2018 30273544 IL8 ENSG00000169429 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,cell proliferation assay,ELISA analysis,gene promoter analysis. cell lines (MG-63 and HOS) up-regulated resistant ABCB1 NA validated NA mRNA and protein overexpression related 351 Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species Clin Cancer Res 2016 26634271 NPM1 ENSG00000181163 acute myelogenous leukemia Ixazomib DB09570 qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,shRNA transfection experiments,cell viability assay,flow cytometric analysis of apoptosis and ROS,western blot analysis,GSH and GSH-GSSG assay. cell lines (K562, OCI-AML3) down-regulated sensitive ROS NA validated mutation NA related 352 c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells J Biol Chem 2014 25266721 c-REL ENSG00000162924 leukemia GSK126 NA qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,immunoblotting analysis,DNA affinity precipitation assay,electroporation,luciferase assay,ChIP analysis,cell Viability Assay,annexin V and propidium iodide staining. cell lines up-regulated resistant Ezh2 NA validated NA mRNA and protein overexpression related 353 c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells J Biol Chem 2014 25266721 EZH2 ENSG00000106462 leukemia GSK126 NA qRT-PCR The effect of the mRNA expression on the drug sensitivity were detected by the qRT-PCR,immunoblotting analysis,DNA affinity precipitation assay,electroporation,luciferase assay,ChIP analysis,cell Viability Assay,annexin V and propidium iodide staining. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 354 Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells Mol Biosyst 2014 24292090 HNRNPC ENSG00000092199 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,IRNA transfection assay,MALDI-TOF-MS analysis,image analysis,2-DE analysis,cell apoptosis and viablity assays,MTT. cell lines (MCF-7) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 355 Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells Mol Biosyst 2014 24292090 SET ENSG00000119335 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,IRNA transfection assay,MALDI-TOF-MS analysis,image analysis,2-DE analysis,cell apoptosis and viablity assays,MTT. cell lines (MCF-7) up-regulated resistant PP2A and Nm23-H1 AKT/ERK signaling pathway validated NA mRNA and protein overexpression related 356 Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells Mol Biosyst 2014 24292090 AAT ENSG00000120053 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,IRNA transfection assay,MALDI-TOF-MS analysis,image analysis,2-DE analysis,cell apoptosis and viablity assays,MTT. cell lines (MCF-7) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 357 Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells Mol Biosyst 2014 24292090 TAGLN2 ENSG00000158710 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,IRNA transfection assay,MALDI-TOF-MS analysis,image analysis,2-DE analysis,cell apoptosis and viablity assays,MTT. cell lines (MCF-7) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 358 Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells Mol Biosyst 2014 24292090 NDPKA ENSG00000239672 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,western blotting analysis,IRNA transfection assay,MALDI-TOF-MS analysis,image analysis,2-DE analysis,cell apoptosis and viablity assays,MTT. cell lines (MCF-7) down-regulated resistant MMP9 IGF1Rb/Akt and ERK pathways validated NA mRNA and protein low expression related 359 Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy Lung Cancer 2011 21529986 ERCC1 ENSG00000012061 lung cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The mRNA expression was detected by the qRT-PCR,IHC analysis. cell lines and patients tissues down-regulated sensitive NA NA validated NA mRNA and protein low expression related 360 Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy Lung Cancer 2011 21529986 ABRX ENSG00000163322 lung cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The mRNA expression was detected by the qRT-PCR,IHC analysis. cell lines and patients tissues down-regulated sensitive NA NA validated NA mRNA and protein low expression related 361 Effects of SMYD3 overexpression on transformation, serum dependence, and apoptosis sensitivity in NIH3T3 cells IUBMB Life 2009 19472189 SMYD3 ENSG00000185420 cancer Dexamethasone DB01234 (APRD00674) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by RT-PCR,cell transformation assays,cell proliferation and serum dependence assays,RNA transfection experiments. cell lines (NIH3T3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 362 The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment Oncogene 2013 23108394 FOXM1 ENSG00000111206 breast cancer Epirubicin DB00445 (APRD00361) qRT-PCR The mRNA expression was detected by the qRT-PCR,western blotting analysis,comet assay,promoter assays, immunofluorescent staining,siRNAs transfection experiments. cell lines (MCF-7) up-regulated resistant BRIP1 DNA repair pathways validated NA mRNA and protein overexpression related 363 The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment Oncogene 2013 23108394 BRIP1 ENSG00000136492 breast cancer Epirubicin DB00445 (APRD00361) qRT-PCR The mRNA expression was detected by the qRT-PCR,western blotting analysis,comet assay,promoter assays, immunofluorescent staining,siRNAs transfection experiments. cell lines (MCF-7) up-regulated resistant NA DNA repair pathways validated NA mRNA and protein overexpression related 364 Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst 2007 17623797 HDAC1 ENSG00000116478 neuroblastoma Melphalan DB01042 (APRD00118) RT-PCR RNA expression of selected overexpressed genes was quantified by reverse transcription-polymerase chain reaction (RT-PCR). Small-interfering RNAs (siRNAs) were used for silencing gene expression. Cytotoxicity of melphalan, carboplatin, etoposide, and vincristine and cytotoxic synergy (expressed as combination index calculated by CalcuSyn software, where combination index < 1 indicates synergy and > 1 indicates antagonism) were measured in cell lines with a fluorescence-based assay of cell viability. cell lines (SMS-SAN, CHLA-15, CHLA-42, CHLA-122, SMS-LHN, SMSKCNR) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 365 Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst 2007 17623797 HDAC1 ENSG00000116479 neuroblastoma Carboplatin DB00958 (APRD00466) RT-PCR RNA expression of selected overexpressed genes was quantified by reverse transcription-polymerase chain reaction (RT-PCR). Small-interfering RNAs (siRNAs) were used for silencing gene expression. Cytotoxicity of melphalan, carboplatin, etoposide, and vincristine and cytotoxic synergy (expressed as combination index calculated by CalcuSyn software, where combination index < 1 indicates synergy and > 1 indicates antagonism) were measured in cell lines with a fluorescence-based assay of cell viability. cell lines (SMS-SAN, CHLA-15, CHLA-42, CHLA-122, SMS-LHN, SMSKCNR) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 366 Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst 2007 17623797 HDAC1 ENSG00000116480 neuroblastoma Etoposide DB00773 (APRD00239) RT-PCR RNA expression of selected overexpressed genes was quantified by reverse transcription-polymerase chain reaction (RT-PCR). Small-interfering RNAs (siRNAs) were used for silencing gene expression. Cytotoxicity of melphalan, carboplatin, etoposide, and vincristine and cytotoxic synergy (expressed as combination index calculated by CalcuSyn software, where combination index < 1 indicates synergy and > 1 indicates antagonism) were measured in cell lines with a fluorescence-based assay of cell viability. cell lines (SMS-SAN, CHLA-15, CHLA-42, CHLA-122, SMS-LHN, SMSKCNR) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 367 Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst 2007 17623797 HDAC1 ENSG00000116481 neuroblastoma Vincristine DB00541 (APRD00495) RT-PCR RNA expression of selected overexpressed genes was quantified by reverse transcription-polymerase chain reaction (RT-PCR). Small-interfering RNAs (siRNAs) were used for silencing gene expression. Cytotoxicity of melphalan, carboplatin, etoposide, and vincristine and cytotoxic synergy (expressed as combination index calculated by CalcuSyn software, where combination index < 1 indicates synergy and > 1 indicates antagonism) were measured in cell lines with a fluorescence-based assay of cell viability. cell lines (SMS-SAN, CHLA-15, CHLA-42, CHLA-122, SMS-LHN, SMSKCNR) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 368 Bortezomib resistance in a myeloma cell line is associated to PSMbeta5 overexpression and polyploidy Leuk Res 2012 21978467 PSMB5 ENSG00000100804 melanoma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The mRNA expression was detected by the RT-PCR,western blotting analysis,fluorescence microscopy and flow cytometry analysis,cell culture and toxicity assays. cell lines (8226) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 369 Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells Clin Cancer Res 2006 16609009 NCOR1 ENSG00000141027 breast cancer Calcitriol (1¦Á,25-dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by qRT-PCR,western blotting analysis,cell cycle analysis,soft agar analysis,liquid proliferation assay. cell lines (T-47D, ZR-75-1, MCF-7, and MDA-MB-231) up-regulated resistant VDR VDR signaling pathway validated NA mRNA and protein overexpression related 370 Knockdown of frizzled-7 inhibits cell growth and metastasis and promotes chemosensitivity of esophageal squamous cell carcinoma cells by inhibiting Wnt signaling Biochem Biophys Res Commun 2017 28669726 FZD7 ENSG00000155760 esophageal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The mRNA and protein of FZD7 was detected and extracted by real-time quantitative PCR (RT-qPCR) , western blot analysis. The association between the FZD7 and Cisplatin was detected by iRNA knockeddown experiment, cell proliferation assay , colony formation assay, cell apoptosis assay , transwell migration and invasion assays , luciferase reporter assay cell lines (TE-1, EC109, TE-10, TE-11, HEEC) up-regulated resistant MDR1 WNT singaling pathway validated NA mRNA and protein overexpression related 371 Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis Hepatology 2016 27015352 MT1G ENSG00000125144 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The mRNA and protein of MT1G was detected and extracted real-time quantitative PCR (RT-qPCR) , western blot analysis. The association between the MT1G and Sorafenib was detected by iRNA knockdown experiment, cell viability assay , survival clonogenic assay,iron assay,lipid peroxidation assay,glutathione assay,NRF2 transcriptional activity assay,animal models experiment. cell lines (Huh7, HepaG2, Hep3B) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 372 Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis Hepatology 2016 27015352 NRF2 ENSG00000116044 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The mRNA and protein of MT1G was detected and extracted real-time quantitative PCR (RT-qPCR) , western blot analysis. The association between the MT1G and Sorafenib was detected by iRNA knockdown experiment, cell viability assay , survival clonogenic assay,iron assay,lipid peroxidation assay,glutathione assay,NRF2 transcriptional activity assay,animal models experiment. cell lines (Huh7, HepaG2, Hep3B) and patients tissues up-regulated resistant MT1G NA validated NA mRNA and protein overexpression related 373 Tubulin-targeted drug action: functional significance of class ii and class IVb beta-tubulin in vinca alkaloid sensitivity Cancer Res 2008 19047161 TUBB2A ENSDARG00000039522 lung cancer Vincristine DB00541 (APRD00495) RT-PCR The mRNA and protein TUBB2A was detected and extracted RT-PCR , western blot analysis. The association between the TUBB2A and Vincristine was detected by iRNA knockdown study,drug-treated clonogenic assay,immunofluorescence staining,cell cycle analysis. cell lines (Calu-6, H460) up-regulated resistant NA NA validated NA mRNA overexpression related 374 Tubulin-targeted drug action: functional significance of class ii and class IVb beta-tubulin in vinca alkaloid sensitivity Cancer Res 2008 19047161 TUBB4B ENSG00000188229 lung cancer Vincristine DB00541 (APRD00495) RT-PCR The mRNA and protein TUBB4B was detected and extracted RT-PCR , western blot analysis. The association between the TUBB4B and Vincristine was detected by iRNA knockdown study,drug-treated clonogenic assay,immunofluorescence staining,cell cycle analysis. cell lines (Calu-6, H460) up-regulated resistant NA NA validated NA mRNA overexpression related 375 Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia J Natl Cancer Inst 2006 17018783 ACTG1 ENSG00000184009 lymphoblastic leukemia Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR Two dimensional polyacrylamide gel electrophoresis and mass spectrometry were used to identify actin proteins in human acute lymphoblastic leukemia cell lines resistant to vinblastine (CCRF-CEM/VLB100 cells) and desoxyepothilone B (CCRF-CEM/dEpoB140 cells). Fluorescence-based cycle sequencing was used to detect gene mutations. Clonogenic analysis was used for drug sensitivity studies. A small interfering RNA (siRNA) was used to block ¦Ã -actin gene expression in human neuroblastoma SH-EP cells. Expression of ¦Ã -actin was examined using quantitative reverse transcription _ polymerase chain reaction. cell lines (CCRF-CEM, SH-EP, NIH/3T3) down-regulated resistant NA NA validated NA mRNA and protein low expression related 376 Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia J Natl Cancer Inst 2006 17018783 ACTG1 ENSG00000184009 lymphoblastic leukemia Vinblastine DB00570 (APRD00708) qRT-PCR Two dimensional polyacrylamide gel electrophoresis and mass spectrometry were used to identify actin proteins in human acute lymphoblastic leukemia cell lines resistant to vinblastine (CCRF-CEM/VLB100 cells) and desoxyepothilone B (CCRF-CEM/dEpoB141 cells). Fluorescence-based cycle sequencing was used to detect gene mutations. Clonogenic analysis was used for drug sensitivity studies. A small interfering RNA (siRNA) was used to block ¦Ã -actin gene expression in human neuroblastoma SH-EP cells. Expression of ¦Ã -actin was examined using quantitative reverse transcription _ polymerase chain reaction. cell lines (CCRF-CEM, SH-EP, NIH/3T3) down-regulated resistant NA NA validated NA mRNA and protein low expression related 377 Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia J Natl Cancer Inst 2006 17018783 ACTG1 ENSG00000184009 lymphoblastic leukemia Patupilone DB03010 (EXPT01349) qRT-PCR Two dimensional polyacrylamide gel electrophoresis and mass spectrometry were used to identify actin proteins in human acute lymphoblastic leukemia cell lines resistant to vinblastine (CCRF-CEM/VLB100 cells) and desoxyepothilone B (CCRF-CEM/dEpoB142 cells). Fluorescence-based cycle sequencing was used to detect gene mutations. Clonogenic analysis was used for drug sensitivity studies. A small interfering RNA (siRNA) was used to block ¦Ã -actin gene expression in human neuroblastoma SH-EP cells. Expression of ¦Ã -actin was examined using quantitative reverse transcription _ polymerase chain reaction. cell lines (CCRF-CEM, SH-EP, NIH/3T3) down-regulated resistant NA NA validated NA mRNA and protein low expression related 378 Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia J Natl Cancer Inst 2006 17018783 ACTG1 ENSG00000184009 lymphoblastic leukemia Vinblastine DB00570 (APRD00708) qRT-PCR Two dimensional polyacrylamide gel electrophoresis and mass spectrometry were used to identify actin proteins in human acute lymphoblastic leukemia cell lines resistant to vinblastine (CCRF-CEM/VLB100 cells) and desoxyepothilone B (CCRF-CEM/dEpoB143 cells). Fluorescence-based cycle sequencing was used to detect gene mutations. Clonogenic analysis was used for drug sensitivity studies. A small interfering RNA (siRNA) was used to block ¦Ã -actin gene expression in human neuroblastoma SH-EP cells. Expression of ¦Ã -actin was examined using quantitative reverse transcription _ polymerase chain reaction. cell lines (CCRF-CEM, SH-EP, NIH/3T3) down-regulated resistant NA NA validated mutation NA related 379 Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia J Natl Cancer Inst 2006 17018783 ACTG1 ENSG00000184009 lymphoblastic leukemia Desoxyepothilone B DB01873 (EXPT01350) qRT-PCR Two dimensional polyacrylamide gel electrophoresis and mass spectrometry were used to identify actin proteins in human acute lymphoblastic leukemia cell lines resistant to vinblastine (CCRF-CEM/VLB100 cells) and desoxyepothilone B (CCRF-CEM/dEpoB144 cells). Fluorescence-based cycle sequencing was used to detect gene mutations. Clonogenic analysis was used for drug sensitivity studies. A small interfering RNA (siRNA) was used to block ¦Ã -actin gene expression in human neuroblastoma SH-EP cells. Expression of ¦Ã -actin was examined using quantitative reverse transcription _ polymerase chain reaction. cell lines (CCRF-CEM, SH-EP, NIH/3T3) down-regulated resistant NA NA validated mutation NA related 380 Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells Tumour Biol 2013 23188704 LIVIN ENSG00000101197 colon cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of LIVIN was determined by RT-PCR analysis,western blot analysis,RNA interference (RNAi) knockdown study,WST-1 assay,DEVDase activity,colony-forming assay,Immunocytochemistry. cell lines (HCT116, RKO, KM12C, and SW620) up-regulated resistant caspase-3 apoptotic pathway validated NA mRNA and protein overexpression related 381 RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer Oncol Rep 2014 24452636 RPRD1B ENSG00000101413 endometrial_ancer Raloxifene DB00481 (APRD00400) qRT-PCR The role of RPRD1B was determined by quantitative real-time PCR,western blot analysis,MTT assay,colony formation assay,cell cycle analysis,tumor growth assay. cell lines (Ishikawa, KLE, RL95-2, HEC-1B, SPEC-2 and AN3CA) and patients tissues up-regulated resistant cyclin D1, CDK4 and CDK6 NA validated NA mRNA and protein overexpression related 382 SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway J Exp Clin Cancer Res 2019 31196136 SIRT7 ENSG00000187531 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR Expression of SIRT7 was examined by immunohistochemistry and Western blot,immunoprecipitation,siRNA transfection experiments. The mRNA expression of SIRT7 quantitative RT-PCR. cell lines (Huh7.5, Hep3B, HeLa) and patients tissues up-regulated resistant P53 NA validated NA mRNA and protein overexpression related 383 SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway J Exp Clin Cancer Res 2019 31196136 P53 ENSG00000141510 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR Expression of SIRT7 was examined by immunohistochemistry and Western blot,immunoprecipitation,siRNA transfection experiments. The mRNA expression of SIRT7 quantitative RT-PCR. cell lines (Huh7.5, Hep3B, HeLa) and patients tissues down-regulated resistant NOXA NA validated NA gene deacetylation related 384 Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer Endocr Relat Cancer 2008 18310279 FDFR4 ENSG00000160867 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR FGFR4 were quantified by real-time reverse transcriptase PCR. cell lines (ZR-75-1) and patients tissues up-regulated resistant NA MAPK and the PI3K/AKT pathways validated NA mRNA and protein overexpression related 385 Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer Endocr Relat Cancer 2008 18310279 FGF17 ENSG00000158815 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR FGFR17 were quantified by real-time reverse transcriptase PCR. cell lines (ZR-75-1) and patients tissues up-regulated resistant NA MAPK and the PI3K/AKT pathways validated NA mRNA and protein overexpression related 386 Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene 2006 16532342 HIF1A ENSG00000100644 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR Quantitative RT-PCR and western blot analysis were used to detect the expressions of HIF1A_RNA_nd protein, respectively.The relationship between the drug sensitivity and mRNA expression was detected by the iRNA knockdown experiments,MTT analysis,clonogenic assay. cell lines (SPCA1,A549) up-regulated resistant P-glycoprotein HIF1 signaling pathway validated NA mRNA and protein overexpression related 387 Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene 2006 16532342 HIF1A ENSG00000100644 lung cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR Quantitative RT-PCR and western blot analysis were used to detect the expressions of HIF1A_RNA_nd protein, respectively.The iRNA knockdown experiments were used to detected the role of HIF1A. cell lines (SPCA1,A549) up-regulated resistant P-glycoprotein HIF1 signaling pathway validated NA mRNA and protein overexpression related 388 Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells Cell Mol Biol (Noisy-le-grand 2018 29808798 SIRT1 ENSG00000096717 cervical_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR We used qPCR and western blots to measure SIRT1_RNA_nd protein expressions. We compared the expression levels of SIRT1 between sensitive CC cell lines and PTX-resistant cell lines. Subsequently, we used SIRT1 siRNA to knockdown the expression of SIRT1, and then measured cell proliferation, cell apoptosis rate, cell cycle distribution. cell lines up-regulated resistant MRP NA validated NA mRNA and protein overexpression related 389 Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma Int J Cancer 2013 22821831 MIF ENSG00000240972 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of MIF was deteced by by qRT-PCR ,western blotting,immunohistochemistry,iRNA knockdown experiments,invasion assay,cell proliferation assay,drug sensitivity assay,immunofluorescence. cell lines (Capan 2, Panc 1 ) and patients tissues up-regulated resistant E-cadherin/vimentin EMT_ransition pathway validated NA mRNA and protein overexpression related 390 Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma Int J Cancer 2013 22821831 CDH1 ENSG00000039068 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of EMT marker was deteced by by qRT-PCR ,western blotting,immunohistochemistry,iRNA knockdown experiments,invasion assay,cell proliferation assay,drug sensitivity assay,immunofluorescence. cell lines (Capan 2, Panc 1 ) and patients tissues down-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein low expression related 391 Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma Int J Cancer 2013 22821831 VIM ENSG00000026025 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of EMT marker was deteced by by qRT-PCR ,western blotting,immunohistochemistry,iRNA knockdown experiments,invasion assay,cell proliferation assay,drug sensitivity assay,immunofluorescence. cell lines (Capan 2, Panc 1 ) and patients tissues up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 392 Methylation mediated silencing of TMS1 in breast cancer and its potential contribution to docetaxel cytotoxicity Anticancer Res 2009 19661336 TMS1 ENSG00000132824 breast cancer Docetaxel DB01248 (APRD00932) RT-PCR The role of TMS1 was deteced by by RT-PCR ,Methylation-specific PCR (MS-PCR),Apoptosis assay. cell lines (ZR75-1, MB-231, MCF7, SKBR3, Hs578t) down-regulated resistant NA apoptotic pathway validated NA promoter hypermethylation related 393 A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line Int J Cancer 2016 27072400 YBX1 ENSG00000065978 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The mRNA and protein YBX1 was detected and extracted by RT-PCR , western blot analysis . The association between the YBX1 and Paclitaxel was detected by interfering RNA study,cell enumeration assays, IncuCyte assays,flow cytometry analysis,bioinformatic analyses of breast cancer datasets. cell line (MDA-MB-231) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 394 A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line Int J Cancer 2016 27072400 EGR1 ENSG00000120738 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The mRNA and protein EGR1 was detected and extracted by RT-PCR , western blot analysis . The association between the EGR1 and Paclitaxel was detected by interfering RNA study,cell enumeration assays, IncuCyte assays,Flow cytometry analysis,bioinformatic analyses of breast cancer datasets. cell line (MDA-MB-231) down-regulated resistant NA NA validated NA mRNA and protein low expression related 395 Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance Nat Med 2012 22683778 DUSP4 ENSG00000120875 breast cancer Docetaxel DB01248 (APRD00932) NanoString nCounter analysis The relationship between the mRNA expression and the drug sensitivity was detected by nanoString nCounter analysis,immunohistochemistry,immunoblotting analysis,reverse-phase protein array analysis,iRNA transfection experiments,tumor xenograft studys. cell lines (MDA-231, MCF-7, MDA-436 and T47D) and patients tissues down-regulated resistant NA Ras-ERK pathway validated NA promoter hypermethylation related 396 Preliminary study of the prohibitin protein and paclitaxel resistance in ovarian cancer Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012 23281375 PHB ENSG00000167085 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR Western blot and real time-PCR were used to assay the expression of PHB protein and mRNA .The role of PHB was detected by RNA knockdown experiment. MTT and flow cytometry assay were used to test the cell proliferation, IC50 of paclitaxel, and cell apoptosis. cell lines (SKOV3/Taxol-25,SKOV3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 397 FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFkappaB-BMP Signaling Cross-talk Cancer Res 2017 28883005 FSTL1 ENSG00000163430 esophageal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR qRT-PCR and Western blot analysis were used to detect the expressions of FSTL1 mRNA_nd protein, respectively.The iRNA knockdown experiments were used to detected the role of FSTL1. cell lines (EC109, HKESC1, EC9706, and KYSE520) and patients tissues up-regulated resistant NA NF¦ÊB and BMP signaling pathway validated amplification NA related 398 STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo Int J Cancer 2014 23934972 STAT3 ENSG00000168610 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The mRNA and protein of STAT3 was detected and extracted by qRT-PCR , western blot analysis . The role of STAT3 was detected by siRNA-mediated gene silencing study, small molecule-mediated STAT3 inhibition,cell viability assay,dual luciferase reporter assay,immunohistochemistry,animal model studies. cell lines (HCT116 and Caco-2) up-regulated resistant NA STAT3 signaling pathway validated NA mRNA and protein overexpression related 399 STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo Int J Cancer 2014 23934972 STAT3 ENSG00000168610 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The mRNA and protein of STAT3 was detected and extracted by qRT-PCR , western blot analysis . The role of STAT3 was detected by siRNA-mediated gene silencing study, small molecule-mediated STAT3 inhibition,cell viability assay,dual luciferase reporter assay,immunohistochemistry,animal model studies. cell lines (HCT116 and Caco-2) NA resistant NA STAT3 signaling pathway validated NA gene phosphorylation related 400 The differential expression of cytokeratin 18 in cisplatin-sensitive and -resistant human ovarian adenocarcinoma cells and its association with drug sensitivity Cancer Res 1995 7585575 KRT18 ENSG00000111057 ovarian_ancer Cisplatin DB00515 (APRD00359) Northern blot The role of KRT18 was deteced by Northern blot,Southern blot analysis,MspI analysis. cell lines down-regulated resistant NA NA validated NA mRNA and proteion low expression related 401 Marked reduction of type I keratin (K14) in cisplatin-resistant human lung squamous-carcinoma cell lines Biochem Pharmacol 1993 7683471 KRT14 ENSG00000186847 lung cancer Cisplatin DB00515 (APRD00359) UV assay The relationship between the mRNA expression and the drug sensitivity was detected by two-dimensional gel electrophoresis,S-Carboxymethylation,In situ digestion,Peptide mapping,Amino acidsequencing,MTT assay . cell lines (PC10, PClO-B3 and PClO-ES ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 402 Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones Anticancer Drugs 2015 25187316 RRM1 ENSG00000167325 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR ,Northern bloting,Western blotting,vitro MTT assay. cell lines (BxPC-3, BxG30) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 403 Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones Anticancer Drugs 2015 25187316 BCL2 ENSG00000171791 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR ,Northern bloting,Western blotting,vitro MTT assay. cell lines (BxPC-3, BxG30) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 404 Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones Anticancer Drugs 2015 25187316 RRM2 ENSG00000171848 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR ,Northern bloting,Western blotting,vitro MTT assay. cell lines (BxPC-3, BxG30) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 405 Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones Anticancer Drugs 2015 25187316 RRM1 ENSG00000167325 pancreatic cancer 5-Fluorouracil DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR ,Northern bloting,Western blotting,vitro MTT assay. cell lines (BxPC-3, BxG30) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 406 Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones Anticancer Drugs 2015 25187316 BCL2 ENSG00000171791 pancreatic cancer 5-Fluorouracil DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR ,Northern bloting,Western blotting,vitro MTT assay. cell lines (BxPC-3, BxG30) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 407 Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones Anticancer Drugs 2015 25187316 RRM2 ENSG00000171848 pancreatic cancer 5-Fluorouracil DB00441 (APRD00201) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR ,Northern bloting,Western blotting,vitro MTT assay. cell lines (BxPC-3, BxG30) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 408 Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis Clin Orthop Relat Res 2011 21656314 ET1 ENSG00000078401 osteosarcoma Cisplatin DB00515 (APRD00359) qRT-PCR We cultured primary OS specimens from 22 patients with Stages II (OS-II) and III (OS-III) in real-time quantitative RT-PCR and ELISA to compare ET-1 expression. We used Transwell(_) cell invasion assays (in triplicate) to assess the invasion ability of cells in the presence or absence of exogenous ET-1 and/or ET receptor antagonists. We compared cell apoptosis rate among the cells treated with cisplatin in the presence or absence of exogenous ET-1 and/or ET receptor antagonists. We used OS cell line MG-63 in all experiments as a reference. cell lines (MG-63) and patients tissues up-regulated resistant NA ET-1/ETA_athway validated NA mRNA and protein overexpression related 409 Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy Am J Pathol 2011 21356353 FABP5 ENSG00000164687 breast cancer Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) NanoDrop 1000 spectrophotometer and RT-PCR The role of FABP5 was deteced by gene expression microarray analysis, NanoDrop 1000 spectrophotometer,RT-PCR ,siRNA knockdown, western blot analysis, and Immunohistochemistry,tissue microarray analysis. cell lines (MCF-7, Hs578T) and patients tissues up-regulated resistant RA (retinoic acid) RA-FABP5-PPAR¦Â signaling pathway validated NA mRNA and protein overexpression related 410 Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy Am J Pathol 2011 21356353 CRABP2 ENSG00000143320 breast cancer Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) NanoDrop 1000 spectrophotometer and RT-PCR The role of CRABP2 was deteced by gene expression microarray analysis, NanoDrop 1000 spectrophotometer,RT-PCR ,siRNA knockdown, western blot analysis, and Immunohistochemistry,tissue microarray analysis. cell lines (MCF-7, Hs578T) and patients tissues down-regulated resistant RA (retinoic acid) RA-CRABP2-RAR pathway validated NA mRNA and protein low expression related 411 beta-Catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl-xl Mol Med Rep 2016 26860078 BCLXL ENSG00000171552 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The mRNA and protein expressions of BCLXL were examined by reverse transcription_quantitative polymerase chain reaction and western blotting.Cell proliferation was determined using the MTS assay. Cell apoptosis was evaluated using Annexin V/propidium iodide double staining, followed by flow cytometry. cell lines (A549/WT, A549/CDDP) up-regulated resistant NA _nt/¦Â-catenin signaling pathway validated NA mRNA and protein overexpression related 412 beta-Catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl-xl Mol Med Rep 2016 26860078 CTMMB1 ENSG00000168036 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The mRNA and protein expressions of ¦Â-catenin were examined by reverse transcription_quantitative polymerase chain reaction and western blotting.Cell proliferation was determined using the MTS assay. Cell apoptosis was evaluated using Annexin V/propidium iodide double staining, followed by flow cytometry. cell lines (A549/WT, A549/CDDP) up-regulated resistant BCLXL _nt/¦Â-catenin signaling pathway validated NA mRNA and protein overexpression related 413 Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in nasopharyngeal carcinoma cells by regulating the levels of NADPH and ribose-5-phosphate Biomed Pharmacother 2017 27916418 TKTL1 ENSG00000007350 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) qRT-PCR The mRNA and protein levels of TKTL1 were determined by qRT-PCR and western blot, respectively. MTT assay and flow cytometry were used to access the viability and apoptosis of CNE2 and HONE1 cells. The effect of TKTL1 knockdown was assessed by using Comet assay. cell lines (CNE2,HONE1) up-regulated resistant NA Pentose phosphate pathway validated NA mRNA and protein overexpression related 414 Silencing of myeloid cell leukemia-1 by small interfering RNA improves chemosensitivity to etoposide in u-937 leukemic cells J Biol Regul Homeost Agents 2016 27049076 MCL1 ENSG00000143384 acute myeloid leukemia Etoposide DB00773 (APRD00239) qRT-PCR Quantitative real-time RT-PCR (qRT-PCR) and Western blot analysis were employed to measure the expression levels of mRNA and protein, respectively. To evaluate tumor cell growth after siRNA transfection, Trypan blue exclusion assay was conducted. The cytotoxic effects of siRNA and etoposide were determined using MTT assay on their own and in combination. DNA-histone ELISA and annexin-V/FITC assays were performed to study the apoptosis. cell line (U-937) up-regulated resistant NA apoptotic pathway validated NA mRNA and protein overexpression related 415 Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells Cancer Lett 2005 15890238 P53R2 ENSG00000048392 oral_ancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR We investigated p53R2 expression with the reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting. The sensitivity to anticancer agents was evaluated by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. cell lines (SAS, HSC-4, Ca9-22, MCF-7, NHDF) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 416 Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells Sci Rep 2013 24113164 FGF13 ENSG00000129682 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of FGF13 was deteced by qRT-PCR,iRNA interfence assay,flow cytometric analysis,measurement of intracellular platinum and copper,immunocytochemistry,measurement of intracellular GSH levels. cell line (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 417 Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells Sci Rep 2013 24113164 FGF13 ENSG00000129682 cervical_ancer Carboplatin DB00958 (APRD00466) qRT-PCR The role of FGF13 was deteced by qRT-PCR,iRNA interfence assay,flow cytometric analysis,measurement of intracellular platinum and copper,immunocytochemistry,measurement of intracellular GSH levels. cell line (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 418 Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells Sci Rep 2013 24113164 FGF13 ENSG00000129682 cervical_ancer Oxaliplatin DB00526 (APRD00186) qRT-PCR The role of FGF13 was deteced by qRT-PCR,iRNA interfence assay,flow cytometric analysis,measurement of intracellular platinum and copper,immunocytochemistry,measurement of intracellular GSH levels. cell line (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 419 Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells Sci Rep 2013 24113164 SLC7A11 ENSG00000151012 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of SLC7A11 was deteced by qRT-PCR,iRNA interfence assay,flow cytometric analysis,measurement of intracellular platinum and copper,immunocytochemistry,measurement of intracellular GSH levels. cell line (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 420 Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells Sci Rep 2013 24113164 FGF13 ENSG00000129682 cervical_ancer Copper DB09130 qRT-PCR The role of FGF13 was deteced by qRT-PCR,iRNA interfence assay,flow cytometric analysis,measurement of intracellular platinum and copper,immunocytochemistry,measurement of intracellular GSH levels. cell line (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 421 IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma Cancer Res 2018 29483095 IRAK1 ENSG00000184216 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA-sequencing analysis The relationship of the drug sensitivity and the mRNA expression was detected by RNA-sequencing ,western blot analysis,drug treatment assay,immunofluorescence staining analysis,iRNA knockdown experiments, sphere formation assay,Annexin V staining. cell lines (MHCC97L, Huh7, Hep3B, PLC/PRF/5, Bel7402, SMMC7721) up-regulated resistant AKR1B10 NA validated NA mRNA and protein overexpression related 422 IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma Cancer Res 2018 29483095 IRAK1 ENSG00000184216 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) RNA-sequencing analysis The relationship of the drug sensitivity and the mRNA expression was detected by RNA-sequencing ,western blot analysis,drug treatment assay,immunofluorescence staining analysis,iRNA knockdown experiments, sphere formation assay,Annexin V staining. cell lines (MHCC97L, Huh7, Hep3B, PLC/PRF/5, Bel7402, SMMC7721) up-regulated resistant AKR1B10 NA validated NA mRNA and protein overexpression related 423 IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma Cancer Res 2018 29483095 IRAK4 ENSG00000198001 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA-sequencing analysis The relationship of the drug sensitivity and the mRNA expression was detected by RNA-sequencing ,western blot analysis,drug treatment assay,immunofluorescence staining analysis,iRNA knockdown experiments, sphere formation assay,Annexin V staining. cell lines (MHCC97L, Huh7, Hep3B, PLC/PRF/5, Bel7402, SMMC7721) up-regulated resistant IRAK1 NA validated NA mRNA and protein overexpression related 424 IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma Cancer Res 2018 29483095 IRAK4 ENSG00000198001 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) RNA-sequencing analysis The relationship of the drug sensitivity and the mRNA expression was detected by RNA-sequencing ,western blot analysis,drug treatment assay,immunofluorescence staining analysis,iRNA knockdown experiments, sphere formation assay,Annexin V staining. cell lines (MHCC97L, Huh7, Hep3B, PLC/PRF/5, Bel7402, SMMC7721) up-regulated resistant IRAK1 NA validated NA mRNA and protein overexpression related 425 IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma Cancer Res 2018 29483095 AKR1B10 ENSG00000198074 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA-sequencing analysis The relationship of the drug sensitivity and the mRNA expression was detected by RNA-sequencing ,western blot analysis,drug treatment assay,immunofluorescence staining analysis,iRNA knockdown experiments, sphere formation assay,Annexin V staining. cell lines (MHCC97L, Huh7, Hep3B, PLC/PRF/5, Bel7402, SMMC7721) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 426 IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma Cancer Res 2018 29483095 AKR1B10 ENSG00000198074 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) RNA-sequencing analysis The relationship of the drug sensitivity and the mRNA expression was detected by RNA-sequencing ,western blot analysis,drug treatment assay,immunofluorescence staining analysis,iRNA knockdown experiments, sphere formation assay,Annexin V staining. cell lines (MHCC97L, Huh7, Hep3B, PLC/PRF/5, Bel7402, SMMC7721) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 427 Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells Clin Cancer Res 2006 16609009 VDR ENSG00000111424 breast cancer Calcitriol (1¦Á,25-dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) qRT-PCR The mRNA and protein levels of NCOR1 were determined by qRT-PCR and western blot, liquid proliferation assay,clonal proliferation in soft agar,cell cycle analysis. cell lines (T-47D, ZR-75-1, MCF-7, MDA-MB-231) down-regulated resistant NA VDR signaling pathway validated NA mRNA and proteion low expression related 428 Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells Clin Cancer Res 2006 16609009 NCOR1 ENSG00000141027 breast cancer Calcitriol (1¦Á,25-dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) qRT-PCR The mRNA and protein levels of NCOR1 were determined by qRT-PCR and western blot, liquid proliferation assay,clonal proliferation in soft agar,cell cycle analysis. cell lines (T-47D, ZR-75-1, MCF-7, MDA-MB-231) up-regulated resistant VDR VDR signaling pathway validated NA mRNA and protein overexpression related 429 Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells Clin Cancer Res 2006 16609009 NCOR2 ENSG00000196498 breast cancer Calcitriol (1¦Á,25-dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) qRT-PCR The mRNA and protein levels of NCOR1 were determined by qRT-PCR and western blot, liquid proliferation assay,clonal proliferation in soft agar,cell cycle analysis. cell lines (T-47D, ZR-75-1, MCF-7, MDA-MB-231) up-regulated resistant VDR VDR signaling pathway validated NA mRNA and protein overexpression related 430 Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells Clin Cancer Res 2006 16609009 COPS2 ENSG00000166200 breast cancer Calcitriol (1¦Á,25-dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) qRT-PCR The mRNA and protein levels of NCOR1 were determined by qRT-PCR and western blot, liquid proliferation assay,clonal proliferation in soft agar,cell cycle analysis. cell lines (T-47D, ZR-75-1, MCF-7, MDA-MB-231) up-regulated resistant VDR VDR signaling pathway validated NA mRNA and protein overexpression related 431 ERK/MAPK regulates ERRgamma expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer Febs j 2014 24684682 ERR-gamma ENSG00000196482 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR mRNA_nd protein expression/phosphorylation were monitored by RT-PCR and western blotting, respectively. Site-directed mutagenesis was used to disrupt consensus extracellular signal-regulated kinase (ERK)_arget_ites. Cell proliferation and cell-cycle progression were measured by flow cytometric methods. ERR¦Ã transcriptional activity was assessed by dual-luciferase promoter-reporter assays. cell lines (MCF7, SUM44) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 432 High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil Clin Cancer Res 1998 9796967 TYMP ENSG00000025708 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The role of TYMP was detected by RT-PCR. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 433 High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil Clin Cancer Res 1998 9796967 TYMP ENSG00000025708 colorectal cancer Leucovorin DB00650 (APRD00698) RT-PCR The role of TYMP was detected by RT-PCR. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 434 High-mobility group nucleosome-binding domain 5 increases drug resistance in osteosarcoma through upregulating autophagy Tumour Biol 2014 24664583 HMGN5 ENSG00000198157 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of HMGN5 was detected by RT-PCR,western blot assay,RNA knockdown experiments, autophagy assays,cell proliferation assay,immunohistochemical staining. cell lines (HOS, MG63, U2-OS, SaO2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 435 High-mobility group nucleosome-binding domain 5 increases drug resistance in osteosarcoma through upregulating autophagy Tumour Biol 2014 24664583 HMGN5 ENSG00000198157 osteosarcoma Cisplatin DB00515 (APRD00359) RT-PCR The role of HMGN5 was detected by RT-PCR,western blot assay,RNA knockdown experiments, autophagy assays,cell proliferation assay,immunohistochemical staining. cell lines (HOS, MG63, U2-OS, SaO2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 436 High-mobility group nucleosome-binding domain 5 increases drug resistance in osteosarcoma through upregulating autophagy Tumour Biol 2014 24664583 HMGN5 ENSG00000198157 osteosarcoma Methotrexate DB00563 (APRD00353) RT-PCR The role of HMGN5 was detected by RT-PCR,western blot assay,RNA knockdown experiments, autophagy assays,cell proliferation assay,immunohistochemical staining. cell lines (HOS, MG63, U2-OS, SaO2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 437 Inhibition of Src by microRNA-23b increases the cisplatin sensitivity of chondrosarcoma cells Cancer Biomark 2017 28085008 SRC ENSG00000197122 chondrosarcoma Cisplatin DB00563 (APRD00353) qRT-PCR The role of SRC was detected by qRT-PCR,western blot assay,RNA knockdown experiments, luciferase reporter assay,cell viability assay,cell migration assay and transwell assay. cell lines (SW1353, OUMS-27, CH-2879) NA resistant AKT Src-Akt pathway validated NA protein phosphorylation related 438 Inhibition of Src by microRNA-23b increases the cisplatin sensitivity of chondrosarcoma cells Cancer Biomark 2017 28085008 AKT ENSG00000142208 chondrosarcoma Cisplatin DB00563 (APRD00353) qRT-PCR The role of AKT was detected by qRT-PCR,western blot assay,RNA knockdown experiments, luciferase reporter assay,cell viability assay,cell migration assay and transwell assay. cell lines (SW1353, OUMS-27, CH-2879) NA resistant NA Src-Akt pathway validated NA protein phosphorylation related 439 Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin Oncotarget 2012 23045411 JIP1 ENSG00000121653 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The mRNA and protein levels of JIP1 were determined by qRT-PCR and western blot. The role of JIP1 was detected by doxorubicin dose response analysis and apoptosis assay,tissue micro arrays and immunohistochemistry,tissue micro array scoring. cell lines (SaOS-2, MG-63, U2OS, LM7) up-regulated resistant NA JNK signaling pathway validated NA mRNA and protein overexpression related 440 Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line FEBS Lett 2011 21334329 TCRP1 ENSG00000054965 oral cancer Cisplatin DB00563 (APRD00353) RT-PCR The role of TCRP1 was detected by RT-PCR assay,western blot analysis,shRNAi silencing experiment,immunofluorescence microscopy,cytotoxicity assay and plate colony assay,comet assay and DNA ladder,apoptosis assay. cell line (Tca8113/PYM) up-regulated resistant caspases-3 and PARP NA validated NA mRNA and protein overexpression related 441 Downregulation of GLUT3 Promotes Apoptosis and Chemosensitivity of Acute Myeloid Leukemia Cells via EGFR Signaling Arch Iran Med 2018 29664658 GLUT3 ENSG00000059804 acute myeloid leukemia Vincristine DB00541 (APRD00495) qRT-PCR The siRNA transfection was conducted using LipofectamineTM 2000. Quantitative real-time RT-PCR (qRT-PCR) and Western blot analyses were employed to measure the expression levels of mRNA and protein for GLUT3, respectively. The cytotoxic effects of siRNA and vincristine were determined using the MTT assay. Flow cytometry was performed to analyze apoptosis. cell lines (U937, THP-1) up-regulated resistant EGFR EGFR signaling pathways validated NA mRNA and protein overexpression related 442 FoxM1 mediates resistance to herceptin and paclitaxel Cancer Res 2010 20530690 FOXM1 ENSG00000111206 breast cancer Herceptin DB00072 (BTD00098, BIOD00098) qRT-PCR The role of FOXM1 was detected by qRT-PCR,western blot analysis,chromatin immunoprecipitation,tubulin assay. cell lines (SKBR3, MDA-MB-453, BT474) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 443 FoxM1 mediates resistance to herceptin and paclitaxel Cancer Res 2010 20530690 FOXM1 ENSG00000111206 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of FOXM1 was detected by qRT-PCR,western blot analysis,chromatin immunoprecipitation,tubulin assay. cell lines (SKBR3, MDA-MB-453, BT474) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 444 Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy Oncotarget 2015 26362401 IRF1 ENSG00000125347 glioblastoma Bevacizumab DB00112 (BTD00087, BIOD00087) RT-PCR The role of IRF1 was detected by RT-PCR,western blot analysis,immunohistochemistry,immunofluorescence staining,transmission electron microscopy (TEM),acridine orange staining,apoptosis assays,tumor xenografts study. cell lines (GSC11, U87 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 445 RNA interference (RNAi)-mediated vascular endothelial growth factor-C (VEGF-C) reduction interferes with lymphangiogenesis and enhances epirubicin sensitivity of breast cancer cells Mol Cell Biochem 2008 17938864 VEGF-C ENSG00000150630 breast cancer Epirubicin DB00445 (APRD00361) RT-PCR We silenced the expression of VEGF-C with RNA interference (RNAi) .The expression of VEGF-C was examined by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), and the effect of plasmid on human lymphatic endothelial cells (HLECs) in vitro was analyzed by migration and MTT assay. The sensitivity to anticancer agents was evaluated by MTT and apoptosis assay, and apoptosis-related genes bcl-2/bax ratio was determined by Western Blotting. cell lines (MCF-7) up-regulated resistant BCL2/BAX apoptotic pathway validated NA mRNA and protein overexpression related 446 Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib Cancer Res 2006 17047074 IGF1R ENSG00000140443 lung cancer Erlotinib DB00530 (APRD00951) Northern blot The mRNA of IGF1R was found by northern blot analysis.The role of the mRNA was determined by cell proliferation assay,clonogenic growth assay,cell cycle and apoptosis assays,immunoblotting and coimmunoprecipitation. cell lines ( H596, H226B, H226Br, H460, H1299, A549, H358, H661, H322) up-regulated resistant NA IGF-IR pathway validated NA mRNA and protein overexpression related 447 The mechanism of cross-resistance to proteasome inhibitor bortezomib and overcoming resistance in Ewing's family tumor cells Int J Oncol 2007 17786311 P-glycoprotein ENSG00000085563 Ewing tumor Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The role of P-glycoprotein was detected by reverse transcriptase (RT)-PCR,western blot analysis,cell viability and chemosensitivity assays,TUNEL assay,tumor xenograft exepriment. cell lines (WE-68, VH-64) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 448 The mechanism of cross-resistance to proteasome inhibitor bortezomib and overcoming resistance in Ewing's family tumor cells Int J Oncol 2007 17786311 MRP1 ENSG00000103222 Ewing tumor Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The role of MRP1 was detected by reverse transcriptase (RT)-PCR,western blot analysis,cell viability and chemosensitivity assays,TUNEL assay,tumor xenograft exepriment. cell lines (WE-68, VH-64) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 449 Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells J Cell Physiol 2011 21506106 BCAR4 ENSG00000262117 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR The role of BCAR4 was detected by RT-PCR,SiRNA experiment,proliferation assays,xenograft formation experiment. cell lines (ZR-75-1,MCF7) up-regulated resistant NA ER signaling pathway validated NA mRNA and protein overexpression related 450 Arsenic Trioxide Promotes Paclitaxel Cytotoxicity in Resistant Breast Cancer Cells Asian Pac J Cancer Prev 2015 26225652 PPM1D ENSG00000170836 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR MTT assays were applied to determine the rate of cell survival. DAPI staining using fluorescent microscopy was employed to study apoptotic bodies. Real-time RT-PCR analysis was also applied to determine PPM1D_RNA_evels. cell line (MCF-7£© up-regulated resistant NA DNA damage signaling pathways validated NA mRNA and protein overexpression related 451 Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer Mol Cancer Ther 2012 22973056 PPM1D ENSG00000170836 oral cancer Cisplatin DB00563 (APRD00353) NA The relationship between the mRNA expression and the drug sensitivity was deteced by immunoblotting,comet assay,xenograft tumor study. cell lines up-regulated resistant NA DNA damage signaling pathways validated NA mRNA and protein overexpression related 452 Down-regulated clusterin expression enhances sensitivity of hepatoma cells to anti-cancer drugs Zhonghua Gan Zang Bing Za Zhi 2015 26743245 CLU ENSG00000120885 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR CLU mRNA amd protein expression was quantified by RT-PCR,western blotting. Four short-hairpin (sh)RNAs designed to block CLU-mRNA were generated, screened by RT-PCR, and transfected into the cells to determine effects of CLU on cell viability and apoptosis. Effects of CLU blockade on drug efflux pump activity were measured by flow cytometry. cell lines (Hep3B, SMMC7721, PLC, HepG2, HepG2/ADM) up-regulated resistant MDR1/P-gp NA validated NA mRNA and protein overexpression related 453 Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance Cell Cycle 2016 26825230 USP1 ENSG00000162607 lung cancer Cisplatin DB00563 (APRD00353) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR,siRNA transfection experiment,proliferation assay. cell lines (A549,A549-R£© up-regulated resistant NA FA pathway validated NA mRNA and protein overexpression related 454 Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance Cell Cycle 2016 26825230 FANCF ENSG00000183161 lung cancer Cisplatin DB00563 (APRD00353) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR,siRNA transfection experiment,proliferation assay. cell lines (A549,A549-R£© up-regulated resistant NA FA pathway validated NA mRNA and protein overexpression related 455 Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance Cell Cycle 2016 26825230 FANCB ENSG00000181544 lung cancer Cisplatin DB00563 (APRD00353) RT-PCR The relationship between the mRNA expression and the drug sensitivity was deteced by RT-PCR,siRNA transfection experiment,proliferation assay. cell lines (A549,A549-R£© up-regulated resistant NA FA pathway validated NA mRNA and protein overexpression related 456 PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines Clin Transl Sci 2016 27766744 PTTG1 ENSG00000164611 ovarian_ancer Saracatinib DB11805 Bioinformatics The role of PTTG1 was detected by bioinformatics technology,Western blot assays,RNA interference experiments,MTT assay. cell lines and patients tissues up-regulated resistant FGF2 NA validated NA mRNA and protein overexpression related 457 PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines Clin Transl Sci 2016 27766744 FGF2 ENSG00000138685 ovarian_ancer Saracatinib DB11805 Bioinformatics The role of FGF2 was detected by bioinformatics technology,Western blot assays,RNA interference experiments,MTT assay. cell lines and patients tissues up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 458 WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer Neoplasia 2013 23359789 WNT5A ENSG00000114251 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The role of WNT5A was detected by Real-Time PCR,immunoblot analysis,interfering RNA experiment,luciferase reporter assays,apoptosis assays,fluorescence-activated cell sorting (FACS),immunohistochemistry,tumors xenografts experiment. cell lines (ImimPC1,PaTu-8988t) up-regulated resistant NFATC2 WNT singaling pathway validated NA mRNA and protein overexpression related 459 WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer Neoplasia 2013 23359789 NFATC2 ENSG00000101096 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The role of NFATC2 was detected by Real-Time PCR,immunoblot analysis,interfering RNA experiment,luciferase reporter assays,apoptosis assays,fluorescence-activated cell sorting (FACS),immunohistochemistry,tumors xenografts experiment. cell lines (ImimPC1,PaTu-8988t) up-regulated resistant NA WNT singaling pathway validated NA mRNA and protein overexpression related 460 CUX1: target of Akt signalling and mediator of_esistance_o_poptosis_n_ancreatic_ancer Gut 2010 20442202 CUX1 ENSG00000257923 pancreatic cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship of the drug sensitivity and the mRNA expression was detected by RT-PCR,siRNA transfection experiments,immunoblotting analysis,cell apoptosis assays,ISH,IHC. cell lines up-regulated resistant NA IGF/PI3K/Akt signalling pathway validated NA mRNA and protein overexpression related 461 CUX1: target of Akt signalling and mediator of_esistance_o_poptosis_n_ancreatic_ancer Gut 2010 20442202 CUX1 ENSG00000257923 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The relationship of the drug sensitivity and the mRNA expression was detected by RT-PCR,siRNA transfection experiments,immunoblotting analysis,cell apoptosis assays,ISH,IHC. cell lines up-regulated resistant NA IGF/PI3K/Akt signalling pathway validated NA mRNA and protein overexpression related 462 LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro Mol Cancer 2007 17451600 LEDGF ENSG00000164985 acute myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of LEDGF was detected by RT-PCR,western blot analysis,dot-blot analysis of differentially expressed genes ,5'-RACE experiments,assessment of apoptosis. cell lines(Flp-In 293) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 463 siRNA targeting survivin inhibits the growth and enhances the chemosensitivity of hepatocellular carcinoma cells Oncol Rep 2013 23254641 BIRC5 ENSG00000089685 hepatocellular carcinoma Cisplatin DB00563 (APRD00353) qRT-PCR Quantitative RT-PCR and western blotting were used to determine the expression of survivin mRNA and protein, respectively. Tumor cell proliferation was assessed by trypan blue exclusion. We evaluated the change in caspase-3 activity, and the rate of cell apoptosis and the cell cycle distribution were analyzed by flow cytometry. Assessment of chemosensitivity was carried out by MTT assay. cell lines (HepG2,SMMC_7721) up-regulated resistant NA apoptotic pathway validated NA mRNA and protein overexpression related 464 Aldo-keto reductase 1C3 (AKR1C3) is associated with the doxorubicin resistance in human breast cancer via PTEN loss Biomed Pharmacother 2015 25661377 AKR1C3 ENSG00000196139 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The mRNA and protein of AKR1CE was detected by qRT-PCR and western blotting,cell viability assay,cell apoptotic assay. cell lines (MCF-7) and patients tissues up-regulated resistant PTEN PTEN/AKT signaling pathway validated NA mRNA and protein overexpression related 465 Aldo-keto reductase 1C3 (AKR1C3) is associated with the doxorubicin resistance in human breast cancer via PTEN loss Biomed Pharmacother 2015 25661377 PTEN ENSG00000171862 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The mRNA and protein of PTEN was detected by qRT-PCR and western blotting,cell viability assay,cell apoptotic assay. cell lines (MCF-7) and patients tissues down-regulated resistant NA PTEN/AKT signaling pathway validated NA mRNA and protein low expression related 466 Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells Mol Cancer Ther 2005 15767545 RAD21 ENSG00000164754 breast cancer Etoposide DB00773 (APRD00239) RT-PCR The role of RAD21 was detected by RT-PCR,iRNA knockdown experiment,cell proliferation and apoptosis assays,clonogenic survival assay. cell lines (MCF-7, T-47D, Hs 578Bst, ZR-75-1, HCC1937, Au-565, Hs578, BT-474, HCC1395, HCC1428, HCC1500, SK-BR-3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 467 Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells Mol Cancer Ther 2005 15767545 RAD21 ENSG00000164754 breast cancer Bleomycin DB00290 (APRD00453, EXPT00718) RT-PCR The role of RAD21 was detected by RT-PCR,iRNA knockdown experiment,cell proliferation and apoptosis assays,clonogenic survival assay. cell lines (MCF-7, T-47D, Hs 578Bst, ZR-75-1, HCC1937, Au-565, Hs578, BT-474, HCC1395, HCC1428, HCC1500, SK-BR-3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 468 Effect of tissue factor on invasion inhibition and apoptosis inducing effect of oxaliplatin in human gastric cancer cell Asian Pac J Cancer Prev 2012 22901134 TF ENSG00000117525 gastric cancer Oxaliplatin DB00526 (APRD00186) RT-PCR The target gene TF was obtained from human placenta by nested PCR and introduced into the human gastric cell line SGC7901 through transfection mediated by lipofectamine. Stably-transfected cells were screened using G418. Examples successfully transfected with TF-pcDNA3 recombinant (experimental group), and empty vector pcDNA3 (control group) were incubated with oxaliplatin. Transwell chambers were used to show change in invasive ability. Caspase-3 activity was detected using a colorimetric method and annexin-V/PI double- staining was applied to detect apoptosis. cell line ( SGC7901) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 469 Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming Genes Dev 2017 29269484 RUNX2 ENSG00000124813 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The Tamoxifen on mRNA RUNX2 was detected by quantitative real-time PCR (RT-qPCR) and analysis,anchorage-dependent colony formation assays,cell cycle analysis,cell proliferation assay. cell lines (MCF7,BR7) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 470 Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming Genes Dev 2017 29269484 EIF4E ENSG00000151247 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The Tamoxifen on mRNA RUNX2 was detected by quantitative real-time PCR (RT-qPCR) and analysis,anchorage-dependent colony formation assays,cell cycle analysis,cell proliferation assay. up-regulated resistant NA NA validated NA mRNA and protein overexpression related 471 Downregulation of ABCE1 via siRNA affects the sensitivity of A549 cells against chemotherapeutic agents Med Oncol 2015 25744244 ABCE1 ENSG00000164163 lung cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR Cytotoxicity, cell proliferation and apoptosis/necrosis evaluations were performed in order to examine the effects of the combined treatment by MTT,RTCA,oechst 33342 fluorescent dye and DAPI. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to confirm the downregulation of ABCE1. cell lines (A549) up-regulated resistant BCL2 and mTOR NA validated NA mRNA and protein overexpression related 472 Downregulation of ABCE1 via siRNA affects the sensitivity of A549 cells against chemotherapeutic agents Med Oncol 2015 25744244 ABCE1 ENSG00000164163 lung cancer Irinotecan DB00762 (APRD00579) RT-PCR Cytotoxicity, cell proliferation and apoptosis/necrosis evaluations were performed in order to examine the effects of the combined treatment by MTT,RTCA,oechst 33342 fluorescent dye and DAPI. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to confirm the downregulation of ABCE1. cell lines (A549) up-regulated sensitive BCL2 and mTOR NA validated NA mRNA and protein overexpression related 473 Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer J Natl Cancer Inst 2003 12618500 SRC3 ENSG00000124151 breast cancer Tamoxifen DB00675 (APRD00123) NA AIB1 and HER-2 protein levels in tumors from 316 breast_ancer_atients were determined using western blot analysis. Molecular variables (e.g.,_xpression_f AIB1, ER, progesterone_eceptor, p53, Bcl-2), tumor characteristics, and patient outcome were assessed using Spearman rank correlation. Disease-free_urvival(DFS) curves were derived from Kaplan-Meier estimates, and the curves were compared by log-rank tests. The effect of AIB1 on DFS adjusted for other prognostic factors was assessed by multivariable analysis using the Cox proportional hazards model. All statistical tests were two-sided. cell lines (MCF-7) and patients tissues up-regulated resistant NA Her2 signaling pathway validated NA mRNA and protein overexpression related 474 Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer J Natl Cancer Inst 2003 12618500 ERBB2 ENSG00000141736 breast cancer Tamoxifen DB00675 (APRD00123) NA AIB1 and HER-2 protein levels in tumors from 316 breast_ancer_atients were determined using western blot analysis. Molecular variables (e.g.,_xpression_f AIB1, ER, progesterone_eceptor, p53, Bcl-2), tumor characteristics, and patient outcome were assessed using Spearman rank correlation. Disease-free_urvival(DFS) curves were derived from Kaplan-Meier estimates, and the curves were compared by log-rank tests. The effect of AIB1 on DFS adjusted for other prognostic factors was assessed by multivariable analysis using the Cox proportional hazards model. All statistical tests were two-sided. cell lines (MCF-7) and patients tissues up-regulated resistant NA Her2 signaling pathway validated NA mRNA and protein overexpression related 475 Effects of hepatocyte growth factor gene transfection on adriamycin-induced apoptosis of gastric cancer cells in vitro Zhonghua Zhong Liu Za Zhi 2007 17892127 HGF ENSG00000019991 gastric cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR RT-PCR and western blot were used to determine the_arget_ene expression. Function of HGF was determined by MDCK cell scattering assay. Cell viability was tested by MTT assay. Apoptosis was evaluated by DNA fragmentation assay as well as flow cytometry using PI staining. cell lines (MKN-45) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 476 FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients J Exp Clin Cancer Res 2017 28482906 FOXM1 ENSG00000111206 ovarian_ancer Cisplatin DB00563 (APRD00353) qRT-PCR Validation of FOXM1 expression was performed by RT-qPCR and immunohistochemistry.Correlations of FOXM1 expression to clinic-pathological parameters and patients' prognosis were evaluated by Kaplan-Meier and Cox proportional-hazards analyses.Effects of FOXM1 inhibition by transient siRNA transfection were evaluated on cell-proliferation, cell-cycle, colony formation, invasion, and response to conventional first- and second-line anticancer agents, and to the PARP-inhibitor olaparib. Gene signatures of FOXM1-silenced cell lines were generated by microarray and confirmed by RT-qPCR. cell lines (OVCAR-3,EOC-CC1,OSPC2) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 477 FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients J Exp Clin Cancer Res 2017 28482906 FOXM1 ENSG00000111206 ovarian_ancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR Validation of FOXM1 expression was performed by RT-qPCR and immunohistochemistry.Correlations of FOXM1 expression to clinic-pathological parameters and patients' prognosis were evaluated by Kaplan-Meier and Cox proportional-hazards analyses.Effects of FOXM1 inhibition by transient siRNA transfection were evaluated on cell-proliferation, cell-cycle, colony formation, invasion, and response to conventional first- and second-line anticancer agents, and to the PARP-inhibitor olaparib. Gene signatures of FOXM1-silenced cell lines were generated by microarray and confirmed by RT-qPCR. cell lines (OVCAR-3,EOC-CC1,OSPC2) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 478 FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients J Exp Clin Cancer Res 2017 28482906 FOXM1 ENSG00000111206 ovarian_ancer Olaparib DB09074 (DB05940) qRT-PCR Validation of FOXM1 expression was performed by RT-qPCR and immunohistochemistry.Correlations of FOXM1 expression to clinic-pathological parameters and patients' prognosis were evaluated by Kaplan-Meier and Cox proportional-hazards analyses.Effects of FOXM1 inhibition by transient siRNA transfection were evaluated on cell-proliferation, cell-cycle, colony formation, invasion, and response to conventional first- and second-line anticancer agents, and to the PARP-inhibitor olaparib. Gene signatures of FOXM1-silenced cell lines were generated by microarray and confirmed by RT-qPCR. cell lines (OVCAR-3,EOC-CC1,OSPC2) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 479 FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients J Exp Clin Cancer Res 2017 28482906 FOXM1 ENSG00000111206 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT-PCR Validation of FOXM1 expression was performed by RT-qPCR and immunohistochemistry.Correlations of FOXM1 expression to clinic-pathological parameters and patients' prognosis were evaluated by Kaplan-Meier and Cox proportional-hazards analyses.Effects of FOXM1 inhibition by transient siRNA transfection were evaluated on cell-proliferation, cell-cycle, colony formation, invasion, and response to conventional first- and second-line anticancer agents, and to the PARP-inhibitor olaparib. Gene signatures of FOXM1-silenced cell lines were generated by microarray and confirmed by RT-qPCR. cell lines (OVCAR-3,EOC-CC1,OSPC2) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 480 Inhibition of EZH2 reverses chemotherapeutic drug TMZ chemosensitivity in glioblastoma Int J Clin Exp Pathol 2014 25400745 EZH2 ENSG00000106462 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The association between EZH2 and Temozolomide was detected by quantitative RT-PCR,western blotting analysis,MTT assay,SiRNA transfection experiment,flow cytometry analysis. cell lines (U251,U87) up-regulated resistant MDR, MRP and BCRP NA validated NA mRNA and protein overexpression related 481 Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma J Exp Clin Cancer Res 2016 27473117 SAM68 ENSG00000121774 tongue squamous_ancer Cisplatin DB00563 (APRD00353) RT-PCR The effect of Sam68 on apoptosis induced by cisplatin was examined both in vitro and in vivo, using Annexin V staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays. Real-time PCR and Western blotting analysis were used to detect mRNA and protein expression levels. cell lines (SCC-9,SCC25) up-regulated resistant NA apoptotic pathway validated NA mRNA and protein overexpression related 482 HtrA1 downregulation induces cisplatin resistance in lung adenocarcinoma by promoting cancer stem cell-like properties J Cell Biochem 2014 24356998 HTRA1 ENSG00000166033 lung cancer Cisplatin DB00563 (APRD00353) RT-PCR The role of HTRA1 was detected by real-time PCR,western blotting analysis,shRNA transfection experiment,MTT assay,flow cytometry analysis,immunostaining assay,tumor xenograft experiments. cell lines (A549/CDDP,A549) down-regulated resistant NA PI3K/AKT signaling pathway validated NA mRNA and protein low expression related 483 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity J Clin Invest 2006 16767218 HTRA1 ENSG00000166033 gastric cancer Cisplatin DB00563 (APRD00353) NA The relationship between the drug sensitivity and the mRNA expression was detected by siRNA transfection experiments,immunoblotting analysis,annexin V labeling and hoechst staining,MTT survival assays,lactate dehydrogenase release assays,caspase assays,clonogenic survival assays,LC-MS/MS analysis,immunohistochemistry. cell lines (SKOV3, OVCAR3, OVCAR5, OV167, OV177, OV202, OV266, OSE,A2780, Cp70, and C200) down-regulated resistant NA NA validated NA mRNA and protein low expression related 484 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity J Clin Invest 2006 16767218 HTRA1 ENSG00000166033 ovarian_ancer Cisplatin DB00563 (APRD00353) NA The relationship between the drug sensitivity and the mRNA expression was detected by siRNA transfection experiments,immunoblotting analysis,annexin V labeling and hoechst staining,MTT survival assays,lactate dehydrogenase release assays,caspase assays,clonogenic survival assays,LC-MS/MS analysis,immunohistochemistry. cell lines (SKOV3, OVCAR3, OVCAR5, OV167, OV177, OV202, OV266, OSE,A2780, Cp70, and C200) down-regulated resistant NA NA validated NA mRNA and protein low expression related 485 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity J Clin Invest 2006 16767218 HTRA1 ENSG00000166033 gastric cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) NA The relationship between the drug sensitivity and the mRNA expression was detected by siRNA transfection experiments,immunoblotting analysis,annexin V labeling and hoechst staining,MTT survival assays,lactate dehydrogenase release assays,caspase assays,clonogenic survival assays,LC-MS/MS analysis,immunohistochemistry. cell lines (SKOV3, OVCAR3, OVCAR5, OV167, OV177, OV202, OV266, OSE,A2780, Cp70, and C200) down-regulated resistant NA NA validated NA mRNA and protein low expression related 486 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity J Clin Invest 2006 16767218 HTRA1 ENSG00000166033 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) NA The relationship between the drug sensitivity and the mRNA expression was detected by siRNA transfection experiments,immunoblotting analysis,annexin V labeling and hoechst staining,MTT survival assays,lactate dehydrogenase release assays,caspase assays,clonogenic survival assays,LC-MS/MS analysis,immunohistochemistry. cell lines (SKOV3, OVCAR3, OVCAR5, OV167, OV177, OV202, OV266, OSE,A2780, Cp70, and C200) down-regulated resistant NA NA validated NA mRNA and protein low expression related 487 HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor Int J Cancer 2014 23996744 HSP27 ENSG00000106211 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of HSP27 was detect by quantitative RT-PCR,western blotting analysis,motility and migration assays. cell lines (TOV-21G,SK-OV-3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 488 Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP501 in vitro Mol Cancer Ther 2014 25053821 NRF2 ENSG00000116044 lung cancer CBP501 NA RNeasy Mini Kit Microarray analysis was performed on cell lines to identify gene expression patterns that correlated with CBP501 sensitivity. We found that Nrf2 target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in NSCLC cell lines also indicated higher protein level in CBP501-insensitive cell lines. cell lines (NCI-H1755, NCI-H2030, NCI-H1437, NCI-H2122, NCI-H2172, NCI-H2228, NCI-H1563, NCI-H1944, NCI-H1993, NCI-H1734, NCI-H1568, NCI-H2444, NCI-H2291, NCI-H2347, NCI-H1838, NCI-H1299, HCC827, NCI-H1975, NCI-H1155, NCI-H522, and NCI-H1703) up-regulated resistant GSR,G6PD,ABCC2,AKR1C1,AKR1C3 NRF2 signaling pathway validated NA mRNA and protein overexpression related 489 Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP502 in vitro Mol Cancer Ther 2014 25053821 GSR ENSG00000104687 lung cancer CBP501 NA RNeasy Mini Kit Microarray analysis was performed on cell lines to identify gene expression patterns that correlated with CBP501 sensitivity. We found that Nrf2 target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in NSCLC cell lines also indicated higher protein level in CBP501-insensitive cell lines. cell lines (NCI-H1755, NCI-H2030, NCI-H1437, NCI-H2122, NCI-H2172, NCI-H2228, NCI-H1563, NCI-H1944, NCI-H1993, NCI-H1734, NCI-H1568, NCI-H2444, NCI-H2291, NCI-H2347, NCI-H1838, NCI-H1299, HCC827, NCI-H1975, NCI-H1155, NCI-H522, and NCI-H1703) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 490 Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP503 in vitro Mol Cancer Ther 2014 25053821 G6PD ENSG00000160211 lung cancer CBP501 NA RNeasy Mini Kit Microarray analysis was performed on cell lines to identify gene expression patterns that correlated with CBP501 sensitivity. We found that Nrf2 target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in NSCLC cell lines also indicated higher protein level in CBP501-insensitive cell lines. cell lines (NCI-H1755, NCI-H2030, NCI-H1437, NCI-H2122, NCI-H2172, NCI-H2228, NCI-H1563, NCI-H1944, NCI-H1993, NCI-H1734, NCI-H1568, NCI-H2444, NCI-H2291, NCI-H2347, NCI-H1838, NCI-H1299, HCC827, NCI-H1975, NCI-H1155, NCI-H522, and NCI-H1703) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 491 Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP504 in vitro Mol Cancer Ther 2014 25053821 ABCC2 ENSG00000023839 lung cancer CBP501 NA RNeasy Mini Kit Microarray analysis was performed on cell lines to identify gene expression patterns that correlated with CBP501 sensitivity. We found that Nrf2 target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in NSCLC cell lines also indicated higher protein level in CBP501-insensitive cell lines. cell lines (NCI-H1755, NCI-H2030, NCI-H1437, NCI-H2122, NCI-H2172, NCI-H2228, NCI-H1563, NCI-H1944, NCI-H1993, NCI-H1734, NCI-H1568, NCI-H2444, NCI-H2291, NCI-H2347, NCI-H1838, NCI-H1299, HCC827, NCI-H1975, NCI-H1155, NCI-H522, and NCI-H1703) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 492 Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP505 in vitro Mol Cancer Ther 2014 25053821 AKR1C1 ENSG00000187134 lung cancer CBP501 NA RNeasy Mini Kit Microarray analysis was performed on cell lines to identify gene expression patterns that correlated with CBP501 sensitivity. We found that Nrf2 target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in NSCLC cell lines also indicated higher protein level in CBP501-insensitive cell lines. cell lines (NCI-H1755, NCI-H2030, NCI-H1437, NCI-H2122, NCI-H2172, NCI-H2228, NCI-H1563, NCI-H1944, NCI-H1993, NCI-H1734, NCI-H1568, NCI-H2444, NCI-H2291, NCI-H2347, NCI-H1838, NCI-H1299, HCC827, NCI-H1975, NCI-H1155, NCI-H522, and NCI-H1703) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 493 Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP506 in vitro Mol Cancer Ther 2014 25053821 AKR1C3 ENSG00000196139 lung cancer CBP501 NA RNeasy Mini Kit Microarray analysis was performed on cell lines to identify gene expression patterns that correlated with CBP501 sensitivity. We found that Nrf2 target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in NSCLC cell lines also indicated higher protein level in CBP501-insensitive cell lines. cell lines (NCI-H1755, NCI-H2030, NCI-H1437, NCI-H2122, NCI-H2172, NCI-H2228, NCI-H1563, NCI-H1944, NCI-H1993, NCI-H1734, NCI-H1568, NCI-H2444, NCI-H2291, NCI-H2347, NCI-H1838, NCI-H1299, HCC827, NCI-H1975, NCI-H1155, NCI-H522, and NCI-H1703) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 494 FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer Cancer Res 2010 20179196 FGFR1 ENSG00000077782 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The role of FGFR1 was detected by quantitative reverse transcription-PCR, immunohistochemistry, siRNA transfection study. cell lines (S68,MDA-MB-134,PD173074,ICI-182780,U0126) up-regulated resistant NA NA validated Amplification NA related 495 Upregulated KLK10 inhibits esophageal cancer proliferation and enhances cisplatin sensitivity in vitro Oncol Rep 2015 26479703 KLK10 ENSG00000129451 esophageal_ancer Cisplatin DB00563 (APRD00353) qRT-PCR The expression of KLK10 in human esophageal and non-esophageal cancer tissues was investigated by immunohistochemistry. Quantitative RT-PCR and western blot analysis were utilized to detect KLK10 mRNA and protein expression in human esophageal cancer cell lines (TE-1 and Eca-109). Small interference RNA was utilized to specifically knockdown KLK10 expression in Eca-109 and TE-1 cells. Cell proliferation, cell cycle analysis as well as CDDP-dependent apoptosis were determined using a CCK-8 assay and flow cytometry. cell lines (Eca-109,TE-1) up-regulated resistant caspase-3, cleaved PARP NA validated NA mRNA and protein overexpression related 496 A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy PLoS One 2013 23483975 CHK1 ENSG00000149554 lung cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The association between the Gemcitabine and CHK1 was detected by qRT-PCR,western blot analysis,cell viability assay and synthetic lethality screening. cell lines (H23, H125, H650, H1299,H1648,H2122) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 497 A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy PLoS One 2013 23483975 RRM1 ENSG00000167325 lung cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The association between the Gemcitabine and mRNA expression was detected by qRT-PCR,western blot analysis,cell viability assay and synthetic lethality screening. cell lines (H23, H125, H650, H1299,H1648,H2122) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 498 Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes Carcinogenesis 2013 23299407 TNFAIP8 ENSG00000145779 cervical_ancer Cisplatin DB00563 (APRD00353) qRT-PCR The association between the Platinum and mRNA TNFAIP8 was detected by qRT-PCR,transient transfection and treatment,cell proliferation assay and viability assay,apoptosis analysis,chemiluminescence immumo-assay. patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 499 Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes Carcinogenesis 2013 23299407 TNFAIP8 ENSG00000145779 cervical_ancer Nedaplatin DB13145 qRT-PCR The association between the Platinum and mRNA TNFAIP8 was detected by qRT-PCR,transient transfection and treatment,cell proliferation assay and viability assay,apoptosis analysis,chemiluminescence immumo-assay. patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 500 Rab11a sustains GSK3beta/Wnt/beta-catenin signaling to enhance cancer progression in pancreatic cancer Tumour Biol 2016 27481517 RAB11A ENSG00000103769 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The association betweent the RAB11A mRNA and Gemcitabine was detected by qRT-PCT,western blot analysis,immunohistochemistry, iRNA transfection experiment,CCK-8 cell viability assay,cell cycle and apoptosis analysis,invasion assay,immunofluorescence assay. cell lines (Capan2, Bxpc3,CFPAC1) up-regulated resistant cyclin D1, cyclin E, MMP7, and cmyc WNT singaling pathway validated NA mRNA and protein overexpression related 501 Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line Leukemia 2010 20200558 TOP2B ENSG00000077097 acute promyelocytic leukemia Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) qRT-PCR The role of mRNA TOP2B on ATRA was detected by quantitative real-time PCR,western blot analysis,decatenation assay, transfection experiment,immunofluorescence,differentiation assays. cell lines (NB4-MR2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 502 Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line Leukemia 2010 20200558 PRKCD ENSG00000163932 acute promyelocytic leukemia Tretinoin (ATRA) DB00755 (NUTR00051, APRD00362) qRT-PCR The role of mRNA PRKCD on ATRA was detected by quantitative real-time PCR,western blot analysis,decatenation assay, transfection experiment,immunofluorescence,differentiation assays. cell lines (NB4-MR2) up-regulated resistant TOP2B NA validated NA mRNA and protein overexpression related 503 MMP7 Induces T-DM1 Resistance and Leads to the Poor Prognosis of Gastric Adenocarcinoma via a DKK1-Dependent Manner Anticancer Agents Med Chem 2018 30501604 MMP7 ENSG00000137673 gastric cancer Trastuzumab emtansine (T-DM1) DB05773 qRT-PCR Quantitative Real-Time PCR and Western-blot were used in detection of mRNA and protein expression. Lentivirus infection was used to overexpression or knock down target gene. Alarma blue assay was used to monitor cells proliferation. Flow cytometry analysis was performed to test protein expression and apoptosis level. Immunohistochemistry was used to identify protein expression in tissue. cell lines (NCI-N87) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 504 MMP7 Induces T-DM1 Resistance and Leads to the Poor Prognosis of Gastric Adenocarcinoma via a DKK1-Dependent Manner Anticancer Agents Med Chem 2018 30501604 DKK1 ENSG00000107984 gastric cancer Trastuzumab emtansine (T-DM1) DB05773 qRT-PCR Quantitative Real-Time PCR and Western-blot were used in detection of mRNA and protein expression. Lentivirus infection was used to overexpression or knock down target gene. Alarma blue assay was used to monitor cells proliferation. Flow cytometry analysis was performed to test protein expression and apoptosis level. Immunohistochemistry was used to identify protein expression in tissue. cell lines (NCI-N87) up-regulated resistant MMP7 NA validated NA mRNA and protein overexpression related 505 Differential sensitivity of MCF-7 and LCC2 cells, to multiple growth inhibitory agents: possible relation to high bcl-2/bax ratio Cancer Lett 2000 11078910 BCL2 ENSG00000171791 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR The role of Tamoxifen on mRNA BCL2/BAX ratio was detect by RT-PCR,western blotting analysis,gene antisense treatment experiments,cell viability and apoptosis assays. cell lines (LCC2,MCF-7) up-regulated resistant NA apoptotic pathway validated NA mRNA and protein overexpression related 506 Differential sensitivity of MCF-7 and LCC2 cells, to multiple growth inhibitory agents: possible relation to high bcl-2/bax ratio Cancer Lett 2000 11078910 BAX ENSG00000087088 breast cancer Tamoxifen DB00675 (APRD00123) RT-PCR The role of Tamoxifen on mRNA BCL2/BAX ratio was detect by RT-PCR,western blotting analysis,gene antisense treatment experiments,cell viability and apoptosis assays. cell lines (LCC2,MCF-7) down-regulated resistant NA apoptotic pathway validated NA mRNA and protein low expression related 507 Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance Cancer Res 1996 8653701 TUBB3 ENSG00000258947 prostate cancer Estramustine DB01196 (APRD00625) RT-PCR The association between the Estramustine and TUBB3 was detected by RT-PCT, Immunofluorescence and confocal scanning,cytosol preparation and western analysis. cell line (DU145) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 508 Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance Cancer Res 1996 8653701 TUBB4A ENSG00000104833 prostate cancer Estramustine DB01196 (APRD00625) RT-PCR The association between the Estramustine and TUBB4A was detected by RT-PCT, Immunofluorescence and confocal scanning,cytosol preparation and western analysis. cell line (DU145) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 509 Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer J Transl Med 2015 25947066 FASN ENSG00000169710 ovarian_ancer Cisplatin DB00563 (APRD00353) qRT-PCR FASN expression at mRNA and protein levels was determined by quantitative real-time polymerase chain reaction and immunoblotting and immunohistochemistry, respectively. FASN inhibition's impact on cell viability, apoptosis, and fatty acid metabolism was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide assay, cell death detection enzyme-linked immunosorbent assay, immunoblotting, and (18) F-fluoromethylcholine uptake measurement, respectively. cell lines (Hey, Igrov-1, Skov-3) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 510 Increased expression of MyD88 and association with paclitaxel resistance in breast cancer Increased expression of MyD88 and association with paclitaxel resistance in breast cancer 2016 26596839 MYD88 ENSG00000172936 breast cancer Paclitaxel (Taxol ) DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR Real-time PCR and Western blots were further used to measure the messenger RNA (mRNA) and protein expression. The proliferation was assessed by WST-1. Flow cytometry was used to measure the cell cycle and apoptosis. The transwell assay was used to observe the change of migration and invasion of transfected cells. cell lines (MCF-7) and patients tissues up-regulated resistant PI3K/Akt and NF-¦ÊB PI3K/Akt and NF-¦ÊB signaling pathway validated NA mRNA and protein overexpression related 511 MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer Yale J Biol Med 2006 17940625 MYD88 ENSG00000172936 ovarian_ancer Paclitaxel (Taxol ) DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) NA The association between the drug and mRNA was detected by western blotting analysis,immunocytochemistry . patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 512 EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer Carcinogenesis 2014 24379240 EDD ENSG00000104517 ovarian_ancer Cisplatin DB00563 (APRD00353) qRT-PCR The expression of EDD mRNA was detected by quantitative real-time PCR,western blotting analysis,transfection of small interfering RNA study,MTT analysis,luciferase analysis,apoptosis assay,crystal violet staining. cell lines (A2780ip2, OVCAR5,ES-2 ) up-regulated resistant MCL1 NA validated NA mRNA and protein overexpression related 513 EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer Carcinogenesis 2014 24379240 MCL1 ENSG00000143384 ovarian_ancer Cisplatin DB00563 (APRD00353) qRT-PCR The expression of MCL1 mRNA was detected by quantitative real-time PCR,western blotting analysis,transfection of small interfering RNA study,MTT analysis,luciferase analysis,apoptosis assay,crystal violet staining. cell lines (A2780ip2, OVCAR5,ES-2 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 514 TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-kappaB activation Int J Oncol 2014 24337061 FN14 ENSG00000006327 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The role of 5-fluorouracil on mRNA was FN14 was detected by real-time RT-PCR,western blot analyses,uciferase reporter assays,siRNA transfection experiments,cell growth assay,caspase-3/7 assay. cell lines (SNU-216,293T) up-regulated resistant NA TWEAK/Fn14/NF-¦ªb signaling pathway validated NA mRNA and protein overexpression related 515 TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-kappaB activation Int J Oncol 2014 24337061 TNFSF12 ENSG00000239697 gastric cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The association between the drug and mRNA was detected by real-time RT-PCR,western blot analyses,uciferase reporter assays,siRNA transfection experiments,cell growth assay,caspase-3/7 assay. cell lines (SNU-216,293T) up-regulated resistant FN14 TWEAK/Fn14/NF-¦ªb signaling pathway validated NA mRNA and protein overexpression related 516 Psoriasin overexpression confers drug resistance to cisplatin by activating ERK in gastric cancer Int J Oncol 2018 29956751 PSORIASIN ENSG00000143556 gastric cancer Cisplatin DB00563 (APRD00353) qRT-PCR Expression of psoriasin_RNA_nd protein were analyzed using quantitative polymerase chain reaction and immunohistochemistry of gastric_ancer_ohorts, respectively. Gastric_ancer_ell models with differential expression of psoriasin were generated using stable cell lines that overexpressed psoriasin. The in_itro biological functions of the cells in response to psoriasin overexpression and to chemotherapeutic agents were assessed using various cell-based assays cell lines (AGS,HGC-27) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 517 Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor Am J Respir Crit Care Med 2011 21037017 SLUG ENSG00000019549 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The expression level of SLUG was determined using quantitative real-time reverse transcription-polymerase chain reaction and Western blot analysis. Molecular manipulations (silencing or overexpression) were performed to investigate the effects of EMT regulators on gefitinib resistance in vitro, and a xenograft mouse model was used for in vivo confirmation. In addition, cancer cells from 44 patients with malignant pleural effusions of lung adenocarcinoma were collected for analysis of EMT regulator mRNA by quantitative real-time reverse transcription-polymerase chain reaction. cell lines (PC9,PC9/gef) up-regulated resistant BIM apoptotic pathway validated NA mRNA and protein overexpression related 518 Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor Am J Respir Crit Care Med 2011 21037017 BIM ENSG00000153094 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The expression level of SLUG was determined using quantitative real-time reverse transcription-polymerase chain reaction and Western blot analysis. Molecular manipulations (silencing or overexpression) were performed to investigate the effects of EMT regulators on gefitinib resistance in vitro, and a xenograft mouse model was used for in vivo confirmation. In addition, cancer cells from 44 patients with malignant pleural effusions of lung adenocarcinoma were collected for analysis of EMT regulator mRNA by quantitative real-time reverse transcription-polymerase chain reaction. cell lines (PC9,PC9/gef) down-regulated resistant NA apoptotic pathway validated NA mRNA and proteion low expression related 519 Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor Am J Respir Crit Care Med 2011 21037017 SLUG ENSG00000019549 lung cancer Erlotinib DB00530 (APRD00951) qRT-PCR The expression level of SLUG was determined using quantitative real-time reverse transcription-polymerase chain reaction and Western blot analysis. Molecular manipulations (silencing or overexpression) were performed to investigate the effects of EMT regulators on gefitinib resistance in vitro, and a xenograft mouse model was used for in vivo confirmation. In addition, cancer cells from 44 patients with malignant pleural effusions of lung adenocarcinoma were collected for analysis of EMT regulator mRNA by quantitative real-time reverse transcription-polymerase chain reaction. cell lines (PC9,PC9/gef) up-regulated resistant BIM apoptotic pathway validated NA mRNA and protein overexpression related 520 Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor Am J Respir Crit Care Med 2011 21037017 BIM ENSG00000153094 lung cancer Erlotinib DB00530 (APRD00951) qRT-PCR The expression level of SLUG was determined using quantitative real-time reverse transcription-polymerase chain reaction and Western blot analysis. Molecular manipulations (silencing or overexpression) were performed to investigate the effects of EMT regulators on gefitinib resistance in vitro, and a xenograft mouse model was used for in vivo confirmation. In addition, cancer cells from 44 patients with malignant pleural effusions of lung adenocarcinoma were collected for analysis of EMT regulator mRNA by quantitative real-time reverse transcription-polymerase chain reaction. cell lines (PC9,PC9/gef) up-regulated resistant NA apoptotic pathway validated NA mRNA and protein overexpression related 521 PLAUR Confers Resistance to Gefitinib Through EGFR/P-AKT/Survivin Signaling Pathway Cell Physiol Biochem 2018 29961070 PLAUR ENSG00000011422 lung cancer Gefitinib DB00317 (APRD00997, DB07998) RT-PCR Real-time PCR was used to examine the expression of PLAUR mRNA and Western blot was applied to examine the expression of related proteins. The gene knockdown was achieved by Lentivirus based RNA silence technique. The cell counting kit-8 assay and EdU incorporation were used to examine cell proliferation. The flow cytometry was applied to determine cell apoptosis and cell cycle, while the mitochondrial membrane potential was measured by JC-1 dye assay. Signaling pathway affected by PLAUR knockdown was identified by cDNA Microarray. The effect of PLAUR knockdown on tumorigenesis was analyzed in vivo. cell lines (PC9,PC9/gef) up-regulated resistant NA EGFR/P-AKT/Survivin Signaling Pathway validated NA mRNA and protein overexpression related 522 Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways Neuro Oncol 2013 23444257 P4HB ENSG00000185624 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The expression and role of P4HB was detected by qRT_PCR ,cell transfection experiments,clonogenic and survival assays,cellular fractionation and immunoblotting analysis,flow cytometry analysis,Immunohistochemistry,tumor xenograft experiment. cell lines (D54-S,D54-R; U87-S,U87-R) up-regulated resistant NA ERSR signaling pathway validated NA mRNA and protein overexpression related 523 HIF-1alpha and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia Asian Pac J Cancer Prev 2014 24641416 GLUT1 ENSG00000117394 acute myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR RNA_nterference with short hairpin_NA(shRNA) was used to stably silence GLUT1 or HIF-1¦Á gene expression in an AML cell line and HIF-1¦Á and GLUT1_RNA_xpression was measured by real-time quantitative polymerase chain reaction assay (qPCR). cell lines (HL-60) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 524 HIF-1alpha and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia Asian Pac J Cancer Prev 2014 24641416 HIF1A ENSG00000100644 acute myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR RNA_nterference with short hairpin_NA(shRNA) was used to stably silence GLUT1 or HIF-1¦Á gene expression in an AML cell line and HIF-1¦Á and GLUT1_RNA_xpression was measured by real-time quantitative polymerase chain reaction assay (qPCR). cell lines (HL-60) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 525 Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia Mol Cancer Ther 2017 28428443 ABCB1 ENSG00000085563 leukemia Pinometostat DB12920 qRT-PCR The role of ABCB1 was detected by quantitative real-time PCR,western blot analysis,RNA sequencing. cell lines (KOPN-8,NOMO-1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 526 The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity J Biol Chem 2005 16006564 RHEB ENSG00000106615 cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The role of RHEB was detected by qRT-PCR,protein analysis,TaqMan analysis,transfections experiment. cell lines (MCF-7 ,ES-2) up-regulated resistant NA MTOR signaling pathway validated NA mRNA and protein overexpression related 527 The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity J Biol Chem 2005 16006564 RHEB ENSG00000106615 cancer Docetaxel DB01248 (APRD00932) qRT-PCR The role of RHEB was detected by qRT-PCR,protein analysis,TaqMan analysis,transfections experiment. cell lines (MCF-7 ,ES-2) up-regulated resistant NA MTOR signaling pathway validated NA mRNA and protein overexpression related 528 Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia Br J Cancer 2007 17726463 BFL1 ENSG00000140379 B-cell chronic lymphocytic leukaemia Fludarabine DB01073 (APRD00594) RT-PCR In this study, bfl-1 mRNA levels have been determined by competitive PCR in an extended population of B-CLL patients to characterise its role in disease progression and development of chemoresistance. cell lines up-regulated resistant NA apoptotic pathway validated NA mRNA and protein overexpression related 529 Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate J Biol Chem 2006 16950787 HO1 ENSG00000100292 lung cancer Green Tea Extract DB14307 RT-PCR&Northern blot The role of HO1 was detected by RT-PCR and northern blotting,analysis,western blotting analysis,electrophoretic mobility shift assay,transient transfection expriment,RNA Interference experiment,flow cytometric analysis,soft agar colony formation assay,Immunocytochemistry. cell line (A549, LNCaP, DU145, PC-3, AsPC-1, HCC1419, SKOV-3, HT-29, H196, H441 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 530 Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate 2006 16950787 NRF2 ENSG00000116044 lung cancer Green Tea Extract DB14307 RT-PCR&Northern blot The role of NRF2 was detected by RT-PCR and northern blotting,analysis,western blotting analysis,electrophoretic mobility shift assay,transient transfection expriment,RNA Interference experiment,flow cytometric analysis,soft agar colony formation assay,Immunocytochemistry. cell line (A549, LNCaP, DU145, PC-3, AsPC-1, HCC1419, SKOV-3, HT-29, H196, H441 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 531 Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma Oncotarget 2014 24811082 MCL1 ENSG00000143384 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The association between the Temozolomide and the BAK/MCL1 expression was detected by qRT-PCR,western blotting analysis,siRNA transfection experiment,cell cycle analysis,cell viability assays,caspase activity,LDH activity assay. cell line (U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 532 Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma Oncotarget 2014 24811082 BAK ENSG00000030110 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The association between the Temozolomide and the BAK/MCL1 expression was detected by qRT-PCR,western blotting analysis,siRNA transfection experiment,cell cycle analysis,cell viability assays,caspase activity,LDH activity assay. cell line (U251) down-regulated resistant NA NA validated NA mRNA and protein overexpression related 533 Knockdown of dual specificity phosphatase 4 enhances the chemosensitivity of MCF-7 and MCF-7/ADR breast cancer cells to doxorubicin Exp Cell Res 2013 24012960 DUSP4 ENSG00000120875 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR We used cell viability assays,qRT-PCR, Western blotting and immunofluorescent staining, combined with siRNA interference, to evaluate chemoresistance and the EMT in MCF-7 and adriamycin-resistant MCF-7/ADR breast_ancer_ells, and investigate the underlying mechanisms cell lines (MCF-7, MCF-7/ADR) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 534 FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide Pharmacol Rep 2017 29128799 NRF2 ENSG00000116044 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The role of NRF2 was deteced by qRT-PCR,western blotting analysis,cell viability assay,RNA interference experiments,migration and invasion assay. cell lines (U251MG, U87MG) up-regulated resistant NA Nrf2/ARE signaling pathway validated NA mRNA and protein overexpression related 535 Overexpression of iASPP-SV in glioma is associated with poor prognosis by promoting cell viability and antagonizing apoptosis Tumour Biol 2016 26628298 PPP1R13L ENSG00000104881 glioma Temozolomide DB00853 (APRD00557) qRT-PCR The expression of the PPP1T13L was detected by qRT-PCR,western blot assays,immunofluorescence staining, drug treatment study,growth inhibition assay,apoptosis assessment. cell lines (U87) and patients tissues up-regulated resistant P53 P53 signaling pathway validated NA Gene spliced and mRNA and protein overexpression related 536 Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide Oncotarget 2014 25337721 BRCC3 ENSG00000185515 glioma Temozolomide DB00853 (APRD00557) qRT-PCR The role of BRCC3 expression on the Temozolomide was detected by qRT-PCR,western blotting analysis,immunofluorescence,shRNA transfection experiments,MTT assay,cell scratch assay,colony formation assay. cell lines (U251, A172) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 537 Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide Oncotarget 2014 25337721 BRCC3 ENSG00000185515 glioma Carmustine (BCNU) DB00262 (APRD00006) qRT-PCR The role of BRCC3 expression on the drugs was detected by qRT-PCR,western blotting analysis,immunofluorescence,shRNA transfection experiments,MTT assay,cell scratch assay,colony formation assay. cell lines (U251, A172) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 538 Musashi1 Promotes Non-Small Cell Lung Carcinoma Malignancy and Chemoresistance via Activating the Akt Signaling Pathway Cell Physiol Biochem 2017 29141252 MSI1 ENSG00000135097 lung cancer Cisplatin DB00563 (APRD00353) RT-PCR Colony formation, MTT, glucose uptake and lactate production assays were employed to study lung cancer cell malignancy and chemoresistance. RT-PCR and Western blotting were performed to detect mRNA and protein expressions of genes. We used immunohistochemistry and Pearson correlation analysis to study the relationship of gene expression. cell lines (A549, H522) up-regulated resistant NA Akt signaling pathway validated NA mRNA and protein overexpression related 539 Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer Breast Cancer Res 2014 24472707 HIF1A ENSG00000100644 breast cancer Letrozole DB01006 (APRD01066) RT-PCR Western blot analysis and RT-PCR analyses were conducted to compare protein and mRNA expression. cell lines (MCF-7Ca, MCF-7, AC1) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 540 Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4 Mol Cell Endocrinol 2004 15062554 AC4 ENSG00000129467 adrenocortical_umor Forskolin DB02587 (EXPT01467) RT-PCR The role of AC4 was determined by Western blot and RT-PCR analysis. cell lines down-regulated resistant NA NA validated mutaion NA related 541 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 HUR ENSG00000066044 glioma Etoposide DB00773 (APRD00239) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 542 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 HUR ENSG00000066044 glioma Cisplatin DB00563 (APRD00353) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 543 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 HUR ENSG00000066044 glioma Topotecan DB01030 (APRD00687) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 544 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 BCL2 ENSG00000171791 glioma Etoposide DB00773 (APRD00239) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 545 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 BCL2 ENSG00000171791 glioma Cisplatin DB00563 (APRD00353) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 546 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 BCL2 ENSG00000171791 glioma Topotecan DB01030 (APRD00687) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 547 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 MCL1 ENSG00000143384 glioma Etoposide DB00773 (APRD00239) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 548 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 MCL1 ENSG00000143384 glioma Cisplatin DB00563 (APRD00353) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 549 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 MCL1 ENSG00000143384 glioma Topotecan DB01030 (APRD00687) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 550 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 BCLXL ENSG00000171552 glioma Etoposide DB00773 (APRD00239) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 551 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 BCLXL ENSG00000171552 glioma Cisplatin DB00563 (APRD00353) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 552 The RNA-binding protein HuR promotes glioma growth and treatment resistance Mol Cancer Res 2011 21498545 BCLXL ENSG00000171552 glioma Topotecan DB01030 (APRD00687) qRT-PCR and UV cross-linking assays The role of HUR on the drugs sensitivity was detected by qRT-PCR,western blotting analysis,UV cross-linking analysis, immunoprecipitation,RNA interference experiment,chemosensitivity assays. cell lines (U251 ,GBM2, GBM10, GBM12) up-regulated resistant bcl-2 family apoptotic pathway validated NA mRNA and protein overexpression related 553 Transcriptional upregulation of c-MYC by AXL confers epirubicin resistance in esophageal adenocarcinoma Mol Oncol 2018 30353671 AXL ENSG00000167601 esophageal_ancer Epirubicin DB00445 (APRD00361) qRT-PCR The role of AXL was detected by quantitative real_time RT_PCR,western blot analysis,mRNA decay analysis, MTT assay,apoptosis assay,short interfering RNA experiments,luciferase reporter assays,tumor xenograft stduy,immunohistochemistry. cell lines (OE33, SK_GT_4, ESO26, ESO51, OAC M5.1,OE19) up-regulated resistant c-MYC AKT/¦Â_catenin pathway validated NA mRNA and protein overexpression related 554 Transcriptional upregulation of c-MYC by AXL confers epirubicin resistance in esophageal adenocarcinoma Mol Oncol 2018 30353671 MYC ENSG00000136997 esophageal_ancer Epirubicin DB00445 (APRD00361) qRT-PCR The role of c-myc was detected by quantitative real_time RT_PCR,western blot analysis,mRNA decay analysis, MTT assay,apoptosis assay,short interfering RNA experiments,luciferase reporter assays,tumor xenograft stduy,immunohistochemistry. cell lines (OE33, SK_GT_4, ESO26, ESO51, OAC M5.1,OE19) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 555 Nuclear respiratory factor-1 and bioenergetics in tamoxifen-resistant breast cancer cells Exp Cell Res 2016 27515002 NRF1 ENSG00000106459 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The role of the NRF1 was detected by the qRT-PCR, western blotting analysis. cell lines (LCC1, LCC2,LCC9,MCF-7,T47D) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 556 Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib PLoS One 2016 27023064 NRF2 ENSG00000116044 neuroblastoma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The role of the mRNA expression on the Bortezomib was detected by RT-PCR,western blotting analysis,small interfering RNA experiment,proteasome activity assay,cytotoxicity assay,chromatin immunoprecipitation assay. cell line (HTLA-230) up-regulated resistant HO1 and GSH NA validated NA mRNA and protein overexpression related 557 Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib PLoS One 2016 27023064 HO1 ENSG00000100292 neuroblastoma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The role of the mRNA expression on the Bortezomib was detected by RT-PCR,western blotting analysis,small interfering RNA experiment,proteasome activity assay,cytotoxicity assay,chromatin immunoprecipitation assay. cell line (HTLA-230) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 558 Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib PLoS One 2016 27023064 GSH ENSG00000160882 neuroblastoma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The role of the mRNA expression on the Bortezomib was detected by RT-PCR,western blotting analysis,small interfering RNA experiment,proteasome activity assay,cytotoxicity assay,chromatin immunoprecipitation assay. cell line (HTLA-230) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 559 Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers Carcinogenesis 2017 28379297 PYCR1 ENSG00000183010 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) NA The role of PYCT1 expression was detected by western blot analysis,invasion assay,cell proliferation and cytotoxicity assay,quantitative immunohistochemistry assays. cell lines (MCF-7, MDA-MB-231) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 560 The expression of PLK-1 in cervical carcinoma: a possible target for enhancing chemosensitivity J Exp Clin Cancer Res 2009 19775446 PLK1 ENSG00000166851 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR We examined PLK-1 expression in cervical carcinoma tissues using qRT-PCR,immunohistochemical staining. Furthermore, we blocked PLK-1 expression in HeLa cells using specific siRNA and detected the cell cycle, cell proliferation and chemosensitivity using western blotting, MTT and flow cytometry. cell line (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 561 ATP-binding cassette sub-family C member 4 (ABCC4) is overexpressed in human NK/T-cell lymphoma and regulates chemotherapy sensitivity: Potential as a functional therapeutic target Leuk Res 2015 26499190 ABCC4 ENSG00000125257 NK/T-cell lymphoma Cisplatin DB00515 (APRD00359) RT-PCR The expression of the ABCC4 was comfirmed by the RT-PCR,western blotting analysis,apoptosis detection and analysis,immunohistochemical staining. cell lines (YTS, SNK-6) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 562 ATP-binding cassette sub-family C member 4 (ABCC4) is overexpressed in human NK/T-cell lymphoma and regulates chemotherapy sensitivity: Potential as a functional therapeutic target Leuk Res 2015 26499190 ABCC4 ENSG00000125257 NK/T-cell lymphoma Epirubicin DB00445 (APRD00361) RT-PCR The expression of the ABCC4 was comfirmed by the RT-PCR,western blotting analysis,apoptosis detection and analysis,immunohistochemical staining. cell lines (YTS, SNK-6) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 563 Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro Int J Mol Med 2013 23503641 DEPTOR ENSG00000155792 melanoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR RNA interference was used to reduce the expression of DEPTOR. Cytotoxicity was evaluated by MTT assay. Apoptosis was examined by flow cytometry. DEPTOR mRNA and protein expression in RPMI_8226 cells treated with DEPTOR-specific short hairpin RNA (shRNA) was evaluated by RT-PCR, quantitative PCR and western blot analysis. The expression of apoptosis_associated proteins, autophagy_associated proteins, and the activation of the phosphoinositide 3_kinase (PI3K)/Akt signaling pathway were detected by western blot analysis. Autophagy was also measured by transmission electron microscopy and monodansylcadaverine (MDC). cell lines (RPMI-8226) up-regulated resistant caspase-3and cleaved PARP PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 564 The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance Neuro Oncol 2018 29897522 FN14 ENSG00000006327 glioblastoma Temozolomide DB00853 (APRD00557) Bioinformatics Immunohistochemistry was performed using nonneoplastic brain, patient-matched primary and recurrent GBM, and gliosarcoma (GSM) specimens to examine Fn14 protein levels. The mRNA expression was detected by the database bioinformatics analysis technology. Western blot analysis was used to compare Fn14 expression in parental TMZ-sensitive or matched TMZ-resistant patient-derived xenografts (PDXs) established from primary or recurrent_umor_amples. patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 565 Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer Sci Rep 2016 27833130 PTPN3 ENSG00000070159 ovarian_ancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The relationship of the drug sensitivity and the mRNA expression was detected by qRT-PCR,IHC,western blotting analysis,iRNA interference experiments. cell lines (A2780) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 566 Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer Sci Rep 2016 27833130 PTPN3 ENSG00000070159 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The relationship of the drug sensitivity and the mRNA expression was detected by qRT-PCR,IHC,western blotting analysis,iRNA interference experiments. cell lines (A2780) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 567 VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance Int J Cancer 2014 24585459 VEGFC ENSG00000150630 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the VEGFC was detected by the RT-PCR,western blot analysis,ELISA assay,immunohistochemistry,RNA interference experiments,invasion analysis,ChIP analysis. cell lines (SNU-484, SNU-638, SNU-719, MKN-28 and MKN-45) up-regulated resistant BCL2 NA validated NA mRNA and protein overexpression related 568 VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance Int J Cancer 2014 24585459 ARHGDIB ENSG00000111348 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,ELISA assay,immunohistochemistry,RNA interference experiments,invasion analysis,ChIP analysis. cell lines (SNU-484, SNU-638, SNU-719, MKN-28 and MKN-45) up-regulated resistant VEGFC NA validated NA mRNA and protein overexpression related 569 Identification of genes involved in the sensitivity to antitumour drug 17-allylamino,17-demethoxygeldanamycin (17AAG) Mol Biosyst 2006 16880941 TRAM ENSG00000067167 lung cancer Tanespimycin(17-AAG) DB05134 (DB06398) qRT-PCR The role of the TRAM on the sensitivity of the 17-AAG was detected by the qRT-PCR. cell lines (NCI-H226) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 570 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells Ann Hematol 2009 19125248 BSG ENSG00000172270 lymphoid_eoplasm Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant MMPs MAPK pathway validated NA mRNA and protein overexpression related 571 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells Ann Hematol 2009 19125248 BSG ENSG00000172270 lymphoid_eoplasm Docetaxel DB01248 (APRD00932) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant MMPs MAPK pathway validated NA mRNA and protein overexpression related 572 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells Ann Hematol 2009 19125248 BSG ENSG00000172270 lymphoid_eoplasm Vincristine DB00541 (APRD00495) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant MMPs MAPK pathway validated NA mRNA and protein overexpression related 573 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells Ann Hematol 2009 19125248 BSG ENSG00000172270 lymphoid_eoplasm Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant MMPs MAPK pathway validated NA mRNA and protein overexpression related 574 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D2 cells Ann Hematol 2009 19125248 MMP11 ENSG00000099953 lymphoid_eoplasm Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant NA MAPK pathway validated NA mRNA and protein overexpression related 575 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D3 cells Ann Hematol 2009 19125248 MMP11 ENSG00000099953 lymphoid_eoplasm Docetaxel DB01248 (APRD00932) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant NA MAPK pathway validated NA mRNA and protein overexpression related 576 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D4 cells Ann Hematol 2009 19125248 MMP11 ENSG00000099953 lymphoid_eoplasm Vincristine DB00541 (APRD00495) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant NA MAPK pathway validated NA mRNA and protein overexpression related 577 Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D5 cells Ann Hematol 2009 19125248 MMP11 ENSG00000099953 lymphoid_eoplasm Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of the expression of the CD147 on the drug chemosensitivity was detected by the RT-PCR,western blotting analysis,iRNA interference expreriment,MTT assay,soft agar colony formation assay,migration assay,tumor progression assay. cell line (P388D1) up-regulated resistant NA MAPK pathway validated NA mRNA and protein overexpression related 578 Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1 Haematologica 2012 21993678 XBP1 ENSG00000100219 myeloma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The role of the XBP1 was detected by the RT-PCR,DNase I assays,cytotoxicity assays,shRNA knockdown experiment. cell lines (RPMI-8226, KMS-11, KMS-18, OPM2, H929 and U266) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 579 Increased level of Oct-1 protein in tumor cells modulates cellular response to anticancer drugs Dokl Biochem Biophys 2016 27599509 OCT ENSG00000143190 burkitt lymphoma Dexamethasone DB01234 (APRD00674) RT-PCR The role of the OCT1 was detected by RT-PCR. cell lines up-regulated resistant MYC, BCL6, ITMB2,TSC22D, EIF2AK2,SH3KBP1,TP63 NA validated NA mRNA and protein overexpression related 580 Increased level of Oct-1 protein in tumor cells modulates cellular response to anticancer drugs Dokl Biochem Biophys 2016 27599509 OCT ENSG00000143190 burkitt lymphoma Camptothecin DB04690 RT-PCR The role of the OCT1 was detected by RT-PCR. cell lines up-regulated sensitive ITMB2,MYC,BCL6, TP63, EIF2AK, TSC22D3, and SH3KBP1 NA validated NA mRNA and protein overexpression related 581 Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients Tumour Biol 2016 26733163 ABCC3 ENSG00000108846 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the expression of the ABCC3 was detected by the RT-PCR,western blotting analysis,RNA interference expreriments,glucose consumption and lactate production assay. cell lines (5637, UMUC-3) and patients tissues up-regulated resistant LDHA NA validated NA mRNA and protein overexpression related 582 Inhibition of Beclin 1 expression enhances cisplatin-induced apoptosis through a mitochondrial-dependent pathway in human ovarian cancer SKOV3/DDP cells Oncol Res 2014 24854102 BECN1 ENSG00000126581 ovarian_ancer Cisplatin DB00515 (APRD00359) NA NA cell lines (SKOV3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 583 Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide FEBS Lett 2007 17981155 EI24 ENSG00000149547 cancer Etoposide DB00773 (APRD00239) RT-PCR The role of the EI24 was detected by the RT-PCR,TUNEL reaction assay,flow cytometry assay. cell lines (MCF-7 ) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 584 Silencing of high mobility group A1 enhances gemcitabine chemosensitivity of lung adenocarcinoma cells Chin Med J (Engl) 2011 21542969 HMGA1 ENSG00000137309 lung cancer Gemcitabine DB00441 (APRD00201) RT-PCR The expression of HMGA1 was determined by retrotranscriptase polymerase chain reaction (RT-PCR) and Western blotting. The effect of gemcitabine on proliferation of positive and negative cells was observed by methyl thiazolyl tetrazolium (MTT) assay and clonogenic survival assay. Apoptosis was observed by flow cytometery. Chemosensitivity to gemcitabine was determined by IC50 analysis. Caspase activity was quantitated by a caspase colorimetric protease assay kit. cell lines (SPCA-1 ) up-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 585 Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1-Survivin axis Cancer Commun (Lond) 2019 31796105 FOXM1 ENSG00000111206 glioma Temozolomide DB00853 (APRD00557) qRT-PCR Cell viability and proliferation were detected by MTT assay, tumor cell spheroid growth, and colony formation assay. Cell apoptosis and cell cycle were detected by flow cytometry. The mRNA levels of interested genes were measured via reverse transcription-quantitative polymerase chain reaction, and protein levels were determined via Western blotting/immunofluorescent staining in cell lines and immunohistochemical staining in paraffin-embedded sections. Via inoculating U87 cells subcutaneously, glioma xenograft models in nude mice were established for drug experiments. Patient survival data were analyzed using the Kaplan-Meier method. cell lines (U87, U251, LN229, A172, SF295, SF268) and patients tissues up-regulated resistant NA FOXM1/Survivin signaling pathway validated NA mRNA and protein overexpression related 586 Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1-Survivin axis Cancer Commun (Lond) 2019 31796105 BIRC5 ENSG00000089685 glioma Temozolomide DB00853 (APRD00557) qRT-PCR Cell viability and proliferation were detected by MTT assay, tumor cell spheroid growth, and colony formation assay. Cell apoptosis and cell cycle were detected by flow cytometry. The mRNA levels of interested genes were measured via reverse transcription-quantitative polymerase chain reaction, and protein levels were determined via Western blotting/immunofluorescent staining in cell lines and immunohistochemical staining in paraffin-embedded sections. Via inoculating U87 cells subcutaneously, glioma xenograft models in nude mice were established for drug experiments. Patient survival data were analyzed using the Kaplan-Meier method. cell lines (U87, U251, LN229, A172, SF295, SF268) and patients tissues up-regulated resistant NA FOXM1/Survivin signaling pathway validated NA mRNA and protein overexpression related 587 Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b Clin Exp Pharmacol Physiol 2020 31531888 GRIM19 ENSG00000186010 prostate cancer Docetaxel DB01248 (APRD00932) RT-PCR mRNA_nd protein expression in cells and tissues of PC were measured by quantitative real-time PCR and western blot, respectively. Knock-down of GRIM-19 in PC cells was performed using siRNA. Cell apoptosis was determined by flow cytometric analysis. DNA damage in PC cells was detected by ¦Ã-H2AX staining. cell lines (PC_3, LNCaP, DU145, RWPE_1) and patients tissues down-regulated resistant Rad23b NA validated NA mRNA and protein low expression related 588 Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b Clin Exp Pharmacol Physiol 2020 31531888 Rad23b ENSG00000119318 prostate cancer Docetaxel DB01248 (APRD00932) RT-PCR mRNA_nd protein expression in cells and tissues of PC were measured by quantitative real-time PCR and western blot, respectively. Knock-down of GRIM-19 in PC cells was performed using siRNA. Cell apoptosis was determined by flow cytometric analysis. DNA damage in PC cells was detected by ¦Ã-H2AX staining. cell lines (PC_3, LNCaP, DU145, RWPE_1) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 589 Establishment and Characterization of Pemetrexed-resistant NCI-H460/PMT Cells Anticancer Agents Med Chem 2019 30848214 TYMS ENSG00000176890 lung cancer Pemetrexed DB00642 (APRD00573, EXPT02075) qRT-PCR MTT assay and colony formation were performed to detect cell proliferation. Immunofluorescence was used to detect the expression of Ki-67. Transwell assay was performed to measure cell migration ability. qPCR and Western blot were used to detect the mRNA and protein expression levels of indicated genes. Small interfering RNAs (siRNA) were used to knockdown TYMS. cell lines (NCI-H460) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 590 IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer Cancers (Basel) 2019 30609749 IGFBP7 ENSG00000163453 lung cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the bioinformatics analysis,qRT-PCR,western blotting analysis,ELISA,cytotoxicity assay,apoptosis assay,immunohistochemical staining. cell lines (PC9, HCC827, HCC4006) up-regulated resistant NA EGFR signaling pathways validated NA mRNA and protein overexpression related 591 IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer Cancers (Basel) 2019 30609749 IGFBP7 ENSG00000163453 lung cancer Erlotinib DB00530 (APRD00951) qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the bioinformatics analysis,qRT-PCR,western blotting analysis,ELISA,cytotoxicity assay,apoptosis assay,immunohistochemical staining. cell lines (PC9, HCC827, HCC4006) up-regulated resistant NA EGFR signaling pathways validated NA mRNA and protein overexpression related 592 IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer Cancers (Basel) 2019 30609749 IGFBP7 ENSG00000163453 lung cancer Afatinib DB08916 qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the bioinformatics analysis,qRT-PCR,western blotting analysis,ELISA,cytotoxicity assay,apoptosis assay,immunohistochemical staining. cell lines (PC9, HCC827, HCC4006) up-regulated resistant NA EGFR signaling pathways validated NA mRNA and protein overexpression related 593 CCL2 influences the sensitivity of lung cancer A549 cells to docetaxel Oncol Lett 2018 30061946 CCL2 ENSG00000108691 lung cancer Docetaxel DB01248 (APRD00932) qRT-PCR Reverse transcription-quantitative polymerase chain reaction and western blot analysis revealed that DTX treatment increased the mRNA and protein expression of CCL2 in lung cancer A549 cells. CCL2 was knocked down by small interfering RNA or was overexpressed by recombinant CCL2 lentivirus, and cell viability was determined. cell lines (A549) up-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 594 Cisplatin may induce frataxin expression J Nippon Med Sch 2003 12928720 FXN ENSG00000165060 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression on the efficacy of the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence microscopy. cell lines (A2780CP70, A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 595 MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway Eur Rev Med Pharmacol Sci 2018 30536307 MALAT1 ENSG00000251562 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effects of different doses of cisplatin on the proliferation and apoptosis of cervical cancer cells were detected by cell counting kit-8 (CCK-8) assay and apoptosis assay, respectively. We used bioinformatics methods to predict the downstream genes of MALAT1 and examined the expression relationship between the target gene BRWD1 and MALAT1 by quantitative Real-time polymerase chain reaction (qRT-PCR). Western blot was performed to detect the expression levels of apoptosis-related proteins and key genes in PI3K/AKT signaling pathway. cell lines (HeLa, C-33A) up-regulated resistant BRWD1 PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 596 MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway Eur Rev Med Pharmacol Sci 2018 30536307 BRWD1 ENSG00000185658 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effects of different doses of cisplatin on the proliferation and apoptosis of cervical cancer cells were detected by cell counting kit-8 (CCK-8) assay and apoptosis assay, respectively. We used bioinformatics methods to predict the downstream genes of MALAT1 and examined the expression relationship between the target gene BRWD1 and MALAT1 by quantitative Real-time polymerase chain reaction (qRT-PCR). Western blot was performed to detect the expression levels of apoptosis-related proteins and key genes in PI3K/AKT signaling pathway. cell lines (HeLa, C-33A) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 597 BIRC6 mediates imatinib resistance independently of Mcl-1 PLoS One 2017 28520795 BIRC6 ENSG00000115760 chronic myelogenous leukemia Imatinib DB00619 (APRD01028, EXPT02967, DB03261) qRT-PCR The role of the mRNA was detected by the qRT-PCR,immunoblot analysis,shRNA interference study,flow cytometry analysis. cell lines (MYL-R, MYL-S, MYL) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 598 Effects of apoptosis protein XIAP inhibitor on the apoptosis and sensitivity of chemotherapy in A549 cell Zhongguo Fei Ai Za Zhi 2008 20731936 XIAP ENSG00000101966 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR The_RNA_evels of XIAP gene in A549 cells were assessed using a semi-quantitative reverse transcriptase-PCR (RT-PCR). The expression vector of XIAP small interfering_NA(XIAP siRNAwas constructed and transfected into A549 cells. The transfection was proved effective by the fluorescence microscope. Cell proliferation and cell killing rate after chemotherapeutics treatment were investigated by MTT assay. The rate of apoptosis was detected by flow cytometry assay. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 599 CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression Apoptosis 2019 31177396 CNOT3 ENSG00000088038 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the qRT-PCR,western blotting analysis,RNA interference assay,flow cytometry analysis,cell survival, cytotoxicity and cell proliferation assay. cell lines (A549) up-regulated resistant RIPK3 CNOT3/RIPK3 signaling pathway validated NA mRNA and protein overexpression related 600 CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression Apoptosis 2019 31177396 RIPK3 ENSG00000129465 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the qRT-PCR,western blotting analysis,RNA interference assay,flow cytometry analysis,cell survival, cytotoxicity and cell proliferation assay. cell lines (A549) down-regulated resistant NA CNOT3/RIPK3 signaling pathway validated NA mRNA and protein low expression related 601 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 hENT NA colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630, H630-cTFT, H630-4TFT) down-regulated resistant NA NA validated deletion NA related 602 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 sPLA2 ENSG00000117215 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630, H630-cTFT, H630-4TFT) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 603 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 hCNT NA colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630, H630-cTFT, H630-4TFT) down-regulated resistant NA NA validated deletion NA related 604 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 TYMP ENSG00000025708 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630, H630-cTFT, H630-4TFT) down-regulated resistant NA NA validated deletion NA related 605 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 TYMS ENSG00000176890 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630, H630-cTFT, H630-4TFT) down-regulated resistant NA NA validated deletion NA related 606 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 DUT ENSG00000128951 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630, H630-cTFT, H630-4TFT) down-regulated resistant NA NA validated deletion NA related 607 Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance Oncotarget 2018 29423065 PRL3 ENSG00000184489 acute lymphoblastic leukemia Cytarabine DB00987 (APRD00499) qRT-PCR PRL-3 expression at_RNA_nd protein level was higher in B-ALL cells than in normal cells, as measured by qRT-PCR or flow cytometry. Further, we demonstrate that inhibition of PRL-3 using shRNA or a small molecular inhibitor reduced cell migration cell lines (Reh, MHH-CALL-4, Tanoue, SUP-B15) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 608 Silodosin inhibits the growth of bladder cancer cells and enhances the cytotoxic activity of cisplatin via ELK1 inactivation Am J Cancer Res 2015 26693052 ELK1 ENSG00000126767 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The assosiciation between the drug and the expression of mRNA was detected by the RT-PCR,western blotting analysis,reporter gene assay,cell proliferation and cell migration assays,bladder tissue microarray (TMA) and immunohistochemistry. _ell lines (TCCSUP, UMUC3, 5637) up-regulated resistant NA PKC/Raf-1/ERK pathway validated NA mRNA and protein overexpression related 609 Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer World J Gastroenterol 2019 31636474 CCN4 ENSG00000104415 gastric cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR WISP1 levels were measured at both the mRNA and protein levels by RT-qPCR, Western blot analysis, and immunohistochemistry (IHC). In addition, the in situ expression of WISP1 in the GC tissues was determined by IHC.WISP1 was knocked down by RNA interference. patients tissues up-regulated resistant NA Wnt1 signaling pathway validated NA mRNA and protein overexpression related 610 Silencing RIF1 decreases cell growth, migration and increases cisplatin sensitivity of human cervical cancer cells Oncotarget 2017 29291010 RIF1 ENSG00000080345 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,flow cytometric analysis,ShRNA transfection study,cell viability analysis,colony formation assay and wound healing assay. cell lines (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 611 Downregulation of high mobility group protein box-1 resensitizes ovarian cancer cells to carboplatin Oncol Lett 2018 30214593 HMGB1 ENSG00000189403 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT-PCR The expression of HMGB1 was silenced by small interference RNA technology. Reverse transcription-quantitative polymerase chain reaction and western blot analysis indicated that mRNA and protein expression levels of HMGB1.Cell proliferation and apoptosis analyses were performed to evaluate the effect of HMGB1 silencing on resistant ovarian cancer cells. An MTT assay revealed that the proliferation of HMGB1-silenced SKOV3 and SKOV3-Carb cells were decreased compared with the proliferation of non-silenced control cells. cell lines (SKOV3,SKOV3-Carb) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 612 Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer J Biomed Res 2012 23554769 SOX2 ENSG00000181449 gastric cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The assosiciation between the expression of mRNA and the drug resistance was detected by the RT-PCR,western blotting analysis,RNA interference,tumor xenograft study,doxorubicin efflux analysis. cell lines (SGC-7901, BGC-823, MGC-803, HGC-27, MKN-28) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 613 Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer J Biomed Res 2012 23554769 SOX2 ENSG00000181449 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The assosiciation between the expression of mRNA and the drug resistance was detected by the RT-PCR,western blotting analysis,RNA interference,tumor xenograft study,doxorubicin efflux analysis. cell lines (SGC-7901, BGC-823, MGC-803, HGC-27, MKN-28) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 614 Claudin-1 silencing increases sensitivity of liver cancer HepG2 cells to 5-fluorouracil by inhibiting autophagy Oncol Lett 2019 31788043 CLDN1 ENSG00000163347 hepatocellular carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR Reverse transcription-quantitative polymerase chain reaction and western blot analysis indicated that_RNA_nd protein expression levels of CLDN1 were significantly increased in Hep/5FU cells, compared with HepG2 cells. CLDN1 was knocked down by transfection with small interference_NA. MTT and Annexin V-fluorescein isothiocyanate/propidium iodide assays demonstrated that CLDN1 silencing significantly inhibits proliferation and enhances apoptosis induced by 5-FU treatment in Hep/5FU cells, compared with non-silenced Hep/5FU cells. cell lines (HepG2, HepG2/5FU) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 615 High level of RNF187 contributes to the progression and drug resistance of osteosarcoma J Cancer 2020 32047542 RBF187 ENSG00000168159 osteosarcoma Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR We employed the quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) to determine the expression of RNF187 in OS tissues and cells. Migration and invasion capacities were analyzed by wound healing and transwell assays, and colony formation and CCK8 assays were performed to investigate proliferative ability. The functional effects of RNF187 on OS drugs resistance were further determined by CCK8 and western blot assays. Then, the relationship between RNF187 expression and clinical implications was analyzed by tissue microarrays (TMAs) including 51 OS cases. cell lines (U-2OS, MG-63, Saos, HOS) up-regulated resistant ERK1/2 and bcl2 ERK1/2 signaling pathway validated NA mRNA and protein overexpression related 616 High level of RNF187 contributes to the progression and drug resistance of osteosarcoma J Cancer 2020 32047542 RBF187 ENSG00000168159 osteosarcoma Docetaxel DB01248 (APRD00932) qRT-PCR We employed the quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) to determine the expression of RNF187 in OS tissues and cells. Migration and invasion capacities were analyzed by wound healing and transwell assays, and colony formation and CCK8 assays were performed to investigate proliferative ability. The functional effects of RNF187 on OS drugs resistance were further determined by CCK8 and western blot assays. Then, the relationship between RNF187 expression and clinical implications was analyzed by tissue microarrays (TMAs) including 51 OS cases. cell lines (U-2OS, MG-63, Saos, HOS) up-regulated resistant ERK1/2 and bcl2 ERK1/2 signaling pathway validated NA mRNA and protein overexpression related 617 Inhibition of beta-Catenin to Overcome Endocrine Resistance in Tamoxifen-Resistant Breast Cancer Cell Line PLoS One 2016 27196739 CTNNB ENSG00000168036 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR We established tamoxifen-resistant (TamR) cell line via long-term exposure of MCF-7 breast_ancer_ells to gradually increasing concentrations of tamoxifen. The levels of protein expression and_RNA_ranscripts were determined using western blot analysis and real-time quantitative PCR. The transcriptional activity of ¦Â-catenin was measured using luciferase activity assay. cell lines (MCF-7) up-regulated resistant NA Wnt/¦Â-Catenin signaling pathway validated NA mRNA and protein overexpression related 618 Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway Cancer Cell Int 2017 28878571 IL6 ENSG00000136244 laryngeal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR IL-6 mRNA and protein expressions were examined with quantitative real-time polymerase chain reaction and Western blot, respectively. Cell proliferation was measured by MTT assay. Tumorigenicity was measured by a colony formation assay and invasion was determined by a cell invasion assay. Apoptotic cells were counted by flow cytometry. Immunohistochemistry was performed to detect immunoreactive IL-6 cells in xenografts. cell lines (Hep2 ) up-regulated resistant STAT3 and HIF1 IL-6/STAT3/HIF1 pathway validated NA mRNA and protein overexpression related 619 TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells Oncol Rep 2018 29436678 TRIB2 ENSG00000071575 chronic myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR&qRT-PCR The_RNA_nd protein expression levels of were determined by reverse transcription_polymerase chain reaction (RT_PCR), RT_quantitative PCR and western blot analysis. cell line (K562) up-regulated resistant MDR1/MPR1 ERK signaling pathway validated NA mRNA and protein overexpression related 620 TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells Oncol Rep 2018 29436678 MDR1 ENSG00000085563 chronic myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR&qRT-PCR The_RNA_nd protein expression levels of were determined by reverse transcription_polymerase chain reaction (RT_PCR), RT_quantitative PCR and western blot analysis. cell line (K562) up-regulated resistant NA ERK signaling pathway validated NA mRNA and protein overexpression related 621 TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells Oncol Rep 2018 29436678 MRP1 ENSG00000103222 chronic myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR&qRT-PCR The_RNA_nd protein expression levels of were determined by reverse transcription_polymerase chain reaction (RT_PCR), RT_quantitative PCR and western blot analysis. cell line (K562) up-regulated resistant NA ERK signaling pathway validated NA mRNA and protein overexpression related 622 E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells Genes Cancer 2016 28191284 PIRH2 ENSG00000163743 lung cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The role of the drug on the expression of the mRNA was detected by the qRT-PCR,western blotting analysis,annexin V staining,MTT assay,colony formation assay,wound healing (scratch) assay, cell line (H1299) up-regulated resistant c-MYC NA validated NA mRNA and protein overexpression related 623 Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity Clin Cancer Res 2007 17404098 MCL1 ENSG00000143384 acute lymphoid leukemia Rituximab DB00073 (BTD00014, BIOD00014) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,immunoblot analysis,ADCC and CDC assay,apoptosis and flow cytometric studies,transfection studys. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 624 Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity Clin Cancer Res 2007 17404098 MCL1 ENSG00000143384 chronic lymphoid leukemia Rituximab DB00073 (BTD00014, BIOD00014) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,immunoblot analysis,ADCC and CDC assay,apoptosis and flow cytometric studies,transfection studys. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 625 Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer World J Gastroenterol 2019 31602160 ADAM28 ENSG00000042980 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR RNA-sequence analysis was applied to explore the potential targets involved in the gemcitabine of pancreatic_ancer. SW1990 pancreatic_ancer_ells were treated with an increased dose of gemcitabine, and the_RNA_evels of ADAM28 were evaluated by RT-PCR. The protein and_RNA_evels of ADAM28 were confirmed in the gemcitabine resistant and parallel SW1990 cells. The ADAM28 expression was also assessed in TCGA and GEO databases, and the results were confirmed in the collected tumor and adjacent normal tissues. cell line (SW1990) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 626 Potential crosstalk of the interleukin-6-heme oxygenase-1-dependent mechanism involved in resistance to lenalidomide in multiple myeloma cells Febs j 2016 26700310 HO1 ENSG00000100292 melanoma Lenalidomide DB00480 (APRD01303) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,apoptosis analysis,cell viability assays,ELISA,lentiviral vector transfections experiments. cell lines (U266, RPMI8226,CD138(+) cells) up-regulated resistant NA JAK2/STAT3 signaling pathway validated NA mRNA and protein overexpression related 627 Potential crosstalk of the interleukin-6-heme oxygenase-1-dependent mechanism involved in resistance to lenalidomide in multiple myeloma cells Febs j 2016 26700310 IL6 ENSG00000136244 melanoma Lenalidomide DB00480 (APRD01303) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,apoptosis analysis,cell viability assays,ELISA,lentiviral vector transfections experiments. cell lines (U266, RPMI8226,CD138(+) cells) up-regulated resistant HO1 JAK2/STAT3 signaling pathway validated NA mRNA and protein overexpression related 628 Downregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma Onco Targets Ther 2018 29872321 CPT2 ENSG00000157184 hepatocellular carcinoma Cisplatin DB00515 (APRD00359) qRT-PCR We performed quantitative reverse transcriptase polymerase chain reaction to investigate carnitine palmitoyltransferase-2 (CPT2) expression and then systematically analyzed its relationship with clinicopathologic features. We further performed proliferation, colony formation, migration and invasion, drug resistance, and lipogenesis assays to determine the function of CPT2 in HCC. cell lines (HepG2, Huh7, SMMC-7721, HCC-LM3,SK-Hep1) down-regulated resistant NA CPT2 signaling pathway validated NA mRNA and protein low expression related 629 ShRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib Int J Mol Med 2014 24913180 BMI1 ENSG00000168283 melanoma Bortezomib DB00188 (APRD00828, DB07475) qRT-PCR A cell counting kit-8 (CCK-8) assay was performed to analyze cell proliferation and evaluate the 50% inhibitory concentration (IC50) values of bortezomib. Cell cycle progression and apoptosis were analyzed by flow cytometry (FCM), and the_RNA_nd protein expression of associated genes was quantified by RT-qPCR and western blot analysis, respectively. cell lines (U266,RPMI8226) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 630 Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells Tumour Biol 2014 24839008 RLIP76 ENSG00000017797 leukemia Daunorubicin DB00694 (APRD00521) RT-PCR Real-time PCR and western blot analysis revealed that the expression levels of RLIP76_RNA_nd protein in U937 cells were significantly suppressed after transfection with shRNA-containing vector. Knockdown of RLIP76 significantly inhibited cell growth and decreased the colony formation rate, as assessed by trypan blue exclusion and colony formation assay. Flow cytometry analysis showed that reduced RLIP76 expression resulted in cell cycle arrest at G1 phase and induced apoptosis. cell lines (U937 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 631 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 632 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Melphalan DB01042 (APRD00118) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 633 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 634 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Daunorubicin DB00694 (APRD00521) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 635 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Vincristine DB00541 (APRD00495) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 636 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Vinblastine DB00570 (APRD00708) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 637 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Vinorelbine DB00361 (APRD00101) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 638 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Mitomycin DB00305 (APRD00284) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 639 Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma J Cancer 2019 30854133 FZD1 ENSG00000157240 renal cancer Sunitinib DB01268 (DB07417) qRT-PCR We then detected FZD1_RNA_xpression in sunitinib-resistant cells and the corresponding parental cells by qRT-PCR cell lines (786-O ,OS-RC-2 , Caki-1, ACHN , HK-2) up-regulated resistant NA WNT singaling pathway validated NA mRNA and protein overexpression related 640 High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia Blood 2011 21220747 STAT5 ENSG00000126561 chronic myeloid leukemia Imatinib DB00619 (APRD01028, EXPT02967, DB03261) NA NA patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 641 Forkhead box O3 promotes colon cancer proliferation and drug resistance by activating MDR1 expression Mol Genet Genomic Med 2019 30623608 FOXO3 ENSG00000118689 colon cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR MTT and cell count assay were applied to analyze the viability of transfected CC cells. rVista, dual luciferase reporter assay, and chromatin immunoprecipitation assay were used to identify the downstream_arget_f FOXO3 in HCT116 cells. The_RNA_nd protein abundance of FOXO3 and MDR1 were determined by quantitative PCR and Western blot, respectively cell lines ( HCT116,DLD1) up-regulated resistant MDR1 NA validated NA mRNA and protein overexpression related 642 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 NRF2 ENSG00000116044 gastric cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 643 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 AKR1C1 ENSG00000187134 gastric cancer Oxaliplatin DB00526 (APRD00187) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 644 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 AKR1C2 ENSG00000151632 gastric cancer Oxaliplatin DB00526 (APRD00188) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 645 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 AKR1C3 ENSG00000196139 gastric cancer Oxaliplatin DB00526 (APRD00188) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 646 Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells Mol Med Rep 2015 26397212 HOXA5 ENSG00000106004 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR The U937 human leukemia cell line was transfected with a HOXA5_targeted short hairpin_NA(shRNA) to determine the effects of downregulation of the HOXA5 on proliferation, apoptosis, cell cycle distribution and chemoresistance in leukemia cells. Reverse transcription_quantitative polymerase chain reaction and western blot analyses demonstrated that the_RNA_nd protein expression levels of HOXA5 were markedly suppressed following transfection with an shRNA_containing vector. cell line (U937 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 647 Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma Int J Oncol 2016 26891663 B7H6 ENSG00000188211 B-cell non-Hodgkin lymphoma Vincristine DB00541 (APRD00495) RT-PCR Stable B7-H6 knockdown in CA46 cells was established with a lentiviral system. The expression of_RNA_as measured by PCR while protein expression was detected by western blotting and flow cytometry. Cell viability, apoptosis and cell cycle distribution were analyzed using CCK-8, colony formation and flow cytometry assays, respectively. Cell migration and invasion were determined using the Transwell chamber assay. cell lines (CA46 ) up-regulated resistant Bcl-2, Bcl-xL, Caspase-3, Survivin, and c-Myc apoptotic pathway validated NA mRNA and protein overexpression related 648 Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma Int J Oncol 2016 26891663 B7H6 ENSG00000188211 B-cell non-Hodgkin lymphoma Dexamethasone DB01234 (APRD00674) RT-PCR Stable B7-H6 knockdown in CA46 cells was established with a lentiviral system. The expression of_RNA_as measured by PCR while protein expression was detected by western blotting and flow cytometry. Cell viability, apoptosis and cell cycle distribution were analyzed using CCK-8, colony formation and flow cytometry assays, respectively. Cell migration and invasion were determined using the Transwell chamber assay. cell lines (CA46 ) up-regulated resistant Bcl-2, Bcl-xL, Caspase-3, Survivin, and c-Myc apoptotic pathway validated NA mRNA and protein overexpression related 649 Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer Cell Oncol (Dordr) 2016 26868260 MAGEA3 ENSG00000221867 gastric cancer Docetaxel DB01248 (APRD00932) qRT-PCR Samples from two independent gastric_ancer_ohorts (including matched non-malignant gastric samples) were included in this study. MAGE-A3 methylation and_RNA_xpression levels were determined by methylation-specific PCR (MSP) and quantitative real-time PCR (qPCR), respectively. MAGE-A3 expression was knocked down in MKN1 gastric_ancer-derived cells using miRNAs. In addition, in vitro cell proliferation, colony formation, apoptosis, cell cycle,_rug_reatment, immunohistochemistry and Western blot assays were performed. cell lines (MKN1 ) up-regulated resistant Bax, p21 and Puma apoptotic pathway validated NA promoter hypomethylation related 650 Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer Apoptosis 2018 29777330 IL6 ENSG00000136244 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,cell cycle analysis and cell apoptosis analysis by flow cytometry,wound healing assay,transwell invasion assay,colony formation assay,cell viability assay. cell lines (HT29, SW480, HCT116,LOVO) up-regulated resistant NA GP130/MAPK/STAT3 signaling pathway validated NA mRNA and protein overexpression related 651 Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer Apoptosis 2018 29777330 IL6ST ENSG00000134352 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,cell cycle analysis and cell apoptosis analysis by flow cytometry,wound healing assay,transwell invasion assay,colony formation assay,cell viability assay. cell lines (HT29, SW480, HCT116,LOVO) up-regulated resistant NA GP130/MAPK/STAT3 signaling pathway validated NA mRNA and protein overexpression related 652 LIM and SH3 protein 1 regulates cell growth and chemosensitivity of human glioblastoma via the PI3K/AKT pathway BMC Cancer 2018 29980193 LAPS1 ENSG00000002834 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR Oncomine and The_ancer_enome Atlas (TCGA) database was analyzed for the expression and clinical significance of LASP1 in GBM. LASP1_RNA_nd protein level were measured by qRT-PCR and western blotting. The effect of LASP1 on GBM proliferation was examined by MTT assay and colony formation assay, the effect of LASP1 on sensitivity of Temozolomide was measured by flow cytometry and subcutaneous tumor model. The association between LASP1 and PI3K/AKT signaling was assessed by western blotting. cell lines (LN229,U251,U87,T98G) up-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 653 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HO1 ENSG00000100292 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant HIF1A and GLUT1 NA validated NA mRNA and protein overexpression related 654 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HIF1A ENSG00000100644 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 655 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 GLUT1 ENSG00000117394 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 656 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HO1 ENSG00000100292 acute myeloid leukemia Daunorubicin DB00694 (APRD00521) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant HIF1A and GLUT1 NA validated NA mRNA and protein overexpression related 657 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HIF1A ENSG00000100644 acute myeloid leukemia Daunorubicin DB00694 (APRD00521) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 658 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 GLUT1 ENSG00000117394 acute myeloid leukemia Daunorubicin DB00694 (APRD00521) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 659 PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression Acta Biochim Biophys Sin (Shanghai) 2018 30020405 PIM1 ENSG00000137193 T-cell lymphoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR we studied the roles of mRNA in established T-lymphoma cell lines Jurkat and HUT-78. CCK-8 assay was conducted to evaluate cell survival and flow cytometry was performed to evaluate cell death of TCL cells. siRNAs were used to knockdown the expression of PIM1 and c-myc. qRT-PCR was used to evaluate the_RNA_xpression levels of c-myc and PIM1. Western blot analysis was used to evaluate the protein expression levels of PIM1, c-myc, STAT3, and phospho-STAT3. cell lines (Jurkat ,HUT-78) up-regulated resistant c-MYC JAK-STAT3 signaling pathway validated NA mRNA and protein overexpression related 660 PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression Acta Biochim Biophys Sin (Shanghai) 2018 30020405 MYC ENSG00000136997 T-cell lymphoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR we studied the roles of mRNA in established T-lymphoma cell lines Jurkat and HUT-78. CCK-8 assay was conducted to evaluate cell survival and flow cytometry was performed to evaluate cell death of TCL cells. siRNAs were used to knockdown the expression of PIM1 and c-myc. qRT-PCR was used to evaluate the_RNA_xpression levels of c-myc and PIM1. Western blot analysis was used to evaluate the protein expression levels of PIM1, c-myc, STAT3, and phospho-STAT3. cell lines (Jurkat ,HUT-78) up-regulated resistant NA JAK-STAT3 signaling pathway validated NA mRNA and protein overexpression related 661 Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2 J Mol Med (Berl) 2013 23052480 IL6 ENSG00000136244 ovarian_ancer Cisplatin DB00515 (APRD00359) NA The role of the mRNA expression was detected by the western blotting analysis,RNA interference experiment,transfection study,IL-6 ELISA assay. cell lines (SKOV3,OVCAR3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 662 Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2 J Mol Med (Berl) 2013 23052480 BIRC3 ENSG00000023445 ovarian_ancer Cisplatin DB00515 (APRD00359) NA The role of the mRNA expression was detected by the western blotting analysis,RNA interference experiment,transfection study,IL-6 ELISA assay. cell lines (SKOV3,OVCAR3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 663 HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway Ann Clin Lab Sci 2017 28667026 HTRA1 ENSG00000166033 colon cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression was detected by qRT-PCR,the western blotting analysis,RNA interference experiment,MTT. cell lines (SW480 ,SW480 /CDDP) down-regulated resistant XIAP PI3K/Akt_athway validated NA mRNA and protein low expression related 664 HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway Ann Clin Lab Sci 2017 28667026 XIAP ENSG00000101966 colon cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression was detected by qRT-PCR,the western blotting analysis,RNA interference experiment,MTT. cell lines (SW480 ,SW480 /CDDP) up-regulated resistant NA PI3K/Akt_athway validated NA mRNA and protein overexpression related 665 Rad knockdown induces mitochondrial apoptosis in bortezomib resistant leukemia and lymphoma cells Leuk Res 2012 22658652 RRAD ENSG00000166592 leukemia Bortezomib DB00188 (APRD00828, DB07475) Rnase Kit The role of the mRNA expression was detected by the western blotting analysis,cell survival analysis,caspase-3 activity assay,mitochondrial membrane potential analysis,colony formation assay,cell death assessment. cell lines (K-562, Raji, IM-9,Jurkat-R,Sup-B15, JVM-2, U266,Jurkat) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 666 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BCL2 ENSG00000171791 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) down-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein low expression related 667 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BCLXL ENSG00000171552 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) down-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein low expression related 668 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BIRC5 ENSG00000089685 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) down-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein low expression related 669 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BAX ENSG00000087088 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) up-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein overexpression related 670 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 CYC1 ENSG00000179091 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) up-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein overexpression related 671 RON and cisplatin resistance in ovarian cancer cell lines Oncol Res 2010 21141737 RON ENSG00000164078 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence,transfection experiment. cell lines (OVCAR-3,A2780) up-regulated resistant NA RON signaling pathway validated NA mRNA and protein overexpression related 672 RON and cisplatin resistance in ovarian cancer cell lines Oncol Res 2010 21141737 RON ENSG00000164078 ovarian_ancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence,transfection experiment. cell lines (OVCAR-3,A2780) up-regulated resistant NA RON signaling pathway validated NA mRNA and protein overexpression related 673 RON and cisplatin resistance in ovarian cancer cell lines Oncol Res 2010 21141737 RON ENSG00000164078 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence,transfection experiment. cell lines (OVCAR-3,A2780) up-regulated resistant NA RON signaling pathway validated NA mRNA and protein overexpression related 674 Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-kappaB signaling pathway Theranostics 2018 29930725 TRIM31 ENSG00000204616 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The protein and_RNA_xpression of TRIM31 in pancreatic_ancer_ell lines and patient tissues were determined using Real-time PCR and Western blot, respectively. 89 human pancreatic_ancer_issue samples were analyzed by IHC to investigate the association between TRIM31 expression and the clinicopathological characteristics of pancreatic_ancer_atients. Functional assays, such as MTT, FACS, and Tunel assay used to determine the oncogenic role of TRIM31 in human pancreatic_ancer_rogression. Furthermore, western blotting and luciferase assay were used to determine the mechanism of TRIM31 promotes chemoresistance in pancreatic_ancer_ells. cell lines (PANC-1, CFPAC-1, BxPC-3, AsPC-1, Capan-1, Capan-2, MIA PaCa-2, Hs 766T,MIN6) and patients tissues up-regulated resistant BCL2,_IAP, and_URVIVIN NF-¦ÊB signaling pathway validated NA mRNA and protein overexpression related 675 Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation Acta Biochim Biophys Sin (Shanghai) 2018 29961813 MACC1 ENSG00000183742 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR Cisplatin-resistant cell sublines (A549/CR and H446/CR) were induced by stepwise escalation of cisplatin exposure. MTS and flow cytometry assays were performed to measure cell proliferation and apoptosis, respectively. Western blot analysis and qRT-PCR assays were performed to determine the changes in signaling pathway-related protein and_RNA_evels, respectively. A nude mouse xenograft model was used for in vivo experiments. cell lines (A549/CR,H446/CR) up-regulated resistant NA PI3K/Akt_athway validated NA mRNA and protein overexpression related 676 Downregulation of SMC1A inhibits growth and increases apoptosis and chemosensitivity of colorectal cancer cells J Int Med Res 2016 26637483 SMC1A ENSG00000072501 colon cancer Oxaliplatin DB00526 (APRD00186) RT-PCR SMC1A gene expression was silenced by lentivirus-mediated infection with small interfering_NA(siRNA) in the human colorectal_ancer_ell line HT-29. Cell proliferation rates, SMC1A_RNA_nd protein levels, apoptosis and chemosensitivity to oxaliplatin were evaluated using routine in_itro assays, real-time polymerase chain reaction, Western blotting and flow cytometry. cell line(HT-29) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 677 Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma Int J Clin Exp Pathol 2014 24817946 NRF2 ENSG00000116044 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The human ovarian carcinoma cell line, A2780, and its cisplatin-resistant variant, A2780cp were cultivated. Cell viability was determined with WST-8 assay. Western blot was applied to detect the expression of Nrf2, Nrf2 target genes, and autophagy-related proteins. RNA interference was used to knock down target genes. Annexin V and propidium iodide (PI) staining was utilized to quantify apoptosis. The ultrastructural analysis of autophagosomes was performed by transmission electron microscopy (TEM) cell lines (A2780,A2780/cp) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 678 Overcoming Tamoxifen Resistance by Regulation of Del-1 in Breast Cancer Oncology 2019 31330520 EDIL3 ENSG00000164176 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR Del-1 expression in recurrent TAM-R breast_ancer_issue was evaluated and compared to that in the original tumor tissue from the same patients. Del-1 expression was also evaluated in TAM-R cells by quantitative real-time PCR, western blotting, and enzyme-linked immunosorbent assay. The effects of Del-1 knockdown on the proliferation, migration, and invasion of TAM-R cells was assessed with wound-healing and Matrigel transwell assays cell lines (MCF-7) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 679 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN1 ENSG00000117632 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 680 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN2 ENSG00000104435 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 681 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN3 ENSG00000197457 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 682 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN4 ENSG00000015592 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 683 Knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivo Mol Cancer Ther 2005 16373699 CLU ENSG00000120885 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR&Northern blot Clusterin immunostaining was evaluated in a tissue microarray of 379 spotted breast cancers. The effect of drugs on clusterin expression was examined in MCF-7 and MDA-MB-231 cells. Northern, quantitative real-time PCR, and Western analyses were used to measure change in clusterin mRNA and protein levels. cell lines (MCF-7, MDA-MB-231) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 684 A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells BMC Cancer 2018 30103729 GNB4 ENSG00000114450 breast cancer Fulvestrant DB00947 (APRD00654) qRT-PCR The whole-genome gene expression and DNA methylation profilings were performed using fulvestrant-resistant cell line 182R-6 and tamoxifen-resistant cell line TAMR-1 as a model system. In addition, qRT-PCR and Western blot analysis were performed to determine the levels of_RNA_nd protein molecules. MTT, apoptosis and cell cycle analyses were performed to examine the effect of either guanine nucleotide-binding protein beta-4 (GNB4) overexpression or knockdown on cell proliferation, apoptosis and cell cycle. cell lines (182R-6 and TAMR-1 ) up-regulated resistant NA ER signaling pathway validated NA mRNA and protein overexpression related 685 A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells BMC Cancer 2018 30103729 GNB4 ENSG00000114450 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The whole-genome gene expression and DNA methylation profilings were performed using fulvestrant-resistant cell line 182R-6 and tamoxifen-resistant cell line TAMR-1 as a model system. In addition, qRT-PCR and Western blot analysis were performed to determine the levels of_RNA_nd protein molecules. MTT, apoptosis and cell cycle analyses were performed to examine the effect of either guanine nucleotide-binding protein beta-4 (GNB4) overexpression or knockdown on cell proliferation, apoptosis and cell cycle. cell lines (182R-6 and TAMR-1 ) up-regulated resistant NA ER signaling pathway validated NA mRNA and protein overexpression related 686 Effect of inhibition of the adrenomedullin gene on the growth and chemosensitivity of ovarian cancer cells Oncol Rep 2012 22294191 ADM ENSG00000148926 ovarian_ancer Carboplatin DB00958 (APRD00466) RT-PCR HO8910 ovarian_ancer_ells were transfected with iRNA, and the effects of AM on proliferation and chemosensitivity of the cells were examined. RT-PCR, real-time PCR and western blot analysis were performed to detect the AM gene and protein expression. The MTT assay was used to observe the effect of AM on proliferation and chemosensitivity of the cells. cell lines (HO8910) up-regulated resistant NA ADM/ERK/BCL2 signaling pathway validated NA mRNA and protein overexpression related 687 NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells Mol Cell Biochem 2014 24782036 ABCC1 ENSG00000103222 prostate cancer Cisplatin DB00515 (APRD00359) qRT-PCR 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide was used to measure the cell viability. Quantitative real-time PCR and western blotting were utilized to evaluate the_RNA_nd protein levels. ShRNA was employed to knock down_arget_ene expression. Chromatin immunoprecipitation (ChIP) was performed to explore the detailed mechanism underlying ABCC1 expression. cell lines ( LNCaP,PC3) up-regulated resistant NA NOTCH1 signaling pathway validated NA mRNA and protein overexpression related 688 NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells Mol Cell Biochem 2014 24782036 ICN1 NA prostate cancer Cisplatin DB00515 (APRD00359) qRT-PCR 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide was used to measure the cell viability. Quantitative real-time PCR and western blotting were utilized to evaluate the_RNA_nd protein levels. ShRNA was employed to knock down_arget_ene expression. Chromatin immunoprecipitation (ChIP) was performed to explore the detailed mechanism underlying ABCC1 expression. cell lines ( LNCaP,PC3) up-regulated resistant ABCC1 NOTCH1 signaling pathway validated NA mRNA and protein overexpression related 689 Down-regulation of GADD45A enhances chemosensitivity in melanoma Sci Rep 2018 29515153 GADD45A ENSG00000116717 melanoma Cisplatin DB00515 (APRD00359) RT-PCR We investigated the role of GADD45A in chemotherapy response. Firstly, the_RNA_xpression of profiled DNA repair genes in cisplatin-treated melanoma cells was detected by RT2_rofilerTM_CR array. We found the expression of GADD45A upregulated in a dose- and time- dependent manner. In addition, suppression of GADD45A sensitized melanoma cells to cisplatin and enhanced cisplatin-induced DNA damage. Flow cytometry revealed that downregulating GADD45A released cells from cisplatin-induced G2/M arrest and increased apoptosis. By using a MEK inhibitor, GADD45A was shown to be regulated by MAPK-ERK pathway following cisplatin treatment. cell lines (A375,SK-MEL-28) up-regulated resistant NA MAPK signaling pathway validated NA mRNA and protein overexpression related 690 Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance Oncogene 2012 21996734 ERCC1 ENSG00000012061 melanoma Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis. cell lines (A375) up-regulated resistant ERCC1 and XPF MAPK signaling pathway validated NA mRNA and protein overexpression related 691 Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance Oncogene 2012 21996734 DUSP6 ENSG00000139318 melanoma Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis. cell lines (A375) down-regulated resistant NA MAPK signaling pathway validated NA mRNA and protein low expression related 692 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin J Cell Biochem 2018 28786507 SH3BP1 ENSG00000100092 cervical_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,western blotting analysis,active Rac1 pull-down assay,invasion assays,MTT assays. cell lines (HeLa,Caski) and patients tissues up-regulated resistant Rac SH3BP1/Rac1/Wave2 signaling pathway validated NA mRNA and protein overexpression related 693 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin J Cell Biochem 2018 28786507 RAC1 ENSG00000136238 cervical_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,western blotting analysis,active Rac1 pull-down assay,invasion assays,MTT assays. cell lines (HeLa,Caski) and patients tissues up-regulated resistant Wave2 SH3BP1/Rac1/Wave2 signaling pathway validated NA mRNA and protein overexpression related 694 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin J Cell Biochem 2018 28786507 WASF2 ENSG00000158195 cervical_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,western blotting analysis,active Rac1 pull-down assay,invasion assays,MTT assays. cell lines (HeLa,Caski) and patients tissues up-regulated resistant NA SH3BP1/Rac1/Wave2 signaling pathway validated NA mRNA and protein overexpression related 695 Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity Cancer Res 2009 19276367 UPAR ENSG00000011422 lung cancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,immunohistochemistry,chicken embryo metastasis assay,reverse phase protein array,nuclear extracts, electrophoretic mobility shift assay, supershift,chromatin immunoprecipitation assay,ELISA,matrigel invasion,MTT. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 696 Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity Cancer Res 2009 19276367 CDH1 ENSG00000039068 lung cancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,immunohistochemistry,chicken embryo metastasis assay,reverse phase protein array,nuclear extracts, electrophoretic mobility shift assay, supershift,chromatin immunoprecipitation assay,ELISA,matrigel invasion,MTT. cell lines down-regulated resistant NA NA validated NA mRNA and protein low expression related 697 Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance to sorafenib in hepatocellular carcinoma cells Sci Rep 2016 27476430 YAP ENSG00000137693 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The role of YAP was detected by qRT_PCR,western blotting,cell proliferation assay,immunohistochemical assay,immunofluorescence staining,flow cytometry,xenograft tumour growth analysis. cell lines ( HepG2,Bel-7402,SMMC-7721 ) up-regulated resistant NA HIF1 signaling pathway validated NA mRNA and protein overexpression related 698 Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers Breast Cancer Res 2017 28974266 SH3GL1 ENSG00000141985 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) Bioinformatics Endo II expression in human breast tumors and lymph node metastases were analyzed by immunohistochemistry. Stable silencing of Endo II was achieved in HER2+_ancer_ell lines (SK-BR-3 and HCC1954) to test Endo II effects on HER2 levels, localization and signaling, cell motility and tumor metastasis. The effects of Endo II silencing on the responses of HER2+_ancer_ells to trastuzumab or T-DM1 treatments were tested using real-time cell motility and cytotoxicity assays. cell lines (MCF-10A,BT-474, SK-BR-3, MDA-MB-231, HCC1954) up-regulated resistant HER2 Her2 signaling pathway validated NA mRNA and protein overexpression related 699 YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line Oncol Rep 2014 24842123 CHI3L1 ENSG00000133048 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR Gene expression analysis using DNA microarray and quantitative PCR (qPCR) demonstrated that mRNA expression was upregulated in the TMZ-R U87 cell line. cell lines (TMZ-R U87) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 700 YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line Oncol Rep 2014 24842123 STAT3 ENSG00000168610 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR Gene expression analysis using DNA microarray and quantitative PCR (qPCR) demonstrated that mRNA expression was upregulated in the TMZ-R U87 cell line. cell lines (TMZ-R U87) up-regulated resistant NA STAT3 signaling pathway validated NA mRNA and protein overexpression related 701 Par-4 downregulation confers cisplatin resistance in pancreatic cancer cells via PI3K/Akt pathway-dependent EMT Toxicol Lett 2014 24144893 PAWR ENSG00000177425 pancreatic cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the drug sensitivity was detected by the RT-PCR,western blotting analysis,MTT,cell invasion assay,SiRNA transfection experiment,tumor xenograft studys. cell lines (BXPC-3/CDDP,BXPC-3) down-regulated resistant NA PI3K/Akt_athway validated NA mRNA and protein low expression related 702 The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-kappaB signaling pathway J Exp Clin Cancer Res 2017 28978336 GOLPH3L ENSG00000143457 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The protein and_RNA_xpression of GOLPH3L in ovarian_ancer_ell lines and patient tissues were determined using Real-time PCR and Western blot, respectively. 177 human ovarian_ancer_issue samples were analyzed by IHC to investigate the association between GOLPH3L expression and the clinicopathological characteristics of ovarian_ancer_atients. Functional assays, such as MTT, FACS, and Tunel assay used to determine the oncogenic role of GOLPH3L in human ovarian_ancer_rogression. Furthermore, western blotting and luciferase assay were used to determine the mechanism of GOLPH3L promotes chemoresistance in ovarian_ancer_ells. cell lines (IOSE80,SKOV3, CAOV3, OV56, A2780, A2780/cis, COV362, EFO-27, TOV21G, EFO-21,OV90) and patients tissues up-regulated resistant NA NF-¦ÊB pathway validated NA mRNA and protein overexpression related 703 APRIL induces cisplatin resistance in gastric cancer cells via activation of the NF-kappaB pathway Cell Physiol Biochem 2015 25612651 TNFSF13 ENSG00000161955 gastric cancer Cisplatin DB00515 (APRD00359) qRT-PCR Expression of APRIL was assessed by immunohistochemistry and real-time PCR. Prognostic role of APRIL expression was evaluated. We also discovered the effect of APRIL on chemo-resistance in GC cells and the underlying mechanisms. cell lines and patients tissues up-regulated resistant NA NF-¦ÊB pathway validated NA mRNA and protein overexpression related 704 Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression Int J Oncol 2014 24647772 NANOG ENSG00000111704 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of the mRNA expression was detected by the RT-PCR,western blotting analysis,colony formation assay,cell migration assay,cell viability assay. cell line (HepG2 ) up-regulated resistant MDR1 NA validated NA mRNA and protein overexpression related 705 Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression Int J Oncol 2014 24647772 MDR1 ENSG00000085563 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of the mRNA expression was detected by the RT-PCR,western blotting analysis,colony formation assay,cell migration assay,cell viability assay. cell line (HepG2 ) up-regulated resistant P-glycoprotein NA validated NA mRNA and protein overexpression related 706 Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer J Cancer Res Clin Oncol 2012 22714588 NANOG ENSG00000111704 esophageal_ancer Cisplatin DB00515 (APRD00359) RT-PCR We first detected the expression of Nanog in the ESCC and cell lines by RT-PCR, immunofluorescence, and immunohistochemisty. Then, we used small interfering RNA (siRNA) to block Nanog expression while evaluating the effect of Nanog siRNA on cell apoptosis and the combined effects with Cisplatin in ESCC cell lines. cell lines (TE-1 and Eca-109) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 707 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma J Exp Clin Cancer Res 2018 30153855 HSP90AA1 ENSG00000080824 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR shRNAs were transfected into osteosarcoma cells for knockdown of HSP90AA1 gene. Stable HSP90AA1 overexpressing osteosarcoma cell lines were obtained by lentivirus infection._RNA_nd protein expressions of HSP90AA1 in osteosarcoma cells were tested by quantitative real-time PCR and western blot, respectively. Autophagy of osteosarcoma cells was detected by western blot of LC3, transmission electron microscopy and fluorescence microscope. mRFP-GFP-LC3 lentiviral transfection was also performed to detect autophagic flux. NOD/SCID mices were inoculated with MG-63 tumor cells transfected with HSP90AA1 specific shRNA. TUNEL and LC3 staining were performed to detect apoptosis and autophagy of resected tumor tissues. cell lines (MG-63, Saos-2,U-2 OS) up-regulated resistant NA PI3K/Akt/mTOR pathway and JNK/P38 pathway validated NA mRNA and protein overexpression related 708 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma J Exp Clin Cancer Res 2018 30153855 HSP90AA1 ENSG00000080824 osteosarcoma Cisplatin DB00515 (APRD00359) qRT-PCR shRNAs were transfected into osteosarcoma cells for knockdown of HSP90AA1 gene. Stable HSP90AA1 overexpressing osteosarcoma cell lines were obtained by lentivirus infection._RNA_nd protein expressions of HSP90AA1 in osteosarcoma cells were tested by quantitative real-time PCR and western blot, respectively. Autophagy of osteosarcoma cells was detected by western blot of LC3, transmission electron microscopy and fluorescence microscope. mRFP-GFP-LC3 lentiviral transfection was also performed to detect autophagic flux. NOD/SCID mices were inoculated with MG-63 tumor cells transfected with HSP90AA1 specific shRNA. TUNEL and LC3 staining were performed to detect apoptosis and autophagy of resected tumor tissues. cell lines (MG-63, Saos-2,U-2 OS) up-regulated resistant NA PI3K/Akt/mTOR pathway and JNK/P39 pathway validated NA mRNA and protein overexpression related 709 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma J Exp Clin Cancer Res 2018 30153855 HSP90AA1 ENSG00000080824 osteosarcoma Methotrexate DB00563 (APRD00353) qRT-PCR shRNAs were transfected into osteosarcoma cells for knockdown of HSP90AA1 gene. Stable HSP90AA1 overexpressing osteosarcoma cell lines were obtained by lentivirus infection._RNA_nd protein expressions of HSP90AA1 in osteosarcoma cells were tested by quantitative real-time PCR and western blot, respectively. Autophagy of osteosarcoma cells was detected by western blot of LC3, transmission electron microscopy and fluorescence microscope. mRFP-GFP-LC3 lentiviral transfection was also performed to detect autophagic flux. NOD/SCID mices were inoculated with MG-63 tumor cells transfected with HSP90AA1 specific shRNA. TUNEL and LC3 staining were performed to detect apoptosis and autophagy of resected tumor tissues. cell lines (MG-63, Saos-2,U-2 OS) up-regulated resistant NA PI3K/Akt/mTOR pathway and JNK/P40 pathway validated NA mRNA and protein overexpression related 710 Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL8 production in pancreatic cancer Oncol Rep 2019 31002348 IL8 ENSG00000169429 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR We demonstrated that expression of interleukin_8 (IL_8) mRNA was significantly upregulated in Gem_R PaCa cells by cDNA microarray and RT_qPCR analyses. Increased IL_8 secretion by Gem_R cells was confirmed by cytokine array and enzyme_linked immunosorbent assay. cell lines (AsPC_1,MIA PaCa_2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 711 PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells Mol Cancer Ther 2017 28336807 PMP22 ENSG00000109099 gastric cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,iRNA interference experiment,colony formation assays . cell lines ( MGC-803, SGC-7901,SGC-7901/DDP) and patients tissues up-regulated resistant NA Wnt/¦Â-Catenin signaling pathway validated NA mRNA and protein overexpression related 712 The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells Biochim Biophys Acta 2012 22609303 FOSL1 ENSG00000175592 glioma Nimustine DB13069 RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,transfection experiments,gel electrophoresis ,apoptosis and cell cycle distribution,EMSA. cell lines (LN229, U87,U138) up-regulated resistant NA CHK1_Cdk2 pathway validated NA mRNA and protein overexpression related 713 ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses DNA Repair (Amst) 2008 18249159 ATF3 ENSG00000162772 glioblastoma Cisplatin DB13069 Northern blot The relationship between the mRNA expression and the drug sensitivity was detected by the northern blotting analysis,western blotting analysis,cell counting and FACS analysis,lentivirus transfection experiments. cell lines (T98G) up-regulated resistant NA ERK signaling pathway validated NA mRNA and protein overexpression related 714 ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses DNA Repair (Amst) 2008 18249159 FOSL1 ENSG00000175592 glioblastoma Cisplatin DB13069 Northern blot The relationship between the mRNA expression and the drug sensitivity was detected by the northern blotting analysis,western blotting analysis,cell counting and FACS analysis,lentivirus transfection experiments. cell lines (T98G) up-regulated resistant NA ERK and JNK signaling pathway validated NA mRNA and protein overexpression related 715 Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer Oncol Rep 2008 18949417 HSP27 ENSG00000106211 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) NA The role of the HSP27 was detected by the western blotting analysis,cell proliferation assay,HSP27 siRNA transfecion experiment. cell lines (LoVo, HCT15, WiDr, HCT116, HT-29,SW480) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 716 Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1 PLoS One 2014 24846322 HIPK2 ENSG00000064393 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,cell viability assay,RNAi interference experiments. cell lines (RT4-CisR,RT4) down-regulated resistant wip1 NA validated NA mRNA and protein low expression related 717 Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1 PLoS One 2014 24846322 PPM1D ENSG00000170836 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,cell viability assay,RNAi interference experiments. cell lines (RT4-CisR,RT4) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 718 Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia J Oral Pathol Med 2013 23227892 GLUT1 ENSG00000117394 oral cancer Cisplatin DB00515 (APRD00359) RT-PCR Cell viability was measured following culture of the cells in the presence or absence of CDDP, under normoxic or hypoxic conditions, using a CCK-8 assay. Analysis of the expression of HIF target genes in hypoxia-treated cells was performed using an HIF-regulated cDNA plate array. Changes in the mRNA expression of selected HIF target genes were analyzed using RT-PCR, and changes in the protein levels of these genes were analyzed by Western blotting. Tumor cell apoptosis was assessed by flow cytometry. cell lines (HSC-2, Ca9-22,SAS ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 719 Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo Mol Cancer Ther 2004 15026542 CLU ENSG00000120885 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR&Northern blot The role of the mRNA was detected by the RT-PCR,northern blotting analysis,small Interfering RNA and antisense oligonucleotides treatment study,MTT assays,DNA fragmentation analysis,cell growth analysis. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 720 Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo Mol Cancer Ther 2004 15026542 CLU ENSG00000120885 lung cancer Gemcitabine DB00441 (APRD00201) RT-PCR&Northern blot The role of the mRNA was detected by the RT-PCR,northern blotting analysis,small Interfering RNA and antisense oligonucleotides treatment study,MTT assays,DNA fragmentation analysis,cell growth analysis. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 721 CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma IUBMB Life 2008 18379992 BSG ENSG00000172270 hepatocellular carcinoma Curcumin DB11672 RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,soft agar colony formation assay,MTT assay,iRNA interference experiments,tumor xenograft study. cell line (Hepa1-6) up-regulated resistant VEGFA NA validated NA mRNA and protein overexpression related 722 Highly Expressed Integrin-alpha8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse Mol Cells 2016 28008160 ITGA8 ENSG00000077943 melanoma Melphalan DB01042 (APRD00118) RT-PCR The expression of the target mRNA was detected by the RT-PCR,western blotting analysis,plasmid transfection,cell adhesion assay,chemotaxis assay,cell invasion assay,cell viability assay. cell lines (KMS-12-BM, KMS-12-PE, MOLP8, NCI-H929, LP-1,EJM) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 723 Highly Expressed Integrin-alpha8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse Mol Cells 2016 28008160 ITGA8 ENSG00000077943 melanoma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The expression of the target mRNA was detected by the RT-PCR,western blotting analysis,plasmid transfection,cell adhesion assay,chemotaxis assay,cell invasion assay,cell viability assay. cell lines (KMS-12-BM, KMS-12-PE, MOLP8, NCI-H929, LP-1,EJM) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 724 Androgen receptor signaling regulates cell growth and vulnerability to doxorubicin in bladder cancer J Urol 2012 22608749 AR ENSG00000169083 bladder_ancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR We evaluated AR mRNA expression in bladder cancer tissue by quantitative real-time polymerase chain reaction. The role of androgen receptor in cell growth and drug sensitivity was also evaluated in vitro and in vivo in several bladder cancer cell lines. cell lines (UMUC3, MBT-2) and patients tissues up-regulated resistant NA AR signaling pathway validated NA mRNA and protein overexpression related 725 Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib Mol Carcinog 2018 29637613 EGFR ENSG00000146648 gastric cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The expression of the mRNA was detected by the qRT-PCR,western blotting analysis,iRNA interference experiment,MTT assays. cell lines (AGS, MKN-28, MKN-45 ,NCI-N87) up-regulated resistant NA EGFR/HER2 signaling pathway validated NA mRNA and protein overexpression related 726 Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib Mol Carcinog 2018 29637613 HER2 ENSG00000141736 gastric cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The expression of the mRNA was detected by the qRT-PCR,western blotting analysis,siRNA interference transfection experiment,MTT assays. cell lines (AGS, MKN-28, MKN-45 ,NCI-N87) up-regulated resistant NA EGFR/HER2 signaling pathway validated NA mRNA and protein overexpression related 727 Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis Zhonghua Nan Ke Xue 2013 23441447 PKM2 ENSG00000067225 prostate cancer Gambogic Acid NA RT-PCR Three specific PKM2 siRNAs and one negative control siRNA (si-NC) were transfected into PC3 cells. The silencing effect of PKM2 siRNAs was determined by real-time fluorescence quantitative PCR (qRT-PCR) and Western blot, and the effects of PKM2 siRNA on the vitality and apoptosis of GA-stimulated PC3 cells detected by MTT and AO/EB double staining, respectively. The_RNA_nd protein levels of c-myc and cyclin D1 were analyzed by qRT-PCR and Western blot, respectively. cell lines (PC3) up-regulated resistant c-myc and cyclin D1 NA validated NA mRNA and protein overexpression related 728 Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel Cancer Res 2007 17332325 TWIST1 ENSG00000128791 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) Northern blot The role of the drug on the expression of the mRNA was detected by the northern blotting analysis,western blotting analysis,cell invasion assay,soft agar colony formation assay,cell survival assay,luciferase reporter assay,chromatin immunoprecipiatation assay,RNA interference experiments.cell migration and wound healing assay,immunohistochemistry. cell lines ( MCF7,MDA-MB-453,MCF7-I4,MDA-MB-453-I4) up-regulated resistant AKT2 Twist-AKT2_ignaling pathway validated NA mRNA and protein overexpression related 729 Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel Cancer Res 2007 17332325 AKT2 ENSG00000105221 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) Northern blot The role of the drug on the expression of the mRNA was detected by the northern blotting analysis,western blotting analysis,cell invasion assay,soft agar colony formation assay,cell survival assay,luciferase reporter assay,chromatin immunoprecipiatation assay,RNA interference experiments.cell migration and wound healing assay,immunohistochemistry. cell lines ( MCF7,MDA-MB-453,MCF7-I4,MDA-MB-453-I4) up-regulated resistant NA Twist-AKT3_ignaling pathway validated NA mRNA and protein overexpression related 730 Twist transcriptionally up-regulates AKT3 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel Cancer Res 2007 17332325 TWIST2 ENSG00000288335 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) Northern blot The role of the drug on the expression of the mRNA was detected by the northern blotting analysis,western blotting analysis,cell invasion assay,soft agar colony formation assay,cell survival assay,luciferase reporter assay,chromatin immunoprecipiatation assay,RNA interference experiments.cell migration and wound healing assay,immunohistochemistry. cell lines ( MCF7,MDA-MB-453,MCF7-I4,MDA-MB-453-I4) up-regulated resistant AKT2 Twist-AKT4_ignaling pathway validated NA mRNA and protein overexpression related 731 PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis EBioMedicine 2019 30655206 PTGER3 ENSG00000050628 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the role of the drug was detected by the RT-PCR,western blotting analysis,bioinformatic technology,RNA isolation experiments,immunofluorescence,cell proliferation assay,apoptosis and cell cycle analysis,wound healing assay,invasion assay,colony formation assay,tube formation assay,chromatin immunoprecipitation assay,serum stability assay,tumor xenograft study,TUNEL assay,IHC analysis. cell lines (HIO180,OC,OVCAR-3, SKOV3-ip1, HeyA8, A2780-PAR,OVCAR-5,SKOV3-TR, HeyA8-MDR,A2780-CP20) up-regulated resistant NA Ras-ETS1-ELK1 pathway validated NA mRNA and protein overexpression related 732 Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells Oncol Rep 2011 21165561 BSG ENSG00000172270 laryngeal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA was proved by the qRT-PCR,western blotting analysis,iRNA interference experiments,cell proliferation assay,gelatin zymography,cell invasion assay. cell line (Hep2 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 733 TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian cancer J Exp Clin Cancer Res 2012 22248469 TGFBI ENSG00000120708 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The methylation status of TGFBI was examined in ovarian_ancer_nd control groups by methylation-specific PCR (MSP) and bisulfite sequencing PCR (BSP). The TGFBI expression and cell viability were compared by Quantitative Real-Time PCR, Western Blotting and MTT assay before and after demethylating agent 5-aza-2'-deoxycytidine (5-aza-dc) treatment in 6 cell lines cell lines (SKOV3, SKOV3/TR, SKOV3/DDP, A2780, 2780/TR, OVCAR8) and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 734 Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis Mol Med Rep 2018 29512712 COL4A1 ENSG00000187498 gastric cancer Trastuzumab DB00072 (BTD00098, BIOD00098) Bioinformatics analysis The role of the expression of the mRNA was revealed by the bioinformatics analysis and iRNA interference experiments. NA up-regulated resistant NA NA validated NA mRNA and protein overexpression related 735 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway Cancer Res 2016 27013200 RECQL4 ENSG00000160957 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,immunohistochemistry,MTT assay,dual luciferase assay. cell lines (HEK293,AGS,NCI-N87,SNU-1,SNU-16,MKN45,HGC-27) and patients tissues up-regulated resistant YB1 AKT-YB1-MDR1 Signaling Pathway validated NA mRNA and protein overexpression related 736 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway Cancer Res 2016 27013200 YB1 ENSG00000065978 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,immunohistochemistry,MTT assay,dual luciferase assay. cell lines (HEK293,AGS,NCI-N87,SNU-1,SNU-16,MKN45,HGC-27) and patients tissues NA resistant MDR1 AKT-YB1-MDR2 Signaling Pathway validated NA gene phosphorylation related 737 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway Cancer Res 2016 27013200 MDR1 ENSG00000085563 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,immunohistochemistry,MTT assay,dual luciferase assay. cell lines (HEK293,AGS,NCI-N87,SNU-1,SNU-16,MKN45,HGC-27) and patients tissues up-regulated resistant NA AKT-YB1-MDR3 Signaling Pathway validated NA mRNA and protein overexpression related 738 Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells World J Gastroenterol 2012 22408359 IL8 ENSG00000169429 gastric cancer Oxaliplatin DB00526 (APRD00186) RT-PCR The IL-8 cDNA was stably transfected into human GC cell line MKN-45 and selected IL-8-secreting transfectants. The expression of IL-8 in human GC cell line KATO-III was inhibited by_NA_nterference. The expressions of_RNA_nd protein of IL-8 in GC cells were detected by real-time reverse transcription-polymerase chain reaction or enzyme-linked immunosorbent assay (ELISA). cell lines (MKN-45,KATO-III,HUVECs) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 739 FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy Mol Oncol 2018 29633504 FBXW7 ENSG00000109670 lung cancer Gefitinib DB00317 (APRD00997, DB07998) NA The role of the mRNA expression was detected by the western blotting analysis,iRNA interference experiments,motility and invasion assay,wound-healing assay,cell viability assay,MTT. cell lines (PC9,H1299£© down-regulated resistant NA NA validated NA mRNA and protein low expression related 740 Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin Int J Cancer 2009 19598262 ANXA4 ENSG00000196975 ovarian_ancer Carboplatin DB00958 (APRD00466) RT-PCR Enhanced expression of Annexin A4 (Anx A4) was identified in ovarian CCC cells using 2-D differential gel electrophoresis (2D-DIGE) and mass spectrometry. Anx A4 levels were elevated in CCC cells compared with non-CCC cells as determined by real-time RT-PCR and Western blot analysis. Immunohistochemical analysis of Anx A4 was performed in 126 epithelial ovarian cancer tissue samples and demonstrated significantly elevated levels of Anx A4 protein levels in ovarian CCC tumors compared with ovarian serous and endometrioid tumors . Anx A4-transfected ovarian non-CCC cells were more resistant to carboplatin compared with control cells as determined by modified MTT assay cell lines(OVISE, OVTOKO, OVMANA,RMG-1,SAC,OVSAHO,OVKATE) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 741 Establishment of an adriamycin-resistant subline of human small cell lung cancer showing multifactorial mechanisms of resistance Acta Med Okayama 1993 8104372 MDR1 ENSG00000085563 lung cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) Northern blot The expression of the mRNA was detected by the northern blotting analysis.The sensitivity of the drug was detected by the MTT. cell lines (SBC-3,SBC-3/ADM100) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 742 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827,NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 743 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827,NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 744 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Docetaxel DB01248 (APRD00932) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827,NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 745 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Pemetrexed DB00642 (APRD00573, EXPT02075) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827,NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 746 The efficacy of cisplatin on nasopharyngeal carcinoma cells may be increased via the downregulation of fibroblast growth factor receptor 2 Int J Mol Med 2019 31115494 FGFR2 ENSG00000066468 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) qRT-PCR The downregulation of FGFR2 was achieved by transfection with a small interfering RNA against FGFR2. Tissues of patients with NPC were analyzed by immunohistochemistry. Cell viability was examined using a Cell Counting Kit_8 assay. Cell cycle analysis was performed using flow cytometry. mRNA and protein levels were measured by reverse transcription quantitative polymerase chain reaction and western blot analysis, respectively cell lines ( SUNE1, C666_1, 6_10B,HNE_3 ) down-regulated sensitive NA apoptotic pathway validated NA mRNA and protein low expression related 747 FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition Hepatobiliary Pancreat Dis Int 2014 24686546 FBW7 ENSG00000109670 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The cell viability was evaluated by cell counting kit-8, and FBW7 mRNA transcription and protein expression were quantitated by real-time PCR and Western blotting. Expressions of vimentin (mesenchymal biomarker) and E-cadherin (epithelial biomarker) were evaluated by Western blotting and immunocytochemistry. Cell invasion was assayed by Transwell migration, and FBW7 plasmid or siRNA was used to evaluate the effect of FBW7 overexpression or silencing on cell chemosensitivity. cell lines (Hep3B, Huh-7, and SNU-449) up-regulated sensitive NA EMT_ransition pathway validated NA mRNA and protein overexpression related 748 Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro Acta Biochim Biophys Sin (Shanghai) 2013 23419720 MST1 ENSG00000173531 hepatocellular carcinoma Cisplatin DB00563 (APRD00353) qRT-PCR The role of MST1 expression was determined by qRT-PCR,western blot analysis,apoptosis assay,hoechst 33342 staining,cell proliferation analysis. cell lines (HepGw2) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 749 Silencing HO-1 sensitizes SKM-1 cells to apoptosis induced by low concentration 5-azacytidine through enhancing p16 demethylation Int J Oncol 2015 25585641 HO1 ENSG00000100292 myelodysplastic syndrome 5-azacytidine DB00928 (APRD00809) RT-PCR Cell growth was evaluated by MTT assay; cell cycle and apoptosis were detected by flow cytometry;_RNA_xpression was assessed by real-time PCR, protein expression was analyzed through western blotting. Methylation was assessed by MSP. The survival time, and weight of mice were recorded. cell line (SKM-1) down-regulated sensitive P16 NA validated NA mRNA and protein low expression related 750 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma J Exp Clin Cancer Res 2019 30621723 ARNTL ENSG00000133794 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) RT-PCR We employed bisulfite pyrosequencing to determine the epigenetic change of ARNTL in NPC cell lines and tissues. ARNTL_RNA_nd protein expression in cell lines and tissues were detected by real-time PCR and western blotting. Then, we constructed cell lines overexpressing ARNTL and knocked down ARNTL to explore its function and effect on chemotherapy sensitivity of NPC cell lines to cisplatin in vitro and vivo. Finally, we investigated the potential molecular mechanism of ARNTL by gene set enrichment analysis (GSEA), dual Luciferase reporter assay and chromatin immunoprecipitation assay. cell lines (CNE1, CNE2, SUNE1, HONE1, HNE1, 5-8F, 6-10B,NP69) down-regulated resistant CDK5 NA validated NA promoter hypermethylation related 751 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma J Exp Clin Cancer Res 2019 30621723 CDK5 ENSG00000164885 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) RT-PCR We employed bisulfite pyrosequencing to determine the epigenetic change of ARNTL in NPC cell lines and tissues. ARNTL_RNA_nd protein expression in cell lines and tissues were detected by real-time PCR and western blotting. Then, we constructed cell lines overexpressing ARNTL and knocked down ARNTL to explore its function and effect on chemotherapy sensitivity of NPC cell lines to cisplatin in vitro and vivo. Finally, we investigated the potential molecular mechanism of ARNTL by gene set enrichment analysis (GSEA), dual Luciferase reporter assay and chromatin immunoprecipitation assay. cell lines (CNE1, CNE2, SUNE1, HONE1, HNE1, 5-8F, 6-10B,NP69) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 752 XAF1 mRNA expression improves progression-free and overall survival for patients with advanced bladder cancer treated with neoadjuvant chemotherapy Urol Oncol 2009 18555708 XAF1 ENSG00000132530 bladder_ancer Cisplatin DB00515 (APRD00359) qRT-PCR Gene expression was analyzed by a real-time quantitative PCR method in paired samples from 14 bladder_ancer_atients treated with a combination of neoadjuvant gemcitabine and cisplatin. The prognostic significance of XAF1 and XIAP_RNA_xpression as well as the correlation with several clinical and pathological findings were evaluated. cell lines and patients tissues up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 753 XAF1 mRNA expression improves progression-free and overall survival for patients with advanced bladder cancer treated with neoadjuvant chemotherapy Urol Oncol 2009 18555708 XAF1 ENSG00000132530 bladder_ancer Gemcitabine DB00441 (APRD00201) qRT-PCR Gene expression was analyzed by a real-time quantitative PCR method in paired samples from 14 bladder_ancer_atients treated with a combination of neoadjuvant gemcitabine and cisplatin. The prognostic significance of XAF1 and XIAP_RNA_xpression as well as the correlation with several clinical and pathological findings were evaluated. cell lines and patients tissues up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 754 The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase Cancer Res 2009 19487279 HUR ENSG00000066044 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The role of the mRNA was detected by the RT-PCR,immunoblot,immunofluorescence,drug sensitivity assay,case selection and immunohistochemistry. cell lines (MiaPaca2, PL-5,Hs766t) up-regulated sensitive NA HUR signaling pathway validated NA mRNA and protein overexpression related 755 Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy Langenbecks Arch Surg 2016 26691217 CELF2 ENSG00000048740 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR Expression of CUGBP2 was evaluated using qRT-PCR and Western blot methods. Cell viability after treatment with GEM and/or curcumin and siCUGBP2 was evaluated using MTT and crystal violet tests. RNA immunoprecipitation analysis was used to confirm COX-2 and HO-1 post-transcriptional regulation by CUGBP2 protein. cell lines (MiaPaCa-2, Su.86.86, Capan-1) up-regulated sensitive NA CUGBP2 signaling pathway validated NA mRNA and protein overexpression related 756 CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells Oncol Rep 2012 22427101 BSG ENSG00000172270 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of the mRNA expression on the drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell invision assay,cell metastasis assay. cell line (Panc-1) down-regulated sensitive NA CD147 signaling pathway validated NA mRNA and protein low expression related 757 Absence of Bcl-xL down-regulation in response to cisplatin is associated with chemoresistance in ovarian carcinoma cells Gynecol Oncol 2007 17275076 BCLXL ENSG00000171552 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The expression of the mRNA was detected by the RT-PCR,nuclear staining with DAPI,flow cytometry,western blotting analysis,iRNA transfection experiments. cell lines ((IGROV1,OAW42,IGROV1-R10,SKOV3) down-regulated sensitive NA apoptotic pathway validated NA mRNA and protein low expression related 758 Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma Head Neck 2009 19107951 AURKA ENSG00000087586 head and neck_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The expression of the AURKA mRNA and protein were detected by reverse transcriptase-polymerase chain reaction and Western blot analysis. Tumor cells treated with paclitaxel were assessed for cell proliferation by MTT assay and for cell cycle distribution by flow cytometry cell lines (Tu138,UMSCC1, Tu167, OSC19, Tu177, and JMAR£© down-regulated sensitive NA NA validated NA mRNA and protein low expression related 759 Insulin receptor substrate-1 is an important mediator of ovarian cancer cell growth suppression by all-trans retinoic acid Cancer Res 2007 17909034 IRS1 ENSG00000169047 ovarian_ancer All-trans retinoic acid (ATRA) DB00755 (NUTR00051, APRD00362) RT-PCR The expression levels of IRS1 were determined by RT-PCR and Western blotting,immunoprecipitation,Protein stability assay,Immunohistochemistry of ovarian cancer tissue arrays. cell lines ( CA-OV3 and SK-OV3) up-regulated resistant NA IGF-I signaling pathway validated NA mRNA and protein overexpression related 760 Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells Biochem J 2011 21649584 TGIF1 ENSG00000177426 hepatocellular carcinoma Arsenic trioxide DB01169 (APRD00171) RT-PCR The expression levels of TGIF1 were determined by RT-PCR,Western blot analysis,DNA constructs, transient transfection and reporter gene assay,Flow cytometry analysis,In vitro RNA synthesis and biotin-labelled RNA probe pull-down assay,RNA immunoprecipitation. cell lines (HepG2 and Huh7) up-regulated resistant NA EGFR/PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 761 The human immunodeficiency virus protease inhibitor ritonavir inhibits lung_ancer_ells, in part, by inhibition of survivin J Thorac Oncol 2011 21270666 BIRC5 ENSG00000089685 lung cancer Ritonavir DB00503 (APRD00312) RT-PCR The mRNA and protein of SURVIVIN was detected by RT-PCR,western blot analysis,siRNA Transfection and Cell Survival Assay,MTT analysis,Cell Cycle Analysis,Measurement of Apoptosis. cell lines( A549,H522,H23,H838) up-regulated resistant c-Src/transcription protein 3 apoptotic pathway validated NA mRNA and protein overexpression related 762 Enhanced S100 calcium-binding protein P expression sensitizes human bladder cancer cells to cisplatin BJU Int 2011 20726978 S100P ENSG00000163993 bladder_ancer Cisplatin DB00515 (APRD00359) Northern blot S100P mRNA and protein expression levels were investigated by northern and western blot analyses, respectively. _ Intracellular S100P localization was examined by immunocytochemistry and immunohistochemistry. _ S100P over-expression, obtained by transfection with S100P expression plasmid, was used to investigate whether or not S100P affected cellular resistance to cisplatin. cell lines (T24, KK47,T24/DDP10, KK47/DDP20) down-regulated resistant NA NA validated NA mRNA and protein low expression related 763 p8 is a new target of gemcitabine in pancreatic cancer cells Clin Cancer Res 2006 16397047 P8 ENSG00000176046 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of P8 was determined by qRT-PCR analysis.The role of gemcitabine on p8 was determined by siRNA transfection experiment,Cell death analysis,DNA analysis by flow cytometry,Cell viability analysis,Caspase-3 activity analysis. cell lines (Panc-1,Mia-PaCa2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 764 The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression Oncogene 2000 11042697 VDR ENSG00000111424 breast cancer Calcitriol (1-alpha-25-Dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) Northern blot The mRNA and protein was detected and extracted by Northern blot,Western blot analysis, transfection experiment,Analysis of BRCA1 promoter activation. cell lines (LNCaP, TSU-PR-1, BR-20, BT-474 ,PC-3, DU-145, MCF-7, MDAMB-231, MDA-MB-436) down-regulated resistant BRCA1 VDR signaling pathway validated NA mRNA and protein low expression related 765 The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression Oncogene 2000 11042697 VDR ENSG00000111424 prostate cancer Calcitriol (1-alpha-25-Dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) Northern blot The mRNA and protein was detected and extracted by Northern blot,Western blot analysis, transfection experiment,Analysis of BRCA1 promoter activation. cell lines (LNCaP, TSU-PR-1, BR-20, BT-474 ,PC-3, DU-145, MCF-7, MDAMB-231, MDA-MB-436) down-regulated resistant BRCA1 VDR signaling pathway validated NA mRNA and protein low expression related 766 Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells Mol Pharmacol 2013 23229511 AHR ENSG00000106546 lung cancer Tanespimycin(17AAG) DB05134 (DB06398) RT-PCR AhR expression in lung AD cells was modulated by siRNA interference or overexpression. Tumor growth was determined with colony formation in vitro or in vivo. Anticancer activity of 17-AAG was determined by measuring cell viability, cell cycle distribution, and expression of cell cycle regulators. Proteins and mRNA levels were examined by immunoblotting and the real-time reverse transcription-polymerase chain reaction, respectively cell lines (BEAS2B,H1355,CL-5, CL1-5, H1355,BEAS-2B,CL5,CL1-5) up-regulated sensitive NA AHR signaling pathway validated NA mRNA and protein overexpression related 767 Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells Mol Pharmacol 2013 23229511 NQO1 ENSG00000181019 lung cancer Tanespimycin(17AAG) DB05134 (DB06398) RT-PCR Mrna expression in lung AD cells was modulated by siRNA interference or overexpression. Tumor growth was determined with colony formation in vitro or in vivo. Anticancer activity of 17-AAG was determined by measuring cell viability, cell cycle distribution, and expression of cell cycle regulators. Proteins and mRNA levels were examined by immunoblotting and the real-time reverse transcription-polymerase chain reaction, respectively cell lines (BEAS2B,H1355,CL-5, CL1-5, H1355,BEAS-2B,CL5,CL1-5) up-regulated sensitive NA AHR signaling pathway validated NA mRNA and protein overexpression related 768 XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma cells Asian Pac J Cancer Prev 2015 25824780 XAF1 ENSG00000132530 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The expression of XAF1 at both mRNA and protein levels was analyzed by reverse transcription-PCR and western blotting.Transwell invasion assays demonstrated that XAF1 exerted a strong anti-invasive effect in XAF1-overexpressing cells. Moreover, flow cytometry analysis revealed that XAF1 overexpression arrested the cell cycle at G0/G1 phase, and cell apoptosis analysis showed that overexpression of XAF1 enhanced apoptosis of SKOV-3 and SKOV-3/DDP cells .MTT assay confirmed a dose-dependent inhibitory effect of cisplatin in the tested tumor cells, and overexpression of XAF1 increased the sensitivity of SKOV-3 and SKOV-3/DDP cells to cisplatin-mediated anti- proliferative effects. cell lines (SKOV-3,SKOV-3/DDP ) down-regulated resistant XIAP NA validated NA mRNA and protein low expression related 769 XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma cells Asian Pac J Cancer Prev 2015 25824780 XIAP ENSG00000101966 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The expression of XIAP at both mRNA and protein levels was analyzed by reverse transcription-PCR and western blotting.Transwell invasion assays demonstrated that XAF1 exerted a strong anti-invasive effect in XAF1-overexpressing cells. Moreover, flow cytometry analysis revealed that XAF1 overexpression arrested the cell cycle at G0/G1 phase, and cell apoptosis analysis showed that overexpression of XAF1 enhanced apoptosis of SKOV-3 and SKOV-3/DDP cells .MTT assay confirmed a dose-dependent inhibitory effect of cisplatin in the tested tumor cells, and overexpression of XAF1 increased the sensitivity of SKOV-3 and SKOV-3/DDP cells to cisplatin-mediated anti- proliferative effects. cell lines (SKOV-3,SKOV-3/DDP ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 770 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma J Exp Clin Cancer Res 2019 30621723 ARNTL ENSG00000133794 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) RT-PCR ARNTL mRNA and protein expression in cell lines and tissues were detected by real-time PCR and western blotting. Then, we constructed cell lines overexpressing ARNTL and knocked down ARNTL to explore its function and effect on chemotherapy sensitivity of NPC cell lines to cisplatin in vitro and vivo. Finally, we investigated the potential molecular mechanism of ARNTL by gene set enrichment analysis (GSEA), dual Luciferase reporter assay and chromatin immunoprecipitation assay. cell lines (CNE1, CNE2, SUNE1, HONE1, HNE1, 5-8F, 6-10B) and patients tissues down-regulated resistant CDK5 NA validated NA promoter hypermethylation related 771 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 C6orf106 ENSG00000196821 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 772 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CDC7 ENSG00000097046 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 773 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CUL9 ENSG00000112659 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 774 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 FN1 ENSG00000115414 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 775 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 LARP4 ENSG00000161813 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 776 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ANAPC5 ENSG00000089053 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 777 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BAG6 ENSG00000204463 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 778 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BBC3 ENSG00000105327 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 779 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ABCB1 ENSG00000085563 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 780 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 COMMD1 ENSG00000173163 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 781 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 AKR1C2 ENSG00000151632 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 782 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 IFI27 ENSG00000165949 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 783 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TRAF3IP2 ENSG00000056972 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 784 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ALK ENSG00000171094 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 785 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SELENBP1 ENSG00000143416 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 786 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TMEM119 ENSG00000183160 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 787 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 NKD2 ENSG00000145506 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 788 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SUPT20H ENSG00000102710 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 789 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 C6orf106 ENSG00000196821 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 790 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CDC7 ENSG00000097046 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 791 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CUL9 ENSG00000112659 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 792 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 FN1 ENSG00000115414 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 793 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 LARP4 ENSG00000161813 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 794 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ANAPC5 ENSG00000089053 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 795 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BAG6 ENSG00000204463 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 796 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BBC3 ENSG00000105327 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 797 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ABCB1 ENSG00000085563 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 798 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 COMMD1 ENSG00000173163 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 799 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 AKR1C2 ENSG00000151632 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 800 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 IFI27 ENSG00000165949 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 801 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TRAF3IP2 ENSG00000056972 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 802 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ALK ENSG00000171094 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 803 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SELENBP1 ENSG00000143416 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 804 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TMEM119 ENSG00000183160 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 805 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 NKD2 ENSG00000145506 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 806 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SUPT20H ENSG00000102710 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 807 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 C6orf106 ENSG00000196821 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 808 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CDC7 ENSG00000097046 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 809 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CUL9 ENSG00000112659 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 810 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 FN1 ENSG00000115414 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 811 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 LARP4 ENSG00000161813 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 812 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ANAPC5 ENSG00000089053 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 813 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BAG6 ENSG00000204463 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 814 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BBC3 ENSG00000105327 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 815 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ABCB1 ENSG00000085563 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 816 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 COMMD1 ENSG00000173163 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 817 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 AKR1C2 ENSG00000151632 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 818 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 IFI27 ENSG00000165949 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 819 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TRAF3IP2 ENSG00000056972 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 820 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ALK ENSG00000171094 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 821 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SELENBP1 ENSG00000143416 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 822 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TMEM119 ENSG00000183160 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 823 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 NKD2 ENSG00000145506 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 824 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SUPT20H ENSG00000102710 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 825 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 SYT1 ENSG00000067715 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 826 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 FAM171B ENSG00000144369 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 827 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 ZNF331 ENSG00000130844 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 828 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 FAM187B ENSG00000177558 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 829 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 CYP1A1 ENSG00000140465 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 830 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 OAS2 ENSG00000111335 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 831 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 PRR15L ENSG00000167183 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 832 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 C10orf105 ENSG00000214688 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 833 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 IFI6 ENSG00000126709 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 834 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 HIST1H4E ENSG00000276966 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 835 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 NOL4 ENSG00000101746 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 836 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 C3AR1 ENSG00000171860 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 837 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 C9orf150 ENSG00000153714 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 838 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 CXCR2 ENSG00000180871 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 839 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 RAB2B ENSG00000129472 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 840 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 SRXN1 ENSG00000271303 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 841 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 HIST1H2BL ENSG00000185130 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 842 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 TOMM40L ENSG00000158882 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 843 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 SPP1 ENSG00000118785 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 844 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 KRT6B ENSG00000185479 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 845 Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma Oxid Med Cell Longev 2020 32215178 GPX2 ENSG00000176153 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,qRT-PCR,western blotting analysis,lentivirus Infection experiments,cell viability and proliferation analysis,bioinformatics technology,immunohistochemistry. cell lines (A549) up-regulated resistant ABCB6 NA validated NA mRNA and protein overexpression related 846 Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma Oxid Med Cell Longev 2020 32215178 ABCB6 ENSG00000115657 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,qRT-PCR,western blotting analysis,lentivirus Infection experiments,cell viability and proliferation analysis,bioinformatics technology,immunohistochemistry. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 847 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HIST1H4H ENSG00000158406 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 848 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RELN ENSG00000189056 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 849 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARHGAP9 ENSG00000123329 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 850 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RGS6 ENSG00000182732 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 851 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CNTN2 ENSG00000184144 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 852 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DLEU7 ENSG00000186047 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 853 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MAP2 ENSG00000078018 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 854 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MYOG ENSG00000122180 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 855 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CA7 ENSG00000168748 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 856 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PKIA ENSG00000171033 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 857 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 LOX ENSG00000113083 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 858 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE40 ENSG00000134107 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 859 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAB17 ENSG00000124839 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 860 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CDC42EP1 ENSG00000128283 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 861 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 TMEM45A ENSG00000181458 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 862 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE41 ENSG00000123095 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 863 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAMP1 ENSG00000132329 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 864 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HSPA6 ENSG00000173110 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 865 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PLOD2 ENSG00000152952 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 866 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DUOX2 ENSG00000140279 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 867 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARFGEF3 ENSG00000112379 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 868 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 NRN1 ENSG00000124785 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 869 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HIST1H4H ENSG00000158406 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 870 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RELN ENSG00000189056 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 871 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARHGAP9 ENSG00000123329 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 872 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RGS6 ENSG00000182732 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 873 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CNTN2 ENSG00000184144 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 874 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DLEU7 ENSG00000186047 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 875 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MAP2 ENSG00000078018 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 876 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MYOG ENSG00000122180 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 877 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CA7 ENSG00000168748 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 878 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PKIA ENSG00000171033 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 879 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 LOX ENSG00000113083 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 880 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE40 ENSG00000134107 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 881 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAB17 ENSG00000124839 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 882 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CDC42EP1 ENSG00000128283 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 883 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 TMEM45A ENSG00000181458 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 884 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE41 ENSG00000123095 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 885 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAMP1 ENSG00000132329 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 886 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HSPA6 ENSG00000173110 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 887 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PLOD2 ENSG00000152952 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 888 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DUOX2 ENSG00000140279 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 889 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARFGEF3 ENSG00000112379 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 890 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 NRN1 ENSG00000124785 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 891 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HIST1H4H ENSG00000158406 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 892 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RELN ENSG00000189056 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 893 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARHGAP9 ENSG00000123329 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 894 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RGS6 ENSG00000182732 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 895 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CNTN2 ENSG00000184144 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 896 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DLEU7 ENSG00000186047 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 897 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MAP2 ENSG00000078018 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 898 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MYOG ENSG00000122180 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 899 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CA7 ENSG00000168748 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 900 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PKIA ENSG00000171033 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 901 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 LOX ENSG00000113083 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 902 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE40 ENSG00000134107 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 903 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAB17 ENSG00000124839 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 904 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CDC42EP1 ENSG00000128283 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 905 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 TMEM45A ENSG00000181458 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 906 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE41 ENSG00000123095 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 907 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAMP1 ENSG00000132329 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 908 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HSPA6 ENSG00000173110 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 909 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PLOD2 ENSG00000152952 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 910 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DUOX2 ENSG00000140279 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 911 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARFGEF3 ENSG00000112379 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 912 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 NRN1 ENSG00000124785 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 913 Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer Oncogene 2020 32015486 ALDH1A3 ENSG00000184254 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA and drug sensitivity was detected by the cell viability assays,immublotting,siRNA and shRNA experiments analysis,bioinformatic technology. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 914 Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer Oncogene 2020 32015486 ALDH3A1 ENSG00000108602 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA and drug sensitivity was detected by the cell viability assays,immublotting,siRNA and shRNA experiments analysis,bioinformatic technology. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 915 Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer Oncogene 2020 32015486 ALDH1A1 ENSG00000165092 lung cancer Cisplatin DB00515 (APRD00360) RNA sequencing The relationship between the mRNA and drug sensitivity was detected by the cell viability assays,immublotting,siRNA and shRNA experiments analysis,bioinformatic technology. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 916 Aberrant HER3 ligand heregulin-expressing head and neck squamous cell carcinoma is resistant to anti-EGFR antibody cetuximab, but not second-generation EGFR-TKI Oncogenesis 2019 31570699 NRG1 ENSG00000157168 head and neck_ancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The relationship between the mRNA and drug sensitivity was detected by the RT-PCR,ISH,western blotting analysis,growth inhibition assay,comprehensive transcriptome analysis,siRNA transfection experiments. cell lines (FaDuCR ,FaDu) up-regulated resistant HER3/Akt Akt signaling pathway validated NA mRNA and protein overexpression related 917 Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelialmesenchymal transition Mol Med Rep 2019 31485652 SMAD4 ENSG00000141646 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) qRT-PCR A total of 629 colorectal adenocarcinoma cases were downloaded from The Cancer_enome_tlas (TCGA) database, and a Smad4 mutation rate of_21% was demonstrated among the cases. Low expression of Smad4 was present in CRC tissues analyzed by TCGA and in four CRC cell lines, as determined by reverse transcription_quantitative PCR (RT_qPCR) and western blot_nalysis. Cell Counting kit_8(CCK_8) was used to measure the effects of different concentrations of cetuximab on SW480 cell viability at 24 and 48_. cell lines (SW480 ) down-regulated resistant NA NA validated mutation NA related 918 MiR-181a Promotes Apoptosis and Reduces Cisplatin Resistance by Inhibiting Osteopontin in Cervical Cancer Cells Cancer Biother Radiopharm 2019 31436472 SPP1 ENSG00000118785 cervical_ancer Cisplatin DB00515 (APRD00360) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by qRT-PCR,western blotting analysis,cell proliferation detection,cell apoptosis analysis,cell transfection experiments,dual luciferase reporter gene assay. cell lines (CaSki) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 919 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 IGFL1 ENSG00000188293 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 920 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FOXL1 ENSG00000176678 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 921 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 LMO7 ENSG00000136153 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 922 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 HAS2 ENSG00000170961 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 923 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 PCP4 ENSG00000183036 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 924 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 MX1 ENSG00000157601 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 925 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ZBED2 ENSG00000177494 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 926 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FYN ENSG00000010810 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 927 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 HUNK ENSG00000142149 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 928 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 MX2 ENSG00000183486 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 929 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 APOH ENSG00000091583 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 930 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ALB ENSG00000163631 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 931 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 APOB ENSG00000084674 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 932 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 PLG ENSG00000122194 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 933 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FREM1 ENSG00000164946 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 934 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ALDOB ENSG00000136872 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 935 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FGB ENSG00000171564 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 936 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ITIH2 ENSG00000151655 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 937 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 SERPINC1 ENSG00000117601 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 938 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 TF ENSG00000091513 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 939 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 APOBEC3G ENSG00000239713 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 940 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 6-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 ANKRD1 ENSG00000148677 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 941 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 7-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 LCN2 ENSG00000148346 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 942 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 8-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PTHLH ENSG00000087494 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 943 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 9-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 IGFBP3 ENSG00000146674 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 944 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 10-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 ZMAT1 ENSG00000166432 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 945 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 11-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 SAA1 ENSG00000173432 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 946 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 12-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 FOXQ1 ENSG00000164379 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 947 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 13-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PLEKHS1 ENSG00000148735 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 948 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 14-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PMEPA1 ENSG00000124225 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 949 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 15-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 NUP98 ENSG00000110713 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 950 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 16-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 RPS4Y1 ENSG00000129824 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 951 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 17-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 DERL3 ENSG00000099958 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 952 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 18-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 TNK1 ENSG00000174292 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 953 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 19-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 TEC ENSG00000135605 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 954 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 20-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PET100 ENSG00000229833 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 955 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 21-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 MED22 ENSG00000148297 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 956 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 22-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PCDH7 ENSG00000169851 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 957 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 23-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 C2orf56 ENSG00000253499 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 958 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 24-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 C7orf65 ENSG00000221845 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 959 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 25-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 HOXB5 ENSG00000120075 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 960 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 26-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 HOXB6 ENSG00000108511 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 961 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 27-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 KLK1 ENSG00000167748 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 962 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 28-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 KLK5 ENSG00000167754 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 963 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 29-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 KLK6 ENSG00000167755 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 964 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 IL18 ENSG00000150782 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 965 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF93 ENSG00000184635 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 966 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 MTAP ENSG00000099810 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 967 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF254 ENSG00000213096 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 968 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 SOX2 ENSG00000181449 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 969 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF765 ENSG00000196417 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 970 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF845 ENSG00000213799 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 971 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF611 ENSG00000213020 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 972 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 GPR160 ENSG00000173890 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 973 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF675 ENSG00000197372 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 974 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 TFPI2 ENSG00000105825 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 975 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 BAALC ENSG00000164929 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 976 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 DPP4 ENSG00000197635 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 977 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 AHR ENSG00000106546 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 978 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 KYNU ENSG00000115919 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 979 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 BDKRB1 ENSG00000100739 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 980 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 FOXD1 ENSG00000251493 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 981 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 EREG ENSG00000124882 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 982 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 DCN ENSG00000011465 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87 ,U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 983 The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 BMP4 ENSG00000125378 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 984 The noncoding RNA expression profile and the effect of lncRNA AK126699 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 CTSB ENSG00000164733 lung cancer Cisplatin DB00515 (APRD00360) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 985 The noncoding RNA expression profile and the effect of lncRNA AK126700 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 NKD2 ENSG00000145506 lung cancer Cisplatin DB00515 (APRD00361) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 986 The noncoding RNA expression profile and the effect of lncRNA AK126701 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 BAG1 ENSG00000107262 lung cancer Cisplatin DB00515 (APRD00362) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 987 The noncoding RNA expression profile and the effect of lncRNA AK126702 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 TGFB1 ENSG00000105329 lung cancer Cisplatin DB00515 (APRD00363) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 988 The noncoding RNA expression profile and the effect of lncRNA AK126703 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 EGFR ENSG00000146648 lung cancer Cisplatin DB00515 (APRD00364) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 989 The noncoding RNA expression profile and the effect of lncRNA AK126704 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 JUN ENSG00000177606 lung cancer Cisplatin DB00515 (APRD00365) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 990 The noncoding RNA expression profile and the effect of lncRNA AK126705 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 CUL2 ENSG00000108094 lung cancer Cisplatin DB00515 (APRD00366) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 991 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB1 ENSG00000085563 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK8 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 992 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB4 ENSG00000005471 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK9 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 993 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCC3 ENSG00000108846 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK10 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 994 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCG2 ENSG00000118777 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK11 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 995 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB1 ENSG00000085563 ovarian_ancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK12 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 996 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB4 ENSG00000005471 ovarian_ancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK13 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 997 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCC3 ENSG00000108846 ovarian_ancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK14 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 998 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCG2 ENSG00000118777 ovarian_ancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK15 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 999 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB1 ENSG00000085563 ovarian_ancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK16 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1000 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB4 ENSG00000005471 ovarian_ancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK17 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1001 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCC3 ENSG00000108846 ovarian_ancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK18 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1002 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCG2 ENSG00000118777 ovarian_ancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK19 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1003 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 USF2 ENSG00000105698 lung cancer Cisplatin DB00515 (APRD00366) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1004 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 EFTUD2 ENSG00000108883 lung cancer Cisplatin DB00515 (APRD00367) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1005 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 TTC39C ENSG00000168234 lung cancer Cisplatin DB00515 (APRD00368) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1006 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 ZNF836 ENSG00000196267 lung cancer Cisplatin DB00515 (APRD00369) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1007 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 CPA4 ENSG00000128510 lung cancer Cisplatin DB00515 (APRD00370) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1008 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 SNX24 ENSG00000064652 lung cancer Cisplatin DB00515 (APRD00371) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1009 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 TUBD1 ENSG00000108423 lung cancer Cisplatin DB00515 (APRD00372) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1010 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 PAFAH1B3 ENSG00000079462 lung cancer Cisplatin DB00515 (APRD00373) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1011 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 TACC3 ENSG00000013810 lung cancer Cisplatin DB00515 (APRD00374) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1012 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 QKI ENSG00000112531 lung cancer Cisplatin DB00515 (APRD00375) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1013 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 SHISAL2A ENSG00000182183 lung cancer Cisplatin DB00515 (APRD00376) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1014 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 DIAPH2 ENSG00000147202 lung cancer Cisplatin DB00515 (APRD00376) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1015 Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis Sci Rep 2014 24919120 PHF6 ENSG00000156531 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell viability assay,mirConnX bioinformatic technology. cell lines (Hs683, U87, and LNZ308 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1016 The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells Neuro Oncol 2013 23258843 ALKBH2 ENSG00000189046 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR ALKBH2 expression in GBM cell lines and in human GBM was determined by quantitative real-time PCR (qRT-PCR) and gene expression analysis, respectively. Drug sensitivity was assessed in GBM cells overexpressing ALKBH2 and in cells in which ALKBH2 expression was silenced by small-interfering (si)RNA. ALKBH2 expression following activation of the p53 pathway was examined by western blotting and qRT-PCR. cell lines (A172 ,CCF-STTG1,D37 ,GaMg ,HF66 ,LN18, LN229,T98 ,U87, U118, and U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1017 Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level Oncotarget 2015 25595896 PTCH1 ENSG00000185920 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the computational studies, real-time PCR, reporter gene studies, western blots, target protector oligos and ectopic expression. cell lines down-regulated resistant MiR-9 SHH signaling pathway validated NA mRNA and protein low expression related 1018 Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance J Neurooncol 2010 20443131 CD74 ENSG00000019582 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,qRT-PCR,western blotting analysis,shRNA transfection experiments,immunohistochemistry. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1019 FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51 Clin Cancer Res 2012 22977194 FOXM1 ENSG00000111206 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,western blotting analysis,immunofluorescence staining,immunohistochemical analysis,ChIP assay,promoter reporters and dual-luciferase assay,colony formation assays,flow cytometry analysis. cell lines (U87 ) and patients tissues up-regulated resistant RAD51 NA validated NA mRNA and protein overexpression related 1020 FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51 Clin Cancer Res 2012 22977194 RAD51 ENSG00000051180 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,western blotting analysis,immunofluorescence staining,immunohistochemical analysis,ChIP assay,promoter reporters and dual-luciferase assay,colony formation assays,flow cytometry analysis. cell lines (U87 ) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1021 Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma Biochem Biophys Res Commun 2018 29366782 MSH6 ENSG00000116062 glioblastoma Temozolomide DB00853 (APRD00557) Bioinformatics analysis The relationship between the drug sensitivity and the mRNA expression was detected by the western blotting analysis,TCGA data analysis,cell viability assays. cell lines (LN18) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1022 Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing DNA Cell Biol 2018 30113217 RAB3D ENSG00000105514 pancreatic cancer Gemcitabine DB00441 (APRD00201) RNA sequencing & qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,qRT-PCR,GO&KEGG database analysis. cell lines (SW1990) up-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 1023 Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing DNA Cell Biol 2018 30113217 DDX17 ENSG00000100201 pancreatic cancer Gemcitabine DB00441 (APRD00201) RNA sequencing & qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,qRT-PCR,GO&KEGG database analysis. cell lines (SW1990) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1024 Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing DNA Cell Biol 2018 30113217 SPNS2 ENSG00000183018 pancreatic cancer Gemcitabine DB00441 (APRD00201) RNA sequencing & qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,qRT-PCR,GO&KEGG database analysis. cell lines (SW1990) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1025 Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway Mol Carcinog 2017 28767179 ST6GALNAC2 ENSG00000070731 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,western blotting analysis,shRNA interference experiments,cell viability assay,colony formation assays,apoptosis analysis,immunohistochemistry staining,immunofluorescence staining. cell lines (HCT-8) and patients tissues down-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein low expression related 1026 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ABCC3 ENSG00000108846 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1027 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 AKAP12 ENSG00000131016 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1028 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANPEP ENSG00000166825 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1029 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANTXR1 ENSG00000169604 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1030 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 BTG2 ENSG00000159388 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1031 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAPN2 ENSG00000162909 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1032 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAV2 ENSG00000105971 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1033 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CLIP4 ENSG00000115295 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1034 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CRLF1 ENSG00000006016 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1035 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CYBRD1 ENSG00000071967 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1036 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 DKK3 ENSG00000050165 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1037 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 MELTF ENSG00000163975 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1038 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PHF10 ENSG00000130024 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1039 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PSAT1 ENSG00000135069 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1040 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PVR ENSG00000073008 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1041 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TRHDE ENSG00000072657 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1042 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TUSC3 ENSG00000104723 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1043 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ABCC3 ENSG00000108846 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1044 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 AKAP12 ENSG00000131016 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1045 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANPEP ENSG00000166825 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1046 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANTXR1 ENSG00000169604 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1047 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 BTG2 ENSG00000159388 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1048 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAPN2 ENSG00000162909 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1049 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAV2 ENSG00000105971 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1050 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CLIP4 ENSG00000115295 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1051 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CRLF1 ENSG00000006016 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1052 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CYBRD1 ENSG00000071967 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1053 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 DKK3 ENSG00000050165 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1054 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 MELTF ENSG00000163975 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1055 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PHF10 ENSG00000130024 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1056 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PSAT1 ENSG00000135069 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1057 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PVR ENSG00000073008 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1058 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TRHDE ENSG00000072657 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1059 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TUSC3 ENSG00000104723 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7,TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1060 Functional role of BTB and CNC Homology 1 gene in pancreatic cancer and its association with survival in patients treated with gemcitabine Theranostics 2018 29930735 BACH1 ENSG00000156273 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR BACH1_xpression was measured by quantitative real-time PCR, Western blot and immunohistochemistry. The effects of_ACH1_n cell proliferation and sensitivity to gemcitabine were examined by alteration of_ACH1_xpression in PDAC cells. Angiogenesis was determined in vitro using a human umbilical vein endothelial cell model. Reporter gene assays were conducted to compare the effects of microRNA-1257 on rs372883 variation. The associations between rs372883 variants and survival time in patients treated with gemcitabine were estimated by logistic regression. cell lines (CFPAC-1, BXPC-3,Capan-2, ,HUVEC,293T ) down-regulated resistant NA AKT and ERK signaling pathway validated mutation (rs372883T) NA related 1061 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 KEAP1 ENSG00000079999 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1062 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 CAAP1 ENSG00000120159 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1063 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCB1 ENSG00000099956 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1064 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCE1 ENSG00000073584 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1065 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 KEAP1 ENSG00000079999 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1066 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 CAAP1 ENSG00000120159 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1067 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCB1 ENSG00000099956 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1068 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCE1 ENSG00000073584 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1 ,MelJuSo ,SKBR7 ,HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1069 Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity Cancer Res 2014 24240700 CDK12 ENSG00000167258 ovarian_ancer Olaparib DB09074 (DB05940) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,immunohistochemistry,survival analysis,HR assay,shRNA screen. cell lines (PEO1, PEO14, OV56, COV318, COV504, SKOV3) Down-regulated sensitive NA NA validated NA mRNA and protein low expression related 1070 GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer Nature 2009 19553991 GOLPH3 ENSG00000113384 cancer Sirolimus DB00877 (APRD00178, DB02439) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,FISH analyses,RNAi experiments,western blotting analysis,biotinformatics technology. cell lines up-regulated sensitive NA MTOR signaling pathway validated amplification (5p13 ) NA related 1071 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 PSAP ENSG00000197746 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1072 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 MCM2 ENSG00000073111 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1073 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BSG ENSG00000172270 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1074 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TM4SF1 ENSG00000169908 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1075 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TOP1 ENSG00000198900 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1076 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 HMGB1 ENSG00000189403 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1077 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RPS27L ENSG00000185088 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1078 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RSU1 ENSG00000148484 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1079 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 SP3 ENSG00000172845 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1080 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TMF1 ENSG00000144747 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1081 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TIAL1 ENSG00000151923 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1082 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 PLSCR3 ENSG00000187838 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1083 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 CDKN1A ENSG00000124762 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1084 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BAX ENSG00000087088 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1085 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TIMP2 ENSG00000035862 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1086 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RAD1 ENSG00000113456 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1087 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TPD52L1 ENSG00000111907 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1088 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TBX3 ENSG00000135111 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1089 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BTG2 ENSG00000159388 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1090 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 FUT8 ENSG00000033170 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1091 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 VSNL1 ENSG00000163032 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1092 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BATF ENSG00000156127 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1093 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 WWOX ENSG00000186153 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1094 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 CDC14B ENSG00000081377 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1095 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TP53INP1 ENSG00000164938 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1096 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 FILIP1L ENSG00000168386 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1097 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 ESRP1 ENSG00000104413 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1098 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RAB25 ENSG00000132698 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1099 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 SPINT2 ENSG00000167642 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1100 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 ABCG2 ENSG00000118777 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1101 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 HSPA2 ENSG00000126803 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1102 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 PDZK1IP1 ENSG00000162366 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1103 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 ENC1 ENSG00000171617 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1104 MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway Eur Rev Med Pharmacol Sci 2018 30536307 MALAT1 ENSG00000251562 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effects of different doses of cisplatin on the proliferation and apoptosis of cervical cancer cells were detected by cell counting kit-8 (CCK-8) assay and apoptosis assay, respectively. We used bioinformatics methods to predict the downstream genes of MALAT1 and examined the expression relationship between the target gene BRWD1 and MALAT1 by quantitative Real-time polymerase chain reaction (qRT-PCR). Western blot was performed to detect the expression levels of apoptosis-related proteins and key genes in PI3K/AKT signaling pathway. cell lines (HeLa,C-33A) up-regulated resistant BRWD1 PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 1105 MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway Eur Rev Med Pharmacol Sci 2018 30536307 BRWD1 ENSG00000185658 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The effects of different doses of cisplatin on the proliferation and apoptosis of cervical cancer cells were detected by cell counting kit-8 (CCK-8) assay and apoptosis assay, respectively. We used bioinformatics methods to predict the downstream genes of MALAT1 and examined the expression relationship between the target gene BRWD1 and MALAT1 by quantitative Real-time polymerase chain reaction (qRT-PCR). Western blot was performed to detect the expression levels of apoptosis-related proteins and key genes in PI3K/AKT signaling pathway. cell lines (HeLa,C-33A) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1106 BIRC6 mediates imatinib resistance independently of Mcl-1 PLoS One 2017 28520795 BIRC6 ENSG00000115760 chronic myelogenous leukemia Imatinib DB00619 (APRD01028, EXPT02967, DB03261) qRT-PCR The role of the mRNA was detected by the qRT-PCR,immunoblot analysis,shRNA interference study,flow cytometry analysis. cell lines (MYL-R,MYL-S,MYL) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1107 Effects of apoptosis protein XIAP inhibitor on the apoptosis and sensitivity of chemotherapy in A549 cell Zhongguo Fei Ai Za Zhi 2008 20731936 XIAP ENSG00000101966 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR The_RNA_evels of XIAP gene in A549 cells were assessed using a semi-quantitative reverse transcriptase-PCR (RT-PCR). The expression vector of XIAP small interfering_NA(XIAP siRNAwas constructed and transfected into A549 cells. The transfection was proved effective by the fluorescence microscope. Cell proliferation and cell killing rate after chemotherapeutics treatment were investigated by MTT assay. The rate of apoptosis was detected by flow cytometry assay. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1108 CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression Apoptosis 2019 31177396 CNOT3 ENSG00000088038 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the qRT-PCR,western blotting analysis,RNA interference assay,flow cytometry analysis,cell survival, cytotoxicity and cell proliferation assay. cell lines (A549) up-regulated resistant RIPK3 CNOT3/RIPK3 signaling pathway validated NA mRNA and protein overexpression related 1109 CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression Apoptosis 2019 31177396 RIPK3 ENSG00000129465 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The assosiciation between the mRNA and the mechanism of the drug was detected by the qRT-PCR,western blotting analysis,RNA interference assay,flow cytometry analysis,cell survival, cytotoxicity and cell proliferation assay. cell lines (A549) down-regulated resistant NA CNOT3/RIPK3 signaling pathway validated NA mRNA and protein low expression related 1110 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 hENT NA colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630,H630-cTFT,H630-4TFT) down-regulated resistant NA NA validated deletion NA related 1111 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 sPLA2 ENSG00000117215 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630,H630-cTFT,H630-4TFT) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1112 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 hCNT NA colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630,H630-cTFT,H630-4TFT) down-regulated resistant NA NA validated deletion NA related 1113 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 TYMP ENSG00000025708 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630,H630-cTFT,H630-4TFT) down-regulated resistant NA NA validated deletion NA related 1114 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 TYMS ENSG00000176890 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630,H630-cTFT,H630-4TFT) down-regulated resistant NA NA validated deletion NA related 1115 Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2 Mol Cancer Ther 2010 20371715 DUT ENSG00000128951 colon cancer Trifluridine DB00432 (APRD01275) RT-PCR The role of the mRNA was detected by the RT-PCR,western blot analysis,microarray-mRNA analysis,flow cytometry analysis,enzyme assays. cell lines (H630,H630-cTFT,H630-4TFT) down-regulated resistant NA NA validated deletion NA related 1116 Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance Oncotarget 2018 29423065 PRL3 ENSG00000184489 acute lymphoblastic leukemia Cytarabine DB00987 (APRD00499) qRT-PCR PRL-3 expression at_RNA_nd protein level was higher in B-ALL cells than in normal cells, as measured by qRT-PCR or flow cytometry. Further, we demonstrate that inhibition of PRL-3 using shRNA or a small molecular inhibitor reduced cell migration cell lines (Reh, MHH-CALL-4, Tanoue, SUP-B15) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1117 Silodosin inhibits the growth of bladder cancer cells and enhances the cytotoxic activity of cisplatin via ELK1 inactivation Am J Cancer Res 2015 26693052 ELK1 ENSG00000126767 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The assosiciation between the drug and the expression of mRNA was detected by the RT-PCR,western blotting analysis,reporter gene assay,cell proliferation and cell migration assays,bladder tissue microarray (TMA) and immunohistochemistry. _ell lines (TCCSUP, UMUC3, 5637) up-regulated resistant NA PKC/Raf-1/ERK pathway validated NA mRNA and protein overexpression related 1118 Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer World J Gastroenterol 2019 31636474 CCN4 ENSG00000104415 gastric cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR WISP1 levels were measured at both the mRNA and protein levels by RT-qPCR, Western blot analysis, and immunohistochemistry (IHC). In addition, the in situ expression of WISP1 in the GC tissues was determined by IHC.WISP1 was knocked down by RNA interference. patients tissues up-regulated resistant NA Wnt1 signaling pathway validated NA mRNA and protein overexpression related 1119 Silencing RIF1 decreases cell growth, migration and increases cisplatin sensitivity of human cervical cancer cells Oncotarget 2017 29291010 RIF1 ENSG00000080345 cervical_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,flow cytometric analysis,ShRNA transfection study,cell viability analysis,colony formation assay and wound healing assay. cell lines (HeLa) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1120 Downregulation of high mobility group protein box-1 resensitizes ovarian cancer cells to carboplatin Oncol Lett 2018 30214593 HMGB1 ENSG00000189403 ovarian_ancer Carboplatin DB00958 (APRD00466) qRT-PCR The expression of HMGB1 was silenced by small interference RNA technology. Reverse transcription-quantitative polymerase chain reaction and western blot analysis indicated that mRNA and protein expression levels of HMGB1.Cell proliferation and apoptosis analyses were performed to evaluate the effect of HMGB1 silencing on resistant ovarian cancer cells. An MTT assay revealed that the proliferation of HMGB1-silenced SKOV3 and SKOV3-Carb cells were decreased compared with the proliferation of non-silenced control cells. cell lines (SKOV3,SKOV3-Carb) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1121 Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer J Biomed Res 2012 23554769 SOX2 ENSG00000181449 gastric cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The assosiciation between the expression of mRNA and the drug resistance was detected by the RT-PCR,western blotting analysis,RNA interference,tumor xenograft study,doxorubicin efflux analysis. cell lines (SGC-7901, BGC-823, MGC-803, HGC-27,MKN-28) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1122 Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer J Biomed Res 2012 23554769 SOX2 ENSG00000181449 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The assosiciation between the expression of mRNA and the drug resistance was detected by the RT-PCR,western blotting analysis,RNA interference,tumor xenograft study,doxorubicin efflux analysis. cell lines (SGC-7901, BGC-823, MGC-803, HGC-27,MKN-28) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1123 Claudin-1 silencing increases sensitivity of liver cancer HepG2 cells to 5-fluorouracil by inhibiting autophagy Oncol Lett 2019 31788043 CLDN1 ENSG00000163347 hepatocellular carcinoma 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR Reverse transcription-quantitative polymerase chain reaction and western blot analysis indicated that_RNA_nd protein expression levels of CLDN1 were significantly increased in Hep/5FU cells, compared with HepG2 cells. CLDN1 was knocked down by transfection with small interference_NA. MTT and Annexin V-fluorescein isothiocyanate/propidium iodide assays demonstrated that CLDN1 silencing significantly inhibits proliferation and enhances apoptosis induced by 5-FU treatment in Hep/5FU cells, compared with non-silenced Hep/5FU cells. cell lines (HepG2,HepG2/5FU) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1124 High level of RNF187 contributes to the progression and drug resistance of osteosarcoma J Cancer 2020 32047542 RBF187 ENSG00000168159 osteosarcoma Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR We employed the quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) to determine the expression of RNF187 in OS tissues and cells. Migration and invasion capacities were analyzed by wound healing and transwell assays, and colony formation and CCK8 assays were performed to investigate proliferative ability. The functional effects of RNF187 on OS drugs resistance were further determined by CCK8 and western blot assays. Then, the relationship between RNF187 expression and clinical implications was analyzed by tissue microarrays (TMAs) including 51 OS cases. cell lines (U-2OS, MG-63, Saos,HOS) up-regulated resistant ERK1/2 and bcl2 ERK1/2 signaling pathway validated NA mRNA and protein overexpression related 1125 High level of RNF187 contributes to the progression and drug resistance of osteosarcoma J Cancer 2020 32047542 RBF187 ENSG00000168159 osteosarcoma Docetaxel DB01248 (APRD00932) qRT-PCR We employed the quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) to determine the expression of RNF187 in OS tissues and cells. Migration and invasion capacities were analyzed by wound healing and transwell assays, and colony formation and CCK8 assays were performed to investigate proliferative ability. The functional effects of RNF187 on OS drugs resistance were further determined by CCK8 and western blot assays. Then, the relationship between RNF187 expression and clinical implications was analyzed by tissue microarrays (TMAs) including 51 OS cases. cell lines (U-2OS, MG-63, Saos,HOS) up-regulated resistant ERK1/2 and bcl2 ERK1/2 signaling pathway validated NA mRNA and protein overexpression related 1126 Inhibition of beta-Catenin to Overcome Endocrine Resistance in Tamoxifen-Resistant Breast Cancer Cell Line PLoS One 2016 27196739 CTNNB ENSG00000168036 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR We established tamoxifen-resistant (TamR) cell line via long-term exposure of MCF-7 breast_ancer_ells to gradually increasing concentrations of tamoxifen. The levels of protein expression and_RNA_ranscripts were determined using western blot analysis and real-time quantitative PCR. The transcriptional activity of ¦Â-catenin was measured using luciferase activity assay. cell lines (MCF-7) up-regulated resistant NA Wnt/¦Â-Catenin signaling pathway validated NA mRNA and protein overexpression related 1127 Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway Cancer Cell Int 2017 28878571 IL6 ENSG00000136244 laryngeal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR IL-6 mRNA and protein expressions were examined with quantitative real-time polymerase chain reaction and Western blot, respectively. Cell proliferation was measured by MTT assay. Tumorigenicity was measured by a colony formation assay and invasion was determined by a cell invasion assay. Apoptotic cells were counted by flow cytometry. Immunohistochemistry was performed to detect immunoreactive IL-6 cells in xenografts. cell lines (Hep2 ) up-regulated resistant STAT3 and HIF1 IL-6/STAT3/HIF1 pathway validated NA mRNA and protein overexpression related 1128 TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells Oncol Rep 2018 29436678 TRIB2 ENSG00000071575 chronic myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR&qRT-PCR The_RNA_nd protein expression levels of were determined by reverse transcription_polymerase chain reaction (RT_PCR), RT_quantitative PCR and western blot analysis. cell line (K562) up-regulated resistant MDR1/MPR1 ERK signaling pathway validated NA mRNA and protein overexpression related 1129 TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells Oncol Rep 2018 29436678 MDR1 ENSG00000085563 chronic myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR&qRT-PCR The_RNA_nd protein expression levels of were determined by reverse transcription_polymerase chain reaction (RT_PCR), RT_quantitative PCR and western blot analysis. cell line (K562) up-regulated resistant NA ERK signaling pathway validated NA mRNA and protein overexpression related 1130 TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells Oncol Rep 2018 29436678 MRP1 ENSG00000103222 chronic myeloid leukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR&qRT-PCR The_RNA_nd protein expression levels of were determined by reverse transcription_polymerase chain reaction (RT_PCR), RT_quantitative PCR and western blot analysis. cell line (K562) up-regulated resistant NA ERK signaling pathway validated NA mRNA and protein overexpression related 1131 E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells Genes Cancer 2016 28191284 PIRH2 ENSG00000163743 lung cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The role of the drug on the expression of the mRNA was detected by the qRT-PCR,western blotting analysis,annexin V staining,MTT assay,colony formation assay,wound healing (scratch) assay, cell line (H1299) up-regulated resistant c-MYC NA validated NA mRNA and protein overexpression related 1132 Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity Clin Cancer Res 2007 17404098 MCL1 ENSG00000143384 acute lymphoid leukemia Rituximab DB00073 (BTD00014, BIOD00014) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,immunoblot analysis,ADCC and CDC assay,apoptosis and flow cytometric studies,transfection studys. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1133 Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity Clin Cancer Res 2007 17404098 MCL1 ENSG00000143384 chronic lymphoid leukemia Rituximab DB00073 (BTD00014, BIOD00014) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,immunoblot analysis,ADCC and CDC assay,apoptosis and flow cytometric studies,transfection studys. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1134 Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer World J Gastroenterol 2019 31602160 ADAM28 ENSG00000042980 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR RNA-sequence analysis was applied to explore the potential targets involved in the gemcitabine of pancreatic_ancer. SW1990 pancreatic_ancer_ells were treated with an increased dose of gemcitabine, and the_RNA_evels of ADAM28 were evaluated by RT-PCR. The protein and_RNA_evels of ADAM28 were confirmed in the gemcitabine resistant and parallel SW1990 cells. The ADAM28 expression was also assessed in TCGA and GEO databases, and the results were confirmed in the collected tumor and adjacent normal tissues. cell line (SW1990) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1135 Potential crosstalk of the interleukin-6-heme oxygenase-1-dependent mechanism involved in resistance to lenalidomide in multiple myeloma cells Febs j 2016 26700310 HO1 ENSG00000100292 melanoma Lenalidomide DB00480 (APRD01303) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,apoptosis analysis,cell viability assays,ELISA,lentiviral vector transfections experiments. cell lines (U266, RPMI8226,CD138(+) cells) up-regulated resistant NA JAK2/STAT3 signaling pathway validated NA mRNA and protein overexpression related 1136 Potential crosstalk of the interleukin-6-heme oxygenase-1-dependent mechanism involved in resistance to lenalidomide in multiple myeloma cells Febs j 2016 26700310 IL6 ENSG00000136244 melanoma Lenalidomide DB00480 (APRD01303) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,apoptosis analysis,cell viability assays,ELISA,lentiviral vector transfections experiments. cell lines (U266, RPMI8226,CD138(+) cells) up-regulated resistant HO1 JAK2/STAT3 signaling pathway validated NA mRNA and protein overexpression related 1137 Downregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma Onco Targets Ther 2018 29872321 CPT2 ENSG00000157184 hepatocellular carcinoma Cisplatin DB00515 (APRD00359) qRT-PCR We performed quantitative reverse transcriptase polymerase chain reaction to investigate carnitine palmitoyltransferase-2 (CPT2) expression and then systematically analyzed its relationship with clinicopathologic features. We further performed proliferation, colony formation, migration and invasion, drug resistance, and lipogenesis assays to determine the function of CPT2 in HCC. cell lines (HepG2, Huh7, SMMC-7721, HCC-LM3,SK-Hep1) down-regulated resistant NA CPT2 signaling pathway validated NA mRNA and protein low expression related 1138 ShRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib Int J Mol Med 2014 24913180 BMI1 ENSG00000168283 melanoma Bortezomib DB00188 (APRD00828, DB07475) qRT-PCR A cell counting kit-8 (CCK-8) assay was performed to analyze cell proliferation and evaluate the 50% inhibitory concentration (IC50) values of bortezomib. Cell cycle progression and apoptosis were analyzed by flow cytometry (FCM), and the_RNA_nd protein expression of associated genes was quantified by RT-qPCR and western blot analysis, respectively. cell lines (U266,RPMI8226) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1139 Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells Tumour Biol 2014 24839008 RLIP76 ENSG00000017797 leukemia Daunorubicin DB00694 (APRD00521) RT-PCR Real-time PCR and western blot analysis revealed that the expression levels of RLIP76_RNA_nd protein in U937 cells were significantly suppressed after transfection with shRNA-containing vector. Knockdown of RLIP76 significantly inhibited cell growth and decreased the colony formation rate, as assessed by trypan blue exclusion and colony formation assay. Flow cytometry analysis showed that reduced RLIP76 expression resulted in cell cycle arrest at G1 phase and induced apoptosis. cell lines (U937 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1140 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1141 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Melphalan DB01042 (APRD00118) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1142 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1143 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Daunorubicin DB00694 (APRD00521) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1144 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Vincristine DB00541 (APRD00495) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1145 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Vinblastine DB00570 (APRD00708) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1146 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Vinorelbine DB00361 (APRD00101) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1147 RALBP1/RLIP76 mediates multidrug resistance Int J Oncol 2007 17143522 RLIP76 ENSG00000017797 erythroleukemia Mitomycin DB00305 (APRD00284) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis,drug sensitivity assay,Irna transfection experiments,drug uptake and efflux studies,fluorescence microscopy. cell lines (K562) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1148 Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma J Cancer 2019 30854133 FZD1 ENSG00000157240 renal cancer Sunitinib DB01268 (DB07417) qRT-PCR We then detected FZD1_RNA_xpression in sunitinib-resistant cells and the corresponding parental cells by qRT-PCR cell lines (786-O ,OS-RC-2 , Caki-1, ACHN , HK-2) up-regulated resistant NA WNT singaling pathway validated NA mRNA and protein overexpression related 1149 High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia Blood 2011 21220747 STAT5 ENSG00000126561 chronic myeloid leukemia Imatinib DB00619 (APRD01028, EXPT02967, DB03261) NA NA patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1150 Forkhead box O3 promotes colon cancer proliferation and drug resistance by activating MDR1 expression Mol Genet Genomic Med 2019 30623608 FOXO3 ENSG00000118689 colon cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR MTT and cell count assay were applied to analyze the viability of transfected CC cells. rVista, dual luciferase reporter assay, and chromatin immunoprecipitation assay were used to identify the downstream_arget_f FOXO3 in HCT116 cells. The_RNA_nd protein abundance of FOXO3 and MDR1 were determined by quantitative PCR and Western blot, respectively cell lines ( HCT116,DLD1) up-regulated resistant MDR1 NA validated NA mRNA and protein overexpression related 1151 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 NRF2 ENSG00000116044 gastric cancer Oxaliplatin DB00526 (APRD00186) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 1152 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 AKR1C1 ENSG00000187134 gastric cancer Oxaliplatin DB00526 (APRD00187) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 1153 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 AKR1C2 ENSG00000151632 gastric cancer Oxaliplatin DB00526 (APRD00188) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 1154 Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification Biochem Pharmacol 2013 23933386 AKR1C3 ENSG00000196139 gastric cancer Oxaliplatin DB00526 (APRD00188) qRT-PCR The role of the mRNA expression on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence staining,cell viability assay,surface marker staining,small interfering RNA transfection study. cell lines (TSGH,TSGH-S3) up-regulated resistant NA Nrf2/AKR1C signaling pathway validated NA mRNA and protein overexpression related 1155 Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells Mol Med Rep 2015 26397212 HOXA5 ENSG00000106004 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR The U937 human leukemia cell line was transfected with a HOXA5_targeted short hairpin_NA(shRNA) to determine the effects of downregulation of the HOXA5 on proliferation, apoptosis, cell cycle distribution and chemoresistance in leukemia cells. Reverse transcription_quantitative polymerase chain reaction and western blot analyses demonstrated that the_RNA_nd protein expression levels of HOXA5 were markedly suppressed following transfection with an shRNA_containing vector. cell line (U937 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1156 Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma Int J Oncol 2016 26891663 B7H6 ENSG00000188211 B-cell non-Hodgkin lymphoma Vincristine DB00541 (APRD00495) RT-PCR Stable B7-H6 knockdown in CA46 cells was established with a lentiviral system. The expression of_RNA_as measured by PCR while protein expression was detected by western blotting and flow cytometry. Cell viability, apoptosis and cell cycle distribution were analyzed using CCK-8, colony formation and flow cytometry assays, respectively. Cell migration and invasion were determined using the Transwell chamber assay. cell lines (CA46 ) up-regulated resistant Bcl-2, Bcl-xL, Caspase-3, Survivin, and c-Myc apoptotic pathway validated NA mRNA and protein overexpression related 1157 Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma Int J Oncol 2016 26891663 B7H6 ENSG00000188211 B-cell non-Hodgkin lymphoma Dexamethasone DB01234 (APRD00674) RT-PCR Stable B7-H6 knockdown in CA46 cells was established with a lentiviral system. The expression of_RNA_as measured by PCR while protein expression was detected by western blotting and flow cytometry. Cell viability, apoptosis and cell cycle distribution were analyzed using CCK-8, colony formation and flow cytometry assays, respectively. Cell migration and invasion were determined using the Transwell chamber assay. cell lines (CA46 ) up-regulated resistant Bcl-2, Bcl-xL, Caspase-3, Survivin, and c-Myc apoptotic pathway validated NA mRNA and protein overexpression related 1158 Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer Cell Oncol (Dordr) 2016 26868260 MAGEA3 ENSG00000221867 gastric cancer Docetaxel DB01248 (APRD00932) qRT-PCR Samples from two independent gastric_ancer_ohorts (including matched non-malignant gastric samples) were included in this study. MAGE-A3 methylation and_RNA_xpression levels were determined by methylation-specific PCR (MSP) and quantitative real-time PCR (qPCR), respectively. MAGE-A3 expression was knocked down in MKN1 gastric_ancer-derived cells using miRNAs. In addition, in vitro cell proliferation, colony formation, apoptosis, cell cycle,_rug_reatment, immunohistochemistry and Western blot assays were performed. cell lines (MKN1 ) up-regulated resistant Bax, p21 and Puma apoptotic pathway validated NA promoter hypomethylation related 1159 Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer Apoptosis 2018 29777330 IL6 ENSG00000136244 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,cell cycle analysis and cell apoptosis analysis by flow cytometry,wound healing assay,transwell invasion assay,colony formation assay,cell viability assay. cell lines (HT29, SW480, HCT116,LOVO) up-regulated resistant NA GP130/MAPK/STAT3 signaling pathway validated NA mRNA and protein overexpression related 1160 Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer Apoptosis 2018 29777330 IL6ST ENSG00000134352 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,cell cycle analysis and cell apoptosis analysis by flow cytometry,wound healing assay,transwell invasion assay,colony formation assay,cell viability assay. cell lines (HT29, SW480, HCT116,LOVO) up-regulated resistant NA GP130/MAPK/STAT3 signaling pathway validated NA mRNA and protein overexpression related 1161 LIM and SH3 protein 1 regulates cell growth and chemosensitivity of human glioblastoma via the PI3K/AKT pathway BMC Cancer 2018 29980193 LAPS1 ENSG00000002834 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR Oncomine and The_ancer_enome Atlas (TCGA) database was analyzed for the expression and clinical significance of LASP1 in GBM. LASP1_RNA_nd protein level were measured by qRT-PCR and western blotting. The effect of LASP1 on GBM proliferation was examined by MTT assay and colony formation assay, the effect of LASP1 on sensitivity of Temozolomide was measured by flow cytometry and subcutaneous tumor model. The association between LASP1 and PI3K/AKT signaling was assessed by western blotting. cell lines (LN229,U251,U87,T98G) up-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 1162 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HO1 ENSG00000100292 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant HIF1A and GLUT1 NA validated NA mRNA and protein overexpression related 1163 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HIF1A ENSG00000100644 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1164 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 GLUT1 ENSG00000117394 acute myeloid leukemia Cytarabine DB00987 (APRD00499) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1165 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HO1 ENSG00000100292 acute myeloid leukemia Daunorubicin DB00694 (APRD00521) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant HIF1A and GLUT1 NA validated NA mRNA and protein overexpression related 1166 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 HIF1A ENSG00000100644 acute myeloid leukemia Daunorubicin DB00694 (APRD00521) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1167 Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia Hematology 2015 26218201 GLUT1 ENSG00000117394 acute myeloid leukemia Daunorubicin DB00694 (APRD00521) qRT-PCR Small interfering_NA_as used to stably silence HO-1 gene expression in AML cell lines. The expressions of HO-1, hypoxia inducible factor-1¨» (HIF-1¨»), glucose transporter-1 (GLUT1)_RNA_nd proteins were measured by quantitative real-time PCR and Western blot. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction was analyzed by flow cytometry. cell lines (HL60,HL60/R) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1168 PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression Acta Biochim Biophys Sin (Shanghai) 2018 30020405 PIM1 ENSG00000137193 T-cell lymphoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR we studied the roles of mRNA in established T-lymphoma cell lines Jurkat and HUT-78. CCK-8 assay was conducted to evaluate cell survival and flow cytometry was performed to evaluate cell death of TCL cells. siRNAs were used to knockdown the expression of PIM1 and c-myc. qRT-PCR was used to evaluate the_RNA_xpression levels of c-myc and PIM1. Western blot analysis was used to evaluate the protein expression levels of PIM1, c-myc, STAT3, and phospho-STAT3. cell lines (Jurkat ,HUT-78) up-regulated resistant c-MYC JAK-STAT3 signaling pathway validated NA mRNA and protein overexpression related 1169 PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression Acta Biochim Biophys Sin (Shanghai) 2018 30020405 MYC ENSG00000136997 T-cell lymphoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR we studied the roles of mRNA in established T-lymphoma cell lines Jurkat and HUT-78. CCK-8 assay was conducted to evaluate cell survival and flow cytometry was performed to evaluate cell death of TCL cells. siRNAs were used to knockdown the expression of PIM1 and c-myc. qRT-PCR was used to evaluate the_RNA_xpression levels of c-myc and PIM1. Western blot analysis was used to evaluate the protein expression levels of PIM1, c-myc, STAT3, and phospho-STAT3. cell lines (Jurkat ,HUT-78) up-regulated resistant NA JAK-STAT3 signaling pathway validated NA mRNA and protein overexpression related 1170 Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2 J Mol Med (Berl) 2013 23052480 IL6 ENSG00000136244 ovarian_ancer Cisplatin DB00515 (APRD00359) NA The role of the mRNA expression was detected by the western blotting analysis,RNA interference experiment,transfection study,IL-6 ELISA assay. cell lines (SKOV3,OVCAR3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1171 Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2 J Mol Med (Berl) 2013 23052480 BIRC3 ENSG00000023445 ovarian_ancer Cisplatin DB00515 (APRD00359) NA The role of the mRNA expression was detected by the western blotting analysis,RNA interference experiment,transfection study,IL-6 ELISA assay. cell lines (SKOV3,OVCAR3) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1172 HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway Ann Clin Lab Sci 2017 28667026 HTRA1 ENSG00000166033 colon cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression was detected by qRT-PCR,the western blotting analysis,RNA interference experiment,MTT. cell lines (SW480 ,SW480 /CDDP) down-regulated resistant XIAP PI3K/Akt_athway validated NA mRNA and protein low expression related 1173 HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway Ann Clin Lab Sci 2017 28667026 XIAP ENSG00000101966 colon cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression was detected by qRT-PCR,the western blotting analysis,RNA interference experiment,MTT. cell lines (SW480 ,SW480 /CDDP) up-regulated resistant NA PI3K/Akt_athway validated NA mRNA and protein overexpression related 1174 Rad knockdown induces mitochondrial apoptosis in bortezomib resistant leukemia and lymphoma cells Leuk Res 2012 22658652 RRAD ENSG00000166592 leukemia Bortezomib DB00188 (APRD00828, DB07475) Rnase Kit The role of the mRNA expression was detected by the western blotting analysis,cell survival analysis,caspase-3 activity assay,mitochondrial membrane potential analysis,colony formation assay,cell death assessment. cell lines (K-562, Raji, IM-9,Jurkat-R,Sup-B15, JVM-2, U266,Jurkat) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1175 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BCL2 ENSG00000171791 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) down-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein low expression related 1176 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BCLXL ENSG00000171552 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) down-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein low expression related 1177 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BIRC5 ENSG00000089685 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) down-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein low expression related 1178 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 BAX ENSG00000087088 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) up-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein overexpression related 1179 Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells Chem Res Toxicol 2011 21158420 CYC1 ENSG00000179091 breast cancer antrocin NA RT-PCR The role of the drug on the expression of the mRNA was detected by RT-PCR,immunoblot analysis,flow cytometric analysis. cell lines (MDA-MB-231) up-regulated resistant NA Akt/mTOR signaling pathway validated NA mRNA and protein overexpression related 1180 RON and cisplatin resistance in ovarian cancer cell lines Oncol Res 2010 21141737 RON ENSG00000164078 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence,transfection experiment. cell lines (OVCAR-3,A2780) up-regulated resistant NA RON signaling pathway validated NA mRNA and protein overexpression related 1181 RON and cisplatin resistance in ovarian cancer cell lines Oncol Res 2010 21141737 RON ENSG00000164078 ovarian_ancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence,transfection experiment. cell lines (OVCAR-3,A2780) up-regulated resistant NA RON signaling pathway validated NA mRNA and protein overexpression related 1182 RON and cisplatin resistance in ovarian cancer cell lines Oncol Res 2010 21141737 RON ENSG00000164078 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR The role of the mRNA on the drug was detected by the qRT-PCR,western blotting analysis,immunofluorescence,transfection experiment. cell lines (OVCAR-3,A2780) up-regulated resistant NA RON signaling pathway validated NA mRNA and protein overexpression related 1183 Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-kappaB signaling pathway Theranostics 2018 29930725 TRIM31 ENSG00000204616 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The protein and_RNA_xpression of TRIM31 in pancreatic_ancer_ell lines and patient tissues were determined using Real-time PCR and Western blot, respectively. 89 human pancreatic_ancer_issue samples were analyzed by IHC to investigate the association between TRIM31 expression and the clinicopathological characteristics of pancreatic_ancer_atients. Functional assays, such as MTT, FACS, and Tunel assay used to determine the oncogenic role of TRIM31 in human pancreatic_ancer_rogression. Furthermore, western blotting and luciferase assay were used to determine the mechanism of TRIM31 promotes chemoresistance in pancreatic_ancer_ells. cell lines (PANC-1, CFPAC-1, BxPC-3, AsPC-1, Capan-1, Capan-2, MIA PaCa-2, Hs 766T,MIN6) and patients tissues up-regulated resistant BCL2,_IAP, and_URVIVIN NF-¦ÊB signaling pathway validated NA mRNA and protein overexpression related 1184 Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation Acta Biochim Biophys Sin (Shanghai) 2018 29961813 MACC1 ENSG00000183742 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR Cisplatin-resistant cell sublines (A549/CR and H446/CR) were induced by stepwise escalation of cisplatin exposure. MTS and flow cytometry assays were performed to measure cell proliferation and apoptosis, respectively. Western blot analysis and qRT-PCR assays were performed to determine the changes in signaling pathway-related protein and_RNA_evels, respectively. A nude mouse xenograft model was used for in vivo experiments. cell lines (A549/CR,H446/CR) up-regulated resistant NA PI3K/Akt_athway validated NA mRNA and protein overexpression related 1185 Downregulation of SMC1A inhibits growth and increases apoptosis and chemosensitivity of colorectal cancer cells J Int Med Res 2016 26637483 SMC1A ENSG00000072501 colon cancer Oxaliplatin DB00526 (APRD00186) RT-PCR SMC1A gene expression was silenced by lentivirus-mediated infection with small interfering_NA(siRNA) in the human colorectal_ancer_ell line HT-29. Cell proliferation rates, SMC1A_RNA_nd protein levels, apoptosis and chemosensitivity to oxaliplatin were evaluated using routine in_itro assays, real-time polymerase chain reaction, Western blotting and flow cytometry. cell line(HT-29) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1186 Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma Int J Clin Exp Pathol 2014 24817946 NRF2 ENSG00000116044 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The human ovarian carcinoma cell line, A2780, and its cisplatin-resistant variant, A2780cp were cultivated. Cell viability was determined with WST-8 assay. Western blot was applied to detect the expression of Nrf2, Nrf2 target genes, and autophagy-related proteins. RNA interference was used to knock down target genes. Annexin V and propidium iodide (PI) staining was utilized to quantify apoptosis. The ultrastructural analysis of autophagosomes was performed by transmission electron microscopy (TEM) cell lines (A2780,A2780/cp) up-regulated resistant NA NRF2 signaling pathway validated NA mRNA and protein overexpression related 1187 Overcoming Tamoxifen Resistance by Regulation of Del-1 in Breast Cancer Oncology 2019 31330520 EDIL3 ENSG00000164176 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR Del-1 expression in recurrent TAM-R breast_ancer_issue was evaluated and compared to that in the original tumor tissue from the same patients. Del-1 expression was also evaluated in TAM-R cells by quantitative real-time PCR, western blotting, and enzyme-linked immunosorbent assay. The effects of Del-1 knockdown on the proliferation, migration, and invasion of TAM-R cells was assessed with wound-healing and Matrigel transwell assays cell lines (MCF-7) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1188 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN1 ENSG00000117632 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 1189 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN2 ENSG00000104435 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 1190 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN3 ENSG00000197457 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 1191 RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo Cell Biol Toxicol 2018 28589243 STMN4 ENSG00000015592 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) iRNA interference Our study demonstrated that STMN RNA interference (RNAi) enlarged taxol-induced inhibitions in cellular proliferation, colony formation, and multidimensional spaces of cell immigration and decreased half maximal inhibitory concentration (IC50) of taxol in nonsmall cell lung cancer (NSCLC) NCI-H1299 cells cell lines (NCI-H1299) up-regulated resistant NA STMN signaling pathway validated NA mRNA and protein overexpression related 1192 Knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivo Mol Cancer Ther 2005 16373699 CLU ENSG00000120885 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) qRT-PCR&Northern blot Clusterin immunostaining was evaluated in a tissue microarray of 379 spotted breast cancers. The effect of drugs on clusterin expression was examined in MCF-7 and MDA-MB-231 cells. Northern, quantitative real-time PCR, and Western analyses were used to measure change in clusterin mRNA and protein levels. cell lines (MCF-7, MDA-MB-231) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1193 A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells BMC Cancer 2018 30103729 GNB4 ENSG00000114450 breast cancer Fulvestrant DB00947 (APRD00654) qRT-PCR The whole-genome gene expression and DNA methylation profilings were performed using fulvestrant-resistant cell line 182R-6 and tamoxifen-resistant cell line TAMR-1 as a model system. In addition, qRT-PCR and Western blot analysis were performed to determine the levels of_RNA_nd protein molecules. MTT, apoptosis and cell cycle analyses were performed to examine the effect of either guanine nucleotide-binding protein beta-4 (GNB4) overexpression or knockdown on cell proliferation, apoptosis and cell cycle. cell lines (182R-6 and TAMR-1 ) up-regulated resistant NA ER signaling pathway validated NA mRNA and protein overexpression related 1194 A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells BMC Cancer 2018 30103729 GNB4 ENSG00000114450 breast cancer Tamoxifen DB00675 (APRD00123) qRT-PCR The whole-genome gene expression and DNA methylation profilings were performed using fulvestrant-resistant cell line 182R-6 and tamoxifen-resistant cell line TAMR-1 as a model system. In addition, qRT-PCR and Western blot analysis were performed to determine the levels of_RNA_nd protein molecules. MTT, apoptosis and cell cycle analyses were performed to examine the effect of either guanine nucleotide-binding protein beta-4 (GNB4) overexpression or knockdown on cell proliferation, apoptosis and cell cycle. cell lines (182R-6 and TAMR-1 ) up-regulated resistant NA ER signaling pathway validated NA mRNA and protein overexpression related 1195 Effect of inhibition of the adrenomedullin gene on the growth and chemosensitivity of ovarian cancer cells Oncol Rep 2012 22294191 ADM ENSG00000148926 ovarian_ancer Carboplatin DB00958 (APRD00466) RT-PCR HO8910 ovarian_ancer_ells were transfected with iRNA, and the effects of AM on proliferation and chemosensitivity of the cells were examined. RT-PCR, real-time PCR and western blot analysis were performed to detect the AM gene and protein expression. The MTT assay was used to observe the effect of AM on proliferation and chemosensitivity of the cells. cell lines (HO8910) up-regulated resistant NA ADM/ERK/BCL2 signaling pathway validated NA mRNA and protein overexpression related 1196 NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells Mol Cell Biochem 2014 24782036 ABCC1 ENSG00000103222 prostate cancer Cisplatin DB00515 (APRD00359) qRT-PCR 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide was used to measure the cell viability. Quantitative real-time PCR and western blotting were utilized to evaluate the_RNA_nd protein levels. ShRNA was employed to knock down_arget_ene expression. Chromatin immunoprecipitation (ChIP) was performed to explore the detailed mechanism underlying ABCC1 expression. cell lines ( LNCaP,PC3) up-regulated resistant NA NOTCH1 signaling pathway validated NA mRNA and protein overexpression related 1197 NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells Mol Cell Biochem 2014 24782036 ICN1 NA prostate cancer Cisplatin DB00515 (APRD00359) qRT-PCR 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide was used to measure the cell viability. Quantitative real-time PCR and western blotting were utilized to evaluate the_RNA_nd protein levels. ShRNA was employed to knock down_arget_ene expression. Chromatin immunoprecipitation (ChIP) was performed to explore the detailed mechanism underlying ABCC1 expression. cell lines ( LNCaP,PC3) up-regulated resistant ABCC1 NOTCH1 signaling pathway validated NA mRNA and protein overexpression related 1198 Down-regulation of GADD45A enhances chemosensitivity in melanoma Sci Rep 2018 29515153 GADD45A ENSG00000116717 melanoma Cisplatin DB00515 (APRD00359) RT-PCR We investigated the role of GADD45A in chemotherapy response. Firstly, the_RNA_xpression of profiled DNA repair genes in cisplatin-treated melanoma cells was detected by RT2_rofilerTM_CR array. We found the expression of GADD45A upregulated in a dose- and time- dependent manner. In addition, suppression of GADD45A sensitized melanoma cells to cisplatin and enhanced cisplatin-induced DNA damage. Flow cytometry revealed that downregulating GADD45A released cells from cisplatin-induced G2/M arrest and increased apoptosis. By using a MEK inhibitor, GADD45A was shown to be regulated by MAPK-ERK pathway following cisplatin treatment. cell lines (A375,SK-MEL-28) up-regulated resistant NA MAPK signaling pathway validated NA mRNA and protein overexpression related 1199 Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance Oncogene 2012 21996734 ERCC1 ENSG00000012061 melanoma Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis. cell lines (A375) up-regulated resistant ERCC1 and XPF MAPK signaling pathway validated NA mRNA and protein overexpression related 1200 Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance Oncogene 2012 21996734 DUSP6 ENSG00000139318 melanoma Cisplatin DB00515 (APRD00359) RT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,western blotting analysis. cell lines (A375) down-regulated resistant NA MAPK signaling pathway validated NA mRNA and protein low expression related 1201 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin J Cell Biochem 2018 28786507 SH3BP1 ENSG00000100092 cervical_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,western blotting analysis,active Rac1 pull-down assay,invasion assays,MTT assays. cell lines (HeLa,Caski) and patients tissues up-regulated resistant Rac SH3BP1/Rac1/Wave2 signaling pathway validated NA mRNA and protein overexpression related 1202 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin J Cell Biochem 2018 28786507 RAC1 ENSG00000136238 cervical_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,western blotting analysis,active Rac1 pull-down assay,invasion assays,MTT assays. cell lines (HeLa,Caski) and patients tissues up-regulated resistant Wave2 SH3BP1/Rac1/Wave2 signaling pathway validated NA mRNA and protein overexpression related 1203 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin J Cell Biochem 2018 28786507 WASF2 ENSG00000158195 cervical_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,western blotting analysis,active Rac1 pull-down assay,invasion assays,MTT assays. cell lines (HeLa,Caski) and patients tissues up-regulated resistant NA SH3BP1/Rac1/Wave2 signaling pathway validated NA mRNA and protein overexpression related 1204 Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity Cancer Res 2009 19276367 UPAR ENSG00000011422 lung cancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,immunohistochemistry,chicken embryo metastasis assay,reverse phase protein array,nuclear extracts, electrophoretic mobility shift assay, supershift,chromatin immunoprecipitation assay,ELISA,matrigel invasion,MTT. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1205 Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity Cancer Res 2009 19276367 CDH1 ENSG00000039068 lung cancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The role of the mRNA expression on the mechanism of the drug was detected by the RT-PCR,immunohistochemistry,chicken embryo metastasis assay,reverse phase protein array,nuclear extracts, electrophoretic mobility shift assay, supershift,chromatin immunoprecipitation assay,ELISA,matrigel invasion,MTT. cell lines down-regulated resistant NA NA validated NA mRNA and protein low expression related 1206 Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance to sorafenib in hepatocellular carcinoma cells Sci Rep 2016 27476430 YAP ENSG00000137693 hepatocellular carcinoma Sorafenib DB00398 (APRD01304, DB07438) qRT-PCR The role of YAP was detected by qRT_PCR,western blotting,cell proliferation assay,immunohistochemical assay,immunofluorescence staining,flow cytometry,xenograft tumour growth analysis. cell lines ( HepG2,Bel-7402,SMMC-7721 ) up-regulated resistant NA HIF1 signaling pathway validated NA mRNA and protein overexpression related 1207 Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers Breast Cancer Res 2017 28974266 SH3GL1 ENSG00000141985 breast cancer Trastuzumab DB00072 (BTD00098, BIOD00098) Bioinformatics Endo II expression in human breast tumors and lymph node metastases were analyzed by immunohistochemistry. Stable silencing of Endo II was achieved in HER2+_ancer_ell lines (SK-BR-3 and HCC1954) to test Endo II effects on HER2 levels, localization and signaling, cell motility and tumor metastasis. The effects of Endo II silencing on the responses of HER2+_ancer_ells to trastuzumab or T-DM1 treatments were tested using real-time cell motility and cytotoxicity assays. cell lines (MCF-10A,BT-474, SK-BR-3, MDA-MB-231, HCC1954) up-regulated resistant HER2 Her2 signaling pathway validated NA mRNA and protein overexpression related 1208 YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line Oncol Rep 2014 24842123 CHI3L1 ENSG00000133048 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR Gene expression analysis using DNA microarray and quantitative PCR (qPCR) demonstrated that mRNA expression was upregulated in the TMZ-R U87 cell line. cell lines (TMZ-R U87) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1209 YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line Oncol Rep 2014 24842123 STAT3 ENSG00000168610 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR Gene expression analysis using DNA microarray and quantitative PCR (qPCR) demonstrated that mRNA expression was upregulated in the TMZ-R U87 cell line. cell lines (TMZ-R U87) up-regulated resistant NA STAT3 signaling pathway validated NA mRNA and protein overexpression related 1210 Par-4 downregulation confers cisplatin resistance in pancreatic cancer cells via PI3K/Akt pathway-dependent EMT Toxicol Lett 2014 24144893 PAWR ENSG00000177425 pancreatic cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the drug sensitivity was detected by the RT-PCR,western blotting analysis,MTT,cell invasion assay,SiRNA transfection experiment,tumor xenograft studys. cell lines (BXPC-3/CDDP,BXPC-3) down-regulated resistant NA PI3K/Akt_athway validated NA mRNA and protein low expression related 1211 The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-kappaB signaling pathway J Exp Clin Cancer Res 2017 28978336 GOLPH3L ENSG00000143457 ovarian_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The protein and_RNA_xpression of GOLPH3L in ovarian_ancer_ell lines and patient tissues were determined using Real-time PCR and Western blot, respectively. 177 human ovarian_ancer_issue samples were analyzed by IHC to investigate the association between GOLPH3L expression and the clinicopathological characteristics of ovarian_ancer_atients. Functional assays, such as MTT, FACS, and Tunel assay used to determine the oncogenic role of GOLPH3L in human ovarian_ancer_rogression. Furthermore, western blotting and luciferase assay were used to determine the mechanism of GOLPH3L promotes chemoresistance in ovarian_ancer_ells. cell lines (IOSE80,SKOV3, CAOV3, OV56, A2780, A2780/cis, COV362, EFO-27, TOV21G, EFO-21,OV90) and patients tissues up-regulated resistant NA NF-¦ÊB pathway validated NA mRNA and protein overexpression related 1212 APRIL induces cisplatin resistance in gastric cancer cells via activation of the NF-kappaB pathway Cell Physiol Biochem 2015 25612651 TNFSF13 ENSG00000161955 gastric cancer Cisplatin DB00515 (APRD00359) qRT-PCR Expression of APRIL was assessed by immunohistochemistry and real-time PCR. Prognostic role of APRIL expression was evaluated. We also discovered the effect of APRIL on chemo-resistance in GC cells and the underlying mechanisms. cell lines and patients tissues up-regulated resistant NA NF-¦ÊB pathway validated NA mRNA and protein overexpression related 1213 Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression Int J Oncol 2014 24647772 NANOG ENSG00000111704 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of the mRNA expression was detected by the RT-PCR,western blotting analysis,colony formation assay,cell migration assay,cell viability assay. cell line (HepG2 ) up-regulated resistant MDR1 NA validated NA mRNA and protein overexpression related 1214 Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression Int J Oncol 2014 24647772 MDR1 ENSG00000085563 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The role of the mRNA expression was detected by the RT-PCR,western blotting analysis,colony formation assay,cell migration assay,cell viability assay. cell line (HepG2 ) up-regulated resistant P-glycoprotein NA validated NA mRNA and protein overexpression related 1215 Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer J Cancer Res Clin Oncol 2012 22714588 NANOG ENSG00000111704 esophageal_ancer Cisplatin DB00515 (APRD00359) RT-PCR We first detected the expression of Nanog in the ESCC and cell lines by RT-PCR, immunofluorescence, and immunohistochemisty. Then, we used small interfering RNA (siRNA) to block Nanog expression while evaluating the effect of Nanog siRNA on cell apoptosis and the combined effects with Cisplatin in ESCC cell lines. cell lines (TE-1 and Eca-109) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1216 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma J Exp Clin Cancer Res 2018 30153855 HSP90AA1 ENSG00000080824 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR shRNAs were transfected into osteosarcoma cells for knockdown of HSP90AA1 gene. Stable HSP90AA1 overexpressing osteosarcoma cell lines were obtained by lentivirus infection._RNA_nd protein expressions of HSP90AA1 in osteosarcoma cells were tested by quantitative real-time PCR and western blot, respectively. Autophagy of osteosarcoma cells was detected by western blot of LC3, transmission electron microscopy and fluorescence microscope. mRFP-GFP-LC3 lentiviral transfection was also performed to detect autophagic flux. NOD/SCID mices were inoculated with MG-63 tumor cells transfected with HSP90AA1 specific shRNA. TUNEL and LC3 staining were performed to detect apoptosis and autophagy of resected tumor tissues. cell lines (MG-63, Saos-2,U-2 OS) up-regulated resistant NA PI3K/Akt/mTOR pathway and JNK/P38 pathway validated NA mRNA and protein overexpression related 1217 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma J Exp Clin Cancer Res 2018 30153855 HSP90AA1 ENSG00000080824 osteosarcoma Cisplatin DB00515 (APRD00359) qRT-PCR shRNAs were transfected into osteosarcoma cells for knockdown of HSP90AA1 gene. Stable HSP90AA1 overexpressing osteosarcoma cell lines were obtained by lentivirus infection._RNA_nd protein expressions of HSP90AA1 in osteosarcoma cells were tested by quantitative real-time PCR and western blot, respectively. Autophagy of osteosarcoma cells was detected by western blot of LC3, transmission electron microscopy and fluorescence microscope. mRFP-GFP-LC3 lentiviral transfection was also performed to detect autophagic flux. NOD/SCID mices were inoculated with MG-63 tumor cells transfected with HSP90AA1 specific shRNA. TUNEL and LC3 staining were performed to detect apoptosis and autophagy of resected tumor tissues. cell lines (MG-63, Saos-2,U-2 OS) up-regulated resistant NA PI3K/Akt/mTOR pathway and JNK/P39 pathway validated NA mRNA and protein overexpression related 1218 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma J Exp Clin Cancer Res 2018 30153855 HSP90AA1 ENSG00000080824 osteosarcoma Methotrexate DB00563 (APRD00353) qRT-PCR shRNAs were transfected into osteosarcoma cells for knockdown of HSP90AA1 gene. Stable HSP90AA1 overexpressing osteosarcoma cell lines were obtained by lentivirus infection._RNA_nd protein expressions of HSP90AA1 in osteosarcoma cells were tested by quantitative real-time PCR and western blot, respectively. Autophagy of osteosarcoma cells was detected by western blot of LC3, transmission electron microscopy and fluorescence microscope. mRFP-GFP-LC3 lentiviral transfection was also performed to detect autophagic flux. NOD/SCID mices were inoculated with MG-63 tumor cells transfected with HSP90AA1 specific shRNA. TUNEL and LC3 staining were performed to detect apoptosis and autophagy of resected tumor tissues. cell lines (MG-63, Saos-2,U-2 OS) up-regulated resistant NA PI3K/Akt/mTOR pathway and JNK/P40 pathway validated NA mRNA and protein overexpression related 1219 Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL8 production in pancreatic cancer Oncol Rep 2019 31002348 IL8 ENSG00000169429 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR We demonstrated that expression of interleukin_8 (IL_8) mRNA was significantly upregulated in Gem_R PaCa cells by cDNA microarray and RT_qPCR analyses. Increased IL_8 secretion by Gem_R cells was confirmed by cytokine array and enzyme_linked immunosorbent assay. cell lines (AsPC_1,MIA PaCa_2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1220 PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells Mol Cancer Ther 2017 28336807 PMP22 ENSG00000109099 gastric cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA was detected by the qRT-PCR,western blotting analysis,iRNA interference experiment,colony formation assays . cell lines ( MGC-803, SGC-7901,SGC-7901/DDP) and patients tissues up-regulated resistant NA Wnt/¦Â-Catenin signaling pathway validated NA mRNA and protein overexpression related 1221 The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells Biochim Biophys Acta 2012 22609303 FOSL1 ENSG00000175592 glioma Nimustine DB13069 RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,transfection experiments,gel electrophoresis ,apoptosis and cell cycle distribution,EMSA. cell lines (LN229, U87,U138) up-regulated resistant NA CHK1_Cdk2 pathway validated NA mRNA and protein overexpression related 1222 ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses DNA Repair (Amst) 2008 18249159 ATF3 ENSG00000162772 glioblastoma Cisplatin DB13069 Northern blot The relationship between the mRNA expression and the drug sensitivity was detected by the northern blotting analysis,western blotting analysis,cell counting and FACS analysis,lentivirus transfection experiments. cell lines (T98G) up-regulated resistant NA ERK signaling pathway validated NA mRNA and protein overexpression related 1223 ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses DNA Repair (Amst) 2008 18249159 FOSL1 ENSG00000175592 glioblastoma Cisplatin DB13069 Northern blot The relationship between the mRNA expression and the drug sensitivity was detected by the northern blotting analysis,western blotting analysis,cell counting and FACS analysis,lentivirus transfection experiments. cell lines (T98G) up-regulated resistant NA ERK and JNK signaling pathway validated NA mRNA and protein overexpression related 1224 Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer Oncol Rep 2008 18949417 HSP27 ENSG00000106211 colon cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) NA The role of the HSP27 was detected by the western blotting analysis,cell proliferation assay,HSP27 siRNA transfecion experiment. cell lines (LoVo, HCT15, WiDr, HCT116, HT-29,SW480) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1225 Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1 PLoS One 2014 24846322 HIPK2 ENSG00000064393 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,cell viability assay,RNAi interference experiments. cell lines (RT4-CisR,RT4) down-regulated resistant wip1 NA validated NA mRNA and protein low expression related 1226 Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1 PLoS One 2014 24846322 PPM1D ENSG00000170836 bladder_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,cell viability assay,RNAi interference experiments. cell lines (RT4-CisR,RT4) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1227 Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia J Oral Pathol Med 2013 23227892 GLUT1 ENSG00000117394 oral cancer Cisplatin DB00515 (APRD00359) RT-PCR Cell viability was measured following culture of the cells in the presence or absence of CDDP, under normoxic or hypoxic conditions, using a CCK-8 assay. Analysis of the expression of HIF target genes in hypoxia-treated cells was performed using an HIF-regulated cDNA plate array. Changes in the mRNA expression of selected HIF target genes were analyzed using RT-PCR, and changes in the protein levels of these genes were analyzed by Western blotting. Tumor cell apoptosis was assessed by flow cytometry. cell lines (HSC-2, Ca9-22,SAS ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1228 Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo Mol Cancer Ther 2004 15026542 CLU ENSG00000120885 lung cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR&Northern blot The role of the mRNA was detected by the RT-PCR,northern blotting analysis,small Interfering RNA and antisense oligonucleotides treatment study,MTT assays,DNA fragmentation analysis,cell growth analysis. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1229 Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo Mol Cancer Ther 2004 15026542 CLU ENSG00000120885 lung cancer Gemcitabine DB00441 (APRD00201) RT-PCR&Northern blot The role of the mRNA was detected by the RT-PCR,northern blotting analysis,small Interfering RNA and antisense oligonucleotides treatment study,MTT assays,DNA fragmentation analysis,cell growth analysis. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1230 CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma IUBMB Life 2008 18379992 BSG ENSG00000172270 hepatocellular carcinoma Curcumin DB11672 RT-PCR The role of the mRNA on the drug was detected by the RT-PCR,western blotting analysis,soft agar colony formation assay,MTT assay,iRNA interference experiments,tumor xenograft study. cell line (Hepa1-6) up-regulated resistant VEGFA NA validated NA mRNA and protein overexpression related 1231 Highly Expressed Integrin-alpha8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse Mol Cells 2016 28008160 ITGA8 ENSG00000077943 melanoma Melphalan DB01042 (APRD00118) RT-PCR The expression of the target mRNA was detected by the RT-PCR,western blotting analysis,plasmid transfection,cell adhesion assay,chemotaxis assay,cell invasion assay,cell viability assay. cell lines (KMS-12-BM, KMS-12-PE, MOLP8, NCI-H929, LP-1,EJM) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1232 Highly Expressed Integrin-alpha8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse Mol Cells 2016 28008160 ITGA8 ENSG00000077943 melanoma Bortezomib DB00188 (APRD00828, DB07475) RT-PCR The expression of the target mRNA was detected by the RT-PCR,western blotting analysis,plasmid transfection,cell adhesion assay,chemotaxis assay,cell invasion assay,cell viability assay. cell lines (KMS-12-BM, KMS-12-PE, MOLP8, NCI-H929, LP-1,EJM) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1233 Androgen receptor signaling regulates cell growth and vulnerability to doxorubicin in bladder cancer J Urol 2012 22608749 AR ENSG00000169083 bladder_ancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) qRT-PCR We evaluated AR mRNA expression in bladder cancer tissue by quantitative real-time polymerase chain reaction. The role of androgen receptor in cell growth and drug sensitivity was also evaluated in vitro and in vivo in several bladder cancer cell lines. cell lines (UMUC3, MBT-2) and patients tissues up-regulated resistant NA AR signaling pathway validated NA mRNA and protein overexpression related 1234 Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib Mol Carcinog 2018 29637613 EGFR ENSG00000146648 gastric cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The expression of the mRNA was detected by the qRT-PCR,western blotting analysis,iRNA interference experiment,MTT assays. cell lines (AGS, MKN-28, MKN-45 ,NCI-N87) up-regulated resistant NA EGFR/HER2 signaling pathway validated NA mRNA and protein overexpression related 1235 Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib Mol Carcinog 2018 29637613 HER2 ENSG00000141736 gastric cancer Gefitinib DB00317 (APRD00997, DB07998) qRT-PCR The expression of the mRNA was detected by the qRT-PCR,western blotting analysis,siRNA interference transfection experiment,MTT assays. cell lines (AGS, MKN-28, MKN-45 ,NCI-N87) up-regulated resistant NA EGFR/HER2 signaling pathway validated NA mRNA and protein overexpression related 1236 Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis Zhonghua Nan Ke Xue 2013 23441447 PKM2 ENSG00000067225 prostate cancer Gambogic Acid NA RT-PCR Three specific PKM2 siRNAs and one negative control siRNA (si-NC) were transfected into PC3 cells. The silencing effect of PKM2 siRNAs was determined by real-time fluorescence quantitative PCR (qRT-PCR) and Western blot, and the effects of PKM2 siRNA on the vitality and apoptosis of GA-stimulated PC3 cells detected by MTT and AO/EB double staining, respectively. The_RNA_nd protein levels of c-myc and cyclin D1 were analyzed by qRT-PCR and Western blot, respectively. cell lines (PC3) up-regulated resistant c-myc and cyclin D1 NA validated NA mRNA and protein overexpression related 1237 Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel Cancer Res 2007 17332325 TWIST1 ENSG00000128791 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) Northern blot The role of the drug on the expression of the mRNA was detected by the northern blotting analysis,western blotting analysis,cell invasion assay,soft agar colony formation assay,cell survival assay,luciferase reporter assay,chromatin immunoprecipiatation assay,RNA interference experiments.cell migration and wound healing assay,immunohistochemistry. cell lines ( MCF7,MDA-MB-453,MCF7-I4,MDA-MB-453-I4) up-regulated resistant AKT2 Twist-AKT2_ignaling pathway validated NA mRNA and protein overexpression related 1238 Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel Cancer Res 2007 17332325 AKT2 ENSG00000105221 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) Northern blot The role of the drug on the expression of the mRNA was detected by the northern blotting analysis,western blotting analysis,cell invasion assay,soft agar colony formation assay,cell survival assay,luciferase reporter assay,chromatin immunoprecipiatation assay,RNA interference experiments.cell migration and wound healing assay,immunohistochemistry. cell lines ( MCF7,MDA-MB-453,MCF7-I4,MDA-MB-453-I4) up-regulated resistant NA Twist-AKT3_ignaling pathway validated NA mRNA and protein overexpression related 1239 Twist transcriptionally up-regulates AKT3 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel Cancer Res 2007 17332325 TWIST2 ENSG00000288335 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) Northern blot The role of the drug on the expression of the mRNA was detected by the northern blotting analysis,western blotting analysis,cell invasion assay,soft agar colony formation assay,cell survival assay,luciferase reporter assay,chromatin immunoprecipiatation assay,RNA interference experiments.cell migration and wound healing assay,immunohistochemistry. cell lines ( MCF7,MDA-MB-453,MCF7-I4,MDA-MB-453-I4) up-regulated resistant AKT2 Twist-AKT4_ignaling pathway validated NA mRNA and protein overexpression related 1240 PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis EBioMedicine 2019 30655206 PTGER3 ENSG00000050628 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA on the role of the drug was detected by the RT-PCR,western blotting analysis,bioinformatic technology,RNA isolation experiments,immunofluorescence,cell proliferation assay,apoptosis and cell cycle analysis,wound healing assay,invasion assay,colony formation assay,tube formation assay,chromatin immunoprecipitation assay,serum stability assay,tumor xenograft study,TUNEL assay,IHC analysis. cell lines (HIO180,OC,OVCAR-3, SKOV3-ip1, HeyA8, A2780-PAR,OVCAR-5,SKOV3-TR, HeyA8-MDR,A2780-CP20) up-regulated resistant NA Ras-ETS1-ELK1 pathway validated NA mRNA and protein overexpression related 1241 Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells Oncol Rep 2011 21165561 BSG ENSG00000172270 laryngeal_ancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA was proved by the qRT-PCR,western blotting analysis,iRNA interference experiments,cell proliferation assay,gelatin zymography,cell invasion assay. cell line (Hep2 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1242 TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian cancer J Exp Clin Cancer Res 2012 22248469 TGFBI ENSG00000120708 ovarian_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The methylation status of TGFBI was examined in ovarian_ancer_nd control groups by methylation-specific PCR (MSP) and bisulfite sequencing PCR (BSP). The TGFBI expression and cell viability were compared by Quantitative Real-Time PCR, Western Blotting and MTT assay before and after demethylating agent 5-aza-2'-deoxycytidine (5-aza-dc) treatment in 6 cell lines cell lines (SKOV3, SKOV3/TR, SKOV3/DDP, A2780, 2780/TR, OVCAR8) and patients tissues down-regulated resistant NA NA validated NA promoter hypermethylation related 1243 Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis Mol Med Rep 2018 29512712 COL4A1 ENSG00000187498 gastric cancer Trastuzumab DB00072 (BTD00098, BIOD00098) Bioinformatics analysis The role of the expression of the mRNA was revealed by the bioinformatics analysis and iRNA interference experiments. NA up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1244 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway Cancer Res 2016 27013200 RECQL4 ENSG00000160957 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,immunohistochemistry,MTT assay,dual luciferase assay. cell lines (HEK293, AGS, NCI-N87, SNU-1, SNU-16, MKN45, HGC-27) and patients tissues up-regulated resistant YB1 AKT-YB1-MDR1 Signaling Pathway validated NA mRNA and protein overexpression related 1245 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway Cancer Res 2016 27013200 YB1 ENSG00000065978 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,immunohistochemistry,MTT assay,dual luciferase assay. cell lines (HEK293, AGS, NCI-N87, SNU-1, SNU-16, MKN45, HGC-27) and patients tissues NA resistant MDR1 AKT-YB1-MDR2 Signaling Pathway validated NA gene phosphorylation related 1246 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway Cancer Res 2016 27013200 MDR1 ENSG00000085563 gastric cancer Cisplatin DB00515 (APRD00359) RT-PCR The role of the mRNA was detected by the RT-PCR,immunohistochemistry,MTT assay,dual luciferase assay. cell lines (HEK293, AGS, NCI-N87, SNU-1, SNU-16, MKN45, HGC-27) and patients tissues up-regulated resistant NA AKT-YB1-MDR3 Signaling Pathway validated NA mRNA and protein overexpression related 1247 Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells World J Gastroenterol 2012 22408359 IL8 ENSG00000169429 gastric cancer Oxaliplatin DB00526 (APRD00186) RT-PCR The IL-8 cDNA was stably transfected into human GC cell line MKN-45 and selected IL-8-secreting transfectants. The expression of IL-8 in human GC cell line KATO-III was inhibited by_NA_nterference. The expressions of_RNA_nd protein of IL-8 in GC cells were detected by real-time reverse transcription-polymerase chain reaction or enzyme-linked immunosorbent assay (ELISA). cell lines (MKN-45, KATO-III, HUVECs) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1248 FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy Mol Oncol 2018 29633504 FBXW7 ENSG00000109670 lung cancer Gefitinib DB00317 (APRD00997, DB07998) NA The role of the mRNA expression was detected by the western blotting analysis,iRNA interference experiments,motility and invasion assay,wound-healing assay,cell viability assay,MTT. cell lines (PC9, H1299) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1249 Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin Int J Cancer 2009 19598262 ANXA4 ENSG00000196975 ovarian_ancer Carboplatin DB00958 (APRD00466) RT-PCR Enhanced expression of Annexin A4 (Anx A4) was identified in ovarian CCC cells using 2-D differential gel electrophoresis (2D-DIGE) and mass spectrometry. Anx A4 levels were elevated in CCC cells compared with non-CCC cells as determined by real-time RT-PCR and Western blot analysis. Immunohistochemical analysis of Anx A4 was performed in 126 epithelial ovarian cancer tissue samples and demonstrated significantly elevated levels of Anx A4 protein levels in ovarian CCC tumors compared with ovarian serous and endometrioid tumors . Anx A4-transfected ovarian non-CCC cells were more resistant to carboplatin compared with control cells as determined by modified MTT assay cell lines (OVISE, OVTOKO, OVMANA, RMG-1, SAC, OVSAHO, OVKATE) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1250 Establishment of an adriamycin-resistant subline of human small cell lung cancer showing multifactorial mechanisms of resistance Acta Med Okayama 1993 8104372 MDR1 ENSG00000085563 lung cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) Northern blot The expression of the mRNA was detected by the northern blotting analysis.The sensitivity of the drug was detected by the MTT. cell lines (SBC-3, SBC-3/ADM100) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1251 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827, NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 1252 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Cisplatin DB00515 (APRD00359) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827, NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 1253 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Docetaxel DB01248 (APRD00932) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827, NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 1254 Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity Oncotarget 2014 25356753 FOXQ1 ENSG00000164379 lung cancer Pemetrexed DB00642 (APRD00573, EXPT02075) qRT-PCR The role of the mRNA expression on the sensitivity of the drug was detected by the qRT-PCR,western blotting analysis,SiRNA transfection study,cell proliferation assays,tumor tissue microarray (TMA) and immunohistochemistry (IHC) staining, tumor xenograft studys. cell lines (A549, SPC-A-1, HCC827, NCI-H1395) up-regulated resistant NA EMT_ransition pathway validated NA mRNA and protein overexpression related 1255 The efficacy of cisplatin on nasopharyngeal carcinoma cells may be increased via the downregulation of fibroblast growth factor receptor 2 Int J Mol Med 2019 31115494 FGFR2 ENSG00000066468 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) qRT-PCR The downregulation of FGFR2 was achieved by transfection with a small interfering RNA against FGFR2. Tissues of patients with NPC were analyzed by immunohistochemistry. Cell viability was examined using a Cell Counting Kit_8 assay. Cell cycle analysis was performed using flow cytometry. mRNA and protein levels were measured by reverse transcription quantitative polymerase chain reaction and western blot analysis, respectively cell lines ( SUNE1, C666_1, 6_10B, HNE_3 ) down-regulated sensitive NA apoptotic pathway validated NA mRNA and protein low expression related 1256 FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition Hepatobiliary Pancreat Dis Int 2014 24686546 FBW7 ENSG00000109670 hepatocellular carcinoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The cell viability was evaluated by cell counting kit-8, and FBW7 mRNA transcription and protein expression were quantitated by real-time PCR and Western blotting. Expressions of vimentin (mesenchymal biomarker) and E-cadherin (epithelial biomarker) were evaluated by Western blotting and immunocytochemistry. Cell invasion was assayed by Transwell migration, and FBW7 plasmid or siRNA was used to evaluate the effect of FBW7 overexpression or silencing on cell chemosensitivity. cell lines (Hep3B, Huh-7 and SNU-449) up-regulated sensitive NA EMT_ransition pathway validated NA mRNA and protein overexpression related 1257 Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro Acta Biochim Biophys Sin (Shanghai) 2013 23419720 MST1 ENSG00000173531 hepatocellular carcinoma Cisplatin DB00563 (APRD00353) qRT-PCR The role of MST1 expression was determined by qRT-PCR,western blot analysis,apoptosis assay,hoechst 33342 staining,cell proliferation analysis. cell lines (HepGw2) up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 1258 Silencing HO-1 sensitizes SKM-1 cells to apoptosis induced by low concentration 5-azacytidine through enhancing p16 demethylation Int J Oncol 2015 25585641 HO1 ENSG00000100292 myelodysplastic syndrome 5-azacytidine DB00928 (APRD00809) RT-PCR Cell growth was evaluated by MTT assay; cell cycle and apoptosis were detected by flow cytometry;_RNA_xpression was assessed by real-time PCR, protein expression was analyzed through western blotting. Methylation was assessed by MSP. The survival time, and weight of mice were recorded. cell line (SKM-1) down-regulated sensitive P16 NA validated NA mRNA and protein low expression related 1259 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma J Exp Clin Cancer Res 2019 30621723 ARNTL ENSG00000133794 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) RT-PCR We employed bisulfite pyrosequencing to determine the epigenetic change of ARNTL in NPC cell lines and tissues. ARNTL_RNA_nd protein expression in cell lines and tissues were detected by real-time PCR and western blotting. Then, we constructed cell lines overexpressing ARNTL and knocked down ARNTL to explore its function and effect on chemotherapy sensitivity of NPC cell lines to cisplatin in vitro and vivo. Finally, we investigated the potential molecular mechanism of ARNTL by gene set enrichment analysis (GSEA), dual Luciferase reporter assay and chromatin immunoprecipitation assay. cell lines (CNE1, CNE2, SUNE1, HONE1, HNE1, 5-8F, 6-10B, NP69) down-regulated resistant CDK5 NA validated NA promoter hypermethylation related 1260 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma J Exp Clin Cancer Res 2019 30621723 CDK5 ENSG00000164885 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) RT-PCR We employed bisulfite pyrosequencing to determine the epigenetic change of ARNTL in NPC cell lines and tissues. ARNTL_RNA_nd protein expression in cell lines and tissues were detected by real-time PCR and western blotting. Then, we constructed cell lines overexpressing ARNTL and knocked down ARNTL to explore its function and effect on chemotherapy sensitivity of NPC cell lines to cisplatin in vitro and vivo. Finally, we investigated the potential molecular mechanism of ARNTL by gene set enrichment analysis (GSEA), dual Luciferase reporter assay and chromatin immunoprecipitation assay. cell lines (CNE1, CNE2, SUNE1, HONE1, HNE1, 5-8F, 6-10B, NP69) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1261 XAF1 mRNA expression improves progression-free and overall survival for patients with advanced bladder cancer treated with neoadjuvant chemotherapy Urol Oncol 2009 18555708 XAF1 ENSG00000132530 bladder_ancer Cisplatin DB00515 (APRD00359) qRT-PCR Gene expression was analyzed by a real-time quantitative PCR method in paired samples from 14 bladder_ancer_atients treated with a combination of neoadjuvant gemcitabine and cisplatin. The prognostic significance of XAF1 and XIAP_RNA_xpression as well as the correlation with several clinical and pathological findings were evaluated. cell lines and patients tissues up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 1262 XAF1 mRNA expression improves progression-free and overall survival for patients with advanced bladder cancer treated with neoadjuvant chemotherapy Urol Oncol 2009 18555708 XAF1 ENSG00000132530 bladder_ancer Gemcitabine DB00441 (APRD00201) qRT-PCR Gene expression was analyzed by a real-time quantitative PCR method in paired samples from 14 bladder_ancer_atients treated with a combination of neoadjuvant gemcitabine and cisplatin. The prognostic significance of XAF1 and XIAP_RNA_xpression as well as the correlation with several clinical and pathological findings were evaluated. cell lines and patients tissues up-regulated sensitive NA NA validated NA mRNA and protein overexpression related 1263 The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase Cancer Res 2009 19487279 HUR ENSG00000066044 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR The role of the mRNA was detected by the RT-PCR,immunoblot,immunofluorescence,drug sensitivity assay,case selection and immunohistochemistry. cell lines (MiaPaca2, PL-5, Hs766t) up-regulated sensitive NA HUR signaling pathway validated NA mRNA and protein overexpression related 1264 Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy Langenbecks Arch Surg 2016 26691217 CELF2 ENSG00000048740 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR Expression of CUGBP2 was evaluated using qRT-PCR and Western blot methods. Cell viability after treatment with GEM and/or curcumin and siCUGBP2 was evaluated using MTT and crystal violet tests. RNA immunoprecipitation analysis was used to confirm COX-2 and HO-1 post-transcriptional regulation by CUGBP2 protein. cell lines (MiaPaCa-2, Su.86.86, Capan-1) up-regulated sensitive NA CUGBP2 signaling pathway validated NA mRNA and protein overexpression related 1265 CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells Oncol Rep 2012 22427101 BSG ENSG00000172270 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of the mRNA expression on the drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell invision assay,cell metastasis assay. cell line (Panc-1) down-regulated sensitive NA CD147 signaling pathway validated NA mRNA and protein low expression related 1266 Absence of Bcl-xL down-regulation in response to cisplatin is associated with chemoresistance in ovarian carcinoma cells Gynecol Oncol 2007 17275076 BCLXL ENSG00000171552 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The expression of the mRNA was detected by the RT-PCR,nuclear staining with DAPI,flow cytometry,western blotting analysis,iRNA transfection experiments. cell lines (IGROV1, OAW42, IGROV1-R10, SKOV3) down-regulated sensitive NA apoptotic pathway validated NA mRNA and protein low expression related 1267 Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma Head Neck 2009 19107951 AURKA ENSG00000087586 head and neck_ancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RT-PCR The expression of the AURKA mRNA and protein were detected by reverse transcriptase-polymerase chain reaction and Western blot analysis. Tumor cells treated with paclitaxel were assessed for cell proliferation by MTT assay and for cell cycle distribution by flow cytometry cell lines (Tu138, UMSCC1, Tu167, OSC19, Tu177 and JMAR£© down-regulated sensitive NA NA validated NA mRNA and protein low expression related 1268 Insulin receptor substrate-1 is an important mediator of ovarian cancer cell growth suppression by all-trans retinoic acid Cancer Res 2007 17909034 IRS1 ENSG00000169047 ovarian_ancer All-trans retinoic acid (ATRA) DB00755 (NUTR00051, APRD00362) RT-PCR The expression levels of IRS1 were determined by RT-PCR and Western blotting,immunoprecipitation,Protein stability assay,Immunohistochemistry of ovarian cancer tissue arrays. cell lines ( CA-OV3 and SK-OV3) up-regulated resistant NA IGF-I signaling pathway validated NA mRNA and protein overexpression related 1269 Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells Biochem J 2011 21649584 TGIF1 ENSG00000177426 hepatocellular carcinoma Arsenic trioxide DB01169 (APRD00171) RT-PCR The expression levels of TGIF1 were determined by RT-PCR,Western blot analysis,DNA constructs, transient transfection and reporter gene assay,Flow cytometry analysis,In vitro RNA synthesis and biotin-labelled RNA probe pull-down assay,RNA immunoprecipitation. cell lines (HepG2 and Huh7) up-regulated resistant NA EGFR/PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 1270 The human immunodeficiency virus protease inhibitor ritonavir inhibits lung_ancer_ells, in part, by inhibition of survivin J Thorac Oncol 2011 21270666 BIRC5 ENSG00000089685 lung cancer Ritonavir DB00503 (APRD00312) RT-PCR The mRNA and protein of SURVIVIN was detected by RT-PCR,western blot analysis,siRNA Transfection and Cell Survival Assay,MTT analysis,Cell Cycle Analysis,Measurement of Apoptosis. cell lines( A549, H522, H23, H838) up-regulated resistant c-Src/transcription protein 3 apoptotic pathway validated NA mRNA and protein overexpression related 1271 Enhanced S100 calcium-binding protein P expression sensitizes human bladder cancer cells to cisplatin BJU Int 2011 20726978 S100P ENSG00000163993 bladder_ancer Cisplatin DB00515 (APRD00359) Northern blot S100P mRNA and protein expression levels were investigated by northern and western blot analyses, respectively. _ Intracellular S100P localization was examined by immunocytochemistry and immunohistochemistry. _ S100P over-expression, obtained by transfection with S100P expression plasmid, was used to investigate whether or not S100P affected cellular resistance to cisplatin. cell lines (T24, KK47, T24/DDP10, KK47/DDP20) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1272 p8 is a new target of gemcitabine in pancreatic cancer cells Clin Cancer Res 2006 16397047 P8 ENSG00000176046 pancreatic cancer Gemcitabine DB00441 (APRD00201) qRT-PCR The role of P8 was determined by qRT-PCR analysis.The role of gemcitabine on p8 was determined by siRNA transfection experiment,Cell death analysis,DNA analysis by flow cytometry,Cell viability analysis,Caspase-3 activity analysis. cell lines (Panc-1,Mia-PaCa2) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1273 The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression Oncogene 2000 11042697 VDR ENSG00000111424 breast cancer Calcitriol (1-alpha-25-Dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) Northern blot The mRNA and protein was detected and extracted by Northern blot,Western blot analysis, transfection experiment,Analysis of BRCA1 promoter activation. cell lines (LNCaP, TSU-PR-1, BR-20, BT-474 ,PC-3, DU-145, MCF-7, MDAMB-231, MDA-MB-436) down-regulated resistant BRCA1 VDR signaling pathway validated NA mRNA and protein low expression related 1274 The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression Oncogene 2000 11042697 VDR ENSG00000111424 prostate cancer Calcitriol (1-alpha-25-Dihydroxyvitamin D3) DB00136 (NUTR00003, APRD00246, DB05314) Northern blot The mRNA and protein was detected and extracted by Northern blot,Western blot analysis, transfection experiment,Analysis of BRCA1 promoter activation. cell lines (LNCaP, TSU-PR-1, BR-20, BT-474 ,PC-3, DU-145, MCF-7, MDAMB-231, MDA-MB-436) down-regulated resistant BRCA1 VDR signaling pathway validated NA mRNA and protein low expression related 1275 Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells Mol Pharmacol 2013 23229511 AHR ENSG00000106546 lung cancer Tanespimycin(17AAG) DB05134 (DB06398) RT-PCR AhR expression in lung AD cells was modulated by siRNA interference or overexpression. Tumor growth was determined with colony formation in vitro or in vivo. Anticancer activity of 17-AAG was determined by measuring cell viability, cell cycle distribution, and expression of cell cycle regulators. Proteins and mRNA levels were examined by immunoblotting and the real-time reverse transcription-polymerase chain reaction, respectively cell lines (BEAS2B, H1355, CL-5, CL1-5, H1355, BEAS-2B, CL5, CL1-5) up-regulated sensitive NA AHR signaling pathway validated NA mRNA and protein overexpression related 1276 Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells Mol Pharmacol 2013 23229511 NQO1 ENSG00000181019 lung cancer Tanespimycin(17AAG) DB05134 (DB06398) RT-PCR Mrna expression in lung AD cells was modulated by siRNA interference or overexpression. Tumor growth was determined with colony formation in vitro or in vivo. Anticancer activity of 17-AAG was determined by measuring cell viability, cell cycle distribution, and expression of cell cycle regulators. Proteins and mRNA levels were examined by immunoblotting and the real-time reverse transcription-polymerase chain reaction, respectively cell lines (BEAS2B, H1355, CL-5, CL1-5, H1355, BEAS-2B, CL5, CL1-5) up-regulated sensitive NA AHR signaling pathway validated NA mRNA and protein overexpression related 1277 XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma cells Asian Pac J Cancer Prev 2015 25824780 XAF1 ENSG00000132530 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The expression of XAF1 at both mRNA and protein levels was analyzed by reverse transcription-PCR and western blotting.Transwell invasion assays demonstrated that XAF1 exerted a strong anti-invasive effect in XAF1-overexpressing cells. Moreover, flow cytometry analysis revealed that XAF1 overexpression arrested the cell cycle at G0/G1 phase, and cell apoptosis analysis showed that overexpression of XAF1 enhanced apoptosis of SKOV-3 and SKOV-3/DDP cells .MTT assay confirmed a dose-dependent inhibitory effect of cisplatin in the tested tumor cells, and overexpression of XAF1 increased the sensitivity of SKOV-3 and SKOV-3/DDP cells to cisplatin-mediated anti- proliferative effects. cell lines (SKOV-3, SKOV-3/DDP ) down-regulated resistant XIAP NA validated NA mRNA and protein low expression related 1278 XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma cells Asian Pac J Cancer Prev 2015 25824780 XIAP ENSG00000101966 ovarian_ancer Cisplatin DB00515 (APRD00359) RT-PCR The expression of XIAP at both mRNA and protein levels was analyzed by reverse transcription-PCR and western blotting.Transwell invasion assays demonstrated that XAF1 exerted a strong anti-invasive effect in XAF1-overexpressing cells. Moreover, flow cytometry analysis revealed that XAF1 overexpression arrested the cell cycle at G0/G1 phase, and cell apoptosis analysis showed that overexpression of XAF1 enhanced apoptosis of SKOV-3 and SKOV-3/DDP cells .MTT assay confirmed a dose-dependent inhibitory effect of cisplatin in the tested tumor cells, and overexpression of XAF1 increased the sensitivity of SKOV-3 and SKOV-3/DDP cells to cisplatin-mediated anti- proliferative effects. cell lines (SKOV-3, SKOV-3/DDP ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1279 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma J Exp Clin Cancer Res 2019 30621723 ARNTL ENSG00000133794 nasopharyngeal_arcinoma Cisplatin DB00515 (APRD00359) RT-PCR ARNTL mRNA and protein expression in cell lines and tissues were detected by real-time PCR and western blotting. Then, we constructed cell lines overexpressing ARNTL and knocked down ARNTL to explore its function and effect on chemotherapy sensitivity of NPC cell lines to cisplatin in vitro and vivo. Finally, we investigated the potential molecular mechanism of ARNTL by gene set enrichment analysis (GSEA), dual Luciferase reporter assay and chromatin immunoprecipitation assay. cell lines (CNE1, CNE2, SUNE1, HONE1, HNE1, 5-8F, 6-10B) and patients tissues down-regulated resistant CDK5 NA validated NA promoter hypermethylation related 1280 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 C6orf106 ENSG00000196821 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1281 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CDC7 ENSG00000097046 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1282 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CUL9 ENSG00000112659 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1283 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 FN1 ENSG00000115414 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1284 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 LARP4 ENSG00000161813 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1285 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ANAPC5 ENSG00000089053 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1286 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BAG6 ENSG00000204463 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1287 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BBC3 ENSG00000105327 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1288 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ABCB1 ENSG00000085563 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1289 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 COMMD1 ENSG00000173163 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1290 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 AKR1C2 ENSG00000151632 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1291 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 IFI27 ENSG00000165949 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1292 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TRAF3IP2 ENSG00000056972 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1293 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ALK ENSG00000171094 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1294 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SELENBP1 ENSG00000143416 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1295 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TMEM119 ENSG00000183160 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1296 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 NKD2 ENSG00000145506 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1297 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SUPT20H ENSG00000102710 osteosarcoma Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1298 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 C6orf106 ENSG00000196821 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1299 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CDC7 ENSG00000097046 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1300 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CUL9 ENSG00000112659 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1301 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 FN1 ENSG00000115414 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1302 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 LARP4 ENSG00000161813 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1303 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ANAPC5 ENSG00000089053 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1304 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BAG6 ENSG00000204463 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1305 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BBC3 ENSG00000105327 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1306 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ABCB1 ENSG00000085563 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1307 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 COMMD1 ENSG00000173163 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1308 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 AKR1C2 ENSG00000151632 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1309 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 IFI27 ENSG00000165949 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1310 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TRAF3IP2 ENSG00000056972 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1311 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ALK ENSG00000171094 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1312 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SELENBP1 ENSG00000143416 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1313 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TMEM119 ENSG00000183160 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1314 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 NKD2 ENSG00000145506 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1315 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SUPT20H ENSG00000102710 osteosarcoma Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1316 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 C6orf106 ENSG00000196821 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1317 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CDC7 ENSG00000097046 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1318 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 CUL9 ENSG00000112659 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1319 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 FN1 ENSG00000115414 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1320 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 LARP4 ENSG00000161813 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1321 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ANAPC5 ENSG00000089053 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1322 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BAG6 ENSG00000204463 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1323 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 BBC3 ENSG00000105327 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1324 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ABCB1 ENSG00000085563 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1325 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 COMMD1 ENSG00000173163 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1326 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 AKR1C2 ENSG00000151632 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1327 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 IFI27 ENSG00000165949 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1328 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TRAF3IP2 ENSG00000056972 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1329 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 ALK ENSG00000171094 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1330 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SELENBP1 ENSG00000143416 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1331 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 TMEM119 ENSG00000183160 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1332 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 NKD2 ENSG00000145506 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1333 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance Mol Ther 2019 30692017 SUPT20H ENSG00000102710 osteosarcoma Methotrexate DB00563 (APRD00353) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing technology. The expression pattern was validated by the RT-PCR,CCK-8 assay, GO and Pathway analysis,bioinformatics technology,cell transfection technology,western blotting analysis,RNA immunoprecipitation assays. cell lines (MG63, KHOS, U2OS) and patients tissues down-regulated resistant NA NA validated NA mRNA and protein low expression related 1334 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 SYT1 ENSG00000067715 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1335 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 FAM171B ENSG00000144369 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1336 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 ZNF331 ENSG00000130844 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1337 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 FAM187B ENSG00000177558 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1338 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 CYP1A1 ENSG00000140465 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1339 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 OAS2 ENSG00000111335 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1340 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 PRR15L ENSG00000167183 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1341 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 C10orf105 ENSG00000214688 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1342 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 IFI6 ENSG00000126709 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1343 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 HIST1H4E ENSG00000276966 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1344 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 NOL4 ENSG00000101746 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1345 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 C3AR1 ENSG00000171860 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1346 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 C9orf150 ENSG00000153714 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1347 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 CXCR2 ENSG00000180871 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1348 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 RAB2B ENSG00000129472 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1349 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 SRXN1 ENSG00000271303 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1350 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 HIST1H2BL ENSG00000185130 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1351 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 TOMM40L ENSG00000158882 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1352 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 SPP1 ENSG00000118785 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1353 Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling Int J Clin Exp Pathol 2015 25755691 KRT6B ENSG00000185479 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR and bioinformatics technology The relationship between the mRNA expression and the drug sensitivity was detected by the RT-PCR,GO analysis and Pathway analysis, cell lines (SW1990 ) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1354 Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma Oxid Med Cell Longev 2020 32215178 GPX2 ENSG00000176153 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,qRT-PCR,western blotting analysis,lentivirus Infection experiments,cell viability and proliferation analysis,bioinformatics technology,immunohistochemistry. cell lines (A549) up-regulated resistant ABCB6 NA validated NA mRNA and protein overexpression related 1355 Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma Oxid Med Cell Longev 2020 32215178 ABCB6 ENSG00000115657 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,qRT-PCR,western blotting analysis,lentivirus Infection experiments,cell viability and proliferation analysis,bioinformatics technology,immunohistochemistry. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1356 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HIST1H4H ENSG00000158406 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1357 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RELN ENSG00000189056 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1358 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARHGAP9 ENSG00000123329 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1359 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RGS6 ENSG00000182732 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1360 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CNTN2 ENSG00000184144 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1361 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DLEU7 ENSG00000186047 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1362 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MAP2 ENSG00000078018 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1363 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MYOG ENSG00000122180 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1364 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CA7 ENSG00000168748 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1365 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PKIA ENSG00000171033 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1366 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 LOX ENSG00000113083 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1367 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE40 ENSG00000134107 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1368 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAB17 ENSG00000124839 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1369 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CDC42EP1 ENSG00000128283 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1370 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 TMEM45A ENSG00000181458 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1371 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE41 ENSG00000123095 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1372 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAMP1 ENSG00000132329 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1373 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HSPA6 ENSG00000173110 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1374 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PLOD2 ENSG00000152952 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1375 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DUOX2 ENSG00000140279 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1376 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARFGEF3 ENSG00000112379 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1377 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 NRN1 ENSG00000124785 retinoblastoma Etoposide DB00773 (APRD00239) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1378 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HIST1H4H ENSG00000158406 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1379 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RELN ENSG00000189056 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1380 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARHGAP9 ENSG00000123329 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1381 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RGS6 ENSG00000182732 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1382 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CNTN2 ENSG00000184144 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1383 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DLEU7 ENSG00000186047 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1384 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MAP2 ENSG00000078018 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1385 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MYOG ENSG00000122180 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1386 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CA7 ENSG00000168748 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1387 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PKIA ENSG00000171033 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1388 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 LOX ENSG00000113083 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1389 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE40 ENSG00000134107 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1390 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAB17 ENSG00000124839 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1391 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CDC42EP1 ENSG00000128283 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1392 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 TMEM45A ENSG00000181458 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1393 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE41 ENSG00000123095 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1394 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAMP1 ENSG00000132329 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1395 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HSPA6 ENSG00000173110 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1396 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PLOD2 ENSG00000152952 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1397 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DUOX2 ENSG00000140279 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1398 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARFGEF3 ENSG00000112379 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1399 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 NRN1 ENSG00000124785 retinoblastoma Carboplatin DB00958 (APRD00466) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1400 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HIST1H4H ENSG00000158406 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1401 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RELN ENSG00000189056 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1402 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARHGAP9 ENSG00000123329 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1403 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RGS6 ENSG00000182732 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1404 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CNTN2 ENSG00000184144 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1405 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DLEU7 ENSG00000186047 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1406 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MAP2 ENSG00000078018 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1407 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 MYOG ENSG00000122180 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1408 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CA7 ENSG00000168748 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) down-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein low expression related 1409 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PKIA ENSG00000171033 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1410 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 LOX ENSG00000113083 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1411 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE40 ENSG00000134107 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1412 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAB17 ENSG00000124839 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1413 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 CDC42EP1 ENSG00000128283 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1414 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 TMEM45A ENSG00000181458 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1415 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 BHLHE41 ENSG00000123095 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1416 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 RAMP1 ENSG00000132329 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1417 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 HSPA6 ENSG00000173110 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1418 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 PLOD2 ENSG00000152952 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1419 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 DUOX2 ENSG00000140279 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1420 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 ARFGEF3 ENSG00000112379 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1421 Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism BMC Ophthalmol 2020 32143590 NRN1 ENSG00000124785 retinoblastoma Vincristine DB00541 (APRD00495) RNA sequencing Y79/EDR and parental Y79 cells were used for RNAseq and bioinformatics_nalysis_o enable a_enome-wide review of DEGs between the two lines using the DESeq R package (1.10.1). Then, DEG enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was analyzed with KOBAS software. Next, real-time quantitative reverse transcription polymerase chain reaction (real time QRT-PCR) and cytotoxicity assays were performed to experimentally and functionally validate the identified candidate biomarkers. cell lines (Y79) up-regulated resistant NA PI3K-AKT signaling pathway validated NA mRNA and protein overexpression related 1422 Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer Oncogene 2020 32015486 ALDH1A3 ENSG00000184254 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA and drug sensitivity was detected by the cell viability assays,immublotting,siRNA and shRNA experiments analysis,bioinformatic technology. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1423 Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer Oncogene 2020 32015486 ALDH3A1 ENSG00000108602 lung cancer Cisplatin DB00515 (APRD00359) RNA sequencing The relationship between the mRNA and drug sensitivity was detected by the cell viability assays,immublotting,siRNA and shRNA experiments analysis,bioinformatic technology. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1424 Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer Oncogene 2020 32015486 ALDH1A1 ENSG00000165092 lung cancer Cisplatin DB00515 (APRD00360) RNA sequencing The relationship between the mRNA and drug sensitivity was detected by the cell viability assays,immublotting,siRNA and shRNA experiments analysis,bioinformatic technology. cell lines up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1425 Aberrant HER3 ligand heregulin-expressing head and neck squamous cell carcinoma is resistant to anti-EGFR antibody cetuximab, but not second-generation EGFR-TKI Oncogenesis 2019 31570699 NRG1 ENSG00000157168 head and neck_ancer Cetuximab DB00002 (BTD00071, BIOD00071) RT-PCR The relationship between the mRNA and drug sensitivity was detected by the RT-PCR,ISH,western blotting analysis,growth inhibition assay,comprehensive transcriptome analysis,siRNA transfection experiments. cell lines (FaDuCR ,FaDu) up-regulated resistant HER3/Akt Akt signaling pathway validated NA mRNA and protein overexpression related 1426 Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelialmesenchymal transition Mol Med Rep 2019 31485652 SMAD4 ENSG00000141646 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) qRT-PCR A total of 629 colorectal adenocarcinoma cases were downloaded from The Cancer_enome_tlas (TCGA) database, and a Smad4 mutation rate of_21% was demonstrated among the cases. Low expression of Smad4 was present in CRC tissues analyzed by TCGA and in four CRC cell lines, as determined by reverse transcription_quantitative PCR (RT_qPCR) and western blot_nalysis. Cell Counting kit_8(CCK_8) was used to measure the effects of different concentrations of cetuximab on SW480 cell viability at 24 and 48_. cell lines (SW480 ) down-regulated resistant NA NA validated mutation NA related 1427 MiR-181a Promotes Apoptosis and Reduces Cisplatin Resistance by Inhibiting Osteopontin in Cervical Cancer Cells Cancer Biother Radiopharm 2019 31436472 SPP1 ENSG00000118785 cervical_ancer Cisplatin DB00515 (APRD00360) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by qRT-PCR,western blotting analysis,cell proliferation detection,cell apoptosis analysis,cell transfection experiments,dual luciferase reporter gene assay. cell lines (CaSki) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1428 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 IGFL1 ENSG00000188293 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1429 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FOXL1 ENSG00000176678 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1430 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 LMO7 ENSG00000136153 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1431 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 HAS2 ENSG00000170961 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1432 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 PCP4 ENSG00000183036 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1433 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 MX1 ENSG00000157601 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1434 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ZBED2 ENSG00000177494 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1435 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FYN ENSG00000010810 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1436 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 HUNK ENSG00000142149 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1437 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 MX2 ENSG00000183486 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1438 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 APOH ENSG00000091583 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1439 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ALB ENSG00000163631 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1440 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 APOB ENSG00000084674 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1441 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 PLG ENSG00000122194 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1442 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FREM1 ENSG00000164946 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1443 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ALDOB ENSG00000136872 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1444 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 FGB ENSG00000171564 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1445 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 ITIH2 ENSG00000151655 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1446 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 SERPINC1 ENSG00000117601 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1447 Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis Cancer Med 2019 30848094 TF ENSG00000091513 colorectal cancer Cetuximab DB00002 (BTD00071, BIOD00071) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing analysis,qRT-PCR,cell viability assay,bioinformatics technology,flow cytometry analysis,cell transfection and treatment experiments,RNA_FISH technology cell lines (NCI_H508) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1448 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 APOBEC3G ENSG00000239713 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1449 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 6-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 ANKRD1 ENSG00000148677 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1450 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 7-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 LCN2 ENSG00000148346 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1451 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 8-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PTHLH ENSG00000087494 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1452 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 9-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 IGFBP3 ENSG00000146674 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1453 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 10-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 ZMAT1 ENSG00000166432 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1454 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 11-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 SAA1 ENSG00000173432 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1455 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 12-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 FOXQ1 ENSG00000164379 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1456 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 13-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PLEKHS1 ENSG00000148735 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1457 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 14-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PMEPA1 ENSG00000124225 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1458 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 15-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 NUP98 ENSG00000110713 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1459 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 16-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 RPS4Y1 ENSG00000129824 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1460 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 17-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 DERL3 ENSG00000099958 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1461 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 18-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 TNK1 ENSG00000174292 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1462 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 19-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 TEC ENSG00000135605 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1463 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 20-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PET100 ENSG00000229833 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1464 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 21-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 MED22 ENSG00000148297 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1465 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 22-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 PCDH7 ENSG00000169851 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1466 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 23-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 C2orf56 ENSG00000253499 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1467 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 24-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 C7orf65 ENSG00000221845 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1468 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 25-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 HOXB5 ENSG00000120075 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1469 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 26-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 HOXB6 ENSG00000108511 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1470 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 27-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 KLK1 ENSG00000167748 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1471 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 28-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 KLK5 ENSG00000167754 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1472 Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 29-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells Asian Pac J Cancer Prev 2015 25921151 KLK6 ENSG00000167755 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) qRT-PCR The relationship between the mRNA and the drug sensitivity was detected by the qRT-PCR,RNA labeling and microarray hybridization,colony formation assay,bioinformatics technology. cell lines (HCT116) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1473 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 IL18 ENSG00000150782 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1474 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF93 ENSG00000184635 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1475 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 MTAP ENSG00000099810 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1476 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF254 ENSG00000213096 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1477 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 SOX2 ENSG00000181449 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1478 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF765 ENSG00000196417 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1479 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF845 ENSG00000213799 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1480 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF611 ENSG00000213020 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1481 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 GPR160 ENSG00000173890 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1482 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 ZNF675 ENSG00000197372 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1483 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 TFPI2 ENSG00000105825 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1484 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 BAALC ENSG00000164929 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1485 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 DPP4 ENSG00000197635 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1486 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 AHR ENSG00000106546 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1487 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 KYNU ENSG00000115919 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1488 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 BDKRB1 ENSG00000100739 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1489 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 FOXD1 ENSG00000251493 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1490 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 EREG ENSG00000124882 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1491 Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells Int J Oncol 2017 28714520 DCN ENSG00000011465 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA and drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell survival assay,GO and KEGG bioinformatics technology,enzyme-linked immunosorbent assay,immunofluorescence staining technology. cell lines (U87, U251) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1492 The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 BMP4 ENSG00000125378 lung cancer Cisplatin DB00515 (APRD00359) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 1493 The noncoding RNA expression profile and the effect of lncRNA AK126699 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 CTSB ENSG00000164733 lung cancer Cisplatin DB00515 (APRD00360) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 1494 The noncoding RNA expression profile and the effect of lncRNA AK126700 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 NKD2 ENSG00000145506 lung cancer Cisplatin DB00515 (APRD00361) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 1495 The noncoding RNA expression profile and the effect of lncRNA AK126701 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 BAG1 ENSG00000107262 lung cancer Cisplatin DB00515 (APRD00362) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 1496 The noncoding RNA expression profile and the effect of lncRNA AK126702 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 TGFB1 ENSG00000105329 lung cancer Cisplatin DB00515 (APRD00363) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 1497 The noncoding RNA expression profile and the effect of lncRNA AK126703 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 EGFR ENSG00000146648 lung cancer Cisplatin DB00515 (APRD00364) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 1498 The noncoding RNA expression profile and the effect of lncRNA AK126704 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 JUN ENSG00000177606 lung cancer Cisplatin DB00515 (APRD00365) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) up-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein overexpression related 1499 The noncoding RNA expression profile and the effect of lncRNA AK126705 on cisplatin resistance in non-small-cell lung cancer cell PLoS One 2013 23741487 CUL2 ENSG00000108094 lung cancer Cisplatin DB00515 (APRD00366) RT-PCR Microarray expression profiling of mRNAs was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and ¦Â-catenin was assessed by realtime RT-PCR and western blot analysis. cell lines (A549) down-regulated resistant NA Wnt/beta-catenin signaling pathway validated NA mRNA and protein low expression related 1500 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB1 ENSG00000085563 ovarian cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK8 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1501 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB4 ENSG00000005471 ovarian cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK9 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1502 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCC3 ENSG00000108846 ovarian cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK10 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1503 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCG2 ENSG00000118777 ovarian cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK11 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1504 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB1 ENSG00000085563 ovarian cancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK12 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1505 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB4 ENSG00000005471 ovarian cancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK13 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1506 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCC3 ENSG00000108846 ovarian cancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK14 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1507 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCG2 ENSG00000118777 ovarian cancer Cisplatin DB00515 (APRD00359) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK15 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1508 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB1 ENSG00000085563 ovarian cancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK16 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1509 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCB4 ENSG00000005471 ovarian cancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK17 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1510 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCC3 ENSG00000108846 ovarian cancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK18 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1511 Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells J Cell Physiol 2018 29219179 ABCG2 ENSG00000118777 ovarian cancer Epirubicin DB00445 (APRD00361) RNA sequencing & qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the RNA sequencing,RT-PCR,CCK19 assay,bioinformatics technology. cell lines (A2780) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1512 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 USF2 ENSG00000105698 lung cancer Cisplatin DB00515 (APRD00366) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1513 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 EFTUD2 ENSG00000108883 lung cancer Cisplatin DB00515 (APRD00367) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1514 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 TTC39C ENSG00000168234 lung cancer Cisplatin DB00515 (APRD00368) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1515 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 ZNF836 ENSG00000196267 lung cancer Cisplatin DB00515 (APRD00369) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1516 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 CPA4 ENSG00000128510 lung cancer Cisplatin DB00515 (APRD00370) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1517 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 SNX24 ENSG00000064652 lung cancer Cisplatin DB00515 (APRD00371) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1518 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 TUBD1 ENSG00000108423 lung cancer Cisplatin DB00515 (APRD00372) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1519 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 PAFAH1B3 ENSG00000079462 lung cancer Cisplatin DB00515 (APRD00373) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1520 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 TACC3 ENSG00000013810 lung cancer Cisplatin DB00515 (APRD00374) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1521 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 QKI ENSG00000112531 lung cancer Cisplatin DB00515 (APRD00375) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1522 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 SHISAL2A ENSG00000182183 lung cancer Cisplatin DB00515 (APRD00376) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1523 Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma Biomed Res Int 2017 29279851 DIAPH2 ENSG00000147202 lung cancer Cisplatin DB00515 (APRD00376) qRT-PCR The relationship between the mRNA expression and the drug sensitivitiy was detected by the bioinformatics technology,qRT-PCR,iRNA transfection experiments,CCK-8 assays. cell lines (A549) down-regulated resistant NA NA validated NA mRNA and protein low expression related 1524 Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis Sci Rep 2014 24919120 PHF6 ENSG00000156531 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the mRNA expression and the drug sensitivity was detected by the qRT-PCR,western blotting analysis,cell viability assay,mirConnX bioinformatic technology. cell lines (Hs683, U87 and LNZ308 ) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1525 The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells Neuro Oncol 2013 23258843 ALKBH2 ENSG00000189046 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR ALKBH2 expression in GBM cell lines and in human GBM was determined by quantitative real-time PCR (qRT-PCR) and gene expression analysis, respectively. Drug sensitivity was assessed in GBM cells overexpressing ALKBH2 and in cells in which ALKBH2 expression was silenced by small-interfering (si)RNA. ALKBH2 expression following activation of the p53 pathway was examined by western blotting and qRT-PCR. cell lines (A172, CCF-STTG1, D37, GaMg, HF66, LN18, LN229, T98, U87, U118 and U251) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1526 Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level Oncotarget 2015 25595896 PTCH1 ENSG00000185920 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the computational studies, real-time PCR, reporter gene studies, western blots, target protector oligos and ectopic expression. cell lines down-regulated resistant MiR-9 SHH signaling pathway validated NA mRNA and protein low expression related 1527 Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance J Neurooncol 2010 20443131 CD74 ENSG00000019582 glioblastoma Temozolomide DB00853 (APRD00557) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,qRT-PCR,western blotting analysis,shRNA transfection experiments,immunohistochemistry. cell lines and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1528 FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51 Clin Cancer Res 2012 22977194 FOXM1 ENSG00000111206 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,western blotting analysis,immunofluorescence staining,immunohistochemical analysis,ChIP assay,promoter reporters and dual-luciferase assay,colony formation assays,flow cytometry analysis. cell lines (U87 ) and patients tissues up-regulated resistant RAD51 NA validated NA mRNA and protein overexpression related 1529 FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51 Clin Cancer Res 2012 22977194 RAD51 ENSG00000051180 glioblastoma Temozolomide DB00853 (APRD00557) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,western blotting analysis,immunofluorescence staining,immunohistochemical analysis,ChIP assay,promoter reporters and dual-luciferase assay,colony formation assays,flow cytometry analysis. cell lines (U87 ) and patients tissues up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1530 Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma Biochem Biophys Res Commun 2018 29366782 MSH6 ENSG00000116062 glioblastoma Temozolomide DB00853 (APRD00557) Bioinformatics analysis The relationship between the drug sensitivity and the mRNA expression was detected by the western blotting analysis,TCGA data analysis,cell viability assays. cell lines (LN18) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1531 Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing DNA Cell Biol 2018 30113217 RAB3D ENSG00000105514 pancreatic cancer Gemcitabine DB00441 (APRD00201) RNA sequencing & qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,qRT-PCR,GO&KEGG database analysis. cell lines (SW1990) up-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein overexpression related 1532 Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing DNA Cell Biol 2018 30113217 DDX17 ENSG00000100201 pancreatic cancer Gemcitabine DB00441 (APRD00201) RNA sequencing & qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,qRT-PCR,GO&KEGG database analysis. cell lines (SW1990) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1533 Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing DNA Cell Biol 2018 30113217 SPNS2 ENSG00000183018 pancreatic cancer Gemcitabine DB00441 (APRD00201) RNA sequencing & qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,qRT-PCR,GO&KEGG database analysis. cell lines (SW1990) up-regulated resistant NA NA validated NA mRNA and protein overexpression related 1534 Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway Mol Carcinog 2017 28767179 ST6GALNAC2 ENSG00000070731 colorectal cancer 5-Fluorouracil DB00544 (APRD00516, EXPT03204) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,western blotting analysis,shRNA interference experiments,cell viability assay,colony formation assays,apoptosis analysis,immunohistochemistry staining,immunofluorescence staining. cell lines (HCT-8) and patients tissues down-regulated resistant NA PI3K/Akt signaling pathway validated NA mRNA and protein low expression related 1535 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ABCC3 ENSG00000108846 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1536 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 AKAP12 ENSG00000131016 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1537 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANPEP ENSG00000166825 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1538 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANTXR1 ENSG00000169604 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1539 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 BTG2 ENSG00000159388 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1540 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAPN2 ENSG00000162909 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1541 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAV2 ENSG00000105971 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1542 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CLIP4 ENSG00000115295 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1543 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CRLF1 ENSG00000006016 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1544 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CYBRD1 ENSG00000071967 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1545 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 DKK3 ENSG00000050165 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1546 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 MELTF ENSG00000163975 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1547 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PHF10 ENSG00000130024 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1548 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PSAT1 ENSG00000135069 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1549 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PVR ENSG00000073008 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1550 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TRHDE ENSG00000072657 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1551 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TUSC3 ENSG00000104723 breast cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1552 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ABCC3 ENSG00000108846 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1553 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 AKAP12 ENSG00000131016 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1554 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANPEP ENSG00000166825 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1555 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 ANTXR1 ENSG00000169604 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1556 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 BTG2 ENSG00000159388 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1557 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAPN2 ENSG00000162909 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1558 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CAV2 ENSG00000105971 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1559 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CLIP4 ENSG00000115295 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1560 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CRLF1 ENSG00000006016 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1561 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 CYBRD1 ENSG00000071967 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1562 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 DKK3 ENSG00000050165 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1563 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 MELTF ENSG00000163975 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1564 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PHF10 ENSG00000130024 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) down-regulated resistant NA NA validated NA DNA methylation dysregulation related 1565 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PSAT1 ENSG00000135069 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1566 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 PVR ENSG00000073008 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1567 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TRHDE ENSG00000072657 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1568 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer Sci Rep 2016 27094684 TUSC3 ENSG00000104723 breast cancer Paclitaxel DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281) RNA sequencing The relationship between the drug sensitivity and the mRNA expression was detected by the RNA sequencing technology,bioinformatics database analysis. cell lines (MCF-7, TNBC ) up-regulated resistant NA NA validated NA DNA methylation dysregulation related 1569 Functional role of BTB and CNC Homology 1 gene in pancreatic cancer and its association with survival in patients treated with gemcitabine Theranostics 2018 29930735 BACH1 ENSG00000156273 pancreatic cancer Gemcitabine DB00441 (APRD00201) RT-PCR BACH1 expression was measured by quantitative real-time PCR, Western blot and immunohistochemistry. The effects of_ACH1in cell proliferation and sensitivity to gemcitabine were examined by alteration of_ACH1_xpression in PDAC cells. Angiogenesis was determined in vitro using a human umbilical vein endothelial cell model. Reporter gene assays were conducted to compare the effects of microRNA-1257 on rs372883 variation. The associations between rs372883 variants and survival time in patients treated with gemcitabine were estimated by logistic regression. cell lines (CFPAC-1, BXPC-3, Capan-2, HUVEC, 293T ) down-regulated resistant NA AKT and ERK signaling pathway validated mutation (rs372883T) NA related 1570 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 KEAP1 ENSG00000079999 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1571 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 CAAP1 ENSG00000120159 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1572 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCB1 ENSG00000099956 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1573 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCE1 ENSG00000073584 cancer Doxorubicin DB00997 (APRD00185, DB05331, DB05847) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1574 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 KEAP1 ENSG00000079999 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1575 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 CAAP1 ENSG00000120159 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1576 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCB1 ENSG00000099956 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1577 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Res 2015 26260527 SMARCE1 ENSG00000073584 cancer Etoposide DB00773 (APRD00239) RT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the RT-PCR,bioinformatics database analysis,siRNA transfections experiments,long-term proliferation assays,short-term growth inhibition assays,coimmunoprecipitation and western blotting analysis,chromatin association assay,confocal microscopy. cell lines (HAP1, MelJuSo, SKBR7, HCC1937) down-regulated resistant NA DNA double-strand break (DSB) and repair pathway validated NA mRNA and protein low expression related 1578 Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity Cancer Res 2014 24240700 CDK12 ENSG00000167258 ovarian_ancer Olaparib DB09074 (DB05940) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,immunohistochemistry,survival analysis,HR assay,shRNA screen. cell lines (PEO1, PEO14, OV56, COV318, COV504, SKOV3) Down-regulated sensitive NA NA validated NA mRNA and protein low expression related 1579 GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer Nature 2009 19553991 GOLPH3 ENSG00000113384 cancer Sirolimus DB00877 (APRD00178, DB02439) qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,FISH analyses,RNAi experiments,western blotting analysis,biotinformatics technology. cell lines up-regulated sensitive NA MTOR signaling pathway validated amplification (5p13 ) NA related 1580 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 PSAP ENSG00000197746 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1581 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 MCM2 ENSG00000073111 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1582 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BSG ENSG00000172270 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1583 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TM4SF1 ENSG00000169908 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1584 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TOP1 ENSG00000198900 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1585 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 HMGB1 ENSG00000189403 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1586 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RPS27L ENSG00000185088 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1587 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RSU1 ENSG00000148484 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1588 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 SP3 ENSG00000172845 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1589 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TMF1 ENSG00000144747 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1590 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TIAL1 ENSG00000151923 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1591 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 PLSCR3 ENSG00000187838 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1592 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 CDKN1A ENSG00000124762 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1593 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BAX ENSG00000087088 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1594 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TIMP2 ENSG00000035862 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1595 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RAD1 ENSG00000113456 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1596 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TPD52L1 ENSG00000111907 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1597 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TBX3 ENSG00000135111 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1598 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BTG2 ENSG00000159388 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1599 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 FUT8 ENSG00000033170 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1600 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 VSNL1 ENSG00000163032 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1601 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 BATF ENSG00000156127 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1602 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 WWOX ENSG00000186153 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1603 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 CDC14B ENSG00000081377 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1604 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 TP53INP1 ENSG00000164938 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1605 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 FILIP1L ENSG00000168386 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1606 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 ESRP1 ENSG00000104413 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1607 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 RAB25 ENSG00000132698 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1608 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 SPINT2 ENSG00000167642 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related 1609 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 ABCG2 ENSG00000118777 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1610 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 HSPA2 ENSG00000126803 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1611 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 PDZK1IP1 ENSG00000162366 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) up-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein overexpression related 1612 Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells Acta Pharmacol Sin 2011 21293479 ENC1 ENSG00000171617 gastric cancer 10-hydroxycamptothecin DB12385 qRT-PCR The relationship between the drug sensitivity and the mRNA expression was detected by the qRT-PCR,SRB assay,whole genome gene expression microarray,gene ontology and pathway analysis. cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87 and AGS) down-regulated resistant NA irinotecan pathway and the IL-3 pathway validated NA mRNA and protein low expression related